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avrg: GFI1 WT vs 36n/n vs KD

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Results for Gbx2

Z-value: 0.62

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Transcription factors associated with Gbx2

Gene Symbol Gene ID Gene Info
Gbx2
ENSMUSG00000034486.9 gastrulation brain homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gbx2mm39_v1_chr1_-_89858901_89858920-0.932.3e-02Click!

Activity profile of Gbx2 motif

Sorted Z-values of Gbx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_23947641 1.09 ENSMUST00000055770.4
H1f1
H1.1 linker histone, cluster member
chr2_+_87609827 0.75 ENSMUST00000105210.3
Olfr152
olfactory receptor 152
chr19_-_12313274 0.69 ENSMUST00000208398.3
Olfr1438-ps1
olfactory receptor 1438, pseudogene 1
chrM_+_14138 0.53 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chrM_-_14061 0.53 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr17_-_37974666 0.45 ENSMUST00000215414.2
ENSMUST00000213638.3
Olfr117
olfactory receptor 117
chrX_+_137815171 0.36 ENSMUST00000064937.14
ENSMUST00000113052.8
Nrk
Nik related kinase
chr4_-_139695337 0.31 ENSMUST00000105031.4
Klhdc7a
kelch domain containing 7A
chr11_+_97206542 0.31 ENSMUST00000019026.10
ENSMUST00000132168.2
Mrpl45
mitochondrial ribosomal protein L45
chr2_-_85966272 0.31 ENSMUST00000216566.3
ENSMUST00000214364.2
Olfr1039
olfactory receptor 1039
chr2_-_87838612 0.29 ENSMUST00000215457.2
Olfr1160
olfactory receptor 1160
chr1_-_156301821 0.24 ENSMUST00000188027.2
ENSMUST00000187507.7
ENSMUST00000189661.7
Soat1
sterol O-acyltransferase 1
chr1_-_155293141 0.24 ENSMUST00000111775.8
ENSMUST00000111774.2
Xpr1
xenotropic and polytropic retrovirus receptor 1
chr11_-_103158190 0.23 ENSMUST00000021324.3
Map3k14
mitogen-activated protein kinase kinase kinase 14
chr16_-_97883632 0.23 ENSMUST00000231268.2
ENSMUST00000231741.2
A630089N07Rik
RIKEN cDNA A630089N07 gene
chr1_+_92533504 0.22 ENSMUST00000217316.2
ENSMUST00000216553.2
Olfr1410
olfactory receptor 1410
chr13_+_49697919 0.22 ENSMUST00000177948.2
ENSMUST00000021820.14
Aspn
asporin
chr11_-_58521327 0.21 ENSMUST00000214132.2
Olfr323
olfactory receptor 323
chr8_+_72837021 0.21 ENSMUST00000213940.2
Olfr373
olfactory receptor 373
chr5_+_113873864 0.21 ENSMUST00000065698.7
Ficd
FIC domain containing
chr2_+_84818538 0.20 ENSMUST00000028466.12
Prg3
proteoglycan 3
chr7_-_140402037 0.20 ENSMUST00000106052.2
ENSMUST00000080651.13
Zfp941
zinc finger protein 941
chr10_-_128918779 0.19 ENSMUST00000213579.2
Olfr767
olfactory receptor 767
chr2_-_111324108 0.17 ENSMUST00000208881.2
ENSMUST00000208695.2
ENSMUST00000217611.2
Olfr1290
olfactory receptor 1290
chr4_+_118818775 0.16 ENSMUST00000058651.5
Lao1
L-amino acid oxidase 1
chr10_-_95337783 0.14 ENSMUST00000075829.3
ENSMUST00000217777.2
ENSMUST00000218893.2
Mrpl42
mitochondrial ribosomal protein L42
chr7_-_12829100 0.13 ENSMUST00000209822.3
ENSMUST00000235753.2
Vmn1r85
vomeronasal 1 receptor 85
chr2_+_152596075 0.13 ENSMUST00000010020.12
Cox4i2
cytochrome c oxidase subunit 4I2
chr18_+_57487908 0.13 ENSMUST00000238069.2
Prrc1
proline-rich coiled-coil 1
chr3_+_84573499 0.12 ENSMUST00000107682.2
Tmem154
transmembrane protein 154
chr9_+_108708939 0.11 ENSMUST00000192235.2
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3
chr11_-_79394904 0.09 ENSMUST00000164465.3
Omg
oligodendrocyte myelin glycoprotein
chr16_-_26190578 0.09 ENSMUST00000023154.3
Cldn1
claudin 1
chr11_-_73707875 0.09 ENSMUST00000118463.4
ENSMUST00000144724.3
Olfr392
olfactory receptor 392
chr7_-_105230807 0.09 ENSMUST00000191011.7
Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr2_+_70392351 0.08 ENSMUST00000094934.11
Gad1
glutamate decarboxylase 1
chr7_-_105230698 0.07 ENSMUST00000189378.7
Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr3_-_96359622 0.07 ENSMUST00000093126.11
ENSMUST00000098841.4
BC107364
cDNA sequence BC107364
chr14_+_45225641 0.07 ENSMUST00000046891.6
Ptger2
prostaglandin E receptor 2 (subtype EP2)
chr5_-_5315968 0.05 ENSMUST00000115451.8
ENSMUST00000115452.8
ENSMUST00000131392.8
Cdk14
cyclin-dependent kinase 14
chr7_-_105230395 0.05 ENSMUST00000188726.2
ENSMUST00000188440.7
Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr1_-_52991993 0.05 ENSMUST00000050567.11
1700019D03Rik
RIKEN cDNA 1700019D03 gene
chr4_+_32657105 0.05 ENSMUST00000071642.11
ENSMUST00000178134.2
Mdn1
midasin AAA ATPase 1
chrX_+_105964224 0.04 ENSMUST00000060576.8
Lpar4
lysophosphatidic acid receptor 4
chr2_-_73410632 0.04 ENSMUST00000028515.4
Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr12_-_98225676 0.03 ENSMUST00000021390.9
Galc
galactosylceramidase
chr4_-_26346882 0.03 ENSMUST00000041374.8
ENSMUST00000153813.2
Manea
mannosidase, endo-alpha
chr14_-_66451001 0.02 ENSMUST00000178730.8
Ptk2b
PTK2 protein tyrosine kinase 2 beta
chr3_-_86827664 0.02 ENSMUST00000194452.2
ENSMUST00000191752.6
Dclk2
doublecortin-like kinase 2
chr12_+_79344119 0.02 ENSMUST00000079533.12
Rad51b
RAD51 paralog B
chr4_+_110254858 0.02 ENSMUST00000106589.9
ENSMUST00000106587.9
ENSMUST00000106591.8
ENSMUST00000106592.8
Agbl4
ATP/GTP binding protein-like 4
chr2_+_70392491 0.01 ENSMUST00000148210.8
Gad1
glutamate decarboxylase 1
chr10_+_129610507 0.01 ENSMUST00000203598.3
Olfr809
olfactory receptor 809
chr10_-_5144699 0.01 ENSMUST00000215467.2
Syne1
spectrin repeat containing, nuclear envelope 1
chr7_+_28510310 0.01 ENSMUST00000038572.15
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr4_+_110254907 0.01 ENSMUST00000097920.9
ENSMUST00000080744.13
Agbl4
ATP/GTP binding protein-like 4
chr8_-_65471175 0.01 ENSMUST00000078409.5
ENSMUST00000048565.9
Trim61
Trim60
tripartite motif-containing 61
tripartite motif-containing 60
chr11_-_46597885 0.01 ENSMUST00000055102.13
ENSMUST00000125008.2
Timd2
T cell immunoglobulin and mucin domain containing 2
chr1_-_74932266 0.01 ENSMUST00000006721.3
Cryba2
crystallin, beta A2
chr9_-_40875414 0.01 ENSMUST00000034521.8
Jhy
junctional cadherin complex regulator
chr16_-_13548833 0.01 ENSMUST00000023364.7
Pla2g10
phospholipase A2, group X
chr1_-_161807205 0.00 ENSMUST00000162676.2
4930558K02Rik
RIKEN cDNA 4930558K02 gene
chr9_+_37656402 0.00 ENSMUST00000216982.2
Olfr874
olfactory receptor 874
chr14_-_48904958 0.00 ENSMUST00000144465.8
ENSMUST00000133479.8
ENSMUST00000119070.8
ENSMUST00000226501.2
Otx2
orthodenticle homeobox 2
chr2_-_85632888 0.00 ENSMUST00000217410.3
ENSMUST00000216425.3
Olfr1016
olfactory receptor 1016
chr3_-_86827640 0.00 ENSMUST00000195561.6
Dclk2
doublecortin-like kinase 2
chr19_+_38121214 0.00 ENSMUST00000112329.3
Pde6c
phosphodiesterase 6C, cGMP specific, cone, alpha prime
chr18_-_78640066 0.00 ENSMUST00000235389.2
ENSMUST00000237674.2
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr19_+_38121248 0.00 ENSMUST00000025956.13
Pde6c
phosphodiesterase 6C, cGMP specific, cone, alpha prime
chr5_+_7354130 0.00 ENSMUST00000160634.2
ENSMUST00000159546.2
Tex47
testis expressed 47

Network of associatons between targets according to the STRING database.

First level regulatory network of Gbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0060722 spongiotrophoblast cell proliferation(GO:0060720) cell proliferation involved in embryonic placenta development(GO:0060722)
0.1 0.2 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.1 0.5 GO:0033762 response to glucagon(GO:0033762)
0.0 0.2 GO:0045575 basophil activation(GO:0045575)
0.0 0.2 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.2 GO:0050760 thymidylate synthase biosynthetic process(GO:0050757) regulation of thymidylate synthase biosynthetic process(GO:0050758) negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.0 0.1 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.1 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.0 0.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.2 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 0.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 0.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway