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avrg: GFI1 WT vs 36n/n vs KD

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Results for Hoxa1

Z-value: 1.31

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Transcription factors associated with Hoxa1

Gene Symbol Gene ID Gene Info
Hoxa1
ENSMUSG00000029844.10 homeobox A1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxa1mm39_v1_chr6_-_52135261_52135332-0.276.7e-01Click!

Activity profile of Hoxa1 motif

Sorted Z-values of Hoxa1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_12355604 4.45 ENSMUST00000168193.8
ENSMUST00000064204.14
Actn2
actinin alpha 2
chr2_+_158217558 1.01 ENSMUST00000109488.8
Snhg11
small nucleolar RNA host gene 11
chr4_+_138503046 0.69 ENSMUST00000030528.9
Pla2g2d
phospholipase A2, group IID
chr10_+_81068980 0.67 ENSMUST00000144087.2
ENSMUST00000117798.8
Zfr2
zinc finger RNA binding protein 2
chr18_+_82929451 0.63 ENSMUST00000235902.2
Zfp516
zinc finger protein 516
chr14_+_50656083 0.55 ENSMUST00000216949.2
Olfr739
olfactory receptor 739
chrX_-_133062677 0.45 ENSMUST00000033611.5
Xkrx
X-linked Kx blood group related, X-linked
chr15_+_6552270 0.44 ENSMUST00000226412.2
Fyb
FYN binding protein
chr12_-_80307110 0.43 ENSMUST00000021554.16
Actn1
actinin, alpha 1
chr1_+_153750081 0.41 ENSMUST00000055314.4
Teddm1b
transmembrane epididymal protein 1B
chr4_-_106656976 0.41 ENSMUST00000145061.8
ENSMUST00000102762.10
Acot11
acyl-CoA thioesterase 11
chrX_+_109857866 0.40 ENSMUST00000078229.5
Pou3f4
POU domain, class 3, transcription factor 4
chr13_+_41040657 0.38 ENSMUST00000069958.15
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr14_-_69522431 0.36 ENSMUST00000183882.2
ENSMUST00000037064.5
Slc25a37
solute carrier family 25, member 37
chr14_-_69740670 0.35 ENSMUST00000180059.3
ENSMUST00000179116.3
Gm16867
predicted gene, 16867
chr11_-_99134885 0.34 ENSMUST00000103132.10
ENSMUST00000038214.7
Krt222
keratin 222
chr7_-_103320398 0.33 ENSMUST00000062144.4
Olfr624
olfactory receptor 624
chr7_-_102507962 0.33 ENSMUST00000213481.2
ENSMUST00000209952.2
Olfr566
olfactory receptor 566
chr19_+_42040681 0.32 ENSMUST00000164518.4
4933411K16Rik
RIKEN cDNA 4933411K16 gene
chr2_-_104324035 0.32 ENSMUST00000111124.8
Hipk3
homeodomain interacting protein kinase 3
chr3_+_97920819 0.32 ENSMUST00000079812.8
Notch2
notch 2
chr17_-_25300112 0.29 ENSMUST00000024984.7
Tmem204
transmembrane protein 204
chr19_-_47452557 0.29 ENSMUST00000111800.4
Sh3pxd2a
SH3 and PX domains 2A
chr9_-_21223631 0.29 ENSMUST00000115433.11
Ap1m2
adaptor protein complex AP-1, mu 2 subunit
chr19_+_45036037 0.28 ENSMUST00000062213.13
Sfxn3
sideroflexin 3
chr3_+_138058139 0.28 ENSMUST00000090166.5
Adh6b
alcohol dehydrogenase 6B (class V)
chr15_+_89095724 0.27 ENSMUST00000227951.2
ENSMUST00000226221.2
ENSMUST00000238818.2
ENSMUST00000228284.2
Ppp6r2
protein phosphatase 6, regulatory subunit 2
chr19_+_45036220 0.27 ENSMUST00000084493.8
Sfxn3
sideroflexin 3
chr5_+_88731386 0.27 ENSMUST00000031229.11
Rufy3
RUN and FYVE domain containing 3
chr14_+_56813060 0.26 ENSMUST00000161553.2
Parp4
poly (ADP-ribose) polymerase family, member 4
chr11_+_24030663 0.24 ENSMUST00000118955.2
Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr15_+_9140614 0.24 ENSMUST00000227556.3
Lmbrd2
LMBR1 domain containing 2
chr4_+_43669266 0.23 ENSMUST00000107864.8
Tmem8b
transmembrane protein 8B
chr17_-_28841370 0.21 ENSMUST00000233129.2
ENSMUST00000232751.2
ENSMUST00000233794.2
ENSMUST00000114767.3
Srpk1
serine/arginine-rich protein specific kinase 1
chr13_+_63387870 0.20 ENSMUST00000159152.3
ENSMUST00000221820.2
Aopep
aminopeptidase O
chr16_+_38722666 0.20 ENSMUST00000023478.8
Igsf11
immunoglobulin superfamily, member 11
chr9_+_78303059 0.20 ENSMUST00000113367.2
Ddx43
DEAD box helicase 43
chr2_+_119803230 0.19 ENSMUST00000229024.2
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr12_-_80306865 0.17 ENSMUST00000167327.2
Actn1
actinin, alpha 1
chr5_-_107437427 0.17 ENSMUST00000031224.15
Tgfbr3
transforming growth factor, beta receptor III
chr4_-_145041710 0.17 ENSMUST00000030339.13
Tnfrsf8
tumor necrosis factor receptor superfamily, member 8
chr17_+_45866618 0.16 ENSMUST00000024742.9
ENSMUST00000233929.2
Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
chr10_+_67021509 0.15 ENSMUST00000173689.8
Jmjd1c
jumonji domain containing 1C
chr19_+_45035942 0.15 ENSMUST00000237222.2
ENSMUST00000111954.11
Sfxn3
sideroflexin 3
chr17_-_28841006 0.15 ENSMUST00000233353.2
Srpk1
serine/arginine-rich protein specific kinase 1
chrX_+_55500170 0.15 ENSMUST00000039374.9
ENSMUST00000101553.9
ENSMUST00000186445.7
Ints6l
integrator complex subunit 6 like
chr14_-_104081827 0.15 ENSMUST00000022718.11
Ednrb
endothelin receptor type B
chr5_+_125518609 0.15 ENSMUST00000049040.14
Bri3bp
Bri3 binding protein
chr2_+_119803180 0.13 ENSMUST00000066058.8
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr18_+_4994600 0.13 ENSMUST00000140448.8
Svil
supervillin
chr3_+_58913234 0.12 ENSMUST00000040846.15
Med12l
mediator complex subunit 12-like
chr2_+_165436929 0.11 ENSMUST00000088132.13
Eya2
EYA transcriptional coactivator and phosphatase 2
chr8_+_11362805 0.10 ENSMUST00000033899.14
Col4a2
collagen, type IV, alpha 2
chr2_-_103315483 0.10 ENSMUST00000028610.10
Cat
catalase
chr2_-_63014622 0.10 ENSMUST00000075052.10
ENSMUST00000112454.8
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr10_-_125225298 0.09 ENSMUST00000210780.2
Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr5_+_43672856 0.08 ENSMUST00000076939.10
C1qtnf7
C1q and tumor necrosis factor related protein 7
chr18_-_56695333 0.08 ENSMUST00000066208.13
ENSMUST00000172734.8
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr6_-_136852792 0.08 ENSMUST00000032342.3
Mgp
matrix Gla protein
chr4_-_143026068 0.08 ENSMUST00000030317.14
Pdpn
podoplanin
chrX_-_7999009 0.08 ENSMUST00000130832.8
ENSMUST00000033506.13
ENSMUST00000115623.8
ENSMUST00000153839.2
Wdr13
WD repeat domain 13
chr19_+_46385321 0.08 ENSMUST00000039922.13
ENSMUST00000111867.9
ENSMUST00000120778.8
Sufu
SUFU negative regulator of hedgehog signaling
chr15_-_53209513 0.08 ENSMUST00000077273.9
Ext1
exostosin glycosyltransferase 1
chr2_-_165717697 0.07 ENSMUST00000153655.8
Zmynd8
zinc finger, MYND-type containing 8
chr5_+_42225303 0.07 ENSMUST00000087332.5
Gm16223
predicted gene 16223
chr6_+_15727798 0.07 ENSMUST00000128849.3
Mdfic
MyoD family inhibitor domain containing
chr15_-_9140460 0.07 ENSMUST00000110585.10
Skp2
S-phase kinase-associated protein 2
chr2_+_152804405 0.07 ENSMUST00000099197.9
ENSMUST00000103155.10
Ttll9
tubulin tyrosine ligase-like family, member 9
chr7_-_144024451 0.06 ENSMUST00000033407.13
Cttn
cortactin
chr15_+_82136598 0.06 ENSMUST00000136948.3
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr4_-_106657446 0.06 ENSMUST00000148688.2
Acot11
acyl-CoA thioesterase 11
chr5_+_24679154 0.06 ENSMUST00000199856.2
Agap3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr11_+_86375441 0.05 ENSMUST00000020827.7
Rnft1
ring finger protein, transmembrane 1
chr18_+_82929037 0.04 ENSMUST00000236858.2
Zfp516
zinc finger protein 516
chr19_-_3625698 0.04 ENSMUST00000172362.3
ENSMUST00000025846.16
ENSMUST00000226109.2
ENSMUST00000113997.9
Ppp6r3
protein phosphatase 6, regulatory subunit 3
chr4_-_143026033 0.04 ENSMUST00000119654.2
Pdpn
podoplanin
chr19_-_41732104 0.03 ENSMUST00000025993.10
Slit1
slit guidance ligand 1
chr6_-_51989456 0.03 ENSMUST00000078214.8
ENSMUST00000204778.3
Skap2
src family associated phosphoprotein 2
chr5_+_137059127 0.03 ENSMUST00000041543.9
ENSMUST00000186451.2
Vgf
VGF nerve growth factor inducible
chr1_+_153541020 0.03 ENSMUST00000152114.8
ENSMUST00000111812.8
Rgs8
regulator of G-protein signaling 8
chr18_-_56695288 0.03 ENSMUST00000170309.8
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr6_-_21851827 0.02 ENSMUST00000202353.2
ENSMUST00000134635.2
ENSMUST00000123116.8
ENSMUST00000120965.8
ENSMUST00000143531.2
Tspan12
tetraspanin 12
chr3_-_79053182 0.02 ENSMUST00000118340.7
Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chrX_-_36432482 0.02 ENSMUST00000046557.6
Akap14
A kinase (PRKA) anchor protein 14
chr3_-_57202546 0.02 ENSMUST00000196506.2
Tm4sf1
transmembrane 4 superfamily member 1
chr13_-_103901010 0.02 ENSMUST00000210489.2
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr15_-_78272957 0.02 ENSMUST00000169575.2
Tex33
testis expressed 33
chr13_+_113429690 0.01 ENSMUST00000136755.10
Cspg4b
chondroitin sulfate proteoglycan 4B
chr11_-_69439934 0.01 ENSMUST00000108659.2
Dnah2
dynein, axonemal, heavy chain 2
chr10_-_33500583 0.01 ENSMUST00000161692.2
ENSMUST00000160299.2
ENSMUST00000019920.13
Clvs2
clavesin 2
chr12_-_8351954 0.01 ENSMUST00000220073.2
ENSMUST00000037313.6
Gdf7
growth differentiation factor 7
chr9_-_4796217 0.00 ENSMUST00000027020.13
ENSMUST00000163309.2
Gria4
glutamate receptor, ionotropic, AMPA4 (alpha 4)
chrX_-_119222792 0.00 ENSMUST00000122050.2
H2ab3
H2A.B variant histone 3
chr18_+_37108994 0.00 ENSMUST00000193984.2
Gm37388
predicted gene, 37388
chr2_+_156317416 0.00 ENSMUST00000029155.16
Epb41l1
erythrocyte membrane protein band 4.1 like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0051695 actin filament uncapping(GO:0051695)
0.1 0.3 GO:0035622 intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705)
0.1 0.2 GO:1904799 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.1 0.2 GO:0060939 transforming growth factor beta receptor complex assembly(GO:0007181) cardiac fibroblast cell differentiation(GO:0060935) cardiac fibroblast cell development(GO:0060936) epicardium-derived cardiac fibroblast cell differentiation(GO:0060938) epicardium-derived cardiac fibroblast cell development(GO:0060939)
0.1 0.4 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.7 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.3 GO:0007256 activation of JNKK activity(GO:0007256) negative regulation of defense response to bacterium(GO:1900425)
0.0 0.2 GO:0032329 serine transport(GO:0032329)
0.0 0.1 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.0 0.1 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 0.6 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.3 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.4 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0 1.2 GO:0009409 response to cold(GO:0009409)
0.0 0.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.2 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.1 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:1903758 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.0 0.2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0032127 dense core granule membrane(GO:0032127)
0.1 4.5 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.3 GO:0071437 invadopodium(GO:0071437)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.5 GO:0051373 FATZ binding(GO:0051373)
0.1 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.0 0.4 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0004096 catalase activity(GO:0004096)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.5 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.3 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions