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avrg: GFI1 WT vs 36n/n vs KD

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Results for E2f7

Z-value: 3.16

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Transcription factors associated with E2f7

Gene Symbol Gene ID Gene Info
E2f7
ENSMUSG00000020185.17 E2F transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f7mm39_v1_chr10_+_110581293_1105814330.523.7e-01Click!

Activity profile of E2f7 motif

Sorted Z-values of E2f7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_21938258 9.08 ENSMUST00000091709.3
H2bc15
H2B clustered histone 15
chr13_-_21937997 7.99 ENSMUST00000074752.4
H2ac15
H2A clustered histone 15
chr13_+_22017906 7.02 ENSMUST00000180288.2
H2bc24
H2B clustered histone 24
chr13_+_22220000 6.96 ENSMUST00000110455.4
H2bc12
H2B clustered histone 12
chr13_-_23758370 6.92 ENSMUST00000105106.2
H2bc7
H2B clustered histone 7
chr13_+_22227359 6.67 ENSMUST00000110452.2
H2bc11
H2B clustered histone 11
chr13_-_21967540 6.12 ENSMUST00000189457.2
H3c11
H3 clustered histone 11
chr13_-_22219738 4.75 ENSMUST00000091742.6
H2ac12
H2A clustered histone 12
chr13_-_21900313 4.72 ENSMUST00000091756.2
H2bc13
H2B clustered histone 13
chr13_-_21994366 4.70 ENSMUST00000091749.4
H2bc23
H2B clustered histone 23
chr13_-_21934675 4.50 ENSMUST00000102983.2
H4c12
H4 clustered histone 12
chr9_+_3013140 4.10 ENSMUST00000143083.3
Gm10721
predicted gene 10721
chr9_+_3025417 3.45 ENSMUST00000075573.7
Gm10717
predicted gene 10717
chr13_-_22017677 3.37 ENSMUST00000081342.7
H2ac24
H2A clustered histone 24
chr13_-_22227114 3.26 ENSMUST00000091741.6
H2ac11
H2A clustered histone 11
chr9_+_3017408 3.13 ENSMUST00000099049.4
Gm10719
predicted gene 10719
chr13_+_21994588 2.94 ENSMUST00000091745.6
H2ac23
H2A clustered histone 23
chr13_+_21900554 2.87 ENSMUST00000070124.5
H2ac13
H2A clustered histone 13
chr9_+_3037111 2.12 ENSMUST00000177969.2
Gm10715
predicted gene 10715
chr13_+_23758555 2.11 ENSMUST00000090776.7
H2ac7
H2A clustered histone 7
chr9_+_3015654 2.04 ENSMUST00000099050.4
Gm10720
predicted gene 10720
chrX_-_73009933 1.32 ENSMUST00000114372.3
ENSMUST00000033761.13
Hcfc1
host cell factor C1
chr7_-_25454177 1.25 ENSMUST00000206832.2
Hnrnpul1
heterogeneous nuclear ribonucleoprotein U-like 1
chr15_-_58953838 1.25 ENSMUST00000080371.8
Mtss1
MTSS I-BAR domain containing 1
chr7_-_98305737 1.23 ENSMUST00000205911.2
ENSMUST00000038359.6
ENSMUST00000206611.2
ENSMUST00000206619.2
Emsy
EMSY, BRCA2-interacting transcriptional repressor
chr12_-_44257109 1.19 ENSMUST00000015049.5
Dnajb9
DnaJ heat shock protein family (Hsp40) member B9
chr7_+_3648264 1.04 ENSMUST00000206287.2
ENSMUST00000038913.16
Cnot3
CCR4-NOT transcription complex, subunit 3
chr2_+_27776428 0.96 ENSMUST00000028280.14
Col5a1
collagen, type V, alpha 1
chr7_+_44465714 0.96 ENSMUST00000208172.2
Nup62
nucleoporin 62
chr7_-_25454126 0.94 ENSMUST00000108401.3
ENSMUST00000043765.14
Hnrnpul1
heterogeneous nuclear ribonucleoprotein U-like 1
chr9_-_121106209 0.90 ENSMUST00000051479.13
ENSMUST00000171923.8
Ulk4
unc-51-like kinase 4
chr14_-_54491365 0.90 ENSMUST00000128231.2
Dad1
defender against cell death 1
chr7_-_98305986 0.88 ENSMUST00000205276.2
Emsy
EMSY, BRCA2-interacting transcriptional repressor
chr1_-_74544946 0.81 ENSMUST00000044260.11
ENSMUST00000186282.7
Usp37
ubiquitin specific peptidase 37
chr12_+_11316101 0.73 ENSMUST00000218866.2
Smc6
structural maintenance of chromosomes 6
chr7_-_28297565 0.72 ENSMUST00000040531.9
ENSMUST00000108283.8
Samd4b
Pak4
sterile alpha motif domain containing 4B
p21 (RAC1) activated kinase 4
chr11_+_69214789 0.69 ENSMUST00000102602.8
Trappc1
trafficking protein particle complex 1
chr11_+_98441923 0.66 ENSMUST00000081033.13
ENSMUST00000107511.8
ENSMUST00000107509.8
ENSMUST00000017339.12
Zpbp2
zona pellucida binding protein 2
chr11_+_69214971 0.61 ENSMUST00000108662.2
Trappc1
trafficking protein particle complex 1
chr10_-_125225298 0.60 ENSMUST00000210780.2
Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chrX_+_93278588 0.60 ENSMUST00000096369.10
ENSMUST00000113911.9
Klhl15
kelch-like 15
chr15_+_82183143 0.55 ENSMUST00000023089.5
Wbp2nl
WBP2 N-terminal like
chr6_-_30509737 0.51 ENSMUST00000154547.3
ENSMUST00000115160.10
Tmem209
transmembrane protein 209
chr11_+_69214883 0.51 ENSMUST00000102601.10
Trappc1
trafficking protein particle complex 1
chr13_-_97334859 0.49 ENSMUST00000022169.10
Hexb
hexosaminidase B
chr9_-_87137515 0.46 ENSMUST00000093802.6
Cep162
centrosomal protein 162
chrX_+_67722230 0.43 ENSMUST00000114656.8
Fmr1
FMRP translational regulator 1
chr1_+_88034556 0.43 ENSMUST00000113137.2
Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr15_-_97991114 0.42 ENSMUST00000180657.2
Senp1
SUMO1/sentrin specific peptidase 1
chr11_+_69214895 0.42 ENSMUST00000060956.13
Trappc1
trafficking protein particle complex 1
chrX_+_93278526 0.41 ENSMUST00000113908.8
ENSMUST00000113916.10
Klhl15
kelch-like 15
chr1_+_172348611 0.38 ENSMUST00000085894.12
ENSMUST00000161140.8
ENSMUST00000162988.8
Cfap45
cilia and flagella associated protein 45
chr12_+_73333553 0.37 ENSMUST00000140523.8
ENSMUST00000126488.8
Slc38a6
solute carrier family 38, member 6
chr17_-_35265514 0.36 ENSMUST00000007250.14
Msh5
mutS homolog 5
chr14_-_66071337 0.34 ENSMUST00000225853.2
Esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr3_+_88049633 0.31 ENSMUST00000001455.13
ENSMUST00000119251.8
Mef2d
myocyte enhancer factor 2D
chr3_+_60408678 0.31 ENSMUST00000191747.6
ENSMUST00000194069.6
Mbnl1
muscleblind like splicing factor 1
chr4_+_126450762 0.31 ENSMUST00000147675.2
Clspn
claspin
chr3_+_103187162 0.29 ENSMUST00000106860.6
Trim33
tripartite motif-containing 33
chr1_-_88629843 0.27 ENSMUST00000159814.2
Arl4c
ADP-ribosylation factor-like 4C
chr6_+_113054592 0.27 ENSMUST00000113157.8
Setd5
SET domain containing 5
chr17_-_35340966 0.25 ENSMUST00000173915.3
ENSMUST00000172765.9
Csnk2b
casein kinase 2, beta polypeptide
chr6_-_52160816 0.24 ENSMUST00000134831.2
Hoxa3
homeobox A3
chr7_+_44465806 0.23 ENSMUST00000207103.2
ENSMUST00000118125.9
Nup62
Il4i1
nucleoporin 62
interleukin 4 induced 1
chr13_-_47259652 0.19 ENSMUST00000021807.13
ENSMUST00000135278.8
Dek
DEK proto-oncogene (DNA binding)
chr6_-_30509705 0.18 ENSMUST00000064330.13
ENSMUST00000102991.9
ENSMUST00000115157.8
ENSMUST00000148638.2
Tmem209
transmembrane protein 209
chr3_+_88439616 0.15 ENSMUST00000172699.2
Mex3a
mex3 RNA binding family member A
chr8_+_26008773 0.14 ENSMUST00000084027.13
ENSMUST00000178276.8
ENSMUST00000179592.8
Fgfr1
fibroblast growth factor receptor 1
chr2_-_35994072 0.12 ENSMUST00000112961.10
ENSMUST00000112966.10
Lhx6
LIM homeobox protein 6
chr17_-_35069136 0.12 ENSMUST00000046022.16
Skiv2l
superkiller viralicidic activity 2-like (S. cerevisiae)
chr10_+_67374366 0.12 ENSMUST00000127820.2
Egr2
early growth response 2
chr1_+_153300874 0.09 ENSMUST00000042373.12
Shcbp1l
Shc SH2-domain binding protein 1-like
chr1_-_190915441 0.09 ENSMUST00000027941.14
Atf3
activating transcription factor 3
chr6_+_30509826 0.08 ENSMUST00000031797.11
Ssmem1
serine-rich single-pass membrane protein 1
chr19_-_41195213 0.08 ENSMUST00000169941.2
ENSMUST00000025986.15
Tll2
tolloid-like 2
chr14_-_17398733 0.07 ENSMUST00000163719.8
Gm8281
predicted gene, 8281
chrX_+_6690410 0.07 ENSMUST00000145302.3
Dgkk
diacylglycerol kinase kappa
chr16_+_76810588 0.07 ENSMUST00000239066.2
ENSMUST00000023580.8
Usp25
ubiquitin specific peptidase 25
chr2_-_65194344 0.06 ENSMUST00000155962.3
ENSMUST00000112420.8
ENSMUST00000152324.8
Slc38a11
solute carrier family 38, member 11
chr4_+_129000600 0.05 ENSMUST00000148979.2
Tmem54
transmembrane protein 54
chr11_+_85202058 0.04 ENSMUST00000020835.16
Ppm1d
protein phosphatase 1D magnesium-dependent, delta isoform
chr12_+_11506053 0.04 ENSMUST00000124065.2
Rad51ap2
RAD51 associated protein 2
chr4_+_94627755 0.04 ENSMUST00000071168.6
Tek
TEK receptor tyrosine kinase
chr9_+_46194293 0.04 ENSMUST00000074957.5
Bud13
BUD13 homolog
chr14_-_18287197 0.04 ENSMUST00000164512.8
Gm2974
predicted gene 2974
chr4_+_33062999 0.04 ENSMUST00000108162.8
ENSMUST00000024035.9
Gabrr2
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
chr2_+_23211258 0.04 ENSMUST00000102945.2
Nxph2
neurexophilin 2
chr4_+_119280002 0.04 ENSMUST00000094819.5
Zmynd12
zinc finger, MYND domain containing 12
chr14_-_17742998 0.03 ENSMUST00000165619.8
Gm3252
predicted gene 3252
chr14_-_18897750 0.03 ENSMUST00000178728.2
Gm3005
predicted gene 3005
chr4_-_44703413 0.03 ENSMUST00000186542.2
Pax5
paired box 5
chr1_-_135095344 0.02 ENSMUST00000027682.9
Gpr37l1
G protein-coupled receptor 37-like 1
chr14_-_18359247 0.02 ENSMUST00000170207.8
Gm8108
predicted gene 8108
chr14_+_15579811 0.02 ENSMUST00000171906.2
Gm3667
predicted gene 3667
chr14_+_15295240 0.02 ENSMUST00000172431.8
Gm3512
predicted gene 3512
chr14_-_17614197 0.02 ENSMUST00000166776.8
Gm3264
predicted gene 3264
chr14_+_15442324 0.02 ENSMUST00000170738.3
Gm10406
predicted gene 10406
chr2_+_172392678 0.02 ENSMUST00000099058.10
Tfap2c
transcription factor AP-2, gamma
chr19_-_11806388 0.02 ENSMUST00000061235.3
Olfr1417
olfactory receptor 1417
chr19_+_16110176 0.02 ENSMUST00000025541.6
Gnaq
guanine nucleotide binding protein, alpha q polypeptide
chr8_+_26008799 0.02 ENSMUST00000119398.10
ENSMUST00000117179.9
Fgfr1
fibroblast growth factor receptor 1
chrX_+_73637934 0.02 ENSMUST00000054541.3
Olfr1325
olfactory receptor 1325
chr14_-_18659699 0.01 ENSMUST00000170480.8
Gm3002
predicted gene 3002
chr13_-_55477535 0.01 ENSMUST00000021941.8
Mxd3
Max dimerization protein 3
chr11_-_106192627 0.01 ENSMUST00000103071.4
Gh
growth hormone
chr11_+_49039086 0.01 ENSMUST00000059379.2
Olfr1395
olfactory receptor 1395
chr12_+_11315868 0.01 ENSMUST00000020931.6
Smc6
structural maintenance of chromosomes 6
chr16_-_37205302 0.00 ENSMUST00000114781.8
ENSMUST00000114780.8
Stxbp5l
syntaxin binding protein 5-like

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0019046 release from viral latency(GO:0019046)
0.2 1.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 0.7 GO:0098749 cerebellar neuron development(GO:0098749)
0.2 1.3 GO:0034334 adherens junction maintenance(GO:0034334)
0.2 1.2 GO:1903436 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.1 0.4 GO:0099547 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
0.1 1.0 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 0.6 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.1 0.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.5 GO:0006689 ganglioside catabolic process(GO:0006689) penetration of zona pellucida(GO:0007341) oligosaccharide catabolic process(GO:0009313)
0.1 0.8 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 0.2 GO:1903465 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.0 0.9 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.2 GO:0021615 specification of organ position(GO:0010159) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0021666 rhombomere formation(GO:0021594) rhombomere 3 formation(GO:0021660) rhombomere 5 morphogenesis(GO:0021664) rhombomere 5 formation(GO:0021666)
0.0 0.4 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.7 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.5 GO:0007343 egg activation(GO:0007343)
0.0 1.1 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.2 GO:0044838 cell quiescence(GO:0044838)
0.0 0.7 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.0 0.1 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 0.1 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.3 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0005588 collagen type V trimer(GO:0005588)
0.2 0.7 GO:0035061 interchromatin granule(GO:0035061)
0.1 1.2 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.5 GO:0005879 axonemal microtubule(GO:0005879)
0.1 0.4 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.1 2.2 GO:0030008 TRAPP complex(GO:0030008)
0.1 1.0 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 0.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 0.5 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0051425 PTB domain binding(GO:0051425)
0.1 1.3 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 0.4 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.5 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.9 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 1.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.4 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 1.2 GO:0051787 misfolded protein binding(GO:0051787)
0.0 2.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 1.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.3 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.2 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions