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avrg: GFI1 WT vs 36n/n vs KD

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Results for Irx5

Z-value: 0.83

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Transcription factors associated with Irx5

Gene Symbol Gene ID Gene Info
Irx5
ENSMUSG00000031737.12 Iroquois homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx5mm39_v1_chr8_+_93084253_93084379-0.791.1e-01Click!

Activity profile of Irx5 motif

Sorted Z-values of Irx5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_68989763 0.73 ENSMUST00000021271.14
Per1
period circadian clock 1
chr12_-_113223839 0.52 ENSMUST00000194738.6
ENSMUST00000178282.3
Igha
immunoglobulin heavy constant alpha
chr6_+_56974228 0.52 ENSMUST00000228285.2
ENSMUST00000227847.2
ENSMUST00000226689.2
ENSMUST00000227131.2
ENSMUST00000227631.2
ENSMUST00000227188.2
Vmn1r6
vomeronasal 1 receptor 6
chr4_+_112089442 0.50 ENSMUST00000038455.12
ENSMUST00000170945.2
Skint3
selection and upkeep of intraepithelial T cells 3
chr5_+_107655487 0.49 ENSMUST00000143074.2
Gm42669
predicted gene 42669
chr11_+_73851643 0.48 ENSMUST00000213134.2
ENSMUST00000216291.2
Olfr397
olfactory receptor 397
chr16_+_3408906 0.45 ENSMUST00000216259.2
Olfr161
olfactory receptor 161
chr14_+_48358267 0.39 ENSMUST00000073150.6
Peli2
pellino 2
chr10_-_129715720 0.39 ENSMUST00000216966.2
ENSMUST00000213742.2
Olfr814
olfactory receptor 814
chr8_+_85897951 0.37 ENSMUST00000076896.6
Cks1brt
CDC28 protein kinase 1b, retrogene
chr11_-_110142565 0.36 ENSMUST00000044003.14
Abca6
ATP-binding cassette, sub-family A (ABC1), member 6
chr3_+_63203235 0.35 ENSMUST00000194134.6
Mme
membrane metallo endopeptidase
chr12_+_71095112 0.31 ENSMUST00000135709.2
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr6_-_57306479 0.30 ENSMUST00000227283.2
ENSMUST00000228356.2
Vmn1r16
vomeronasal 1 receptor 16
chr4_+_148123554 0.27 ENSMUST00000141283.8
Mthfr
methylenetetrahydrofolate reductase
chr7_-_10292412 0.27 ENSMUST00000236246.2
Vmn1r68
vomeronasal 1 receptor 68
chr4_-_89229256 0.27 ENSMUST00000097981.6
Cdkn2b
cyclin dependent kinase inhibitor 2B
chr4_-_131871797 0.25 ENSMUST00000056336.2
Oprd1
opioid receptor, delta 1
chr5_-_74189898 0.25 ENSMUST00000152408.3
Usp46
ubiquitin specific peptidase 46
chr19_+_26600820 0.24 ENSMUST00000176584.2
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_5900130 0.24 ENSMUST00000026926.5
ENSMUST00000193792.6
ENSMUST00000102981.10
Sec61a2
Sec61, alpha subunit 2 (S. cerevisiae)
chr10_+_3822667 0.23 ENSMUST00000136671.8
ENSMUST00000042438.13
Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr3_+_20011201 0.22 ENSMUST00000091309.12
ENSMUST00000108329.8
ENSMUST00000003714.13
Cp
ceruloplasmin
chr14_+_50360643 0.21 ENSMUST00000215317.2
Olfr727
olfactory receptor 727
chr4_+_111830119 0.21 ENSMUST00000106568.8
ENSMUST00000055014.11
ENSMUST00000163281.2
Skint7
selection and upkeep of intraepithelial T cells 7
chr14_+_54380308 0.20 ENSMUST00000196323.2
Trdc
T cell receptor delta, constant region
chr18_-_35348049 0.19 ENSMUST00000091636.5
ENSMUST00000236680.2
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr3_-_10273628 0.18 ENSMUST00000029041.6
Fabp4
fatty acid binding protein 4, adipocyte
chr3_-_126792056 0.18 ENSMUST00000044443.15
Ank2
ankyrin 2, brain
chr12_-_81426238 0.15 ENSMUST00000062182.8
Gm4787
predicted gene 4787
chr2_+_172994841 0.14 ENSMUST00000029017.6
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chr9_+_110948492 0.12 ENSMUST00000217341.3
Lrrfip2
leucine rich repeat (in FLII) interacting protein 2
chr2_-_87881473 0.12 ENSMUST00000183862.3
Olfr1162
olfactory receptor 1162
chr17_-_87332780 0.11 ENSMUST00000024957.7
Pigf
phosphatidylinositol glycan anchor biosynthesis, class F
chr17_-_35954573 0.10 ENSMUST00000095467.4
Mucl3
mucin like 3
chr7_-_66915756 0.10 ENSMUST00000207715.2
Mef2a
myocyte enhancer factor 2A
chr3_+_90173813 0.10 ENSMUST00000098914.10
Dennd4b
DENN/MADD domain containing 4B
chr2_-_89779008 0.10 ENSMUST00000214846.2
Olfr1259
olfactory receptor 1259
chr19_+_6130059 0.09 ENSMUST00000149347.8
ENSMUST00000143303.2
Tmem262
transmembrane protein 262
chr10_+_81128795 0.08 ENSMUST00000163075.8
ENSMUST00000105327.10
ENSMUST00000045469.15
Pip5k1c
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
chr11_-_121410152 0.08 ENSMUST00000092298.6
Zfp750
zinc finger protein 750
chr7_-_86016045 0.07 ENSMUST00000213255.2
ENSMUST00000216700.2
ENSMUST00000213869.2
Olfr305
olfactory receptor 305
chr6_-_57938488 0.07 ENSMUST00000228097.2
Vmn1r24
vomeronasal 1 receptor 24
chr13_+_25127127 0.06 ENSMUST00000021773.13
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr5_-_46013838 0.06 ENSMUST00000087164.10
ENSMUST00000121573.8
Lcorl
ligand dependent nuclear receptor corepressor-like
chr11_+_69286473 0.06 ENSMUST00000144531.2
Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr12_-_67269323 0.06 ENSMUST00000037181.16
Mdga2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr10_+_86614864 0.06 ENSMUST00000099396.3
Nt5dc3
5'-nucleotidase domain containing 3
chr11_+_78067537 0.05 ENSMUST00000098545.12
Tlcd1
TLC domain containing 1
chr3_-_14843512 0.05 ENSMUST00000094365.11
Car1
carbonic anhydrase 1
chr6_-_113694633 0.04 ENSMUST00000204533.3
Ghrl
ghrelin
chr13_+_76727799 0.04 ENSMUST00000109589.3
Mctp1
multiple C2 domains, transmembrane 1
chr16_-_35951553 0.03 ENSMUST00000161638.2
ENSMUST00000096090.3
Csta1
cystatin A1
chr11_+_117006020 0.03 ENSMUST00000103026.10
ENSMUST00000090433.6
Sec14l1
SEC14-like lipid binding 1
chr12_+_85335365 0.03 ENSMUST00000059341.5
Zc2hc1c
zinc finger, C2HC-type containing 1C
chr8_+_4290105 0.02 ENSMUST00000110994.9
ENSMUST00000110995.8
Map2k7
mitogen-activated protein kinase kinase 7
chr11_-_69286159 0.02 ENSMUST00000108660.8
ENSMUST00000051620.5
Cyb5d1
cytochrome b5 domain containing 1
chr3_-_79645101 0.02 ENSMUST00000078527.13
Rxfp1
relaxin/insulin-like family peptide receptor 1
chr6_+_71470987 0.02 ENSMUST00000114179.3
Rnf103
ring finger protein 103
chr1_-_132635042 0.02 ENSMUST00000043189.14
Nfasc
neurofascin
chr15_-_81742686 0.01 ENSMUST00000050467.9
ENSMUST00000231000.2
Tob2
transducer of ERBB2, 2
chr3_+_87265181 0.01 ENSMUST00000015998.8
Cd5l
CD5 antigen-like
chr16_-_88303859 0.01 ENSMUST00000069549.3
Cldn17
claudin 17
chr16_-_44379226 0.01 ENSMUST00000114634.3
Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr6_-_129303659 0.01 ENSMUST00000203159.2
Clec2m
C-type lectin domain family 2, member m
chr18_-_64794338 0.01 ENSMUST00000025482.10
Atp8b1
ATPase, class I, type 8B, member 1
chr3_+_138911648 0.01 ENSMUST00000062306.7
Stpg2
sperm tail PG rich repeat containing 2
chr14_-_59380335 0.00 ENSMUST00000022548.10
ENSMUST00000162674.8
ENSMUST00000159858.2
ENSMUST00000162271.2
1700129C05Rik
RIKEN cDNA 1700129C05 gene
chr2_+_121991181 0.00 ENSMUST00000036089.8
Trim69
tripartite motif-containing 69
chr7_+_55889488 0.00 ENSMUST00000032633.12
ENSMUST00000155533.2
ENSMUST00000156886.8
Oca2
oculocutaneous albinism II
chr5_-_121641461 0.00 ENSMUST00000079368.5
Adam1b
a disintegrin and metallopeptidase domain 1b
chr11_-_99176086 0.00 ENSMUST00000017255.4
Krt24
keratin 24

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 0.3 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 0.3 GO:0070829 heterochromatin maintenance(GO:0070829)
0.0 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.0 0.4 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.3 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.1 GO:0035660 MyD88-dependent toll-like receptor 4 signaling pathway(GO:0035660)
0.0 0.3 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.2 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.0 0.5 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.1 GO:0010982 GPI anchor release(GO:0006507) regulation of high-density lipoprotein particle clearance(GO:0010982)
0.0 0.3 GO:0060253 negative regulation of glial cell proliferation(GO:0060253)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031417 NatC complex(GO:0031417)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.1 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.3 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.0 GO:0031768 ghrelin receptor binding(GO:0031768)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression