ISMARA results: Foxj3

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avrg: GFI1 WT vs 36n/n vs KD

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Results for Foxj3_Tbl1xr1

Z-value: 3.58

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Transcription factors associated with Foxj3_Tbl1xr1

Gene Symbol	Gene ID	Gene Info
Foxj3 Ensembl NCBI MGI UniProt	ENSMUSG00000032998.17	forkhead box J3
Tbl1xr1 Ensembl NCBI MGI UniProt	ENSMUSG00000027630.14	transducin (beta)-like 1X-linked receptor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tbl1xr1	mm39_v1_chr3_+_22130866_22130961	1.00	4.6e-05	Click!
Foxj3	mm39_v1_chr4_+_119396849_119396912	0.87	5.7e-02	Click!

Activity profile of Foxj3_Tbl1xr1 motif

Sorted Z-values of Foxj3_Tbl1xr1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrX_-_36967692 Show fit	4.08	ENSMUST00000071885.7	Rhox8 Ensembl NCBI MGI UniProt Show fit	reproductive homeobox 8
chr13_-_21934675 Show fit	3.91	ENSMUST00000102983.2	H4c12 Ensembl NCBI MGI UniProt Show fit	H4 clustered histone 12
chr2_+_87609827 Show fit	3.45	ENSMUST00000105210.3	Olfr152 Ensembl NCBI MGI UniProt Show fit	olfactory receptor 152
chr13_-_21967540 Show fit	2.98	ENSMUST00000189457.2	H3c11 Ensembl NCBI MGI UniProt Show fit	H3 clustered histone 11
chr6_-_57340712 Show fit	2.73	ENSMUST00000228156.2 ENSMUST00000227186.2 ENSMUST00000228294.2 ENSMUST00000228342.2	Vmn1r17 Ensembl NCBI MGI UniProt Show fit	vomeronasal 1 receptor 17
chr16_-_36228798 Show fit	2.64	ENSMUST00000023619.8	Stfa2 Ensembl NCBI MGI UniProt Show fit	stefin A2
chr5_+_107655487 Show fit	2.42	ENSMUST00000143074.2	Gm42669 Ensembl NCBI MGI UniProt Show fit	predicted gene 42669
chr16_+_32090286 Show fit	2.23	ENSMUST00000093183.5	Smco1 Ensembl NCBI MGI UniProt Show fit	single-pass membrane protein with coiled-coil domains 1
chr13_+_23715220 Show fit	2.15	ENSMUST00000102972.6	H4c8 Ensembl NCBI MGI UniProt Show fit	H4 clustered histone 8
chr13_+_23930717 Show fit	2.15	ENSMUST00000099703.5	H2bc3 Ensembl NCBI MGI UniProt Show fit	H2B clustered histone 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxj3_Tbl1xr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	128.5	GO:0007606	sensory perception of chemical stimulus(GO:0007606)
0.1	36.1	GO:0050907	detection of chemical stimulus involved in sensory perception(GO:0050907)
0.2	28.6	GO:0019236	response to pheromone(GO:0019236)
0.2	9.5	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	2.7	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	2.6	GO:0007288	sperm axoneme assembly(GO:0007288)
0.1	2.5	GO:0032674	regulation of interleukin-5 production(GO:0032674)
0.2	2.4	GO:0086023	adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.3	2.3	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.1	2.3	GO:0060088	auditory receptor cell stereocilium organization(GO:0060088)

Showing 1 to 10 of 745 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	142.0	GO:0016021	integral component of membrane(GO:0016021)
0.0	4.4	GO:0005930	axoneme(GO:0005930)
0.0	3.0	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	2.9	GO:0030863	cortical cytoskeleton(GO:0030863)
0.0	2.4	GO:0005604	basement membrane(GO:0005604)
0.0	2.3	GO:0030673	axolemma(GO:0030673)
0.1	2.0	GO:0031527	filopodium membrane(GO:0031527)
0.2	1.8	GO:0019815	B cell receptor complex(GO:0019815)
0.1	1.8	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	1.7	GO:0016328	lateral plasma membrane(GO:0016328)

Showing 1 to 10 of 207 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	157.3	GO:0004984	olfactory receptor activity(GO:0004984)
0.2	27.2	GO:0005550	pheromone binding(GO:0005550)
0.0	8.4	GO:0017124	SH3 domain binding(GO:0017124)
0.0	5.6	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0	5.0	GO:0001047	core promoter binding(GO:0001047)
0.1	4.0	GO:0004993	G-protein coupled serotonin receptor activity(GO:0004993)
0.1	3.8	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.1	2.5	GO:0003680	AT DNA binding(GO:0003680)
0.0	2.4	GO:0005518	collagen binding(GO:0005518)
0.0	2.4	GO:0034987	immunoglobulin receptor binding(GO:0034987)

Showing 1 to 10 of 400 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	3.0	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	2.5	PID FGF PATHWAY	FGF signaling pathway
0.0	2.5	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	2.4	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	2.0	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.7	PID BCR 5PATHWAY	BCR signaling pathway
0.0	1.7	PID BMP PATHWAY	BMP receptor signaling
0.1	1.5	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	1.5	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase

Showing 1 to 10 of 64 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.9	REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1	2.9	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.1	2.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	2.6	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.1	2.4	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.1	2.3	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	2.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	2.1	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	2.0	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	1.8	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules

Showing 1 to 10 of 102 entries

Results for Foxj3_Tbl1xr1

Z-value: 3.58

Motif logo

Transcription factors associated with Foxj3_Tbl1xr1

Activity-expression correlation:

Activity profile of Foxj3_Tbl1xr1 motif

Sorted Z-values of Foxj3_Tbl1xr1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxj3_Tbl1xr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: