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avrg: GFI1 WT vs 36n/n vs KD

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Results for Mafa

Z-value: 0.55

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Transcription factors associated with Mafa

Gene Symbol Gene ID Gene Info
ENSMUSG00000047591.6 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mafamm39_v1_chr15_-_75620060_756200870.903.8e-02Click!

Activity profile of Mafa motif

Sorted Z-values of Mafa motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_57340712 0.74 ENSMUST00000228156.2
ENSMUST00000227186.2
ENSMUST00000228294.2
ENSMUST00000228342.2
vomeronasal 1 receptor 17
chr11_+_105858764 0.40 ENSMUST00000001963.14
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chrX_-_72913410 0.36 ENSMUST00000066576.12
ENSMUST00000114430.8
L1 cell adhesion molecule
chr11_+_98818640 0.35 ENSMUST00000107474.8
retinoic acid receptor, alpha
chr6_+_136509922 0.26 ENSMUST00000187429.4
activating transcription factor 7 interacting protein
chr7_-_12418918 0.26 ENSMUST00000167771.2
ENSMUST00000172743.9
ENSMUST00000233763.2
ENSMUST00000232880.2
vomeronasal 2, receptor 55
chr12_-_113379925 0.23 ENSMUST00000194162.6
ENSMUST00000192250.2
immunoglobulin heavy constant delta
chr13_+_97061182 0.22 ENSMUST00000171324.3
glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
chr1_-_121255448 0.21 ENSMUST00000186915.2
ENSMUST00000160968.8
ENSMUST00000162582.2
insulin induced gene 2
chr17_-_47321430 0.21 ENSMUST00000113337.10
ENSMUST00000113335.4
ubiquitin protein ligase E3 component n-recognin 2
chr4_+_155686311 0.20 ENSMUST00000118607.2
solute carrier family 35, member E2
chrX_-_20816841 0.19 ENSMUST00000009550.14
ELK1, member of ETS oncogene family
chr9_-_97915036 0.17 ENSMUST00000162295.2
calsyntenin 2
chr19_+_60878802 0.16 ENSMUST00000236876.2
G protein-coupled receptor kinase 5
chr4_+_155685830 0.15 ENSMUST00000105608.9
solute carrier family 35, member E2
chr12_+_3415143 0.15 ENSMUST00000020999.7
kinesin family member 3C
chr12_+_3415107 0.14 ENSMUST00000220210.2
kinesin family member 3C
chr19_+_5524933 0.14 ENSMUST00000236518.2
epidermal growth factor-containing fibulin-like extracellular matrix protein 2
chr1_-_121255400 0.13 ENSMUST00000159085.8
ENSMUST00000159125.2
ENSMUST00000161818.2
insulin induced gene 2
chr3_+_86131970 0.13 ENSMUST00000192145.6
ENSMUST00000194759.6
ENSMUST00000107635.7
LPS-responsive beige-like anchor
chrX_+_103526380 0.13 ENSMUST00000087867.6
uracil phosphoribosyltransferase
chr5_-_46014809 0.11 ENSMUST00000190036.7
ENSMUST00000189859.7
ENSMUST00000186633.3
ENSMUST00000016026.14
ENSMUST00000045586.13
ENSMUST00000238522.2
ligand dependent nuclear receptor corepressor-like
chr2_+_38821987 0.11 ENSMUST00000057279.6
olfactomedin-like 2A
chr11_+_95152355 0.10 ENSMUST00000021242.5
tachykinin 4
chr16_+_17149235 0.10 ENSMUST00000023450.15
ENSMUST00000231884.2
serine (or cysteine) peptidase inhibitor, clade D, member 1
chrX_+_150961960 0.08 ENSMUST00000096275.5
IQ motif and Sec7 domain 2
chr5_+_111565129 0.08 ENSMUST00000094463.5
meningioma 1
chr8_-_85663976 0.07 ENSMUST00000109741.9
ENSMUST00000119820.2
microtubule associated serine/threonine kinase 1
chr4_+_124696336 0.07 ENSMUST00000138807.8
ENSMUST00000030723.3
metal response element binding transcription factor 1
chr11_-_119119287 0.07 ENSMUST00000207655.2
ENSMUST00000036113.4
TBC1 domain family, member 16
chr17_+_47922497 0.06 ENSMUST00000024778.3
mediator complex subunit 20
chr6_-_35285045 0.06 ENSMUST00000031868.5
solute carrier family 13 (sodium/sulfate symporters), member 4
chr7_-_65020955 0.06 ENSMUST00000102592.10
tight junction protein 1
chr11_-_76514334 0.04 ENSMUST00000238684.2
active BCR-related gene
chr17_+_57665691 0.04 ENSMUST00000086763.13
ENSMUST00000233376.2
ENSMUST00000233840.2
ENSMUST00000232808.2
ENSMUST00000004850.8
adhesion G protein-coupled receptor E1
chr17_-_47922374 0.04 ENSMUST00000024783.9
bystin-like
chr4_+_117706390 0.04 ENSMUST00000132043.9
ENSMUST00000169990.8
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_-_66416621 0.03 ENSMUST00000123454.8
shisa family member 6
chrX_-_138683102 0.03 ENSMUST00000101217.4
ripply transcriptional repressor 1
chr1_-_121255503 0.03 ENSMUST00000160688.2
insulin induced gene 2
chr1_-_121255753 0.02 ENSMUST00000003818.14
insulin induced gene 2
chr9_+_107879700 0.02 ENSMUST00000035214.11
ENSMUST00000176854.7
ENSMUST00000175874.2
inositol hexaphosphate kinase 1
chr19_+_34899778 0.02 ENSMUST00000223907.2
kinesin family member 20B
chr4_+_116578117 0.02 ENSMUST00000045542.13
ENSMUST00000106459.8
testis-specific kinase 2
chr19_+_34899752 0.02 ENSMUST00000087341.7
kinesin family member 20B
chr17_-_28299544 0.02 ENSMUST00000042692.13
ENSMUST00000114836.9
t-complex protein 11
chr15_-_8473918 0.02 ENSMUST00000052965.8
NIPBL cohesin loading factor
chr18_-_42712717 0.01 ENSMUST00000054738.5
G protein-coupled receptor 151
chr17_+_31896781 0.01 ENSMUST00000228716.3
ENSMUST00000019192.8
ENSMUST00000228089.3
crystallin, alpha A
chr2_-_125348305 0.01 ENSMUST00000028633.13
fibrillin 1
chr4_+_102112189 0.01 ENSMUST00000106908.9
phosphodiesterase 4B, cAMP specific
chr6_-_69553484 0.01 ENSMUST00000103357.4
immunoglobulin kappa variable 4-57
chr19_+_5524701 0.01 ENSMUST00000165485.8
ENSMUST00000166253.8
ENSMUST00000167371.8
ENSMUST00000167855.8
ENSMUST00000070118.14
epidermal growth factor-containing fibulin-like extracellular matrix protein 2
chr14_-_24054352 0.01 ENSMUST00000190339.2
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr4_+_124696394 0.01 ENSMUST00000175875.2
metal response element binding transcription factor 1
chr1_+_87111033 0.01 ENSMUST00000044533.9
protease, serine 56
chr17_-_28299569 0.00 ENSMUST00000129046.9
ENSMUST00000043925.16
t-complex protein 11
chr5_-_24628514 0.00 ENSMUST00000030814.11
cyclin-dependent kinase 5
chr11_-_99684173 0.00 ENSMUST00000105058.2
predicted gene 11596
chr4_-_116321348 0.00 ENSMUST00000106486.8
ENSMUST00000106485.8
microtubule associated serine/threonine kinase 2
chr10_+_87695352 0.00 ENSMUST00000121952.8
ENSMUST00000126490.8
insulin-like growth factor 1
chr9_-_44366273 0.00 ENSMUST00000047740.4
uroplakin 2
chr11_+_104023657 0.00 ENSMUST00000093925.5
corticotropin releasing hormone receptor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Mafa

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.1 0.4 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.2 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.0 0.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.4 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0009173 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.4 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.0 0.2 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.1 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.4 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031711 bradykinin receptor binding(GO:0031711)
0.0 0.2 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.4 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.4 GO:0044323 phosphatidylinositol 3-kinase regulator activity(GO:0035014) retinoic acid-responsive element binding(GO:0044323)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.