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avrg: GFI1 WT vs 36n/n vs KD

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Results for Cdx2

Z-value: 0.81

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Transcription factors associated with Cdx2

Gene Symbol Gene ID Gene Info
Cdx2
ENSMUSG00000029646.4 caudal type homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cdx2mm39_v1_chr5_-_147244074_1472440910.997.6e-04Click!

Activity profile of Cdx2 motif

Sorted Z-values of Cdx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_23765546 1.82 ENSMUST00000102968.3
H4c4
H4 clustered histone 4
chr13_+_23728222 1.22 ENSMUST00000075558.5
H3c7
H3 clustered histone 7
chr13_-_24118139 1.21 ENSMUST00000052776.4
H2bc1
H2B clustered histone 1
chr13_-_22219738 0.79 ENSMUST00000091742.6
H2ac12
H2A clustered histone 12
chr2_-_59778560 0.38 ENSMUST00000153136.2
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr19_+_8828132 0.35 ENSMUST00000235683.2
ENSMUST00000096257.3
Lrrn4cl
LRRN4 C-terminal like
chr15_+_3300249 0.34 ENSMUST00000082424.12
ENSMUST00000159158.9
ENSMUST00000159216.10
ENSMUST00000160311.3
Selenop
selenoprotein P
chr14_-_54923517 0.28 ENSMUST00000125265.2
Acin1
apoptotic chromatin condensation inducer 1
chr8_-_5155347 0.27 ENSMUST00000023835.3
Slc10a2
solute carrier family 10, member 2
chr14_+_80237691 0.25 ENSMUST00000228749.2
ENSMUST00000088735.4
Olfm4
olfactomedin 4
chr15_-_50746202 0.24 ENSMUST00000184885.8
Trps1
transcriptional repressor GATA binding 1
chr6_-_52190299 0.24 ENSMUST00000128102.4
Gm28308
predicted gene 28308
chr19_-_34856853 0.20 ENSMUST00000036584.13
Pank1
pantothenate kinase 1
chr2_-_51039112 0.14 ENSMUST00000154545.2
ENSMUST00000017288.9
Rnd3
Rho family GTPase 3
chrX_+_72818003 0.14 ENSMUST00000002081.6
Srpk3
serine/arginine-rich protein specific kinase 3
chr1_-_186438177 0.10 ENSMUST00000045288.14
Tgfb2
transforming growth factor, beta 2
chr8_+_95113066 0.09 ENSMUST00000161576.8
ENSMUST00000034220.8
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr10_-_33920300 0.09 ENSMUST00000048052.7
Calhm4
calcium homeostasis modulator family member 4
chr11_-_99134885 0.07 ENSMUST00000103132.10
ENSMUST00000038214.7
Krt222
keratin 222
chr12_+_113038098 0.07 ENSMUST00000012355.14
ENSMUST00000146107.8
Tex22
testis expressed gene 22
chr6_-_122317484 0.06 ENSMUST00000112600.9
Phc1
polyhomeotic 1
chr9_+_95519654 0.06 ENSMUST00000015498.9
Pcolce2
procollagen C-endopeptidase enhancer 2
chr6_+_17491231 0.05 ENSMUST00000080469.12
Met
met proto-oncogene
chr11_-_79394904 0.04 ENSMUST00000164465.3
Omg
oligodendrocyte myelin glycoprotein
chr18_-_79152504 0.04 ENSMUST00000025430.11
Setbp1
SET binding protein 1
chr8_-_34333573 0.04 ENSMUST00000183062.2
Rbpms
RNA binding protein gene with multiple splicing
chr18_-_35841435 0.04 ENSMUST00000236738.2
ENSMUST00000237995.2
Dnajc18
DnaJ heat shock protein family (Hsp40) member C18
chr1_-_179572765 0.04 ENSMUST00000211943.3
ENSMUST00000131716.4
ENSMUST00000221136.2
Kif28
kinesin family member 28
chr13_-_63712140 0.03 ENSMUST00000195756.6
Ptch1
patched 1
chr2_-_25982160 0.03 ENSMUST00000114159.9
Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr3_+_13536696 0.03 ENSMUST00000191806.3
ENSMUST00000193117.3
Ralyl
RALY RNA binding protein-like
chr4_-_109059414 0.03 ENSMUST00000160774.8
ENSMUST00000194478.6
ENSMUST00000030288.14
ENSMUST00000162787.9
Osbpl9
oxysterol binding protein-like 9
chr9_-_15023396 0.03 ENSMUST00000159985.2
Hephl1
hephaestin-like 1
chr5_+_13448833 0.02 ENSMUST00000137798.10
Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr6_-_71239216 0.02 ENSMUST00000129630.3
ENSMUST00000114186.9
ENSMUST00000074301.10
Smyd1
SET and MYND domain containing 1
chrX_+_138585728 0.02 ENSMUST00000096313.4
Tbc1d8b
TBC1 domain family, member 8B
chr18_+_65715460 0.02 ENSMUST00000169679.8
ENSMUST00000183326.2
Zfp532
zinc finger protein 532
chr18_+_65715156 0.02 ENSMUST00000237553.2
ENSMUST00000237712.2
ENSMUST00000182684.8
Zfp532
zinc finger protein 532
chr3_+_126390951 0.02 ENSMUST00000171289.8
Camk2d
calcium/calmodulin-dependent protein kinase II, delta
chr17_-_90395771 0.02 ENSMUST00000197268.5
ENSMUST00000173917.8
Nrxn1
neurexin I
chr10_-_33920289 0.02 ENSMUST00000218239.2
Calhm4
calcium homeostasis modulator family member 4
chr14_+_54923655 0.01 ENSMUST00000038539.8
ENSMUST00000228027.2
1700123O20Rik
RIKEN cDNA 1700123O20 gene
chr5_+_128677863 0.01 ENSMUST00000117102.4
Fzd10
frizzled class receptor 10
chr2_+_74552322 0.01 ENSMUST00000047904.4
Hoxd4
homeobox D4
chr10_+_118040729 0.01 ENSMUST00000096691.5
Il22
interleukin 22
chr2_+_142920386 0.01 ENSMUST00000028902.3
Otor
otoraplin
chrX_-_50294867 0.01 ENSMUST00000114876.9
Mbnl3
muscleblind like splicing factor 3
chr11_-_99328969 0.01 ENSMUST00000017743.3
Krt20
keratin 20
chrX_+_21581135 0.01 ENSMUST00000033414.8
Slc6a14
solute carrier family 6 (neurotransmitter transporter), member 14
chr1_-_186437760 0.01 ENSMUST00000195201.2
Tgfb2
transforming growth factor, beta 2
chr5_+_67055753 0.01 ENSMUST00000122812.5
ENSMUST00000117601.8
Limch1
LIM and calponin homology domains 1
chr15_+_23036535 0.01 ENSMUST00000164787.8
Cdh18
cadherin 18
chr9_-_65330231 0.01 ENSMUST00000065894.7
Slc51b
solute carrier family 51, beta subunit
chr15_-_101441254 0.01 ENSMUST00000023720.8
Krt84
keratin 84
chr3_+_3699205 0.00 ENSMUST00000108394.3
Hnf4g
hepatocyte nuclear factor 4, gamma
chr6_+_42263609 0.00 ENSMUST00000238845.2
ENSMUST00000031894.13
Clcn1
chloride channel, voltage-sensitive 1
chr3_+_93052089 0.00 ENSMUST00000107300.7
ENSMUST00000195515.2
Crnn
cornulin
chr8_+_55003359 0.00 ENSMUST00000033918.4
Asb5
ankyrin repeat and SOCs box-containing 5
chr18_+_65715351 0.00 ENSMUST00000235669.2
ENSMUST00000183319.8
ENSMUST00000236523.2
ENSMUST00000237886.2
Zfp532
zinc finger protein 532
chr11_-_99433984 0.00 ENSMUST00000107443.8
ENSMUST00000074253.4
Krt40
keratin 40
chr18_+_44249254 0.00 ENSMUST00000212114.2
Gm37797
predicted gene, 37797
chr19_-_47680528 0.00 ENSMUST00000026045.14
ENSMUST00000086923.6
Col17a1
collagen, type XVII, alpha 1
chr10_+_129357661 0.00 ENSMUST00000217228.2
Olfr791
olfactory receptor 791
chr3_+_126391046 0.00 ENSMUST00000106401.8
Camk2d
calcium/calmodulin-dependent protein kinase II, delta
chr17_-_31348576 0.00 ENSMUST00000024827.5
Tff3
trefoil factor 3, intestinal

Network of associatons between targets according to the STRING database.

First level regulatory network of Cdx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.3 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.1 GO:1905006 positive regulation of activation-induced cell death of T cells(GO:0070237) negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905006)
0.0 0.1 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.0 GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter(GO:1900477)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0061574 ASAP complex(GO:0061574)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.3 GO:0042581 specific granule(GO:0042581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism