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avrg: GFI1 WT vs 36n/n vs KD

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Results for Klf3

Z-value: 0.49

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Transcription factors associated with Klf3

Gene Symbol Gene ID Gene Info
Klf3
ENSMUSG00000029178.15 Kruppel-like factor 3 (basic)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Klf3mm39_v1_chr5_+_64969679_64969727-0.977.8e-03Click!

Activity profile of Klf3 motif

Sorted Z-values of Klf3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_24069680 0.28 ENSMUST00000205428.2
ENSMUST00000171904.3
ENSMUST00000205626.2
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr3_+_89987749 0.24 ENSMUST00000127955.2
Tpm3
tropomyosin 3, gamma
chr5_+_137628377 0.23 ENSMUST00000175968.8
Lrch4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr7_-_103477126 0.22 ENSMUST00000023934.8
Hbb-bs
hemoglobin, beta adult s chain
chrX_+_7750558 0.17 ENSMUST00000208640.2
ENSMUST00000207114.2
ENSMUST00000208633.2
ENSMUST00000208397.2
ENSMUST00000153620.3
ENSMUST00000123277.8
Slc35a2
solute carrier family 35 (UDP-galactose transporter), member A2
chr7_+_24310171 0.15 ENSMUST00000206422.2
Phldb3
pleckstrin homology like domain, family B, member 3
chr7_-_140676596 0.14 ENSMUST00000209199.2
Sigirr
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr11_-_6469494 0.12 ENSMUST00000134489.2
Myo1g
myosin IG
chr7_-_16761732 0.12 ENSMUST00000142597.2
Ppp5c
protein phosphatase 5, catalytic subunit
chr9_-_108183162 0.11 ENSMUST00000044725.9
Tcta
T cell leukemia translocation altered gene
chr15_-_36792649 0.10 ENSMUST00000126184.2
Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_+_85992341 0.10 ENSMUST00000027432.9
Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr19_+_10019023 0.09 ENSMUST00000237672.2
Fads3
fatty acid desaturase 3
chr2_+_163389068 0.09 ENSMUST00000109411.8
ENSMUST00000018094.13
Hnf4a
hepatic nuclear factor 4, alpha
chrX_-_73289970 0.08 ENSMUST00000130007.8
Flna
filamin, alpha
chr19_+_10018914 0.08 ENSMUST00000115995.4
Fads3
fatty acid desaturase 3
chr3_-_88241735 0.06 ENSMUST00000107552.2
Tmem79
transmembrane protein 79
chrX_-_73290140 0.06 ENSMUST00000101454.9
ENSMUST00000033699.13
Flna
filamin, alpha
chr9_-_108183356 0.05 ENSMUST00000192886.6
Tcta
T cell leukemia translocation altered gene
chr13_+_55468313 0.05 ENSMUST00000021942.8
Prelid1
PRELI domain containing 1
chr15_+_78810919 0.04 ENSMUST00000089377.6
Lgals1
lectin, galactose binding, soluble 1
chr9_-_44624496 0.04 ENSMUST00000144251.8
ENSMUST00000156918.8
Phldb1
pleckstrin homology like domain, family B, member 1
chr3_+_89986831 0.04 ENSMUST00000029549.16
Tpm3
tropomyosin 3, gamma
chr11_-_97635484 0.04 ENSMUST00000018691.9
Pip4k2b
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr9_-_50657800 0.03 ENSMUST00000239417.2
ENSMUST00000034564.4
2310030G06Rik
RIKEN cDNA 2310030G06 gene
chr3_+_89986925 0.03 ENSMUST00000118566.8
ENSMUST00000119158.8
Tpm3
tropomyosin 3, gamma
chr7_-_16761790 0.03 ENSMUST00000003183.12
Ppp5c
protein phosphatase 5, catalytic subunit
chr13_-_74440402 0.02 ENSMUST00000109640.8
ENSMUST00000022059.14
Ahrr
aryl-hydrocarbon receptor repressor
chr3_+_89173859 0.02 ENSMUST00000040824.2
Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr7_-_142628298 0.02 ENSMUST00000148715.8
Trpm5
transient receptor potential cation channel, subfamily M, member 5
chr19_-_53378990 0.02 ENSMUST00000025997.7
Smndc1
survival motor neuron domain containing 1
chr11_+_98592089 0.01 ENSMUST00000038886.3
Csf3
colony stimulating factor 3 (granulocyte)
chr3_-_108306267 0.01 ENSMUST00000147251.2
Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2
chr19_-_5738177 0.01 ENSMUST00000068169.12
Pcnx3
pecanex homolog 3
chr9_-_95697441 0.00 ENSMUST00000119760.2
Pls1
plastin 1 (I-isoform)
chr14_+_123897383 0.00 ENSMUST00000049681.14
Itgbl1
integrin, beta-like 1
chrX_-_50031587 0.00 ENSMUST00000060650.7
Frmd7
FERM domain containing 7
chr9_-_108183140 0.00 ENSMUST00000195615.2
Tcta
T cell leukemia translocation altered gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.1 GO:0042977 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.0 0.1 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 0.3 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:0042335 cuticle development(GO:0042335)
0.0 0.0 GO:0034117 erythrocyte aggregation(GO:0034117) regulation of erythrocyte aggregation(GO:0034118)
0.0 0.2 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 0.2 GO:0072675 osteoclast fusion(GO:0072675)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.0 0.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0070540 stearic acid binding(GO:0070540)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.0 GO:0048030 disaccharide binding(GO:0048030)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)