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avrg: GFI1 WT vs 36n/n vs KD

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Results for Gsc2_Dmbx1

Z-value: 0.88

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Transcription factors associated with Gsc2_Dmbx1

Gene Symbol Gene ID Gene Info
Gsc2
ENSMUSG00000022738.8 goosecoid homebox 2
Dmbx1
ENSMUSG00000028707.16 diencephalon/mesencephalon homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Dmbx1mm39_v1_chr4_-_115797118_1157971290.885.1e-02Click!
Gsc2mm39_v1_chr16_-_17732923_177329230.612.7e-01Click!

Activity profile of Gsc2_Dmbx1 motif

Sorted Z-values of Gsc2_Dmbx1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_44258112 1.82 ENSMUST00000054801.4
Mettl21e
methyltransferase like 21E
chr8_+_13455080 1.42 ENSMUST00000033827.8
ENSMUST00000209909.2
Grk1
G protein-coupled receptor kinase 1
chr13_+_23936250 1.38 ENSMUST00000091703.3
H3c2
H3 clustered histone 2
chr13_-_21967540 0.87 ENSMUST00000189457.2
H3c11
H3 clustered histone 11
chr6_+_136931519 0.71 ENSMUST00000137768.2
Pde6h
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr14_+_99536111 0.70 ENSMUST00000005279.8
Klf5
Kruppel-like factor 5
chr8_+_117822593 0.67 ENSMUST00000034308.16
ENSMUST00000176860.2
Bco1
beta-carotene oxygenase 1
chr11_-_70350783 0.53 ENSMUST00000019064.9
Cxcl16
chemokine (C-X-C motif) ligand 16
chr11_-_5049082 0.47 ENSMUST00000063232.7
Ewsr1
Ewing sarcoma breakpoint region 1
chr9_+_50528813 0.42 ENSMUST00000141366.8
Pih1d2
PIH1 domain containing 2
chr9_-_50528530 0.40 ENSMUST00000147671.2
ENSMUST00000145139.8
ENSMUST00000155435.8
Nkapd1
NKAP domain containing 1
chr3_-_103645311 0.37 ENSMUST00000029440.10
Olfml3
olfactomedin-like 3
chr4_+_84802592 0.36 ENSMUST00000102819.10
Cntln
centlein, centrosomal protein
chr6_+_3993774 0.35 ENSMUST00000031673.7
Gngt1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr10_-_22025169 0.32 ENSMUST00000179054.8
ENSMUST00000069372.7
E030030I06Rik
RIKEN cDNA E030030I06 gene
chr14_-_20027279 0.32 ENSMUST00000160013.8
Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr1_-_84817976 0.31 ENSMUST00000190067.7
Trip12
thyroid hormone receptor interactor 12
chr7_-_98305737 0.28 ENSMUST00000205911.2
ENSMUST00000038359.6
ENSMUST00000206611.2
ENSMUST00000206619.2
Emsy
EMSY, BRCA2-interacting transcriptional repressor
chr19_-_4189603 0.27 ENSMUST00000025761.8
Cabp4
calcium binding protein 4
chr2_+_101455022 0.27 ENSMUST00000044031.4
Rag2
recombination activating gene 2
chr10_+_128061699 0.25 ENSMUST00000026455.8
Mip
major intrinsic protein of lens fiber
chr14_+_28740162 0.25 ENSMUST00000055662.4
Lrtm1
leucine-rich repeats and transmembrane domains 1
chr4_+_136349924 0.24 ENSMUST00000178843.3
Lactbl1
lactamase, beta-like 1
chrX_+_159551009 0.24 ENSMUST00000033650.14
Rs1
retinoschisis (X-linked, juvenile) 1 (human)
chr9_+_30941924 0.24 ENSMUST00000216649.2
ENSMUST00000115222.10
Zbtb44
zinc finger and BTB domain containing 44
chr7_-_98305986 0.23 ENSMUST00000205276.2
Emsy
EMSY, BRCA2-interacting transcriptional repressor
chr5_+_77413282 0.22 ENSMUST00000080359.12
Rest
RE1-silencing transcription factor
chr11_-_5049036 0.21 ENSMUST00000102930.10
ENSMUST00000093365.12
ENSMUST00000073308.11
Ewsr1
Ewing sarcoma breakpoint region 1
chr11_-_51647290 0.20 ENSMUST00000109097.9
Sec24a
Sec24 related gene family, member A (S. cerevisiae)
chr17_+_36172235 0.18 ENSMUST00000172931.2
Nrm
nurim (nuclear envelope membrane protein)
chr1_-_119576632 0.18 ENSMUST00000163147.8
ENSMUST00000052404.13
ENSMUST00000191046.7
Epb41l5
erythrocyte membrane protein band 4.1 like 5
chr1_+_178014983 0.18 ENSMUST00000161075.8
ENSMUST00000027783.14
Desi2
desumoylating isopeptidase 2
chr2_+_121287444 0.17 ENSMUST00000126764.2
Hypk
huntingtin interacting protein K
chr7_+_13132040 0.17 ENSMUST00000005791.14
Cabp5
calcium binding protein 5
chr7_-_126574959 0.17 ENSMUST00000206296.2
ENSMUST00000205437.3
Cdiptos
CDIP transferase, opposite strand
chr2_-_29983618 0.17 ENSMUST00000081838.7
ENSMUST00000102865.11
Zdhhc12
zinc finger, DHHC domain containing 12
chr11_-_5049223 0.16 ENSMUST00000079949.13
Ewsr1
Ewing sarcoma breakpoint region 1
chr11_-_69127848 0.15 ENSMUST00000021259.9
ENSMUST00000108665.8
ENSMUST00000108664.2
Gucy2e
guanylate cyclase 2e
chr6_-_29380467 0.14 ENSMUST00000080428.13
Opn1sw
opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
chr17_+_36172210 0.14 ENSMUST00000074259.15
ENSMUST00000174873.2
Nrm
nurim (nuclear envelope membrane protein)
chr1_-_13730732 0.13 ENSMUST00000027071.7
Lactb2
lactamase, beta 2
chr4_+_126503611 0.12 ENSMUST00000097886.4
ENSMUST00000164362.2
5730409E04Rik
RIKEN cDNA 5730409E04Rik gene
chr7_-_127324788 0.12 ENSMUST00000076091.4
Ctf2
cardiotrophin 2
chr3_-_88368489 0.12 ENSMUST00000166237.8
Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr11_-_52173391 0.12 ENSMUST00000086844.10
Tcf7
transcription factor 7, T cell specific
chr7_-_4755971 0.12 ENSMUST00000183971.8
ENSMUST00000182173.2
ENSMUST00000182738.8
ENSMUST00000182111.8
ENSMUST00000184143.8
ENSMUST00000182048.2
ENSMUST00000063324.14
Cox6b2
cytochrome c oxidase subunit 6B2
chr8_-_96033213 0.12 ENSMUST00000119870.9
ENSMUST00000093268.5
Cngb1
cyclic nucleotide gated channel beta 1
chr7_+_101619327 0.12 ENSMUST00000210475.2
Numa1
nuclear mitotic apparatus protein 1
chr2_-_22930149 0.10 ENSMUST00000091394.13
ENSMUST00000093171.13
Abi1
abl interactor 1
chr7_-_105401398 0.10 ENSMUST00000033184.6
Tpp1
tripeptidyl peptidase I
chr18_-_46730547 0.10 ENSMUST00000151189.2
Tmed7
transmembrane p24 trafficking protein 7
chr11_-_70510010 0.10 ENSMUST00000102556.10
ENSMUST00000014753.9
Chrne
cholinergic receptor, nicotinic, epsilon polypeptide
chr7_+_57069417 0.09 ENSMUST00000085240.11
Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr1_-_132294807 0.08 ENSMUST00000136828.3
Tmcc2
transmembrane and coiled-coil domains 2
chr5_-_31359276 0.08 ENSMUST00000031562.11
Zfp513
zinc finger protein 513
chr19_+_26582450 0.08 ENSMUST00000176769.9
ENSMUST00000208163.2
ENSMUST00000025862.15
ENSMUST00000176030.8
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr7_+_101619019 0.07 ENSMUST00000084852.13
Numa1
nuclear mitotic apparatus protein 1
chr17_-_35383867 0.07 ENSMUST00000025253.12
Prrc2a
proline-rich coiled-coil 2A
chr6_+_115111872 0.06 ENSMUST00000009538.12
ENSMUST00000203450.2
Syn2
synapsin II
chr6_-_124817155 0.06 ENSMUST00000024206.6
Gnb3
guanine nucleotide binding protein (G protein), beta 3
chr11_+_5049608 0.06 ENSMUST00000139742.8
Rhbdd3
rhomboid domain containing 3
chr3_+_28835425 0.05 ENSMUST00000060500.9
Eif5a2
eukaryotic translation initiation factor 5A2
chr19_+_4189786 0.05 ENSMUST00000096338.5
Gpr152
G protein-coupled receptor 152
chr7_+_103684652 0.04 ENSMUST00000213214.2
Olfr641
olfactory receptor 641
chr2_-_73316809 0.04 ENSMUST00000141264.8
Wipf1
WAS/WASL interacting protein family, member 1
chr15_-_65848649 0.03 ENSMUST00000239034.2
ENSMUST00000100584.3
Hhla1
HERV-H LTR-associating 1
chr11_+_67586140 0.03 ENSMUST00000021290.2
Rcvrn
recoverin
chr19_+_8595369 0.03 ENSMUST00000010250.4
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr7_-_132616977 0.03 ENSMUST00000169570.8
Ctbp2
C-terminal binding protein 2
chr8_-_106863423 0.03 ENSMUST00000146940.2
Esrp2
epithelial splicing regulatory protein 2
chr17_-_85397627 0.03 ENSMUST00000072406.5
ENSMUST00000171795.9
ENSMUST00000234676.2
Prepl
prolyl endopeptidase-like
chr3_-_84167119 0.02 ENSMUST00000107691.8
Trim2
tripartite motif-containing 2
chr11_+_70350963 0.02 ENSMUST00000126105.2
Zmynd15
zinc finger, MYND-type containing 15
chr17_-_35265514 0.02 ENSMUST00000007250.14
Msh5
mutS homolog 5
chr7_+_43361930 0.02 ENSMUST00000066834.8
Klk13
kallikrein related-peptidase 13
chr7_-_80053063 0.02 ENSMUST00000147150.2
Furin
furin (paired basic amino acid cleaving enzyme)
chr9_+_32305259 0.02 ENSMUST00000172015.3
Kcnj1
potassium inwardly-rectifying channel, subfamily J, member 1
chr11_+_117090465 0.02 ENSMUST00000093907.11
Septin9
septin 9
chr14_-_55762416 0.02 ENSMUST00000178694.3
Nrl
neural retina leucine zipper gene
chr14_+_36776775 0.01 ENSMUST00000120052.2
Lrit1
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr6_-_29380423 0.01 ENSMUST00000147483.3
Opn1sw
opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
chr14_-_55762432 0.01 ENSMUST00000062232.15
Nrl
neural retina leucine zipper gene
chr16_-_17732923 0.01 ENSMUST00000012279.6
ENSMUST00000232493.2
Gsc2
goosecoid homebox 2
chr4_-_137493785 0.01 ENSMUST00000139951.8
Alpl
alkaline phosphatase, liver/bone/kidney
chr11_-_99176086 0.01 ENSMUST00000017255.4
Krt24
keratin 24
chr1_+_82817794 0.01 ENSMUST00000186043.2
Agfg1
ArfGAP with FG repeats 1
chr7_-_132725575 0.01 ENSMUST00000171968.8
Ctbp2
C-terminal binding protein 2
chr11_-_90578397 0.01 ENSMUST00000107869.9
ENSMUST00000154599.2
ENSMUST00000107868.8
ENSMUST00000020849.9
Tom1l1
target of myb1-like 1 (chicken)
chr11_+_3981769 0.01 ENSMUST00000019512.8
Sec14l4
SEC14-like lipid binding 4
chr11_+_70350725 0.01 ENSMUST00000147289.2
Zmynd15
zinc finger, MYND-type containing 15
chr19_-_47680528 0.01 ENSMUST00000026045.14
ENSMUST00000086923.6
Col17a1
collagen, type XVII, alpha 1
chr1_-_155108455 0.01 ENSMUST00000035914.5
BC034090
cDNA sequence BC034090
chr19_-_13080648 0.01 ENSMUST00000076729.4
Olfr1458
olfactory receptor 1458
chr13_-_64645606 0.01 ENSMUST00000180282.2
Fam240b
family with sequence similarity 240 member B
chr19_-_46314945 0.01 ENSMUST00000225781.2
ENSMUST00000223903.2
Psd
pleckstrin and Sec7 domain containing
chr11_-_43792013 0.01 ENSMUST00000067258.9
ENSMUST00000139906.2
Adra1b
adrenergic receptor, alpha 1b
chr5_-_137643954 0.01 ENSMUST00000057314.4
Irs3
insulin receptor substrate 3
chr16_+_17051423 0.01 ENSMUST00000090190.14
ENSMUST00000232082.2
ENSMUST00000232426.2
Hic2
Gm49573
hypermethylated in cancer 2
predicted gene, 49573
chr4_-_140781015 0.01 ENSMUST00000102491.10
Crocc
ciliary rootlet coiled-coil, rootletin
chr4_-_139974062 0.01 ENSMUST00000039331.9
Igsf21
immunoglobulin superfamily, member 21
chr1_-_154692678 0.01 ENSMUST00000238369.2
Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr5_-_66161621 0.00 ENSMUST00000201351.4
9130230L23Rik
RIKEN cDNA 9130230L23 gene
chr13_-_113755082 0.00 ENSMUST00000109241.5
Snx18
sorting nexin 18
chr2_+_22958956 0.00 ENSMUST00000226571.2
ENSMUST00000114529.10
ENSMUST00000114526.9
ENSMUST00000228050.2
Acbd5
acyl-Coenzyme A binding domain containing 5
chr17_+_47221377 0.00 ENSMUST00000024773.6
Prph2
peripherin 2
chr1_+_178015287 0.00 ENSMUST00000159284.2
Desi2
desumoylating isopeptidase 2
chr2_+_164404499 0.00 ENSMUST00000017867.10
ENSMUST00000109344.9
ENSMUST00000109345.9
Wfdc2
WAP four-disulfide core domain 2
chrX_+_133195974 0.00 ENSMUST00000037687.8
Tmem35a
transmembrane protein 35A
chr4_-_139560831 0.00 ENSMUST00000030508.14
Pax7
paired box 7
chr16_-_29197485 0.00 ENSMUST00000143373.8
ENSMUST00000075806.11
Atp13a5
ATPase type 13A5
chrX_+_132809166 0.00 ENSMUST00000033606.15
Srpx2
sushi-repeat-containing protein, X-linked 2
chr7_+_43418404 0.00 ENSMUST00000014063.6
Klk12
kallikrein related-peptidase 12
chr17_-_72059865 0.00 ENSMUST00000057405.9
Pcare
photoreceptor cilium actin regulator
chr7_+_63803583 0.00 ENSMUST00000085222.12
ENSMUST00000206277.2
Trpm1
transient receptor potential cation channel, subfamily M, member 1
chr7_+_63803663 0.00 ENSMUST00000206314.2
Trpm1
transient receptor potential cation channel, subfamily M, member 1
chr19_+_12861219 0.00 ENSMUST00000049624.3
Olfr1445
olfactory receptor 1445
chr6_-_38086484 0.00 ENSMUST00000114908.5
Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr7_+_12246415 0.00 ENSMUST00000032541.5
2900092C05Rik
RIKEN cDNA 2900092C05 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.1 0.3 GO:0008594 photoreceptor cell morphogenesis(GO:0008594)
0.1 0.2 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.2 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 0.2 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.1 0.7 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 0.3 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.2 GO:0002331 pre-B cell allelic exclusion(GO:0002331) B cell homeostatic proliferation(GO:0002358)
0.0 0.2 GO:1902365 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.7 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.4 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.2 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.5 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.7 GO:0007602 phototransduction(GO:0007602)
0.0 0.7 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 0.1 GO:0002568 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0046691 intracellular canaliculus(GO:0046691)
0.0 0.2 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.0 1.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.3 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.1 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.0 0.5 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.7 GO:0030553 cGMP binding(GO:0030553)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.7 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0043855 cyclic nucleotide-gated ion channel activity(GO:0043855)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.8 PID BARD1 PATHWAY BARD1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines