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avrg: GFI1 WT vs 36n/n vs KD
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Results for Ebf1
Z-value: 3.90
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Transcription factors associated with Ebf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ebf1 | mm39_v1_chr11_+_44508137_44508169 | 0.89 | 4.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ebf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 57.8 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.1 | 4.1 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 3.1 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.8 | 3.0 | GO:0060434 | bronchus morphogenesis(GO:0060434) |
| 0.0 | 2.9 | GO:0046579 | positive regulation of Ras protein signal transduction(GO:0046579) |
| 0.4 | 2.6 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 0.2 | 2.5 | GO:0032494 | response to peptidoglycan(GO:0032494) |
| 0.1 | 2.4 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.3 | 2.3 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.7 | 2.1 | GO:0060060 | post-embryonic retina morphogenesis in camera-type eye(GO:0060060) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 4.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 3.2 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 2.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 2.5 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.0 | 2.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 2.1 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 2.0 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 2.0 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 1.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 62.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 19.5 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 8.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 6.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 4.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 3.1 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 3.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.4 | 2.5 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.1 | 2.5 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 2.4 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 2.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 2.0 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 1.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 1.6 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.6 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 1.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 1.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 3.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 2.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 2.2 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.1 | 2.0 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 1.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.8 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 0.1 | 1.8 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 1.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.5 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |