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avrg: GFI1 WT vs 36n/n vs KD

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Results for Irx4

Z-value: 0.55

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Transcription factors associated with Irx4

Gene Symbol Gene ID Gene Info
Irx4
ENSMUSG00000021604.16 Iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx4mm39_v1_chr13_+_73408591_73408616-0.903.9e-02Click!

Activity profile of Irx4 motif

Sorted Z-values of Irx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_16964801 0.47 ENSMUST00000232479.2
ENSMUST00000232344.2
ENSMUST00000069064.7
Ydjc
YdjC homolog (bacterial)
chr6_-_83294526 0.38 ENSMUST00000005810.9
Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr16_+_49620883 0.27 ENSMUST00000229640.2
Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr3_+_27371168 0.27 ENSMUST00000046383.12
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
chr19_-_32443978 0.25 ENSMUST00000078034.5
Rpl9-ps6
ribosomal protein L9, pseudogene 6
chr8_-_25215778 0.19 ENSMUST00000171438.8
ENSMUST00000171611.9
Adam3
a disintegrin and metallopeptidase domain 3 (cyritestin)
chr15_-_35938155 0.17 ENSMUST00000156915.3
Cox6c
cytochrome c oxidase subunit 6C
chr8_-_25215856 0.15 ENSMUST00000033958.15
Adam3
a disintegrin and metallopeptidase domain 3 (cyritestin)
chr6_-_130208601 0.12 ENSMUST00000088011.11
ENSMUST00000112013.8
ENSMUST00000049304.14
Klra7
killer cell lectin-like receptor, subfamily A, member 7
chr3_+_27371206 0.09 ENSMUST00000174840.2
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
chr3_+_84832783 0.09 ENSMUST00000107675.8
Fbxw7
F-box and WD-40 domain protein 7
chr8_+_85598734 0.08 ENSMUST00000170296.2
ENSMUST00000136026.8
Syce2
synaptonemal complex central element protein 2
chr17_-_27352876 0.07 ENSMUST00000119227.3
ENSMUST00000025045.15
Uqcc2
ubiquinol-cytochrome c reductase complex assembly factor 2
chr1_+_45350698 0.07 ENSMUST00000087883.13
Col3a1
collagen, type III, alpha 1
chr6_-_69584812 0.05 ENSMUST00000103359.3
Igkv4-55
immunoglobulin kappa variable 4-55
chr2_+_85805557 0.04 ENSMUST00000082191.5
Olfr1029
olfactory receptor 1029
chr9_+_13660450 0.04 ENSMUST00000155679.8
Mtmr2
myotubularin related protein 2
chr11_-_11920540 0.03 ENSMUST00000109653.8
Grb10
growth factor receptor bound protein 10
chr6_-_3494587 0.02 ENSMUST00000049985.15
Hepacam2
HEPACAM family member 2
chr9_+_38883609 0.02 ENSMUST00000216238.3
Olfr933
olfactory receptor 933
chr10_+_129611696 0.01 ENSMUST00000059891.3
ENSMUST00000218237.2
Olfr809
olfactory receptor 809
chr3_+_59637203 0.01 ENSMUST00000168156.3
Aadacl2fm2
AADACL2 family member 2
chr9_+_19691579 0.01 ENSMUST00000212363.2
ENSMUST00000215112.3
Olfr58
olfactory receptor 58
chr7_+_106413336 0.01 ENSMUST00000166880.3
ENSMUST00000075414.8
Olfr701
olfactory receptor 701
chr7_-_104383569 0.01 ENSMUST00000211596.2
Olfr664
olfactory receptor 664
chr2_-_89587193 0.01 ENSMUST00000215988.2
Olfr1253
olfactory receptor 1253
chr14_+_50645025 0.01 ENSMUST00000214853.2
ENSMUST00000214320.2
Olfr738
olfactory receptor 738
chr8_+_105048856 0.01 ENSMUST00000041973.7
Cmtm2b
CKLF-like MARVEL transmembrane domain containing 2B
chr14_-_50139398 0.01 ENSMUST00000053290.8
Olfr722
olfactory receptor 722
chr8_+_27937128 0.01 ENSMUST00000209669.2
Gm45861
predicted gene 45861
chr2_-_79738734 0.01 ENSMUST00000090756.11
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr2_-_79738773 0.00 ENSMUST00000102652.10
ENSMUST00000102651.10
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr3_+_104974160 0.00 ENSMUST00000070584.5
4930564D02Rik
RIKEN cDNA 4930564D02 gene
chr9_-_7388047 0.00 ENSMUST00000047888.8
Mmp1b
matrix metallopeptidase 1b (interstitial collagenase)
chrY_-_797405 0.00 ENSMUST00000189888.7
ENSMUST00000065545.6
Zfy1
zinc finger protein 1, Y-linked
chr18_+_44096300 0.00 ENSMUST00000069245.8
Spink5
serine peptidase inhibitor, Kazal type 5
chr12_-_111946560 0.00 ENSMUST00000190680.2
Rd3l
retinal degeneration 3-like
chr4_+_48663504 0.00 ENSMUST00000030033.5
Cavin4
caveolae associated 4
chr18_+_44467133 0.00 ENSMUST00000025349.12
ENSMUST00000115498.2
Myot
myotilin

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0008228 opsonization(GO:0008228)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.4 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.3 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis