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avrg: GFI1 WT vs 36n/n vs KD
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Results for Etv1_Etv5_Gabpa
Z-value: 5.34
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Transcription factors associated with Etv1_Etv5_Gabpa
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Etv1 | mm39_v1_chr12_+_38830081_38830116 | -0.86 | 6.5e-02 | Click! |
| Etv5 | mm39_v1_chr16_-_22255264_22255315 | 0.81 | 9.5e-02 | Click! |
| Gabpa | mm39_v1_chr16_+_84631956_84632012 | 0.70 | 1.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_126391388 Show fit | 5.76 |
ENSMUST00000206570.2
|
protein phosphatase 4, catalytic subunit |
|
| chr11_-_48707763 Show fit | 5.58 |
ENSMUST00000140800.2
|
tripartite motif-containing 41 |
|
| chr18_-_36916148 Show fit | 4.25 |
ENSMUST00000001416.8
|
histidyl-tRNA synthetase |
|
| chr6_+_85429023 Show fit | 4.17 |
ENSMUST00000204592.3
|
chaperonin containing Tcp1, subunit 7 (eta) |
|
| chr17_-_24292453 Show fit | 4.08 |
ENSMUST00000017090.6
|
potassium channel tetramerisation domain containing 5 |
|
| chr13_-_74465353 Show fit | 4.00 |
ENSMUST00000022060.7
|
programmed cell death 6 |
|
| chr2_-_130021229 Show fit | 3.91 |
ENSMUST00000103199.9
|
small nuclear ribonucleoprotein B |
|
| chr6_-_124689094 Show fit | 3.55 |
ENSMUST00000004379.8
|
EMG1 N1-specific pseudouridine methyltransferase |
|
| chr1_-_133537953 Show fit | 3.45 |
ENSMUST00000164574.2
ENSMUST00000166291.8 ENSMUST00000164096.2 ENSMUST00000166915.8 |
small nuclear ribonucleoprotein E |
|
| chr19_+_11747721 Show fit | 3.44 |
ENSMUST00000167199.3
|
mitochondrial ribosomal protein L16 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Etv1_Etv5_Gabpa
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 13.8 | GO:1904869 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 0.2 | 12.3 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.1 | 11.9 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.3 | 11.3 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.3 | 9.2 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 0.2 | 9.0 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 1.8 | 8.8 | GO:0030576 | Cajal body organization(GO:0030576) |
| 0.4 | 8.6 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.3 | 8.3 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.2 | 8.0 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 59.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 27.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 18.6 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.1 | 14.9 | GO:0005840 | ribosome(GO:0005840) |
| 0.3 | 14.8 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.7 | 12.9 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 12.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 12.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.6 | 11.8 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.2 | 10.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 19.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 18.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 18.1 | GO:0070035 | ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035) |
| 0.3 | 13.4 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.1 | 11.5 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.3 | 11.2 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.4 | 9.2 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
| 0.6 | 8.4 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.0 | 8.3 | GO:0051015 | actin filament binding(GO:0051015) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 10.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 6.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.9 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 5.9 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 5.0 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 4.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 4.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 4.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 3.9 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 27.1 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.3 | 21.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 18.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 15.4 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.5 | 14.5 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.4 | 11.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.2 | 10.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.5 | 10.6 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.2 | 9.4 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.6 | 7.8 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |