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avrg: GFI1 WT vs 36n/n vs KD

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Results for Hnf1a

Z-value: 0.93

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Transcription factors associated with Hnf1a

Gene Symbol Gene ID Gene Info
Hnf1a
ENSMUSG00000029556.13 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf1amm39_v1_chr5_-_115109118_1151091380.227.2e-01Click!

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_66204228 0.80 ENSMUST00000029419.8
Veph1
ventricular zone expressed PH domain-containing 1
chr1_+_172525613 0.75 ENSMUST00000038495.5
Crp
C-reactive protein, pentraxin-related
chr16_+_24266829 0.70 ENSMUST00000078988.10
Lpp
LIM domain containing preferred translocation partner in lipoma
chr3_-_122778052 0.66 ENSMUST00000199401.2
ENSMUST00000197314.5
ENSMUST00000197934.5
ENSMUST00000090379.7
Usp53
ubiquitin specific peptidase 53
chr12_+_76580386 0.63 ENSMUST00000219063.2
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr2_-_34990689 0.60 ENSMUST00000226631.2
ENSMUST00000045776.5
ENSMUST00000226972.2
AI182371
expressed sequence AI182371
chr7_+_75259778 0.59 ENSMUST00000207923.2
Akap13
A kinase (PRKA) anchor protein 13
chr6_-_116693849 0.57 ENSMUST00000056623.13
Tmem72
transmembrane protein 72
chr5_-_114796425 0.54 ENSMUST00000112225.8
ENSMUST00000071968.9
Trpv4
transient receptor potential cation channel, subfamily V, member 4
chr8_-_122671588 0.52 ENSMUST00000057653.8
Car5a
carbonic anhydrase 5a, mitochondrial
chr3_+_94305824 0.51 ENSMUST00000050975.6
Lingo4
leucine rich repeat and Ig domain containing 4
chr19_-_30526916 0.51 ENSMUST00000025803.9
Dkk1
dickkopf WNT signaling pathway inhibitor 1
chr4_-_139695337 0.49 ENSMUST00000105031.4
Klhdc7a
kelch domain containing 7A
chr12_-_103597663 0.47 ENSMUST00000121625.2
ENSMUST00000044231.12
Serpina10
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr9_+_21746785 0.44 ENSMUST00000058777.8
Angptl8
angiopoietin-like 8
chr19_-_14575395 0.40 ENSMUST00000052011.15
ENSMUST00000167776.3
Tle4
transducin-like enhancer of split 4
chr7_+_101583283 0.38 ENSMUST00000209639.2
ENSMUST00000210679.2
Numa1
nuclear mitotic apparatus protein 1
chr8_+_117822593 0.35 ENSMUST00000034308.16
ENSMUST00000176860.2
Bco1
beta-carotene oxygenase 1
chr19_+_42034231 0.34 ENSMUST00000172244.8
ENSMUST00000081714.5
Hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr14_+_80237691 0.29 ENSMUST00000228749.2
ENSMUST00000088735.4
Olfm4
olfactomedin 4
chr11_+_118319029 0.28 ENSMUST00000124861.2
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr19_+_13208692 0.23 ENSMUST00000207246.4
Olfr1463
olfactory receptor 1463
chr10_-_75946790 0.22 ENSMUST00000120757.2
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr8_+_65399831 0.21 ENSMUST00000026595.13
ENSMUST00000209852.2
ENSMUST00000079896.9
Tmem192
transmembrane protein 192
chr4_+_19818718 0.20 ENSMUST00000035890.8
Slc7a13
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr3_-_133250889 0.20 ENSMUST00000197118.5
Tet2
tet methylcytosine dioxygenase 2
chr14_-_79718890 0.19 ENSMUST00000022601.7
Wbp4
WW domain binding protein 4
chr14_+_51333816 0.19 ENSMUST00000169895.3
Rnase4
ribonuclease, RNase A family 4
chr11_+_115802828 0.18 ENSMUST00000132961.2
Smim6
small integral membrane protein 6
chr7_-_79492091 0.17 ENSMUST00000049004.8
Anpep
alanyl (membrane) aminopeptidase
chr9_+_99511549 0.16 ENSMUST00000131095.8
ENSMUST00000078367.12
ENSMUST00000112885.9
Dzip1l
DAZ interacting protein 1-like
chr11_-_78313043 0.15 ENSMUST00000001122.6
Slc13a2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr12_+_59142439 0.15 ENSMUST00000219140.3
Mia2
MIA SH3 domain ER export factor 2
chr14_-_36641270 0.15 ENSMUST00000182797.8
Ccser2
coiled-coil serine rich 2
chr1_+_88139678 0.13 ENSMUST00000073049.7
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr8_-_105350898 0.13 ENSMUST00000212882.2
ENSMUST00000163783.4
Cdh16
cadherin 16
chr19_-_47907628 0.12 ENSMUST00000237029.2
Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr17_-_35351026 0.12 ENSMUST00000025249.7
Apom
apolipoprotein M
chr2_+_162829422 0.10 ENSMUST00000117123.2
Sgk2
serum/glucocorticoid regulated kinase 2
chr10_+_87694924 0.10 ENSMUST00000095360.11
Igf1
insulin-like growth factor 1
chr18_+_65158873 0.09 ENSMUST00000226058.2
Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr5_+_122529941 0.08 ENSMUST00000102525.11
Arpc3
actin related protein 2/3 complex, subunit 3
chr9_+_99511876 0.07 ENSMUST00000112886.9
Dzip1l
DAZ interacting protein 1-like
chr10_+_34359395 0.07 ENSMUST00000019913.15
Frk
fyn-related kinase
chr2_-_29641647 0.07 ENSMUST00000129574.3
Gm13420
predicted gene 13420
chr4_+_97665992 0.06 ENSMUST00000107062.9
ENSMUST00000052018.12
ENSMUST00000107057.8
Nfia
nuclear factor I/A
chr7_-_44711771 0.06 ENSMUST00000210101.2
ENSMUST00000209219.2
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr5_+_102992873 0.06 ENSMUST00000070000.6
Arhgap24
Rho GTPase activating protein 24
chr2_-_91466739 0.05 ENSMUST00000111335.2
ENSMUST00000028681.15
F2
coagulation factor II
chr4_-_94538370 0.05 ENSMUST00000053419.9
Lrrc19
leucine rich repeat containing 19
chr1_+_88066086 0.05 ENSMUST00000014263.6
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr14_-_70867588 0.04 ENSMUST00000228009.2
Dmtn
dematin actin binding protein
chr6_-_52160816 0.04 ENSMUST00000134831.2
Hoxa3
homeobox A3
chr14_-_36641470 0.04 ENSMUST00000182042.2
Ccser2
coiled-coil serine rich 2
chr7_-_101519914 0.04 ENSMUST00000106985.8
ENSMUST00000151706.8
Folr1
folate receptor 1 (adult)
chr14_-_36832044 0.04 ENSMUST00000179488.3
2610528A11Rik
RIKEN cDNA 2610528A11 gene
chr6_-_41681273 0.03 ENSMUST00000031899.14
Kel
Kell blood group
chr2_-_34951443 0.03 ENSMUST00000028233.7
Hc
hemolytic complement
chr13_+_54849268 0.03 ENSMUST00000037145.8
Cdhr2
cadherin-related family member 2
chr11_-_6180127 0.03 ENSMUST00000004505.3
Npc1l1
NPC1 like intracellular cholesterol transporter 1
chr3_+_3573084 0.03 ENSMUST00000108393.8
Hnf4g
hepatocyte nuclear factor 4, gamma
chr1_-_82746169 0.03 ENSMUST00000027331.3
Tm4sf20
transmembrane 4 L six family member 20
chr11_+_73051228 0.03 ENSMUST00000006104.10
ENSMUST00000135202.8
ENSMUST00000136894.3
P2rx5
purinergic receptor P2X, ligand-gated ion channel, 5
chr5_+_35198853 0.02 ENSMUST00000030985.10
ENSMUST00000202573.2
Hgfac
hepatocyte growth factor activator
chr13_+_55300453 0.02 ENSMUST00000005452.6
Fgfr4
fibroblast growth factor receptor 4
chr3_+_82933383 0.02 ENSMUST00000029630.15
ENSMUST00000166581.4
Fga
fibrinogen alpha chain
chr4_-_140344373 0.02 ENSMUST00000154979.2
Arhgef10l
Rho guanine nucleotide exchange factor (GEF) 10-like
chr13_-_53440087 0.02 ENSMUST00000021918.10
Ror2
receptor tyrosine kinase-like orphan receptor 2
chr1_+_133237516 0.02 ENSMUST00000094557.7
ENSMUST00000192465.2
ENSMUST00000193888.6
ENSMUST00000194044.6
ENSMUST00000184603.8
Golt1a
Gm28040
Gm28040
golgi transport 1A
predicted gene, 28040
predicted gene, 28040
chr15_-_42540363 0.02 ENSMUST00000022921.7
Angpt1
angiopoietin 1
chr1_+_125604706 0.02 ENSMUST00000027581.7
Gpr39
G protein-coupled receptor 39
chr1_-_20688196 0.02 ENSMUST00000088448.12
Pkhd1
polycystic kidney and hepatic disease 1
chr15_+_7840327 0.02 ENSMUST00000022744.5
Gdnf
glial cell line derived neurotrophic factor
chr5_+_31454787 0.01 ENSMUST00000201166.4
ENSMUST00000072228.9
Gckr
glucokinase regulatory protein
chr4_+_119494901 0.01 ENSMUST00000024015.3
Guca2a
guanylate cyclase activator 2a (guanylin)
chr6_+_141575226 0.01 ENSMUST00000042812.9
Slco1b2
solute carrier organic anion transporter family, member 1b2
chr2_+_163348728 0.01 ENSMUST00000143911.8
Hnf4a
hepatic nuclear factor 4, alpha
chr7_+_127865472 0.01 ENSMUST00000033045.11
Slc5a2
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr17_+_12803019 0.01 ENSMUST00000046959.9
ENSMUST00000233066.2
Slc22a2
solute carrier family 22 (organic cation transporter), member 2
chr4_-_63090355 0.01 ENSMUST00000156618.9
ENSMUST00000030042.3
Kif12
kinesin family member 12
chr2_+_74557418 0.01 ENSMUST00000111980.4
Hoxd4
homeobox D4
chr11_-_11848044 0.01 ENSMUST00000066237.10
Ddc
dopa decarboxylase
chr17_+_35960600 0.01 ENSMUST00000171166.3
Sfta2
surfactant associated 2
chr10_+_75983285 0.01 ENSMUST00000020450.4
Slc5a4a
solute carrier family 5, member 4a
chr12_-_103623418 0.01 ENSMUST00000044159.7
Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr11_+_70410009 0.01 ENSMUST00000057685.3
Gltpd2
glycolipid transfer protein domain containing 2
chrX_+_100420873 0.01 ENSMUST00000052130.14
Gjb1
gap junction protein, beta 1
chr4_-_102883905 0.00 ENSMUST00000084382.6
ENSMUST00000106869.3
Insl5
insulin-like 5
chr8_+_123920682 0.00 ENSMUST00000212409.2
Dpep1
dipeptidase 1
chr4_-_111755892 0.00 ENSMUST00000102720.8
Slc5a9
solute carrier family 5 (sodium/glucose cotransporter), member 9
chr9_-_76953070 0.00 ENSMUST00000034911.7
Tinag
tubulointerstitial nephritis antigen
chr11_+_78068931 0.00 ENSMUST00000147819.8
Tlcd1
TLC domain containing 1
chr9_-_71070506 0.00 ENSMUST00000074465.9
Aqp9
aquaporin 9
chr7_-_144305705 0.00 ENSMUST00000155175.8
Ano1
anoctamin 1, calcium activated chloride channel
chr7_+_30193047 0.00 ENSMUST00000058280.13
ENSMUST00000133318.8
ENSMUST00000142575.8
ENSMUST00000131040.2
Prodh2
proline dehydrogenase (oxidase) 2
chr5_+_33261563 0.00 ENSMUST00000011178.5
Slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr10_+_34359513 0.00 ENSMUST00000170771.3
Frk
fyn-related kinase
chr5_+_88635834 0.00 ENSMUST00000199104.5
ENSMUST00000031222.9
Enam
enamelin
chr11_+_70410445 0.00 ENSMUST00000179000.2
Gltpd2
glycolipid transfer protein domain containing 2
chr11_+_7147779 0.00 ENSMUST00000020704.8
Igfbp1
insulin-like growth factor binding protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0071640 regulation of macrophage inflammatory protein 1 alpha production(GO:0071640)
0.2 0.5 GO:1904956 regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081) regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.1 0.4 GO:0055048 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.1 0.8 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.3 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.1 0.6 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.4 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0019858 cytosine metabolic process(GO:0019858)
0.0 0.1 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 0.1 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
0.0 0.3 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.3 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.2 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.7 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.1 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 0.2 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.0 0.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.2 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.3 GO:0042581 specific granule(GO:0042581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.1 0.8 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.3 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.5 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.2 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.4 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes