Project

avrg: GFI1 WT vs 36n/n vs KD

Navigation
Downloads

Results for E2f8

Z-value: 2.61

Motif logo

Transcription factors associated with E2f8

Gene Symbol Gene ID Gene Info
ENSMUSG00000046179.18 E2F transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f8mm39_v1_chr7_-_48531344_48531367-0.875.6e-02Click!

Activity profile of E2f8 motif

Sorted Z-values of E2f8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_75836187 2.82 ENSMUST00000164309.3
ENSMUST00000212426.2
ENSMUST00000212811.2
minichromosome maintenance complex component 5
chr12_+_24758968 2.37 ENSMUST00000154588.2
ribonucleotide reductase M2
chr12_+_24758724 2.37 ENSMUST00000153058.8
ribonucleotide reductase M2
chr1_-_128287347 2.35 ENSMUST00000190495.2
ENSMUST00000027601.11
minichromosome maintenance complex component 6
chr2_+_162896602 2.26 ENSMUST00000018005.10
myeloblastosis oncogene-like 2
chr3_-_90603013 1.62 ENSMUST00000069960.12
ENSMUST00000117167.2
S100 calcium binding protein A9 (calgranulin B)
chr15_+_97990431 1.61 ENSMUST00000229280.2
ENSMUST00000163507.8
ENSMUST00000230445.2
phosphofructokinase, muscle
chr12_-_55045887 1.54 ENSMUST00000173529.2
bromodomain adjacent to zinc finger domain 1A
chr11_+_87938626 1.49 ENSMUST00000107920.10
serine and arginine-rich splicing factor 1
chr4_+_132495636 1.42 ENSMUST00000102561.11
replication protein A2
chr11_-_101676076 1.39 ENSMUST00000164750.8
ENSMUST00000107176.8
ENSMUST00000017868.7
ets variant 4
chr7_+_101714943 1.29 ENSMUST00000094130.4
ENSMUST00000084843.10
Xrcc1 N-terminal domain containing 1
Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough
chr17_+_56610321 1.25 ENSMUST00000001258.15
ubiquitin-like, containing PHD and RING finger domains, 1
chr9_-_36637670 1.25 ENSMUST00000172702.9
ENSMUST00000172742.2
checkpoint kinase 1
chr7_-_44198157 1.19 ENSMUST00000145956.2
ENSMUST00000049343.15
polymerase (DNA directed), delta 1, catalytic subunit
chr11_+_79883885 1.16 ENSMUST00000163272.2
ENSMUST00000017692.15
SUZ12 polycomb repressive complex 2 subunit
chr6_+_125016723 1.16 ENSMUST00000140131.8
ENSMUST00000032480.14
inhibitor of growth family, member 4
chr12_+_55883101 1.15 ENSMUST00000059250.8
breast cancer metastasis-suppressor 1-like
chr11_+_87938128 1.11 ENSMUST00000139129.9
serine and arginine-rich splicing factor 1
chr9_-_36637923 1.08 ENSMUST00000034625.12
checkpoint kinase 1
chr17_+_56610396 1.07 ENSMUST00000113038.8
ubiquitin-like, containing PHD and RING finger domains, 1
chr9_-_50571080 1.04 ENSMUST00000034567.4
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
chr2_-_34803988 1.03 ENSMUST00000028232.7
ENSMUST00000202907.2
PHD finger protein 19
chr11_+_87938519 1.03 ENSMUST00000079866.11
serine and arginine-rich splicing factor 1
chr6_-_88875646 1.01 ENSMUST00000058011.8
minichromosome maintenance complex component 2
chr15_-_55421144 0.93 ENSMUST00000172387.8
mitochondrial ribosomal protein L13
chr7_+_101714692 0.89 ENSMUST00000106950.8
ENSMUST00000146450.8
Xrcc1 N-terminal domain containing 1
chr17_+_56347424 0.88 ENSMUST00000002914.10
chromatin assembly factor 1, subunit A (p150)
chr6_+_35154319 0.83 ENSMUST00000201374.4
ENSMUST00000043815.16
nucleoporin 205
chr5_+_123887759 0.83 ENSMUST00000031366.12
kinetochore associated 1
chr10_+_127851031 0.82 ENSMUST00000178041.8
ENSMUST00000026461.8
DNA primase, p49 subunit
chr17_+_34129221 0.81 ENSMUST00000174541.9
Fas death domain-associated protein
chr17_+_88282472 0.77 ENSMUST00000005503.5
mutS homolog 6
chr15_+_101071948 0.77 ENSMUST00000000544.12
activin A receptor, type 1B
chr2_-_157046386 0.71 ENSMUST00000029170.8
RB transcriptional corepressor like 1
chr5_-_137785903 0.68 ENSMUST00000196022.2
methylphosphate capping enzyme
chr19_+_38919353 0.67 ENSMUST00000025965.12
helicase, lymphoid specific
chr4_+_135583018 0.62 ENSMUST00000105853.10
ENSMUST00000097844.9
ENSMUST00000102544.9
ENSMUST00000126641.2
serine and arginine-rich splicing factor 10
chr11_-_21521934 0.61 ENSMUST00000239073.2
malate dehydrogenase 1, NAD (soluble)
chr11_-_21522193 0.59 ENSMUST00000102874.11
ENSMUST00000238916.2
malate dehydrogenase 1, NAD (soluble)
chr7_+_109721230 0.58 ENSMUST00000033326.10
WEE 1 homolog 1 (S. pombe)
chr6_+_117894242 0.58 ENSMUST00000180020.8
ENSMUST00000177570.2
heterogeneous nuclear ribonucleoprotein F
chr15_+_55420950 0.57 ENSMUST00000170046.8
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr11_+_26337194 0.52 ENSMUST00000136830.2
ENSMUST00000109509.8
Fanconi anemia, complementation group L
chr3_+_32583602 0.50 ENSMUST00000091257.11
mitofusin 1
chr2_-_91067212 0.49 ENSMUST00000111352.8
damage specific DNA binding protein 2
chr6_-_87827993 0.46 ENSMUST00000204890.3
ENSMUST00000113617.3
ENSMUST00000113619.8
ENSMUST00000204653.3
ENSMUST00000032138.15
cellular nucleic acid binding protein
chr9_-_35028100 0.45 ENSMUST00000034537.8
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr1_-_93729650 0.45 ENSMUST00000027503.14
deoxythymidylate kinase
chr5_-_33809640 0.45 ENSMUST00000151081.2
ENSMUST00000139518.8
ENSMUST00000101354.10
stem-loop binding protein
chr5_-_33809872 0.44 ENSMUST00000057551.14
stem-loop binding protein
chr10_-_21036792 0.44 ENSMUST00000188495.8
myeloblastosis oncogene
chr17_+_34128455 0.43 ENSMUST00000173626.8
ENSMUST00000170075.9
Fas death domain-associated protein
chr8_+_57964956 0.42 ENSMUST00000210871.2
high mobility group box 2
chr6_+_117893942 0.41 ENSMUST00000179478.8
heterogeneous nuclear ribonucleoprotein F
chr7_-_128342158 0.39 ENSMUST00000119081.2
ENSMUST00000057557.14
minichromosome maintenance complex binding protein
chr10_+_59538467 0.38 ENSMUST00000171409.8
mitochondrial calcium uptake 1
chr15_+_55420795 0.34 ENSMUST00000022998.14
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr2_-_91067312 0.33 ENSMUST00000028696.5
damage specific DNA binding protein 2
chr17_+_34128382 0.32 ENSMUST00000173028.8
ENSMUST00000079421.15
Fas death domain-associated protein
chr2_-_154411765 0.29 ENSMUST00000103145.11
E2F transcription factor 1
chr2_-_154411640 0.26 ENSMUST00000000894.6
E2F transcription factor 1
chr6_+_116241146 0.25 ENSMUST00000112900.9
ENSMUST00000036503.14
ENSMUST00000223495.2
zinc finger, AN1-type domain 4
chr16_-_18630365 0.24 ENSMUST00000096990.10
cell division cycle 45
chr6_+_29348068 0.24 ENSMUST00000173216.8
ENSMUST00000173694.5
ENSMUST00000172974.8
ENSMUST00000031779.17
ENSMUST00000090481.14
calumenin
chr11_+_21522221 0.24 ENSMUST00000131135.3
ENSMUST00000020568.10
WD repeat containing planar cell polarity effector
chr3_+_32583681 0.24 ENSMUST00000147350.8
mitofusin 1
chr6_+_38528738 0.24 ENSMUST00000161227.8
LUC7-like 2 (S. cerevisiae)
chr16_-_15455141 0.23 ENSMUST00000023353.4
minichromosome maintenance complex component 4
chr6_+_108760025 0.20 ENSMUST00000032196.9
ADP-ribosylation factor-like 8B
chr16_+_18066825 0.19 ENSMUST00000100099.10
TRM2 tRNA methyltransferase 2A
chrX_-_69520778 0.18 ENSMUST00000101506.10
ENSMUST00000114630.3
transmembrane protein 185A
chr16_+_18066730 0.17 ENSMUST00000115640.8
ENSMUST00000140206.8
TRM2 tRNA methyltransferase 2A
chr10_-_128361731 0.14 ENSMUST00000026427.8
extended synaptotagmin-like protein 1
chr17_-_35454729 0.14 ENSMUST00000048994.7
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
chr5_+_75312939 0.13 ENSMUST00000202681.4
ENSMUST00000000476.15
platelet derived growth factor receptor, alpha polypeptide
chr1_-_132067343 0.12 ENSMUST00000112362.3
cyclin-dependent kinase 18
chr3_-_49711765 0.09 ENSMUST00000035931.13
protocadherin 18
chr1_-_172034251 0.09 ENSMUST00000155109.2
phosphoprotein enriched in astrocytes 15A
chr3_-_49711706 0.09 ENSMUST00000191794.2
protocadherin 18
chr10_-_21036824 0.09 ENSMUST00000020158.9
myeloblastosis oncogene
chr12_-_12991828 0.07 ENSMUST00000043396.15
v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
chr13_+_44884757 0.06 ENSMUST00000174086.2
jumonji, AT rich interactive domain 2
chr19_+_4806859 0.05 ENSMUST00000237921.2
RNA binding motif protein 4B
chr11_-_99549786 0.04 ENSMUST00000092695.5
predicted gene 11563
chr8_-_107792264 0.02 ENSMUST00000034393.7
transmembrane p24 trafficking protein 6
chr6_+_21215472 0.02 ENSMUST00000081542.6
potassium voltage-gated channel, Shal-related family, member 2
chr12_+_84498196 0.01 ENSMUST00000137170.3
lin-52 homolog (C. elegans)
chr16_+_10652910 0.00 ENSMUST00000037913.9
RecQ mediated genome instability 2
chr10_+_42736539 0.00 ENSMUST00000157071.8
Scm polycomb group protein like 4
chrX_+_48559327 0.00 ENSMUST00000114904.10
Rho GTPase activating protein 36
chrX_-_167970196 0.00 ENSMUST00000066112.12
ENSMUST00000112118.8
ENSMUST00000112120.8
ENSMUST00000112119.8
amelogenin, X-linked
chrX_+_48559432 0.00 ENSMUST00000042444.7
Rho GTPase activating protein 36

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767)
0.5 1.6 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.4 3.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.4 1.2 GO:0045004 DNA replication proofreading(GO:0045004)
0.3 1.6 GO:0061622 glycolytic process through glucose-1-phosphate(GO:0061622)
0.3 1.6 GO:0072737 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.3 3.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 5.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.2 0.8 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.2 0.9 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.2 2.9 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.2 0.8 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.1 0.7 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.1 1.2 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 1.4 GO:0060762 negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1 0.6 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.1 1.2 GO:0006108 malate metabolic process(GO:0006108)
0.1 1.0 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 1.0 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.8 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.1 0.8 GO:0051096 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.1 3.1 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.7 GO:0040031 snRNA modification(GO:0040031)
0.1 1.2 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 1.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.7 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.2 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.0 0.4 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.6 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.1 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.0 2.3 GO:0090307 mitotic spindle assembly(GO:0090307)
0.0 0.5 GO:0051571 positive regulation of histone H3-K4 methylation(GO:0051571)
0.0 0.9 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.7 GO:0043550 regulation of lipid kinase activity(GO:0043550)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.4 6.8 GO:0042555 MCM complex(GO:0042555)
0.4 1.5 GO:0008623 CHRAC(GO:0008623)
0.4 2.3 GO:0031523 Myb complex(GO:0031523)
0.3 1.0 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.3 1.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.3 0.8 GO:1990423 RZZ complex(GO:1990423)
0.3 0.8 GO:0048179 activin receptor complex(GO:0048179)
0.2 1.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 0.9 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.6 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 1.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.2 GO:0001739 sex chromatin(GO:0001739)
0.1 3.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.6 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.7 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 0.2 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.8 GO:0032300 mismatch repair complex(GO:0032300)
0.1 3.8 GO:0005657 replication fork(GO:0005657)
0.1 0.4 GO:1990246 uniplex complex(GO:1990246)
0.0 1.1 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.7 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 1.6 GO:0001741 XY body(GO:0001741)
0.0 0.5 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.9 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.2 GO:0071004 U2-type prespliceosome(GO:0071004)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.6 2.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.5 3.6 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.3 1.0 GO:0016418 S-acetyltransferase activity(GO:0016418)
0.3 2.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.3 1.6 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.3 0.8 GO:0003896 DNA primase activity(GO:0003896)
0.3 0.8 GO:0032142 single guanine insertion binding(GO:0032142)
0.2 1.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.2 2.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 4.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 2.0 GO:0050786 RAGE receptor binding(GO:0050786)
0.2 0.7 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.1 0.4 GO:0004798 thymidylate kinase activity(GO:0004798)
0.1 1.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 0.8 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 1.4 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 0.9 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 1.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 0.5 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.1 2.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.6 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 2.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.0 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 1.1 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.8 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.0 GO:0008173 RNA methyltransferase activity(GO:0008173)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 2.4 PID ATR PATHWAY ATR signaling pathway
0.0 5.3 PID E2F PATHWAY E2F transcription factor network
0.0 1.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.6 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.5 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 2.9 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 5.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 2.6 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 3.0 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 0.8 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.1 1.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 3.6 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 0.7 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.1 1.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.8 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 1.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.6 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates