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avrg: GFI1 WT vs 36n/n vs KD
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Results for Epas1_Bcl3
Z-value: 4.14
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Transcription factors associated with Epas1_Bcl3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Epas1 | mm39_v1_chr17_+_87061117_87061137 | 0.99 | 1.1e-03 | Click! |
| Bcl3 | mm39_v1_chr7_-_19556612_19556712 | 0.98 | 3.8e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Epas1_Bcl3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.1 | 3.9 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.1 | 3.7 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.7 | 3.5 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 1.1 | 3.3 | GO:0015734 | beta-alanine transport(GO:0001762) taurine transport(GO:0015734) |
| 0.4 | 3.0 | GO:0002925 | positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) |
| 0.2 | 3.0 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.1 | 2.7 | GO:0010165 | response to X-ray(GO:0010165) |
| 0.2 | 2.6 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.2 | 2.6 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.0 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.2 | 3.2 | GO:0038037 | G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648) |
| 0.0 | 3.0 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.1 | 2.3 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 2.2 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.1 | 2.1 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 2.1 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 2.1 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 1.6 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 1.6 | GO:0016328 | lateral plasma membrane(GO:0016328) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 4.4 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
| 0.0 | 3.7 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 3.6 | GO:0030553 | cGMP binding(GO:0030553) |
| 1.1 | 3.3 | GO:0005368 | beta-alanine transmembrane transporter activity(GO:0001761) taurine transmembrane transporter activity(GO:0005368) taurine:sodium symporter activity(GO:0005369) |
| 1.1 | 3.2 | GO:0099530 | PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) |
| 0.4 | 3.1 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.1 | 3.1 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.4 | 3.0 | GO:0019863 | IgE binding(GO:0019863) |
| 0.0 | 3.0 | GO:0001540 | beta-amyloid binding(GO:0001540) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.6 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 3.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.7 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 2.5 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 2.1 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.4 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.6 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.2 | 3.2 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 2.8 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 1.9 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.2 | 1.8 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 1.8 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 1.8 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 1.5 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 1.3 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 1.0 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |