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avrg: GFI1 WT vs 36n/n vs KD
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Results for E2f7
Z-value: 3.16
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Transcription factors associated with E2f7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f7 | mm39_v1_chr10_+_110581293_110581433 | 0.52 | 3.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_21938258 Show fit | 9.08 |
ENSMUST00000091709.3
|
H2B clustered histone 15 |
|
| chr13_-_21937997 Show fit | 7.99 |
ENSMUST00000074752.4
|
H2A clustered histone 15 |
|
| chr13_+_22017906 Show fit | 7.02 |
ENSMUST00000180288.2
|
H2B clustered histone 24 |
|
| chr13_+_22220000 Show fit | 6.96 |
ENSMUST00000110455.4
|
H2B clustered histone 12 |
|
| chr13_-_23758370 Show fit | 6.92 |
ENSMUST00000105106.2
|
H2B clustered histone 7 |
|
| chr13_+_22227359 Show fit | 6.67 |
ENSMUST00000110452.2
|
H2B clustered histone 11 |
|
| chr13_-_21967540 Show fit | 6.12 |
ENSMUST00000189457.2
|
H3 clustered histone 11 |
|
| chr13_-_22219738 Show fit | 4.75 |
ENSMUST00000091742.6
|
H2A clustered histone 12 |
|
| chr13_-_21900313 Show fit | 4.72 |
ENSMUST00000091756.2
|
H2B clustered histone 13 |
|
| chr13_-_21994366 Show fit | 4.70 |
ENSMUST00000091749.4
|
H2B clustered histone 23 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.2 | 1.3 | GO:0034334 | adherens junction maintenance(GO:0034334) |
| 0.2 | 1.2 | GO:1903436 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
| 0.0 | 1.1 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.2 | 1.0 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 1.0 | GO:0071630 | nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630) |
| 0.0 | 0.9 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.1 | 0.8 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.2 | 0.7 | GO:0098749 | cerebellar neuron development(GO:0098749) |
| 0.0 | 0.7 | GO:0001675 | acrosome assembly(GO:0001675) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.1 | 1.3 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.1 | 1.2 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.3 | 1.0 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.1 | 1.0 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.1 | 0.9 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.2 | 0.7 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.1 | 0.5 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.0 | 0.5 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.1 | 0.4 | GO:1902737 | viral replication complex(GO:0019034) dendritic filopodium(GO:1902737) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 1.3 | GO:0043996 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.0 | 1.3 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 1.2 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.0 | 1.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 1.0 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 0.9 | GO:0004579 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 0.7 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 0.6 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.1 | 0.5 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 1.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.0 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.7 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.6 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.5 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |