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avrg: GFI1 WT vs 36n/n vs KD

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Results for Evx2

Z-value: 0.93

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Transcription factors associated with Evx2

Gene Symbol Gene ID Gene Info
Evx2
ENSMUSG00000001815.16 even-skipped homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Evx2mm39_v1_chr2_-_74489763_74489901-0.961.1e-02Click!

Activity profile of Evx2 motif

Sorted Z-values of Evx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_93581946 0.62 ENSMUST00000046290.3
ENSMUST00000210099.2
Lpcat2
lysophosphatidylcholine acyltransferase 2
chr7_-_126399778 0.48 ENSMUST00000141355.4
Aldoa
aldolase A, fructose-bisphosphate
chr19_+_41921903 0.47 ENSMUST00000224258.2
ENSMUST00000026154.9
ENSMUST00000224896.2
Zdhhc16
zinc finger, DHHC domain containing 16
chr4_-_132072988 0.45 ENSMUST00000030726.13
Rcc1
regulator of chromosome condensation 1
chr4_-_132073048 0.41 ENSMUST00000084250.11
Rcc1
regulator of chromosome condensation 1
chr11_-_6217718 0.40 ENSMUST00000004507.11
ENSMUST00000151446.2
Ddx56
DEAD box helicase 56
chr3_-_130503041 0.38 ENSMUST00000043937.9
Ostc
oligosaccharyltransferase complex subunit (non-catalytic)
chr11_-_120269517 0.35 ENSMUST00000026448.10
Faap100
Fanconi anemia core complex associated protein 100
chr10_+_39488930 0.34 ENSMUST00000019987.7
Traf3ip2
TRAF3 interacting protein 2
chr5_-_65090893 0.33 ENSMUST00000197315.5
Tlr1
toll-like receptor 1
chr14_+_19801333 0.31 ENSMUST00000022340.5
Nid2
nidogen 2
chr14_+_62529924 0.31 ENSMUST00000166879.8
Rnaseh2b
ribonuclease H2, subunit B
chr17_+_46807637 0.30 ENSMUST00000046497.8
Dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr10_-_80537805 0.30 ENSMUST00000218090.2
Mob3a
MOB kinase activator 3A
chr5_+_33493529 0.29 ENSMUST00000202113.2
Maea
macrophage erythroblast attacher
chr2_-_154916367 0.29 ENSMUST00000137242.2
ENSMUST00000054607.16
Ahcy
S-adenosylhomocysteine hydrolase
chr14_-_59602859 0.29 ENSMUST00000161031.2
Phf11d
PHD finger protein 11D
chr13_+_51799268 0.28 ENSMUST00000075853.6
Cks2
CDC28 protein kinase regulatory subunit 2
chr11_+_60428788 0.28 ENSMUST00000044250.4
Alkbh5
alkB homolog 5, RNA demethylase
chr12_-_55061117 0.26 ENSMUST00000172875.8
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr6_-_69415741 0.26 ENSMUST00000103354.3
Igkv4-59
immunoglobulin kappa variable 4-59
chr7_+_29515485 0.25 ENSMUST00000178162.3
ENSMUST00000032796.14
Zfp790
zinc finger protein 790
chr7_-_126399574 0.24 ENSMUST00000106348.8
Aldoa
aldolase A, fructose-bisphosphate
chr1_-_171854818 0.23 ENSMUST00000138714.2
ENSMUST00000027837.13
ENSMUST00000111264.8
Vangl2
VANGL planar cell polarity 2
chr4_+_102427247 0.21 ENSMUST00000097950.9
Pde4b
phosphodiesterase 4B, cAMP specific
chrM_+_7758 0.20 ENSMUST00000082407.1
mt-Atp8
mitochondrially encoded ATP synthase 8
chr19_+_47056161 0.18 ENSMUST00000026027.7
Taf5
TATA-box binding protein associated factor 5
chr3_-_129518723 0.17 ENSMUST00000199615.5
ENSMUST00000197079.5
Egf
epidermal growth factor
chr2_-_150097511 0.17 ENSMUST00000063463.6
Gm21994
predicted gene 21994
chr9_-_85631361 0.17 ENSMUST00000039213.15
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr2_-_86109346 0.16 ENSMUST00000217294.2
ENSMUST00000217245.2
ENSMUST00000216432.2
Olfr1051
olfactory receptor 1051
chr4_-_42661893 0.15 ENSMUST00000108006.4
Il11ra2
interleukin 11 receptor, alpha chain 2
chr13_+_38388904 0.15 ENSMUST00000091641.13
ENSMUST00000178564.2
Snrnp48
small nuclear ribonucleoprotein 48 (U11/U12)
chr6_-_69282389 0.15 ENSMUST00000103350.3
Igkv4-68
immunoglobulin kappa variable 4-68
chr18_+_24737009 0.14 ENSMUST00000234266.2
ENSMUST00000025120.8
Elp2
elongator acetyltransferase complex subunit 2
chr1_+_36800874 0.14 ENSMUST00000027291.7
Zap70
zeta-chain (TCR) associated protein kinase
chr10_-_80537652 0.14 ENSMUST00000003438.11
Mob3a
MOB kinase activator 3A
chr10_+_26648473 0.14 ENSMUST00000039557.9
Arhgap18
Rho GTPase activating protein 18
chr2_+_167345009 0.13 ENSMUST00000078050.7
Rnf114
ring finger protein 114
chr8_-_35962641 0.12 ENSMUST00000033927.8
Eri1
exoribonuclease 1
chr14_+_48683581 0.12 ENSMUST00000227440.2
ENSMUST00000124720.8
ENSMUST00000226422.2
ENSMUST00000226400.2
Tmem260
transmembrane protein 260
chr18_-_24736848 0.12 ENSMUST00000070726.10
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr9_+_47441471 0.11 ENSMUST00000114548.8
ENSMUST00000152459.8
ENSMUST00000143026.9
ENSMUST00000085909.9
ENSMUST00000114547.8
ENSMUST00000239368.2
ENSMUST00000214542.2
ENSMUST00000034581.4
Cadm1
cell adhesion molecule 1
chr11_+_116547932 0.11 ENSMUST00000116318.3
Prcd
photoreceptor disc component
chr1_+_134333720 0.11 ENSMUST00000173908.8
Cyb5r1
cytochrome b5 reductase 1
chr14_-_59602882 0.10 ENSMUST00000160425.8
ENSMUST00000095157.11
Phf11d
PHD finger protein 11D
chr7_+_51528788 0.10 ENSMUST00000107591.9
Gas2
growth arrest specific 2
chrX_-_56384089 0.09 ENSMUST00000033468.11
Arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr9_-_66421868 0.09 ENSMUST00000056890.10
Fbxl22
F-box and leucine-rich repeat protein 22
chr10_-_128425519 0.09 ENSMUST00000082059.7
Erbb3
erb-b2 receptor tyrosine kinase 3
chr8_+_14938022 0.08 ENSMUST00000123990.2
ENSMUST00000027554.8
Cln8
CLN8 transmembrane ER and ERGIC protein
chr6_-_51443602 0.08 ENSMUST00000203253.2
Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr6_-_69162381 0.08 ENSMUST00000103344.3
Igkv4-74
immunoglobulin kappa variable 4-74
chr7_-_24423715 0.07 ENSMUST00000081657.6
Lypd11
Ly6/PLAUR domain containing 11
chr17_+_38143840 0.07 ENSMUST00000213857.2
Olfr125
olfactory receptor 125
chr14_+_65612788 0.07 ENSMUST00000224687.2
Zfp395
zinc finger protein 395
chr6_-_69245427 0.07 ENSMUST00000103348.3
Igkv4-70
immunoglobulin kappa chain variable 4-70
chr6_-_69204417 0.07 ENSMUST00000103346.3
Igkv4-72
immunoglobulin kappa chain variable 4-72
chr18_-_24736521 0.07 ENSMUST00000154205.2
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr10_-_129107354 0.06 ENSMUST00000204573.3
Olfr777
olfactory receptor 777
chr3_+_121085471 0.05 ENSMUST00000199554.2
Alg14
asparagine-linked glycosylation 14
chrM_+_7779 0.05 ENSMUST00000082408.1
mt-Atp6
mitochondrially encoded ATP synthase 6
chr9_+_38738911 0.04 ENSMUST00000051238.7
ENSMUST00000219798.2
Olfr923
olfactory receptor 923
chr6_-_131655849 0.04 ENSMUST00000076756.3
Tas2r106
taste receptor, type 2, member 106
chr2_-_86088672 0.04 ENSMUST00000216185.3
Olfr1049
olfactory receptor 1049
chr6_-_69020489 0.04 ENSMUST00000103342.4
Igkv4-79
immunoglobulin kappa variable 4-79
chr6_-_69394425 0.03 ENSMUST00000199160.2
Igkv4-61
immunoglobulin kappa chain variable 4-61
chr6_-_68887922 0.03 ENSMUST00000103337.3
Igkv4-86
immunoglobulin kappa variable 4-86
chr2_-_111100733 0.02 ENSMUST00000099619.6
Olfr1277
olfactory receptor 1277
chr6_-_68784692 0.02 ENSMUST00000103334.4
Igkv4-90
immunoglobulin kappa chain variable 4-90
chr6_-_68887957 0.02 ENSMUST00000200454.2
Igkv4-86
immunoglobulin kappa variable 4-86
chr2_+_91087156 0.02 ENSMUST00000144394.8
ENSMUST00000028694.12
ENSMUST00000168916.8
ENSMUST00000156919.8
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr6_-_69553484 0.02 ENSMUST00000103357.4
Igkv4-57
immunoglobulin kappa variable 4-57
chr10_+_80538115 0.02 ENSMUST00000218184.2
Izumo4
IZUMO family member 4
chr14_-_36820304 0.02 ENSMUST00000022337.11
Cdhr1
cadherin-related family member 1
chr2_+_154390808 0.02 ENSMUST00000045116.11
ENSMUST00000109709.4
1700003F12Rik
RIKEN cDNA 1700003F12 gene
chr17_+_88748139 0.02 ENSMUST00000112238.9
ENSMUST00000155640.2
Foxn2
forkhead box N2
chr17_-_36773221 0.02 ENSMUST00000169950.2
ENSMUST00000057502.14
H2-M10.4
histocompatibility 2, M region locus 10.4
chr7_-_102805563 0.01 ENSMUST00000218483.2
Olfr589
olfactory receptor 589
chr11_-_61157986 0.01 ENSMUST00000066277.10
ENSMUST00000074127.14
ENSMUST00000108715.3
Aldh3a2
aldehyde dehydrogenase family 3, subfamily A2
chr10_+_73782857 0.01 ENSMUST00000191709.6
ENSMUST00000193739.6
ENSMUST00000195531.6
Pcdh15
protocadherin 15
chr7_-_102804952 0.01 ENSMUST00000061055.2
Olfr589
olfactory receptor 589
chr10_-_128361731 0.01 ENSMUST00000026427.8
Esyt1
extended synaptotagmin-like protein 1
chr10_+_97482946 0.01 ENSMUST00000105285.4
Epyc
epiphycan
chr6_-_131667026 0.01 ENSMUST00000080619.3
Tas2r114
taste receptor, type 2, member 114
chr7_-_48493388 0.01 ENSMUST00000167786.4
Csrp3
cysteine and glycine-rich protein 3
chr6_-_68994064 0.01 ENSMUST00000103341.4
Igkv4-80
immunoglobulin kappa variable 4-80
chr11_+_58468556 0.01 ENSMUST00000203418.4
Olfr325
olfactory receptor 325
chr10_+_112151245 0.01 ENSMUST00000218445.2
Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr2_-_86254018 0.01 ENSMUST00000105213.5
Olfr1062
olfactory receptor 1062
chr11_-_113600838 0.01 ENSMUST00000018871.8
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr11_-_100653754 0.01 ENSMUST00000107360.3
ENSMUST00000055083.4
Hcrt
hypocretin
chr6_+_42411469 0.00 ENSMUST00000059534.5
Tas2r126
taste receptor, type 2, member 126
chr6_-_69261303 0.00 ENSMUST00000103349.2
Igkv4-69
immunoglobulin kappa variable 4-69
chr6_-_69377081 0.00 ENSMUST00000177795.2
Igkv4-62
immunoglobulin kappa variable 4-62
chr19_-_55229668 0.00 ENSMUST00000069183.8
Gucy2g
guanylate cyclase 2g
chr10_-_128885867 0.00 ENSMUST00000216460.2
Olfr765
olfactory receptor 765
chr6_-_69377328 0.00 ENSMUST00000198345.2
Igkv4-62
immunoglobulin kappa variable 4-62
chr17_-_37409147 0.00 ENSMUST00000216376.2
ENSMUST00000217372.2
Olfr91
olfactory receptor 91
chr6_-_69678271 0.00 ENSMUST00000103363.2
Igkv4-50
immunoglobulin kappa variable 4-50
chr18_-_64688271 0.00 ENSMUST00000235459.2
Atp8b1
ATPase, class I, type 8B, member 1
chr1_+_135768409 0.00 ENSMUST00000189826.7
Tnnt2
troponin T2, cardiac
chr18_-_88945571 0.00 ENSMUST00000147313.2
Socs6
suppressor of cytokine signaling 6

Network of associatons between targets according to the STRING database.

First level regulatory network of Evx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.1 0.3 GO:0042495 detection of triacyl bacterial lipopeptide(GO:0042495)
0.1 0.3 GO:0048822 enucleate erythrocyte development(GO:0048822)
0.1 0.2 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.1 0.3 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.0 0.3 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.3 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.0 0.1 GO:1990428 miRNA transport(GO:1990428)
0.0 0.1 GO:0043366 beta selection(GO:0043366)
0.0 0.9 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.1 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571) amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 0.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.3 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.1 GO:0031125 rRNA 3'-end processing(GO:0031125)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1 0.2 GO:0060187 cell pole(GO:0060187)
0.1 0.3 GO:0008623 CHRAC(GO:0008623)
0.1 0.3 GO:0034657 GID complex(GO:0034657)
0.1 0.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.3 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 0.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.3 GO:0042497 triacyl lipopeptide binding(GO:0042497)
0.1 0.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.3 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.3 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.0 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.6 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.0 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse