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avrg: GFI1 WT vs 36n/n vs KD

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Results for Klf13

Z-value: 0.81

Motif logo

Transcription factors associated with Klf13

Gene Symbol Gene ID Gene Info
ENSMUSG00000052040.11 Kruppel-like factor 13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Klf13mm39_v1_chr7_-_63586049_63586090-0.961.0e-02Click!

Activity profile of Klf13 motif

Sorted Z-values of Klf13 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_76289888 0.58 ENSMUST00000021204.4
nucleoredoxin
chr14_-_76248274 0.44 ENSMUST00000088922.5
general transcription factor IIF, polypeptide 2
chr18_-_38088062 0.41 ENSMUST00000043498.9
histone deacetylase 3
chr17_+_35278011 0.39 ENSMUST00000007255.13
ENSMUST00000174493.8
dimethylarginine dimethylaminohydrolase 2
chr6_+_137731526 0.39 ENSMUST00000203216.3
ENSMUST00000087675.9
ENSMUST00000203693.3
deoxyribose-phosphate aldolase (putative)
chr6_+_137731599 0.39 ENSMUST00000204356.2
deoxyribose-phosphate aldolase (putative)
chr6_-_119394634 0.37 ENSMUST00000032272.13
adiponectin receptor 2
chr14_-_55828511 0.36 ENSMUST00000161807.8
ENSMUST00000111378.10
ENSMUST00000159687.2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr7_-_30262337 0.35 ENSMUST00000207031.2
presenilin enhancer gamma secretase subunit
chr19_-_24938909 0.31 ENSMUST00000025815.10
COBW domain containing 1
chr4_-_116664729 0.31 ENSMUST00000106455.8
ENSMUST00000030451.10
target of EGR1, member 1 (nuclear)
chr17_-_35827676 0.28 ENSMUST00000160885.2
ENSMUST00000159009.2
ENSMUST00000161012.8
transcription factor 19
chr19_-_42117420 0.27 ENSMUST00000161873.2
ENSMUST00000018965.4
arginine vasopressin-induced 1
chr7_+_43093507 0.27 ENSMUST00000004729.5
ENSMUST00000206286.2
ENSMUST00000206196.2
ENSMUST00000206411.2
electron transferring flavoprotein, beta polypeptide
chr8_-_71938598 0.27 ENSMUST00000093450.6
ENSMUST00000213382.2
anoctamin 8
chr18_+_38088597 0.26 ENSMUST00000070709.9
ENSMUST00000177058.8
ENSMUST00000169360.9
ENSMUST00000163591.9
ENSMUST00000091932.12
RELT-like 2
chr6_+_83771985 0.26 ENSMUST00000113851.8
N-acetylglucosamine kinase
chr17_+_35827997 0.25 ENSMUST00000164242.9
ENSMUST00000045956.14
coiled-coil alpha-helical rod protein 1
chr7_-_4687916 0.25 ENSMUST00000206306.2
ENSMUST00000205952.2
ENSMUST00000079970.6
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr7_-_121620366 0.24 ENSMUST00000033160.15
golgi associated, gamma adaptin ear containing, ARF binding protein 2
chr6_+_83771953 0.24 ENSMUST00000037376.14
N-acetylglucosamine kinase
chr11_+_101556367 0.23 ENSMUST00000039388.3
ADP-ribosylation factor-like 4D
chr15_+_84921283 0.22 ENSMUST00000023069.9
family with sequence similarity 118, member A
chr12_-_79219382 0.21 ENSMUST00000055262.13
vesicle transport through interaction with t-SNAREs 1B
chr6_-_82629835 0.21 ENSMUST00000160281.8
ENSMUST00000095786.6
polymerase (DNA-directed), epsilon 4 (p12 subunit)
chr9_+_69919822 0.21 ENSMUST00000118198.8
ENSMUST00000119905.8
ENSMUST00000119413.8
ENSMUST00000140305.8
ENSMUST00000122087.8
general transcription factor II A, 2
chr7_-_100232276 0.20 ENSMUST00000152876.3
ENSMUST00000150042.8
ENSMUST00000132888.9
mitochondrial ribosomal protein L48
chr4_-_116991150 0.20 ENSMUST00000076859.12
polo like kinase 3
chr2_+_120807498 0.20 ENSMUST00000067582.14
transmembrane protein 62
chr3_-_90416757 0.17 ENSMUST00000107343.8
ENSMUST00000001043.14
ENSMUST00000107344.8
ENSMUST00000076639.11
ENSMUST00000107346.8
ENSMUST00000146740.8
ENSMUST00000107342.2
ENSMUST00000049937.13
chromatin target of PRMT1
chr4_+_116664911 0.17 ENSMUST00000102699.8
ENSMUST00000130359.8
mutY DNA glycosylase
chr11_+_105017251 0.16 ENSMUST00000021030.8
methyltransferase like 2
chr19_-_7460550 0.15 ENSMUST00000088169.7
reticulon 3
chr4_-_119279551 0.15 ENSMUST00000106316.2
ENSMUST00000030385.13
phosphopantothenoylcysteine synthetase
chr4_+_45018583 0.15 ENSMUST00000133157.8
ENSMUST00000029999.15
ENSMUST00000107814.10
polymerase (RNA) I polypeptide E
chr14_+_122344441 0.14 ENSMUST00000026624.11
transmembrane 9 superfamily member 2
chr7_+_101312840 0.14 ENSMUST00000001884.14
ClpB caseinolytic peptidase B
chr10_-_44334711 0.14 ENSMUST00000039174.11
PR domain containing 1, with ZNF domain
chr14_+_47069582 0.13 ENSMUST00000068532.10
cell growth regulator with ring finger domain 1
chr17_-_66258110 0.13 ENSMUST00000233580.2
ENSMUST00000024906.6
twisted gastrulation BMP signaling modulator 1
chr6_+_83772136 0.13 ENSMUST00000113850.2
N-acetylglucosamine kinase
chr16_+_4544221 0.12 ENSMUST00000154117.2
ENSMUST00000004172.15
heme oxygenase 2
chr8_-_95602952 0.12 ENSMUST00000046461.9
docking protein 4
chr15_-_11996084 0.12 ENSMUST00000022816.15
SUB1 homolog, transcriptional regulator
chr14_+_122344531 0.12 ENSMUST00000171318.2
transmembrane 9 superfamily member 2
chr15_-_99149810 0.12 ENSMUST00000163506.3
ENSMUST00000229671.2
ENSMUST00000229359.2
ENSMUST00000041190.17
microspherule protein 1
chr16_+_17437205 0.11 ENSMUST00000006053.13
ENSMUST00000231311.2
ENSMUST00000163476.10
ENSMUST00000231257.2
ENSMUST00000165363.10
ENSMUST00000232043.2
ENSMUST00000090159.13
ENSMUST00000232442.2
sphingomyelin phosphodiesterase 4
chr1_-_161704224 0.11 ENSMUST00000048377.11
SUN domain containing ossification factor
chr19_-_7460600 0.11 ENSMUST00000235593.2
ENSMUST00000088171.12
ENSMUST00000065304.13
ENSMUST00000025667.14
reticulon 3
chr14_-_118943591 0.10 ENSMUST00000036554.14
ENSMUST00000166646.2
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
chr2_+_25152600 0.10 ENSMUST00000114336.4
taperin
chr14_-_69944942 0.09 ENSMUST00000121142.4
R3H domain and coiled-coil containing 1
chr7_-_26878260 0.09 ENSMUST00000093040.13
RAB4B, member RAS oncogene family
chr7_+_18915136 0.09 ENSMUST00000144054.8
ENSMUST00000141718.8
echinoderm microtubule associated protein like 2
chrX_-_8118541 0.09 ENSMUST00000115594.8
ENSMUST00000115595.8
ENSMUST00000033513.10
FtsJ RNA methyltransferase homolog 1 (E. coli)
chr18_+_12301768 0.09 ENSMUST00000126523.9
ENSMUST00000025276.15
regulator of MON1-CCZ1
chr8_+_84335176 0.09 ENSMUST00000212300.2
DnaJ heat shock protein family (Hsp40) member B1
chr17_-_56933872 0.08 ENSMUST00000047226.10
lon peptidase 1, mitochondrial
chr2_+_13579092 0.08 ENSMUST00000193675.2
vimentin
chr8_+_84334805 0.08 ENSMUST00000005620.10
DnaJ heat shock protein family (Hsp40) member B1
chr5_-_115296222 0.08 ENSMUST00000112121.6
malectin
chr6_-_119394436 0.08 ENSMUST00000189710.2
adiponectin receptor 2
chr14_-_69945022 0.08 ENSMUST00000118374.8
R3H domain and coiled-coil containing 1
chr16_+_17437367 0.08 ENSMUST00000231887.2
sphingomyelin phosphodiesterase 4
chr8_+_22996233 0.08 ENSMUST00000210854.2
solute carrier family 20, member 2
chr17_+_57024759 0.07 ENSMUST00000002452.8
ENSMUST00000233832.2
ENSMUST00000233233.2
NADH:ubiquinone oxidoreductase subunit A11
chr18_+_38088179 0.07 ENSMUST00000176902.8
ENSMUST00000176104.8
RELT-like 2
chr19_-_5660057 0.07 ENSMUST00000236229.2
ENSMUST00000235701.2
ENSMUST00000236264.2
K(lysine) acetyltransferase 5
chr10_-_44334683 0.07 ENSMUST00000105490.3
PR domain containing 1, with ZNF domain
chr10_-_40134104 0.07 ENSMUST00000217141.2
general transcription factor IIIC, polypeptide 6, alpha
chr6_+_125072944 0.07 ENSMUST00000112392.8
ENSMUST00000056889.15
chromodomain helicase DNA binding protein 4
chr14_-_63402374 0.07 ENSMUST00000238526.2
farnesyl diphosphate farnesyl transferase 1
chr7_+_30262721 0.06 ENSMUST00000166960.8
ENSMUST00000163330.3
ENSMUST00000043273.16
ENSMUST00000163654.8
ENSMUST00000166510.8
ENSMUST00000163482.8
ENSMUST00000167361.8
ENSMUST00000166257.8
ENSMUST00000163464.8
ENSMUST00000171850.8
ENSMUST00000168931.8
ENSMUST00000167202.8
U2 small nuclear RNA auxiliary factor 1-like 4
chr4_-_150093435 0.06 ENSMUST00000030830.4
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr3_+_60910207 0.06 ENSMUST00000029331.7
ENSMUST00000193201.2
ENSMUST00000193943.2
purinergic receptor P2Y, G-protein coupled 1
chr7_+_101312912 0.06 ENSMUST00000106998.8
ENSMUST00000209579.2
ClpB caseinolytic peptidase B
chr7_+_18915086 0.05 ENSMUST00000120595.8
ENSMUST00000048502.10
echinoderm microtubule associated protein like 2
chr18_+_11790409 0.05 ENSMUST00000047322.8
retinoblastoma binding protein 8, endonuclease
chr19_+_46750016 0.05 ENSMUST00000099373.12
ENSMUST00000077666.6
cyclin M2
chrX_+_149830166 0.05 ENSMUST00000026296.8
FYVE, RhoGEF and PH domain containing 1
chr7_+_18659787 0.05 ENSMUST00000032571.10
ENSMUST00000220302.2
NOVA alternative splicing regulator 2
chr17_-_34247016 0.05 ENSMUST00000236627.2
ENSMUST00000237759.2
ENSMUST00000045467.14
ENSMUST00000114303.4
H2-K region expressed gene 6
chr2_-_136958544 0.05 ENSMUST00000028735.8
jagged 1
chr12_+_72132621 0.04 ENSMUST00000057257.10
ENSMUST00000117449.8
JNK1/MAPK8-associated membrane protein
chr2_-_24825160 0.04 ENSMUST00000102935.10
ENSMUST00000133934.2
ENSMUST00000028349.14
arrestin domain containing 1
chr14_+_70337540 0.04 ENSMUST00000022680.9
bridging integrator 3
chr11_-_120714921 0.04 ENSMUST00000206589.2
fatty acid synthase
chr5_-_137500660 0.04 ENSMUST00000111035.2
ENSMUST00000031728.5
processing of precursor 7, ribonuclease P family, (S. cerevisiae)
chr5_+_135717890 0.04 ENSMUST00000005651.13
ENSMUST00000122113.8
P450 (cytochrome) oxidoreductase
chr12_-_14202041 0.04 ENSMUST00000020926.8
LRAT domain containing 1
chr10_-_81003730 0.03 ENSMUST00000005064.14
protein inhibitor of activated STAT 4
chr10_-_24587884 0.03 ENSMUST00000135846.2
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr8_+_3681127 0.03 ENSMUST00000159911.8
ENSMUST00000004745.9
syntaxin binding protein 2
chr18_-_46730547 0.03 ENSMUST00000151189.2
transmembrane p24 trafficking protein 7
chr12_+_108300599 0.03 ENSMUST00000021684.6
cytochrome P450, family 46, subfamily a, polypeptide 1
chr19_+_56710570 0.02 ENSMUST00000038949.6
adrenergic receptor, beta 1
chr12_-_104010690 0.02 ENSMUST00000043915.4
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr11_-_120715351 0.02 ENSMUST00000055655.9
fatty acid synthase
chr8_+_113296675 0.02 ENSMUST00000034225.7
ENSMUST00000118171.8
contactin associated protein-like 4
chr16_+_22738987 0.01 ENSMUST00000023587.12
fetuin beta
chr11_+_69855584 0.01 ENSMUST00000108597.8
ENSMUST00000060651.6
ENSMUST00000108596.8
claudin 7
chr15_+_92495007 0.01 ENSMUST00000035399.10
PDZ domain containing RING finger 4
chr16_+_22739028 0.01 ENSMUST00000232097.2
fetuin beta
chr11_-_59678462 0.01 ENSMUST00000125307.2
phospholipase D family, member 6
chr1_-_36484328 0.01 ENSMUST00000125304.8
ENSMUST00000115011.8
lectin, mannose-binding 2-like
chr7_-_30292351 0.01 ENSMUST00000108151.3
zinc finger and BTB domain containing 32
chr17_-_57064516 0.01 ENSMUST00000044752.6
neurturin
chr1_+_164624200 0.01 ENSMUST00000027861.6
dermatopontin
chr11_+_69856222 0.01 ENSMUST00000018713.13
claudin 7
chr9_+_57604895 0.01 ENSMUST00000034865.6
cytochrome P450, family 1, subfamily a, polypeptide 1
chr16_+_22739191 0.01 ENSMUST00000116625.10
fetuin beta
chr10_-_77533067 0.00 ENSMUST00000220084.2
predicted gene 9508
chrX_+_6690410 0.00 ENSMUST00000145302.3
diacylglycerol kinase kappa
chr6_-_56546088 0.00 ENSMUST00000203372.3
phosphodiesterase 1C
chr4_+_119280002 0.00 ENSMUST00000094819.5
zinc finger, MYND domain containing 12
chr8_+_70285133 0.00 ENSMUST00000081503.13
pre B cell leukemia homeobox 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.1 0.6 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.1 0.2 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
0.1 0.4 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.2 GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.1 0.2 GO:0002946 tRNA C5-cytosine methylation(GO:0002946)
0.0 0.1 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.0 0.1 GO:0006788 heme oxidation(GO:0006788)
0.0 0.5 GO:0061042 vascular wound healing(GO:0061042)
0.0 0.4 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.3 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.3 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.0 0.4 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.1 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.1 GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 0.1 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.0 0.2 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.0 GO:0046210 nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0017133 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 0.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.2 GO:0099524 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.1 0.5 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 0.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.4 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.1 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.8 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.2 GO:0000700 mismatch base pair DNA N-glycosylase activity(GO:0000700)
0.0 0.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.2 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.1 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.0 0.1 GO:0047936 glucose 1-dehydrogenase [NAD(P)] activity(GO:0047936)
0.0 0.1 GO:0016419 [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297) S-acetyltransferase activity(GO:0016418) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420) phosphopantetheine binding(GO:0031177)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.4 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.1 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.1 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.0 GO:0047726 nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3