Project
avrg: GFI1 WT vs 36n/n vs KD
Navigation
Downloads
Results for Gtf2i_Gtf2f1
Z-value: 5.92
Motif logo
Transcription factors associated with Gtf2i_Gtf2f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gtf2i | mm39_v1_chr5_-_134343491_134343531 | 0.95 | 1.2e-02 | Click! |
| Gtf2f1 | mm39_v1_chr17_-_57318271_57318326 | -0.25 | 6.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_43959637 Show fit | 6.36 |
ENSMUST00000107938.8
|
SH3 and multiple ankyrin repeat domains 1 |
|
| chrX_-_36967692 Show fit | 5.00 |
ENSMUST00000071885.7
|
reproductive homeobox 8 |
|
| chr7_-_127423641 Show fit | 4.85 |
ENSMUST00000106267.5
|
syntaxin 1B |
|
| chr2_-_155315708 Show fit | 3.59 |
ENSMUST00000109670.8
ENSMUST00000123293.8 |
nuclear receptor coactivator 6 |
|
| chr3_+_88857929 Show fit | 3.59 |
ENSMUST00000186583.7
|
ASH1 like histone lysine methyltransferase |
|
| chr8_+_108669276 Show fit | 3.57 |
ENSMUST00000220518.2
|
zinc finger homeobox 3 |
|
| chr11_+_16702203 Show fit | 3.52 |
ENSMUST00000102884.10
ENSMUST00000020329.13 |
epidermal growth factor receptor |
|
| chr7_+_142025575 Show fit | 3.44 |
ENSMUST00000038946.9
|
lymphocyte specific 1 |
|
| chr8_+_108020132 Show fit | 3.06 |
ENSMUST00000151114.8
ENSMUST00000125721.8 ENSMUST00000075922.11 |
nuclear factor of activated T cells 5 |
|
| chrX_-_7242065 Show fit | 3.01 |
ENSMUST00000191497.2
ENSMUST00000115744.2 |
ubiquitin specific peptidase 27, X chromosome |
Network of associatons between targets according to the STRING database.
First level regulatory network of Gtf2i_Gtf2f1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 10.7 | GO:0060235 | lens induction in camera-type eye(GO:0060235) |
| 0.6 | 5.9 | GO:0046959 | habituation(GO:0046959) |
| 0.5 | 5.6 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 1.1 | 5.5 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.3 | 5.4 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 1.1 | 5.3 | GO:1904048 | regulation of spontaneous neurotransmitter secretion(GO:1904048) |
| 0.7 | 5.0 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.8 | 4.5 | GO:1900020 | regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020) |
| 0.4 | 4.3 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.2 | 4.3 | GO:0045060 | negative thymic T cell selection(GO:0045060) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 16.0 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 12.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 12.3 | GO:0045202 | synapse(GO:0045202) |
| 0.3 | 7.8 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 6.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 5.6 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 5.3 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 4.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.3 | 4.6 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 35.3 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 15.5 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 11.6 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 11.0 | GO:0003779 | actin binding(GO:0003779) |
| 0.3 | 7.0 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.9 | 6.4 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.2 | 5.5 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.3 | 5.1 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.2 | 4.9 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.1 | 4.8 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 8.3 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 8.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 6.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 6.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 5.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 4.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 4.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 4.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 4.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.6 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 7.5 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.3 | 6.3 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 5.8 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.4 | 4.5 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.2 | 4.4 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 4.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 4.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.6 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.1 | 3.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |