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avrg: GFI1 WT vs 36n/n vs KD

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Results for Hsf4

Z-value: 2.81

Motif logo

Transcription factors associated with Hsf4

Gene Symbol Gene ID Gene Info
ENSMUSG00000033249.11 heat shock transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hsf4mm39_v1_chr8_+_105996419_105996465-0.612.7e-01Click!

Activity profile of Hsf4 motif

Sorted Z-values of Hsf4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_35658131 3.12 ENSMUST00000071951.14
ENSMUST00000116598.10
ENSMUST00000078205.14
ENSMUST00000076256.8
histocompatibility 2, Q region locus 7
chr17_+_35643818 3.07 ENSMUST00000174699.8
histocompatibility 2, Q region locus 6
chr17_-_34218301 2.82 ENSMUST00000235463.2
histocompatibility 2, K1, K region
chr12_-_110662256 2.57 ENSMUST00000149189.2
heat shock protein 90, alpha (cytosolic), class A member 1
chr17_+_35643853 2.46 ENSMUST00000113879.4
histocompatibility 2, Q region locus 6
chr17_-_45883421 2.42 ENSMUST00000130406.2
heat shock protein 90 alpha (cytosolic), class B member 1
chr15_-_31601652 1.97 ENSMUST00000161266.2
chaperonin containing Tcp1, subunit 5 (epsilon)
chr5_+_129864044 1.85 ENSMUST00000201414.5
chaperonin containing Tcp1, subunit 6a (zeta)
chr11_+_70021155 1.83 ENSMUST00000041550.12
ENSMUST00000165951.8
macrophage galactose N-acetyl-galactosamine specific lectin 2
chr17_+_35598583 1.71 ENSMUST00000081435.5
histocompatibility 2, Q region locus 4
chr6_+_51447317 1.69 ENSMUST00000094623.10
chromobox 3
chr17_+_35780977 1.68 ENSMUST00000174525.8
ENSMUST00000068291.7
histocompatibility 2, Q region locus 10
chr12_+_75355082 1.66 ENSMUST00000118602.8
ENSMUST00000118966.8
ENSMUST00000055390.6
ras homolog family member J
chr6_-_128415640 1.62 ENSMUST00000032508.11
FK506 binding protein 4
chr12_-_110662677 1.61 ENSMUST00000124156.8
heat shock protein 90, alpha (cytosolic), class A member 1
chr4_-_136620376 1.52 ENSMUST00000046332.6
complement component 1, q subcomponent, C chain
chr6_-_129252396 1.49 ENSMUST00000032259.6
CD69 antigen
chr11_-_48836975 1.45 ENSMUST00000104958.2
protease (prosome, macropain) activator subunit 2B
chr8_-_85620537 1.41 ENSMUST00000003907.14
ENSMUST00000109745.8
ENSMUST00000142748.2
glutaryl-Coenzyme A dehydrogenase
chr17_+_27000034 1.38 ENSMUST00000015725.16
ENSMUST00000135824.8
ENSMUST00000137989.2
BCL2/adenovirus E1B interacting protein 1
chr13_+_28441511 1.37 ENSMUST00000223428.2
ribosomal protein S18, pseudogene 5
chr12_+_55431007 1.37 ENSMUST00000163070.8
proteasome subunit alpha 6
chr16_+_22926162 1.35 ENSMUST00000023599.13
ENSMUST00000168891.8
eukaryotic translation initiation factor 4A2
chr5_-_149559636 1.26 ENSMUST00000201452.4
heat shock 105kDa/110kDa protein 1
chr15_-_31601932 1.26 ENSMUST00000022842.16
chaperonin containing Tcp1, subunit 5 (epsilon)
chr16_-_84632439 1.23 ENSMUST00000138279.2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr5_-_149559667 1.23 ENSMUST00000074846.14
heat shock 105kDa/110kDa protein 1
chr5_-_45607485 1.23 ENSMUST00000154962.8
ENSMUST00000118097.8
ENSMUST00000198258.5
quinoid dihydropteridine reductase
chr15_-_38518406 1.23 ENSMUST00000151319.8
antizyme inhibitor 1
chr13_-_97897139 1.21 ENSMUST00000074072.5
ribosomal protein S18, pseudogene 6
chr17_+_35482063 1.16 ENSMUST00000172503.3
histocompatibility 2, D region locus 1
chr11_+_58090382 1.13 ENSMUST00000035266.11
ENSMUST00000094169.11
ENSMUST00000168280.2
ENSMUST00000058704.9
interferon gamma induced GTPase
immunity-related GTPase family M member 2
chr7_+_92210348 1.12 ENSMUST00000032842.13
ENSMUST00000085017.5
coiled-coil domain containing 90B
chr4_-_86587728 1.12 ENSMUST00000149700.8
perilipin 2
chr11_+_22940599 1.08 ENSMUST00000020562.5
chaperonin containing Tcp1, subunit 4 (delta)
chr5_-_45607463 1.08 ENSMUST00000197946.5
ENSMUST00000127562.3
quinoid dihydropteridine reductase
chr17_+_35481702 1.06 ENSMUST00000172785.8
histocompatibility 2, D region locus 1
chr6_+_88061464 1.05 ENSMUST00000032143.8
ribophorin I
chr5_-_45607554 0.99 ENSMUST00000015950.12
quinoid dihydropteridine reductase
chr17_+_13135216 0.99 ENSMUST00000089024.13
ENSMUST00000151287.8
t-complex protein 1
chr9_-_105398346 0.98 ENSMUST00000176770.8
ENSMUST00000085133.13
ATPase, Ca++-sequestering
chr18_+_66591604 0.96 ENSMUST00000025399.9
ENSMUST00000237161.2
ENSMUST00000236933.2
phorbol-12-myristate-13-acetate-induced protein 1
chr7_-_46365108 0.93 ENSMUST00000006956.9
ENSMUST00000210913.2
serum amyloid A 3
chr6_+_40302106 0.93 ENSMUST00000031977.12
acylglycerol kinase
chr11_+_52123016 0.92 ENSMUST00000109072.2
S-phase kinase-associated protein 1
chrX_-_72759748 0.92 ENSMUST00000002091.6
B cell receptor associated protein 31
chr3_+_159545309 0.88 ENSMUST00000068952.10
ENSMUST00000198878.2
wntless WNT ligand secretion mediator
chr11_-_93859064 0.86 ENSMUST00000107844.3
ENSMUST00000170303.2
NME/NM23 nucleoside diphosphate kinase 1
predicted gene 20390
chr15_-_38518458 0.86 ENSMUST00000127848.2
antizyme inhibitor 1
chr14_-_36857083 0.85 ENSMUST00000042564.17
growth hormone inducible transmembrane protein
chr6_-_148847854 0.84 ENSMUST00000139355.8
ENSMUST00000146457.2
ENSMUST00000054080.15
SIN3-HDAC complex associated factor
chr2_-_121287174 0.83 ENSMUST00000110613.9
ENSMUST00000056312.10
serine incorporator 4
chr1_-_33796790 0.83 ENSMUST00000187602.2
ENSMUST00000044691.9
BCL2-associated athanogene 2
chr16_+_22926504 0.80 ENSMUST00000187168.7
ENSMUST00000232287.2
ENSMUST00000077605.12
eukaryotic translation initiation factor 4A2
chr5_+_121342544 0.79 ENSMUST00000031617.13
ribosomal protein L6
chr19_-_4675631 0.78 ENSMUST00000225375.2
ENSMUST00000025823.6
Ras converting CAAX endopeptidase 1
chr10_+_80662490 0.78 ENSMUST00000060987.15
ENSMUST00000177850.8
ENSMUST00000180036.8
ENSMUST00000179172.8
ornithine decarboxylase antizyme 1
chr15_-_78377926 0.76 ENSMUST00000163494.3
interleukin 2 receptor, beta chain
chr6_-_129252323 0.75 ENSMUST00000204411.2
CD69 antigen
chr2_-_24864998 0.75 ENSMUST00000194392.2
mitochondrial ribosomal protein L41
chr8_+_34621717 0.74 ENSMUST00000239436.2
ENSMUST00000033933.8
store-operated calcium entry-associated regulatory factor
chr11_+_22940519 0.73 ENSMUST00000173867.8
chaperonin containing Tcp1, subunit 4 (delta)
chr19_-_4675352 0.72 ENSMUST00000224707.2
ENSMUST00000237059.2
Ras converting CAAX endopeptidase 1
chr7_-_120581535 0.70 ENSMUST00000033169.9
cerebellar degeneration-related 2
chr8_+_40876827 0.69 ENSMUST00000049389.11
ENSMUST00000128166.8
ENSMUST00000167766.2
zinc finger, DHHC domain containing 2
chr10_+_59159118 0.68 ENSMUST00000009789.15
ENSMUST00000092512.11
ENSMUST00000105466.3
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
chr16_-_87292592 0.68 ENSMUST00000176750.2
ENSMUST00000175977.8
chaperonin containing Tcp1, subunit 8 (theta)
chr10_-_79911245 0.67 ENSMUST00000217972.2
strawberry notch 2
chr11_+_6510167 0.67 ENSMUST00000109722.9
cerebral cavernous malformation 2
chr19_-_29790352 0.66 ENSMUST00000099525.5
RAN binding protein 6
chr5_-_130031842 0.65 ENSMUST00000026613.14
glucuronidase, beta
chr10_+_81104006 0.65 ENSMUST00000057798.9
ENSMUST00000219304.2
amyloid beta (A4) precursor protein-binding, family A, member 3
chr2_+_29678248 0.64 ENSMUST00000028137.10
ENSMUST00000148791.2
coenzyme Q4
chr13_-_111626562 0.64 ENSMUST00000091236.11
ENSMUST00000047627.14
GC-rich promoter binding protein 1
chr8_-_22888604 0.64 ENSMUST00000033871.8
solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15
chr11_+_52122836 0.62 ENSMUST00000037324.12
ENSMUST00000166537.8
S-phase kinase-associated protein 1
chr5_+_129097133 0.62 ENSMUST00000031383.14
ENSMUST00000111343.2
RAN, member RAS oncogene family
chr17_-_13135232 0.62 ENSMUST00000079121.4
mitochondrial ribosomal protein L18
chr2_-_37249247 0.62 ENSMUST00000112940.8
ENSMUST00000009174.15
phosducin-like
chr8_-_110419867 0.61 ENSMUST00000034164.6
increased sodium tolerance 1 homolog (yeast)
chr19_+_5416769 0.61 ENSMUST00000025759.9
eukaryotic translation initiation factor 1A domain containing
chr8_-_11528615 0.60 ENSMUST00000033900.7
RAB20, member RAS oncogene family
chr2_+_128942919 0.60 ENSMUST00000028874.8
polymerase (RNA) I polypeptide B
chr7_-_141472218 0.60 ENSMUST00000151890.3
toll interacting protein
chr9_-_36637670 0.60 ENSMUST00000172702.9
ENSMUST00000172742.2
checkpoint kinase 1
chr11_-_5492175 0.60 ENSMUST00000020776.5
coiled-coil domain containing 117
chr5_-_88823989 0.59 ENSMUST00000078945.12
G-rich RNA sequence binding factor 1
chr11_-_86148379 0.59 ENSMUST00000132024.8
ENSMUST00000139285.8
integrator complex subunit 2
chr11_-_23447866 0.59 ENSMUST00000128559.2
ENSMUST00000147157.8
ENSMUST00000109539.8
AHA1, activator of heat shock protein ATPase 2
chr19_-_4675300 0.59 ENSMUST00000225264.2
ENSMUST00000237022.2
ENSMUST00000224675.3
Ras converting CAAX endopeptidase 1
chrX_+_158086253 0.58 ENSMUST00000112491.2
ribosomal protein S6 kinase polypeptide 3
chr17_+_25381414 0.58 ENSMUST00000073277.12
ENSMUST00000182621.8
coiled-coil domain containing 154
chr17_-_56428968 0.57 ENSMUST00000041357.9
leucine-rich alpha-2-glycoprotein 1
chr5_-_23988696 0.57 ENSMUST00000119946.8
pseudouridylate synthase 7
chr6_+_83142902 0.56 ENSMUST00000077407.12
ENSMUST00000113913.8
ENSMUST00000130212.8
dynactin 1
chr4_-_151142351 0.56 ENSMUST00000030797.4
vesicle-associated membrane protein 3
chr9_-_109930078 0.56 ENSMUST00000196455.2
ENSMUST00000062368.13
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr16_-_87292711 0.56 ENSMUST00000176041.8
ENSMUST00000026704.14
chaperonin containing Tcp1, subunit 8 (theta)
chr6_-_72416531 0.55 ENSMUST00000205335.2
ENSMUST00000206692.2
ENSMUST00000059472.10
methionine adenosyltransferase II, alpha
chr9_+_71123061 0.54 ENSMUST00000034723.6
aldehyde dehydrogenase family 1, subfamily A2
chr11_+_17109263 0.54 ENSMUST00000102880.5
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
chr3_-_100876960 0.54 ENSMUST00000076941.12
transcription termination factor, RNA polymerase II
chr15_+_102391614 0.53 ENSMUST00000229432.2
poly(rC) binding protein 2
chr9_-_36637923 0.53 ENSMUST00000034625.12
checkpoint kinase 1
chr2_-_94268426 0.53 ENSMUST00000028617.7
apoptosis inhibitor 5
chr17_+_25992761 0.53 ENSMUST00000237541.2
cytosolic iron-sulfur assembly component 3
chr2_-_51862941 0.53 ENSMUST00000145481.8
ENSMUST00000112705.9
N-myc (and STAT) interactor
chr8_+_11608412 0.52 ENSMUST00000209565.2
inhibitor of growth family, member 1
chr19_-_7017295 0.52 ENSMUST00000025918.9
stress-induced phosphoprotein 1
chr14_+_54457978 0.52 ENSMUST00000103740.2
ENSMUST00000198398.5
T cell receptor alpha constant
chr7_-_19043955 0.52 ENSMUST00000207334.2
ENSMUST00000208505.2
ENSMUST00000207716.2
ENSMUST00000208326.2
ENSMUST00000003640.4
FBJ osteosarcoma oncogene B
chr7_+_49408847 0.51 ENSMUST00000085272.7
ENSMUST00000207895.2
HIV-1 Tat interactive protein 2
chr12_-_110662723 0.51 ENSMUST00000021698.13
heat shock protein 90, alpha (cytosolic), class A member 1
chr7_-_121666486 0.51 ENSMUST00000033159.4
glutamyl-tRNA synthetase 2, mitochondrial
chr17_-_35265702 0.51 ENSMUST00000097338.11
mutS homolog 5
chr11_-_23448030 0.51 ENSMUST00000020529.13
AHA1, activator of heat shock protein ATPase 2
chr4_-_86588267 0.51 ENSMUST00000000466.13
perilipin 2
chr5_-_110220379 0.49 ENSMUST00000210275.2
predicted gene, 17655
chr14_-_66071412 0.49 ENSMUST00000022613.10
establishment of sister chromatid cohesion N-acetyltransferase 2
chr11_-_121119864 0.49 ENSMUST00000137299.8
cytochrome b 245 chaperone 1
chr2_+_158466802 0.49 ENSMUST00000045644.9
ARP5 actin-related protein 5
chr11_+_5048915 0.49 ENSMUST00000101610.10
rhomboid domain containing 3
chr17_-_45903494 0.49 ENSMUST00000163492.8
solute carrier family 29 (nucleoside transporters), member 1
chr15_-_74671382 0.48 ENSMUST00000168815.8
lymphocyte antigen 6 complex, locus K
chr4_+_65523223 0.48 ENSMUST00000050850.14
ENSMUST00000107366.2
tripartite motif-containing 32
chr12_-_110662765 0.48 ENSMUST00000094361.11
heat shock protein 90, alpha (cytosolic), class A member 1
chr2_-_29677634 0.48 ENSMUST00000177467.8
ENSMUST00000113807.10
TruB pseudouridine (psi) synthase family member 2
chr16_+_19578981 0.47 ENSMUST00000079780.10
ENSMUST00000164397.8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr7_-_19005721 0.47 ENSMUST00000032561.9
vasodilator-stimulated phosphoprotein
chr7_-_89590230 0.47 ENSMUST00000075010.12
heat shock protein nuclear import factor
chr4_+_148225139 0.47 ENSMUST00000140049.8
ENSMUST00000105707.2
MAD2 mitotic arrest deficient-like 2
chr3_+_67337429 0.47 ENSMUST00000077271.9
G elongation factor, mitochondrial 1
chr7_-_27713540 0.46 ENSMUST00000180502.8
zinc finger protein 850
chr11_-_86148344 0.46 ENSMUST00000136469.2
ENSMUST00000018212.13
integrator complex subunit 2
chr5_+_149121458 0.46 ENSMUST00000122160.8
ENSMUST00000100410.10
ENSMUST00000119685.8
ubiquitin specific peptidase like 1
chr5_+_25451771 0.46 ENSMUST00000144971.2
polypeptide N-acetylgalactosaminyltransferase 11
chr6_-_51446850 0.45 ENSMUST00000069949.13
heterogeneous nuclear ribonucleoprotein A2/B1
chr2_+_163535925 0.45 ENSMUST00000109400.3
protein kinase inhibitor, gamma
chr19_-_24938909 0.45 ENSMUST00000025815.10
COBW domain containing 1
chr17_+_21926663 0.45 ENSMUST00000073312.7
zinc finger protein 760
chr7_+_136496328 0.44 ENSMUST00000081510.4
O-6-methylguanine-DNA methyltransferase
chr15_+_31602252 0.44 ENSMUST00000042702.7
ENSMUST00000161061.3
ATP synthase C subunit lysine N-methyltransferase
chr5_+_149121355 0.43 ENSMUST00000050472.16
ubiquitin specific peptidase like 1
chr9_-_37166699 0.43 ENSMUST00000161114.2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
chr5_-_149559792 0.43 ENSMUST00000202361.4
ENSMUST00000202089.4
ENSMUST00000200825.2
ENSMUST00000201559.4
heat shock 105kDa/110kDa protein 1
chr1_+_91178288 0.43 ENSMUST00000171112.8
ENSMUST00000191533.2
ubiquitin-conjugating enzyme E2F (putative)
chr2_-_35332101 0.43 ENSMUST00000131745.8
glycoprotein galactosyltransferase alpha 1, 3
chr10_+_80062468 0.42 ENSMUST00000130260.2
PWWP domain containing 3A, DNA repair factor
chr5_-_140375010 0.42 ENSMUST00000031539.12
sorting nexin 8
chr10_+_28544356 0.41 ENSMUST00000060409.13
ENSMUST00000056097.11
ENSMUST00000105516.9
thymocyte selection associated
chr10_+_77449543 0.41 ENSMUST00000124024.3
small ubiquitin-like modifier 3
chr5_-_104059105 0.41 ENSMUST00000031254.9
kelch-like 8
chr12_+_83572774 0.41 ENSMUST00000223291.2
DDB1 and CUL4 associated factor 4
chr1_-_75187417 0.41 ENSMUST00000113623.8
galactosidase, beta 1-like
chr16_+_33614378 0.40 ENSMUST00000115044.8
mucin 13, epithelial transmembrane
chr2_+_85809620 0.39 ENSMUST00000056849.3
olfactory receptor 1030
chr7_+_126575781 0.39 ENSMUST00000206450.2
ENSMUST00000205830.2
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr16_-_84632383 0.38 ENSMUST00000114191.8
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr12_+_8258166 0.38 ENSMUST00000220274.2
lipid droplet associated hydrolase
chr5_+_149121488 0.38 ENSMUST00000139474.8
ENSMUST00000117878.8
ubiquitin specific peptidase like 1
chr1_+_59724108 0.38 ENSMUST00000027174.10
ENSMUST00000190231.7
ENSMUST00000191142.7
ENSMUST00000185772.7
NOP58 ribonucleoprotein
chr6_-_51446752 0.37 ENSMUST00000204188.3
ENSMUST00000203220.3
ENSMUST00000114459.8
ENSMUST00000090002.10
heterogeneous nuclear ribonucleoprotein A2/B1
chr12_-_69274936 0.37 ENSMUST00000221411.2
ENSMUST00000021359.7
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr17_+_31783708 0.37 ENSMUST00000097352.11
ENSMUST00000237248.2
ENSMUST00000235869.2
ENSMUST00000175806.9
Pbx/knotted 1 homeobox
chr3_+_96537484 0.37 ENSMUST00000200647.2
RNA binding motif protein 8a
chr5_-_129864202 0.37 ENSMUST00000136507.4
phosphoserine phosphatase
chr7_-_47178610 0.36 ENSMUST00000172559.2
MAS-related GPR, member A2B
chr17_+_29898221 0.36 ENSMUST00000129864.2
cap methyltransferase 1
chr7_+_19248345 0.36 ENSMUST00000135972.2
trafficking protein particle complex 6A
chr4_-_133273243 0.36 ENSMUST00000030665.7
nudC nuclear distribution protein
chr11_-_121120052 0.35 ENSMUST00000169393.8
ENSMUST00000106115.8
ENSMUST00000038709.14
ENSMUST00000147490.6
cytochrome b 245 chaperone 1
chr9_+_18203421 0.35 ENSMUST00000001825.9
cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
chr19_+_56414114 0.35 ENSMUST00000238892.2
caspase 7
chr11_-_70111796 0.35 ENSMUST00000060010.3
ENSMUST00000190533.2
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr4_-_63779562 0.35 ENSMUST00000030047.3
tumor necrosis factor (ligand) superfamily, member 8
chr11_+_23206565 0.35 ENSMUST00000136235.2
exportin 1
chr10_+_81104041 0.35 ENSMUST00000218742.2
amyloid beta (A4) precursor protein-binding, family A, member 3
chr9_+_40712562 0.34 ENSMUST00000117557.8
heat shock protein 8
chr3_+_79498663 0.34 ENSMUST00000029382.13
peptidylprolyl isomerase D (cyclophilin D)
chr10_+_77458109 0.34 ENSMUST00000174510.8
ENSMUST00000172813.2
ubiquitin-conjugating enzyme E2G 2
chr1_-_119840887 0.34 ENSMUST00000037906.6
transmembrane protein 177
chrX_-_108056995 0.34 ENSMUST00000033597.9
high-mobility group nucleosome binding domain 5
chr1_-_79836344 0.33 ENSMUST00000027467.11
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr1_-_55127183 0.33 ENSMUST00000027123.15
heat shock protein 1 (chaperonin)
chr8_+_84335176 0.33 ENSMUST00000212300.2
DnaJ heat shock protein family (Hsp40) member B1
chr5_+_122988111 0.32 ENSMUST00000031434.8
ENSMUST00000198602.2
ring finger protein 34
chr1_+_135060994 0.32 ENSMUST00000167080.3
protein tyrosine phosphatase, non-receptor type 7
chr15_-_102097387 0.32 ENSMUST00000230288.2
cysteine sulfinic acid decarboxylase
chr18_-_70605538 0.32 ENSMUST00000067556.4
RIKEN cDNA 4930503L19 gene
chr12_-_104964936 0.32 ENSMUST00000109927.2
ENSMUST00000095439.11
spectrin repeat containing, nuclear envelope family member 3
chr17_+_25235310 0.32 ENSMUST00000024983.12
intraflagellar transport 140
chr8_+_27513819 0.31 ENSMUST00000033873.9
ENSMUST00000211043.2
ER lipid raft associated 2
chr6_-_40562700 0.31 ENSMUST00000177178.2
ENSMUST00000129948.9
ENSMUST00000101491.11
C-type lectin domain family 5, member a
chrY_-_90850446 0.31 ENSMUST00000179623.2
predicted gene, 21748
chr14_+_66205932 0.30 ENSMUST00000022616.14
clusterin
chr9_+_5298669 0.30 ENSMUST00000238505.2
caspase 1
chr19_+_17114108 0.30 ENSMUST00000223920.2
ENSMUST00000225351.2
prune homolog 2
chr17_-_74623154 0.29 ENSMUST00000232687.2
dpy-30, histone methyltransferase complex regulatory subunit
chr1_+_194621127 0.29 ENSMUST00000016638.8
ENSMUST00000110815.9
CD34 antigen
chr2_-_118558825 0.29 ENSMUST00000159756.2
phospholipase C, beta 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Hsf4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.0 GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.8 2.4 GO:0036363 transforming growth factor beta activation(GO:0036363) regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.7 5.2 GO:0045585 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.6 9.2 GO:1904869 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.5 2.1 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.5 2.1 GO:0080120 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.5 1.4 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949)
0.4 1.1 GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767)
0.4 1.1 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.3 3.3 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.3 1.3 GO:0032468 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.3 3.1 GO:1903753 negative regulation of p38MAPK cascade(GO:1903753)
0.3 0.9 GO:1904154 protein localization to endoplasmic reticulum exit site(GO:0070973) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.3 0.9 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.3 0.8 GO:1990428 miRNA transport(GO:1990428)
0.3 1.3 GO:0030576 Cajal body organization(GO:0030576)
0.3 12.0 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.2 0.6 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.2 0.6 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.2 0.6 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.2 0.8 GO:1902047 polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267)
0.2 0.5 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.2 0.5 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.2 1.5 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.2 0.7 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.2 0.6 GO:0009838 abscission(GO:0009838)
0.2 0.6 GO:0017126 nucleologenesis(GO:0017126)
0.1 0.6 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.1 1.0 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.7 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.7 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.1 0.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.6 GO:0042412 taurine biosynthetic process(GO:0042412)
0.1 0.3 GO:0097212 late endosomal microautophagy(GO:0061738) protein targeting to vacuole involved in autophagy(GO:0071211) lysosomal membrane organization(GO:0097212) positive regulation of protein folding(GO:1903334)
0.1 0.8 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.6 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 0.3 GO:0061107 seminal vesicle development(GO:0061107)
0.1 0.4 GO:0033580 protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125)
0.1 1.7 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 1.0 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.3 GO:0070103 regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.1 0.5 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 0.6 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 0.3 GO:1903538 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.1 0.3 GO:0072592 oxygen metabolic process(GO:0072592) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 0.5 GO:0035799 ureter maturation(GO:0035799)
0.1 0.7 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 1.0 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 0.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.5 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 0.3 GO:1901256 macrophage colony-stimulating factor production(GO:0036301) granulocyte colony-stimulating factor production(GO:0071611) regulation of granulocyte colony-stimulating factor production(GO:0071655) regulation of macrophage colony-stimulating factor production(GO:1901256)
0.1 0.4 GO:0006116 NADH oxidation(GO:0006116)
0.1 0.4 GO:0097309 cap1 mRNA methylation(GO:0097309)
0.1 0.4 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.1 0.5 GO:0015862 uridine transport(GO:0015862)
0.1 0.2 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.1 0.3 GO:0015811 L-cystine transport(GO:0015811)
0.1 1.6 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 0.9 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 0.3 GO:0035962 response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.1 0.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.3 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 0.5 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.1 1.9 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.3 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.1 0.4 GO:0048254 snoRNA localization(GO:0048254)
0.1 0.3 GO:0090383 phagosome acidification(GO:0090383)
0.1 0.2 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.1 0.4 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.3 GO:1902998 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.1 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.0 0.4 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.2 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.7 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.9 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.4 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 1.0 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.2 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.5 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.2 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.5 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.5 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 0.9 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.2 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.7 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.0 0.5 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.2 GO:0015888 thiamine transport(GO:0015888)
0.0 0.9 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.1 GO:0019043 establishment of viral latency(GO:0019043)
0.0 0.5 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 1.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.2 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:1900195 positive regulation of oocyte maturation(GO:1900195)
0.0 0.2 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.6 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.1 GO:0097240 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 2.2 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.5 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.4 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.3 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.5 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 0.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.0 0.5 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.3 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.1 GO:0016598 protein arginylation(GO:0016598)
0.0 0.3 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.4 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 0.4 GO:0043383 negative T cell selection(GO:0043383)
0.0 0.1 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.0 0.1 GO:0035617 stress granule disassembly(GO:0035617)
0.0 1.4 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 1.6 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.0 0.3 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.4 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.7 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 0.7 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.3 GO:0033033 negative regulation of myeloid cell apoptotic process(GO:0033033)
0.0 0.1 GO:0002879 cell surface pattern recognition receptor signaling pathway(GO:0002752) positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.0 0.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 1.0 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.0 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.0 0.6 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.6 GO:0050687 negative regulation of defense response to virus(GO:0050687)
0.0 0.1 GO:0042908 xenobiotic transport(GO:0042908)
0.0 0.2 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 0.1 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.2 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.0 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.0 0.4 GO:0090077 foam cell differentiation(GO:0090077)
0.0 0.1 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 17.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.9 5.2 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.5 9.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.5 2.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 1.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 0.6 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.2 0.6 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.2 0.5 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.1 0.7 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 0.9 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 1.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.5 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 1.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 0.5 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.3 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 0.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.6 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 1.1 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.1 0.3 GO:0043202 lysosomal lumen(GO:0043202)
0.1 0.6 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.8 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 1.0 GO:0032039 integrator complex(GO:0032039)
0.0 0.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.6 GO:0005869 dynactin complex(GO:0005869)
0.0 0.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.6 GO:0090543 Flemming body(GO:0090543)
0.0 1.6 GO:0015030 Cajal body(GO:0015030)
0.0 0.6 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.6 GO:0031201 SNARE complex(GO:0031201)
0.0 1.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 3.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.9 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133) germinal vesicle(GO:0042585)
0.0 0.0 GO:0098842 postsynaptic early endosome(GO:0098842)
0.0 0.1 GO:0071141 SMAD protein complex(GO:0071141)
0.0 1.0 GO:0031672 A band(GO:0031672)
0.0 0.0 GO:0036501 UFD1-NPL4 complex(GO:0036501)
0.0 0.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.4 GO:0030904 retromer complex(GO:0030904)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.4 GO:0080008 precatalytic spliceosome(GO:0071011) Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)
1.1 7.6 GO:0002135 CTP binding(GO:0002135)
1.1 17.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.5 2.1 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.4 1.3 GO:0070138 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.4 1.8 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.4 4.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 1.3 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.3 1.6 GO:0032767 copper-dependent protein binding(GO:0032767)
0.3 0.9 GO:0001729 ceramide kinase activity(GO:0001729)
0.3 1.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.3 0.8 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.2 0.7 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.2 0.7 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.2 0.8 GO:1990932 5.8S rRNA binding(GO:1990932)
0.2 0.8 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.2 7.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 0.8 GO:0042979 ornithine decarboxylase regulator activity(GO:0042979)
0.1 1.7 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.6 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.1 0.6 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 0.9 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.6 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 0.9 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.7 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 1.7 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 1.1 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.7 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 0.8 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 0.3 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.1 0.6 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.1 0.8 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.5 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 0.3 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.1 0.9 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 0.8 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 0.4 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 0.4 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1 1.4 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 0.4 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.1 0.4 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.4 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.1 0.9 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 1.0 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.2 GO:0000010 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.1 0.6 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 0.4 GO:0070573 metallodipeptidase activity(GO:0070573)
0.1 1.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.2 GO:0001147 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.2 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.9 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.4 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.6 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.3 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.5 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.3 GO:0043199 sulfate binding(GO:0043199)
0.0 1.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 2.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.2 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.2 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 1.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.5 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 0.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.3 GO:0046790 virion binding(GO:0046790)
0.0 0.3 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 2.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.0 GO:0042936 dipeptide transporter activity(GO:0042936)
0.0 0.5 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.3 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521) poly(G) binding(GO:0034046)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.0 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.3 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.2 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.5 GO:0000049 tRNA binding(GO:0000049)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 1.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 2.4 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.9 PID AURORA A PATHWAY Aurora A signaling
0.0 1.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 2.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.3 7.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.2 1.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.5 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.1 0.6 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 1.9 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 0.5 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 4.2 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 2.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 2.3 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.0 0.8 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 6.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.8 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 1.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.8 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.6 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.2 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.8 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination