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avrg: GFI1 WT vs 36n/n vs KD

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Results for Fosb

Z-value: 0.50

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Transcription factors associated with Fosb

Gene Symbol Gene ID Gene Info
Fosb
ENSMUSG00000003545.4 FBJ osteosarcoma oncogene B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Fosbmm39_v1_chr7_-_19043525_19043627-0.801.0e-01Click!

Activity profile of Fosb motif

Sorted Z-values of Fosb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_42326714 0.48 ENSMUST00000203846.3
Zyx
zyxin
chr6_+_42326760 0.37 ENSMUST00000203652.3
ENSMUST00000070635.13
Zyx
zyxin
chr6_+_42326980 0.30 ENSMUST00000203849.2
Zyx
zyxin
chr10_-_85847697 0.30 ENSMUST00000105304.2
ENSMUST00000061699.12
Bpifc
BPI fold containing family C
chr6_+_42326934 0.29 ENSMUST00000203401.3
ENSMUST00000164375.4
Zyx
zyxin
chr16_-_4698148 0.29 ENSMUST00000037843.7
Ubald1
UBA-like domain containing 1
chr18_+_82928782 0.28 ENSMUST00000235793.2
Zfp516
zinc finger protein 516
chr2_-_18053595 0.25 ENSMUST00000142856.2
Skida1
SKI/DACH domain containing 1
chr7_-_80051455 0.24 ENSMUST00000120753.3
Furin
furin (paired basic amino acid cleaving enzyme)
chr17_+_36152383 0.23 ENSMUST00000082337.13
Mdc1
mediator of DNA damage checkpoint 1
chr7_-_29204812 0.23 ENSMUST00000183096.8
ENSMUST00000085809.11
Sipa1l3
signal-induced proliferation-associated 1 like 3
chr3_-_131196213 0.23 ENSMUST00000197057.2
Sgms2
sphingomyelin synthase 2
chr12_-_84240781 0.22 ENSMUST00000110294.2
Mideas
mitotic deacetylase associated SANT domain protein
chr8_-_70426910 0.22 ENSMUST00000116463.4
Gatad2a
GATA zinc finger domain containing 2A
chr11_-_100288566 0.21 ENSMUST00000001592.15
ENSMUST00000107403.2
Jup
junction plakoglobin
chr5_-_62923463 0.19 ENSMUST00000076623.8
ENSMUST00000159470.3
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_124746510 0.18 ENSMUST00000149652.2
ENSMUST00000112476.8
ENSMUST00000004378.15
Eno2
enolase 2, gamma neuronal
chr9_-_32452885 0.18 ENSMUST00000016231.14
Fli1
Friend leukemia integration 1
chr19_-_32188413 0.18 ENSMUST00000151289.9
Sgms1
sphingomyelin synthase 1
chr6_+_42326528 0.18 ENSMUST00000203329.3
Zyx
zyxin
chr8_+_4276827 0.17 ENSMUST00000053035.7
Lrrc8e
leucine rich repeat containing 8 family, member E
chr14_-_55995912 0.17 ENSMUST00000001497.9
Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr11_-_69556904 0.16 ENSMUST00000018918.12
Cd68
CD68 antigen
chr6_+_86826470 0.16 ENSMUST00000089519.13
ENSMUST00000204414.3
Aak1
AP2 associated kinase 1
chr1_-_182345011 0.15 ENSMUST00000068505.10
Capn2
calpain 2
chr14_+_66872699 0.15 ENSMUST00000159365.8
ENSMUST00000054661.8
ENSMUST00000225182.2
ENSMUST00000159068.2
Adra1a
adrenergic receptor, alpha 1a
chr11_-_95966477 0.14 ENSMUST00000090541.12
Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)
chr9_+_44151962 0.14 ENSMUST00000092426.5
ENSMUST00000217221.2
ENSMUST00000213891.2
Ccdc153
coiled-coil domain containing 153
chr6_+_17463925 0.14 ENSMUST00000115442.8
Met
met proto-oncogene
chr4_-_19922599 0.14 ENSMUST00000029900.6
Atp6v0d2
ATPase, H+ transporting, lysosomal V0 subunit D2
chr10_-_43880353 0.14 ENSMUST00000020017.14
Crybg1
crystallin beta-gamma domain containing 1
chr18_+_82928959 0.13 ENSMUST00000171238.8
Zfp516
zinc finger protein 516
chr15_-_64184485 0.13 ENSMUST00000177083.8
ENSMUST00000177371.8
Asap1
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
chr8_+_108020132 0.13 ENSMUST00000151114.8
ENSMUST00000125721.8
ENSMUST00000075922.11
Nfat5
nuclear factor of activated T cells 5
chr11_-_69556888 0.13 ENSMUST00000108654.3
Cd68
CD68 antigen
chr6_+_49013601 0.12 ENSMUST00000204260.2
Gpnmb
glycoprotein (transmembrane) nmb
chr7_-_119461027 0.12 ENSMUST00000137888.2
ENSMUST00000142120.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr1_-_10790120 0.12 ENSMUST00000035577.7
Cpa6
carboxypeptidase A6
chr12_+_71062733 0.12 ENSMUST00000046305.12
Arid4a
AT rich interactive domain 4A (RBP1-like)
chrX_-_47551990 0.12 ENSMUST00000033429.9
ENSMUST00000140486.2
Elf4
E74-like factor 4 (ets domain transcription factor)
chr10_-_5872386 0.11 ENSMUST00000131996.8
ENSMUST00000064225.14
Rgs17
regulator of G-protein signaling 17
chr11_+_80319424 0.11 ENSMUST00000173938.8
ENSMUST00000017572.14
Psmd11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr19_+_5927876 0.10 ENSMUST00000235340.2
Slc25a45
solute carrier family 25, member 45
chr11_-_102255999 0.10 ENSMUST00000006749.10
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr17_+_78815493 0.10 ENSMUST00000024880.11
ENSMUST00000232859.2
Vit
vitrin
chr12_+_83678987 0.09 ENSMUST00000048155.16
ENSMUST00000182618.8
ENSMUST00000183154.8
ENSMUST00000182036.8
ENSMUST00000182347.8
Rbm25
RNA binding motif protein 25
chr3_-_79439181 0.09 ENSMUST00000239298.2
Fnip2
folliculin interacting protein 2
chr5_+_32293145 0.08 ENSMUST00000031017.11
Fosl2
fos-like antigen 2
chr17_+_48080113 0.08 ENSMUST00000160373.8
ENSMUST00000159641.8
Tfeb
transcription factor EB
chr10_-_5872341 0.08 ENSMUST00000117676.8
ENSMUST00000019909.8
Rgs17
regulator of G-protein signaling 17
chr9_-_108888779 0.08 ENSMUST00000061973.5
Trex1
three prime repair exonuclease 1
chr7_-_4781140 0.07 ENSMUST00000094892.12
Il11
interleukin 11
chr5_-_93192881 0.07 ENSMUST00000061328.6
Sowahb
sosondowah ankyrin repeat domain family member B
chr12_+_111132908 0.07 ENSMUST00000139162.8
ENSMUST00000060274.7
Traf3
TNF receptor-associated factor 3
chr15_-_75886166 0.07 ENSMUST00000060807.12
Fam83h
family with sequence similarity 83, member H
chr2_+_118493713 0.07 ENSMUST00000099557.10
Pak6
p21 (RAC1) activated kinase 6
chr12_+_16944896 0.07 ENSMUST00000020904.8
Rock2
Rho-associated coiled-coil containing protein kinase 2
chr7_+_126376099 0.06 ENSMUST00000038614.12
ENSMUST00000170882.8
ENSMUST00000106359.2
ENSMUST00000106357.8
ENSMUST00000145762.8
Ypel3
yippee like 3
chr10_-_121422635 0.05 ENSMUST00000219493.2
ENSMUST00000020316.4
Tbk1
TANK-binding kinase 1
chr8_+_108020092 0.05 ENSMUST00000169453.8
Nfat5
nuclear factor of activated T cells 5
chr3_-_95139472 0.05 ENSMUST00000196025.5
ENSMUST00000198948.5
Mllt11
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11
chr5_-_5315968 0.05 ENSMUST00000115451.8
ENSMUST00000115452.8
ENSMUST00000131392.8
Cdk14
cyclin-dependent kinase 14
chr19_-_4189603 0.04 ENSMUST00000025761.8
Cabp4
calcium binding protein 4
chr4_-_140501507 0.04 ENSMUST00000026381.7
Padi4
peptidyl arginine deiminase, type IV
chr15_-_74599860 0.04 ENSMUST00000023261.4
ENSMUST00000190433.2
Slurp1
secreted Ly6/Plaur domain containing 1
chr2_+_51928017 0.03 ENSMUST00000065927.6
Tnfaip6
tumor necrosis factor alpha induced protein 6
chr17_-_24863907 0.03 ENSMUST00000234505.2
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr7_+_139414057 0.03 ENSMUST00000026548.14
Adgra1
adhesion G protein-coupled receptor A1
chr2_-_90900628 0.03 ENSMUST00000111436.3
ENSMUST00000073575.12
Slc39a13
solute carrier family 39 (metal ion transporter), member 13
chr11_-_120358239 0.03 ENSMUST00000076921.7
Arl16
ADP-ribosylation factor-like 16
chr10_-_63926044 0.03 ENSMUST00000105439.2
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr9_-_108888284 0.03 ENSMUST00000112053.2
Trex1
three prime repair exonuclease 1
chr11_+_51541728 0.03 ENSMUST00000117859.8
ENSMUST00000064493.6
D930048N14Rik
RIKEN cDNA D930048N14 gene
chr19_-_38113249 0.02 ENSMUST00000112335.4
Rbp4
retinol binding protein 4, plasma
chr11_-_100139728 0.02 ENSMUST00000007280.9
Krt16
keratin 16
chr6_+_53264255 0.02 ENSMUST00000203528.3
Creb5
cAMP responsive element binding protein 5
chr18_+_4994600 0.02 ENSMUST00000140448.8
Svil
supervillin
chr17_-_24863956 0.02 ENSMUST00000019684.13
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr10_-_18619439 0.02 ENSMUST00000019999.7
Arfgef3
ARFGEF family member 3
chr19_+_5497575 0.02 ENSMUST00000025850.7
ENSMUST00000236774.2
Fosl1
fos-like antigen 1
chr11_+_61575245 0.02 ENSMUST00000093019.6
Fam83g
family with sequence similarity 83, member G
chr16_+_17379749 0.02 ENSMUST00000171002.10
ENSMUST00000023441.11
P2rx6
purinergic receptor P2X, ligand-gated ion channel, 6
chr1_-_75240551 0.02 ENSMUST00000186178.7
ENSMUST00000189769.7
ENSMUST00000027404.12
Ptprn
protein tyrosine phosphatase, receptor type, N
chr13_+_30843937 0.01 ENSMUST00000091672.13
Dusp22
dual specificity phosphatase 22
chr7_-_141926079 0.01 ENSMUST00000059223.15
Ifitm10
interferon induced transmembrane protein 10
chr9_+_122717536 0.01 ENSMUST00000063980.8
Zkscan7
zinc finger with KRAB and SCAN domains 7
chr7_+_75879603 0.01 ENSMUST00000156166.8
Agbl1
ATP/GTP binding protein-like 1
chr1_-_74932266 0.01 ENSMUST00000006721.3
Cryba2
crystallin, beta A2
chr19_+_4189786 0.01 ENSMUST00000096338.5
Gpr152
G protein-coupled receptor 152
chr15_+_102412157 0.01 ENSMUST00000096145.5
Gm10337
predicted gene 10337
chr11_-_69439934 0.01 ENSMUST00000108659.2
Dnah2
dynein, axonemal, heavy chain 2
chr11_+_4207557 0.00 ENSMUST00000066283.12
Lif
leukemia inhibitory factor
chr7_+_6048160 0.00 ENSMUST00000037728.13
ENSMUST00000121583.2
Nlrp4c
NLR family, pyrin domain containing 4C
chr3_-_92481033 0.00 ENSMUST00000053107.6
Ivl
involucrin
chr5_+_31274064 0.00 ENSMUST00000202769.2
Trim54
tripartite motif-containing 54
chr5_+_31274046 0.00 ENSMUST00000013771.15
Trim54
tripartite motif-containing 54
chr19_-_38113056 0.00 ENSMUST00000236283.2
Rbp4
retinol binding protein 4, plasma
chr18_-_31450095 0.00 ENSMUST00000139924.2
ENSMUST00000153060.8
Rit2
Ras-like without CAAX 2
chr6_-_124746445 0.00 ENSMUST00000156033.2
Eno2
enolase 2, gamma neuronal
chr7_+_140659038 0.00 ENSMUST00000159375.8
Pkp3
plakophilin 3
chr4_+_42158092 0.00 ENSMUST00000098122.3
Gm13306
predicted gene 13306
chr4_+_109263820 0.00 ENSMUST00000124209.8
Ttc39a
tetratricopeptide repeat domain 39A
chr3_+_102377234 0.00 ENSMUST00000035952.5
ENSMUST00000198168.5
ENSMUST00000106925.9
Ngf
nerve growth factor

Network of associatons between targets according to the STRING database.

First level regulatory network of Fosb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0090472 dibasic protein processing(GO:0090472)
0.0 0.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.2 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.0 0.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.1 GO:1902477 defense response to bacterium, incompatible interaction(GO:0009816) regulation of defense response to bacterium, incompatible interaction(GO:1902477)
0.0 0.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.1 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.0 0.1 GO:0044565 dendritic cell proliferation(GO:0044565)
0.0 0.0 GO:0008594 photoreceptor cell morphogenesis(GO:0008594)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.2 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins