Project

avrg: GFI1 WT vs 36n/n vs KD

Navigation
Downloads

Results for Irf3

Z-value: 4.43

Motif logo

logo of

Transcription factors associated with Irf3

Gene Symbol Gene ID Gene Info
Irf3
ENSMUSG00000003184.16 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf3mm39_v1_chr7_+_44647072_446471260.951.3e-02Click!

Activity profile of Irf3 motif

Sorted Z-values of Irf3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_142236086 5.88 ENSMUST00000171263.8
ENSMUST00000045097.11
Gbp7
guanylate binding protein 7
chr11_-_48955028 5.46 ENSMUST00000046745.7
Tgtp2
T cell specific GTPase 2
chr3_+_142265904 5.14 ENSMUST00000128609.8
ENSMUST00000029935.14
Gbp3
guanylate binding protein 3
chr11_-_48883053 4.92 ENSMUST00000059930.3
ENSMUST00000068063.4
Gm12185
Tgtp1
predicted gene 12185
T cell specific GTPase 1
chr3_+_142266113 4.90 ENSMUST00000106221.8
Gbp3
guanylate binding protein 3
chr3_+_142265787 4.89 ENSMUST00000199325.5
ENSMUST00000106222.9
Gbp3
guanylate binding protein 3
chr8_+_62381115 4.67 ENSMUST00000154398.8
ENSMUST00000156980.8
ENSMUST00000093485.3
ENSMUST00000070631.15
Ddx60
DExD/H box helicase 60
chr17_-_34406193 4.11 ENSMUST00000173831.3
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr5_-_121025645 3.52 ENSMUST00000086368.12
Oas1g
2'-5' oligoadenylate synthetase 1G
chr5_-_121045568 3.47 ENSMUST00000080322.8
Oas1a
2'-5' oligoadenylate synthetase 1A
chr3_-_50398027 3.46 ENSMUST00000029297.6
ENSMUST00000194462.6
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr2_-_105229653 3.32 ENSMUST00000006128.7
Rcn1
reticulocalbin 1
chr11_-_48762170 3.23 ENSMUST00000049519.4
ENSMUST00000097271.4
Irgm1
immunity-related GTPase family M member 1
chr5_-_120950570 3.20 ENSMUST00000117193.8
Oas1c
2'-5' oligoadenylate synthetase 1C
chr2_-_155668567 2.94 ENSMUST00000109638.2
ENSMUST00000134278.2
Eif6
eukaryotic translation initiation factor 6
chr17_+_34406762 2.60 ENSMUST00000041633.15
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_34406523 2.44 ENSMUST00000170086.8
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_-_44785603 2.25 ENSMUST00000209467.2
Gm45713
predicted gene 45713
chr16_-_10603389 2.15 ENSMUST00000229866.2
ENSMUST00000038099.6
Socs1
suppressor of cytokine signaling 1
chr16_+_35759346 2.00 ENSMUST00000023622.13
Parp9
poly (ADP-ribose) polymerase family, member 9
chr5_+_115034997 1.98 ENSMUST00000031542.13
ENSMUST00000146072.8
ENSMUST00000150361.2
Oasl2
2'-5' oligoadenylate synthetase-like 2
chr14_-_55828511 1.98 ENSMUST00000161807.8
ENSMUST00000111378.10
ENSMUST00000159687.2
Psme2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr4_-_40239778 1.88 ENSMUST00000037907.13
Ddx58
DEAD/H box helicase 58
chr6_-_34294377 1.86 ENSMUST00000154655.2
ENSMUST00000102980.11
Akr1b3
aldo-keto reductase family 1, member B3 (aldose reductase)
chr11_-_100595019 1.71 ENSMUST00000017974.13
Dhx58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr13_-_23894697 1.64 ENSMUST00000091707.13
ENSMUST00000006787.8
Hfe
homeostatic iron regulator
chr11_+_58090382 1.63 ENSMUST00000035266.11
ENSMUST00000094169.11
ENSMUST00000168280.2
ENSMUST00000058704.9
Igtp
Irgm2
interferon gamma induced GTPase
immunity-related GTPase family M member 2
chr6_-_39095144 1.62 ENSMUST00000038398.7
Parp12
poly (ADP-ribose) polymerase family, member 12
chr9_+_20779924 1.56 ENSMUST00000043911.8
Shfl
shiftless antiviral inhibitor of ribosomal frameshifting
chr14_+_55815879 1.53 ENSMUST00000174563.8
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr7_-_103937301 1.51 ENSMUST00000098179.9
Trim5
tripartite motif-containing 5
chr11_-_115918784 1.50 ENSMUST00000106454.8
H3f3b
H3.3 histone B
chr3_-_104725853 1.50 ENSMUST00000106775.8
ENSMUST00000166979.8
Mov10
Mov10 RISC complex RNA helicase
chr3_+_68598757 1.50 ENSMUST00000107816.4
Il12a
interleukin 12a
chr17_+_19724994 1.49 ENSMUST00000166081.3
ENSMUST00000231465.2
Vmn2r100
vomeronasal 2, receptor 100
chr5_+_123390149 1.47 ENSMUST00000121964.8
Wdr66
WD repeat domain 66
chr3_+_81839908 1.45 ENSMUST00000029649.3
Ctso
cathepsin O
chr19_+_36387123 1.45 ENSMUST00000225411.2
ENSMUST00000062389.6
Pcgf5
polycomb group ring finger 5
chr3_+_27371168 1.44 ENSMUST00000046383.12
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
chr3_-_104725581 1.43 ENSMUST00000168015.8
Mov10
Mov10 RISC complex RNA helicase
chr18_+_24122689 1.43 ENSMUST00000074941.8
Zfp35
zinc finger protein 35
chr8_-_124045292 1.41 ENSMUST00000118395.2
ENSMUST00000035495.15
Fanca
Fanconi anemia, complementation group A
chr6_-_125208738 1.41 ENSMUST00000043422.8
Tapbpl
TAP binding protein-like
chr14_+_55815999 1.40 ENSMUST00000172738.2
ENSMUST00000089619.13
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr7_-_102214636 1.35 ENSMUST00000106913.3
ENSMUST00000033264.12
Trim21
tripartite motif-containing 21
chr19_-_44134872 1.26 ENSMUST00000237630.2
ENSMUST00000079033.6
Bloc1s2
biogenesis of lysosomal organelles complex-1, subunit 2
chr3_-_104725535 1.18 ENSMUST00000002297.12
Mov10
Mov10 RISC complex RNA helicase
chr16_+_23428650 1.14 ENSMUST00000038423.6
ENSMUST00000211349.2
Rtp4
receptor transporter protein 4
chr4_-_40239700 1.11 ENSMUST00000142055.2
Ddx58
DEAD/H box helicase 58
chr2_+_93017887 1.08 ENSMUST00000150462.8
ENSMUST00000111266.8
Trp53i11
transformation related protein 53 inducible protein 11
chr7_-_104002534 1.05 ENSMUST00000130139.3
ENSMUST00000059037.15
Trim12c
tripartite motif-containing 12C
chr2_+_93017916 1.03 ENSMUST00000090554.11
Trp53i11
transformation related protein 53 inducible protein 11
chr19_-_32085532 1.02 ENSMUST00000236030.2
ENSMUST00000237104.2
ENSMUST00000236208.2
ENSMUST00000235273.2
Asah2
N-acylsphingosine amidohydrolase 2
chr7_-_103964662 1.00 ENSMUST00000106837.8
ENSMUST00000106839.9
ENSMUST00000070943.7
Trim12a
tripartite motif-containing 12A
chr14_+_55815580 1.00 ENSMUST00000174484.8
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr4_+_115595610 0.94 ENSMUST00000106524.4
Efcab14
EF-hand calcium binding domain 14
chr11_+_72192455 0.92 ENSMUST00000151440.8
ENSMUST00000146233.8
ENSMUST00000140842.9
Xaf1
XIAP associated factor 1
chr17_+_21229165 0.85 ENSMUST00000232473.2
ENSMUST00000231482.2
ENSMUST00000088811.7
ENSMUST00000232354.2
ENSMUST00000232595.2
ENSMUST00000232320.2
Zfp160
zinc finger protein 160
chr10_+_128106414 0.82 ENSMUST00000085708.3
ENSMUST00000105238.10
Stat2
signal transducer and activator of transcription 2
chr16_+_38167352 0.79 ENSMUST00000050273.9
ENSMUST00000120495.2
ENSMUST00000119704.2
Cox17
Gm21987
cytochrome c oxidase assembly protein 17, copper chaperone
predicted gene 21987
chr11_+_119283887 0.79 ENSMUST00000093902.12
ENSMUST00000131035.10
Rnf213
ring finger protein 213
chr11_-_83421333 0.79 ENSMUST00000035938.3
Ccl5
chemokine (C-C motif) ligand 5
chr7_-_15656285 0.77 ENSMUST00000044355.11
Selenow
selenoprotein W
chr9_-_14956704 0.76 ENSMUST00000164273.9
Panx1
pannexin 1
chr19_-_43741363 0.76 ENSMUST00000045562.6
Cox15
cytochrome c oxidase assembly protein 15
chr18_-_32692967 0.73 ENSMUST00000174000.2
ENSMUST00000174459.2
Gypc
glycophorin C
chr13_-_23894828 0.73 ENSMUST00000091706.14
Hfe
homeostatic iron regulator
chr8_-_71990085 0.71 ENSMUST00000051672.9
Bst2
bone marrow stromal cell antigen 2
chr2_-_51824656 0.71 ENSMUST00000165313.2
Rbm43
RNA binding motif protein 43
chr2_+_180231038 0.71 ENSMUST00000029087.4
Ogfr
opioid growth factor receptor
chr14_-_66071412 0.68 ENSMUST00000022613.10
Esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr10_+_83379805 0.67 ENSMUST00000038388.7
Washc4
WASH complex subunit 4
chr16_-_35691914 0.67 ENSMUST00000042665.9
Parp14
poly (ADP-ribose) polymerase family, member 14
chr6_-_54949587 0.65 ENSMUST00000060655.15
Nod1
nucleotide-binding oligomerization domain containing 1
chr9_-_35087348 0.64 ENSMUST00000119847.2
ENSMUST00000034539.12
Dcps
decapping enzyme, scavenger
chr2_-_62476487 0.63 ENSMUST00000112459.4
ENSMUST00000028259.12
Ifih1
interferon induced with helicase C domain 1
chr4_-_156285247 0.63 ENSMUST00000085425.6
Isg15
ISG15 ubiquitin-like modifier
chr6_+_57557978 0.61 ENSMUST00000031817.10
Herc6
hect domain and RLD 6
chr7_-_100164007 0.60 ENSMUST00000207405.2
Dnajb13
DnaJ heat shock protein family (Hsp40) member B13
chr7_-_126194097 0.52 ENSMUST00000058429.6
Il27
interleukin 27
chr7_+_103893658 0.49 ENSMUST00000106849.9
ENSMUST00000060315.12
Trim34a
tripartite motif-containing 34A
chr1_+_85528392 0.46 ENSMUST00000080204.11
Sp140
Sp140 nuclear body protein
chr3_+_27371206 0.43 ENSMUST00000174840.2
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
chr12_-_83643964 0.43 ENSMUST00000048319.6
Zfyve1
zinc finger, FYVE domain containing 1
chr15_-_82128538 0.42 ENSMUST00000229747.2
ENSMUST00000230408.2
Cenpm
centromere protein M
chr2_-_145776934 0.42 ENSMUST00000001818.5
Crnkl1
crooked neck pre-mRNA splicing factor 1
chr1_-_85087567 0.41 ENSMUST00000161675.3
ENSMUST00000160792.8
A530032D15Rik
RIKEN cDNA A530032D15Rik gene
chr8_-_106665060 0.40 ENSMUST00000034369.10
Psmb10
proteasome (prosome, macropain) subunit, beta type 10
chr16_-_19525122 0.39 ENSMUST00000081880.7
Lamp3
lysosomal-associated membrane protein 3
chr15_+_38976260 0.39 ENSMUST00000022909.10
Dcaf13
DDB1 and CUL4 associated factor 13
chr5_-_120950549 0.39 ENSMUST00000125547.2
Oas1c
2'-5' oligoadenylate synthetase 1C
chr7_+_103893672 0.36 ENSMUST00000106848.8
Trim34a
tripartite motif-containing 34A
chr6_+_34840057 0.36 ENSMUST00000074949.4
Tmem140
transmembrane protein 140
chr14_-_8457069 0.33 ENSMUST00000022257.4
Atxn7
ataxin 7
chr1_-_85087170 0.32 ENSMUST00000161724.8
A530032D15Rik
RIKEN cDNA A530032D15Rik gene
chr15_+_32920869 0.32 ENSMUST00000022871.7
Sdc2
syndecan 2
chr1_-_75293637 0.32 ENSMUST00000185419.7
ENSMUST00000187000.7
Dnpep
aspartyl aminopeptidase
chr6_-_3399451 0.32 ENSMUST00000120087.6
Samd9l
sterile alpha motif domain containing 9-like
chr1_-_85248264 0.30 ENSMUST00000093506.12
ENSMUST00000064341.9
C130026I21Rik
RIKEN cDNA C130026I21 gene
chr1_-_37929414 0.29 ENSMUST00000139725.8
ENSMUST00000027257.10
Mitd1
MIT, microtubule interacting and transport, domain containing 1
chr9_+_54858092 0.28 ENSMUST00000172407.8
Psma4
proteasome subunit alpha 4
chr2_-_51824937 0.28 ENSMUST00000102767.8
ENSMUST00000102768.8
Rbm43
RNA binding motif protein 43
chr19_+_43741513 0.27 ENSMUST00000112047.10
Cutc
cutC copper transporter
chr11_+_20597149 0.26 ENSMUST00000109585.2
Sertad2
SERTA domain containing 2
chr2_+_152804405 0.26 ENSMUST00000099197.9
ENSMUST00000103155.10
Ttll9
tubulin tyrosine ligase-like family, member 9
chr2_-_173117936 0.25 ENSMUST00000139306.2
Pmepa1
prostate transmembrane protein, androgen induced 1
chr1_-_75293997 0.24 ENSMUST00000189282.3
ENSMUST00000191254.7
Dnpep
aspartyl aminopeptidase
chr9_+_108385247 0.23 ENSMUST00000207810.2
ENSMUST00000207862.2
ENSMUST00000208581.2
ENSMUST00000134939.9
ENSMUST00000207713.2
Qars
glutaminyl-tRNA synthetase
chr9_-_22041894 0.23 ENSMUST00000115315.3
Acp5
acid phosphatase 5, tartrate resistant
chr11_+_109253598 0.21 ENSMUST00000106702.4
ENSMUST00000020930.14
Gna13
guanine nucleotide binding protein, alpha 13
chr17_+_21229279 0.20 ENSMUST00000232663.2
Zfp160
zinc finger protein 160
chr14_+_30438334 0.17 ENSMUST00000228006.2
Sfmbt1
Scm-like with four mbt domains 1
chr7_-_115797722 0.13 ENSMUST00000181981.8
Plekha7
pleckstrin homology domain containing, family A member 7
chr15_-_38976034 0.12 ENSMUST00000227323.2
ENSMUST00000022908.10
Slc25a32
solute carrier family 25, member 32
chr6_+_129489551 0.11 ENSMUST00000204741.3
Tmem52b
transmembrane protein 52B
chr15_-_77295234 0.09 ENSMUST00000089452.6
ENSMUST00000081776.11
Apol9a
apolipoprotein L 9a
chr6_-_38331482 0.07 ENSMUST00000031850.10
ENSMUST00000114898.3
Zc3hav1
zinc finger CCCH type, antiviral 1
chr1_+_37929558 0.07 ENSMUST00000027256.12
ENSMUST00000193673.6
ENSMUST00000160082.3
Mrpl30
mitochondrial ribosomal protein L30
chr19_+_34560922 0.06 ENSMUST00000102825.4
Ifit3
interferon-induced protein with tetratricopeptide repeats 3
chr1_-_75293942 0.06 ENSMUST00000187075.7
Dnpep
aspartyl aminopeptidase
chr10_-_81332147 0.06 ENSMUST00000118498.8
Ncln
nicalin
chr6_+_34840151 0.04 ENSMUST00000202010.2
Tmem140
transmembrane protein 140
chr1_+_171216480 0.04 ENSMUST00000056449.9
Arhgap30
Rho GTPase activating protein 30
chr19_+_43741431 0.02 ENSMUST00000026199.14
Cutc
cutC copper transporter
chr2_-_126775136 0.02 ENSMUST00000028844.11
Sppl2a
signal peptide peptidase like 2A
chr17_+_19797489 0.02 ENSMUST00000171914.3
Vmn2r101
vomeronasal 2, receptor 101
chr11_+_74174562 0.01 ENSMUST00000214048.3
ENSMUST00000143976.4
ENSMUST00000205790.2
ENSMUST00000206659.2
Olfr59
olfactory receptor 59
chr7_-_102901712 0.01 ENSMUST00000073394.3
Usp17ld
ubiquitin specific peptidase 17-like D
chr7_+_103065903 0.01 ENSMUST00000079348.4
Usp17lc
ubiquitin specific peptidase 17-like C
chr1_-_75293589 0.01 ENSMUST00000113605.10
Dnpep
aspartyl aminopeptidase
chr15_+_77613239 0.00 ENSMUST00000230979.2
ENSMUST00000109775.4
Apol9b
apolipoprotein L 9b

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0046967 cytosol to ER transport(GO:0046967)
1.3 3.8 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
1.1 6.4 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
1.0 4.1 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
1.0 2.9 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.8 20.8 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.7 4.9 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.6 1.9 GO:0006059 hexitol metabolic process(GO:0006059) naphthalene metabolic process(GO:0018931) naphthalene-containing compound metabolic process(GO:0090420)
0.6 3.6 GO:0035546 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
0.4 4.2 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.3 3.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.3 1.5 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.3 1.4 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.3 0.8 GO:1904959 regulation of cytochrome-c oxidase activity(GO:1904959)
0.2 10.4 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.2 0.6 GO:0036245 cellular response to menadione(GO:0036245)
0.2 0.8 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) positive regulation of natural killer cell chemotaxis(GO:2000503)
0.2 0.8 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.2 1.5 GO:2000510 positive regulation of dendritic cell chemotaxis(GO:2000510)
0.2 0.7 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.2 1.4 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.1 0.6 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 1.6 GO:0035456 response to interferon-beta(GO:0035456)
0.1 1.4 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.1 0.6 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.1 0.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.8 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.5 GO:0045625 regulation of T-helper 1 cell differentiation(GO:0045625)
0.1 2.4 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.1 1.3 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.2 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.3 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 1.8 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 1.1 GO:0051205 protein insertion into membrane(GO:0051205)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.8 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.4 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.7 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 1.7 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 6.3 GO:0009615 response to virus(GO:0009615)
0.0 0.2 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.3 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 0.7 GO:0007032 endosome organization(GO:0007032)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 20.8 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.8 1.6 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.8 4.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.6 5.0 GO:0042825 TAP complex(GO:0042825)
0.6 3.6 GO:0008537 proteasome activator complex(GO:0008537)
0.4 2.9 GO:0005638 lamin filament(GO:0005638)
0.4 1.9 GO:0097454 Schwann cell microvillus(GO:0097454)
0.3 3.0 GO:1990462 omegasome(GO:1990462)
0.3 2.4 GO:1990357 terminal web(GO:1990357)
0.2 3.2 GO:0044754 autolysosome(GO:0044754)
0.1 0.4 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 1.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.9 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 1.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 6.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.4 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 2.0 GO:0000502 proteasome complex(GO:0000502)
0.0 0.8 GO:0070069 cytochrome complex(GO:0070069)
0.0 4.7 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 0.8 GO:0005921 gap junction(GO:0005921)
0.0 3.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.5 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 7.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0046980 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
1.0 12.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.5 5.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.5 3.5 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.3 2.9 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.3 1.5 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.3 1.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 0.8 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298) CCR1 chemokine receptor binding(GO:0031726)
0.2 2.3 GO:0050700 CARD domain binding(GO:0050700)
0.2 2.4 GO:0039706 co-receptor binding(GO:0039706)
0.2 4.1 GO:0070628 proteasome binding(GO:0070628)
0.1 1.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 3.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.0 GO:0017040 ceramidase activity(GO:0017040)
0.1 2.6 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 9.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 0.8 GO:0016531 copper chaperone activity(GO:0016531)
0.1 0.2 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.1 28.7 GO:0003924 GTPase activity(GO:0003924)
0.1 0.6 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 2.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.8 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.6 GO:0031386 protein tag(GO:0031386)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 1.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 1.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.6 GO:0030332 cyclin binding(GO:0030332)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 14.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.8 PID IL27 PATHWAY IL27-mediated signaling events
0.1 1.9 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 2.1 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 1.4 PID BARD1 PATHWAY BARD1 signaling events
0.0 4.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.8 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.7 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.6 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.2 12.1 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.2 1.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 3.0 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 4.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 5.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 1.5 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 3.5 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 0.6 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 0.6 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 2.3 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 1.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation