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avrg: GFI1 WT vs 36n/n vs KD

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Results for Maff

Z-value: 1.43

Motif logo

Transcription factors associated with Maff

Gene Symbol Gene ID Gene Info
ENSMUSG00000042622.15 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Maffmm39_v1_chr15_+_79230777_79230834-0.951.2e-02Click!

Activity profile of Maff motif

Sorted Z-values of Maff motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_23894697 0.98 ENSMUST00000091707.13
ENSMUST00000006787.8
homeostatic iron regulator
chr6_+_4003904 0.95 ENSMUST00000031670.10
guanine nucleotide binding protein (G protein), gamma 11
chr7_-_108769719 0.83 ENSMUST00000208136.2
ENSMUST00000036992.9
LIM domain only 1
chr3_-_106126794 0.77 ENSMUST00000082219.6
chitinase-like 4
chr14_-_36857202 0.76 ENSMUST00000165649.4
ENSMUST00000224769.2
growth hormone inducible transmembrane protein
chr12_-_101943134 0.74 ENSMUST00000221227.2
NADH:ubiquinone oxidoreductase subunit B1
chr4_-_136613498 0.73 ENSMUST00000046384.9
complement component 1, q subcomponent, beta polypeptide
chr11_+_76836330 0.67 ENSMUST00000021197.10
bleomycin hydrolase
chr3_+_127584251 0.67 ENSMUST00000164447.3
TRAF-interacting protein with forkhead-associated domain
chr1_+_135945798 0.56 ENSMUST00000117950.2
transmembrane protein 9
chr1_+_127234441 0.56 ENSMUST00000171405.2
mannoside acetylglucosaminyltransferase 5
chr6_+_30401864 0.54 ENSMUST00000068240.13
ENSMUST00000068259.10
ENSMUST00000132581.8
kelch domain containing 10
chr10_-_121462219 0.54 ENSMUST00000039810.8
ENSMUST00000218004.2
exportin, tRNA (nuclear export receptor for tRNAs)
chr9_+_65368207 0.53 ENSMUST00000034955.8
ENSMUST00000213957.2
SPG21, maspardin
chr11_+_76836545 0.53 ENSMUST00000125145.8
bleomycin hydrolase
chr12_+_17316546 0.52 ENSMUST00000057288.7
ENSMUST00000239402.2
protein disulfide isomerase associated 6
chr1_+_135945705 0.51 ENSMUST00000063719.15
transmembrane protein 9
chr3_+_109481223 0.51 ENSMUST00000106576.3
vav 3 oncogene
chr13_+_67080864 0.50 ENSMUST00000021990.4
phosphatidylserine synthase 1
chr7_-_4687916 0.50 ENSMUST00000206306.2
ENSMUST00000205952.2
ENSMUST00000079970.6
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr13_-_55677109 0.49 ENSMUST00000223563.2
docking protein 3
chr2_-_69036489 0.48 ENSMUST00000127243.8
ENSMUST00000149643.2
ENSMUST00000167875.9
ENSMUST00000005365.15
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr4_-_139079609 0.46 ENSMUST00000030513.13
ENSMUST00000155257.8
mRNA turnover 4, ribosome maturation factor
chr14_-_36857083 0.46 ENSMUST00000042564.17
growth hormone inducible transmembrane protein
chr8_+_72050292 0.44 ENSMUST00000143662.8
niban apoptosis regulator 3
chr2_-_127673738 0.43 ENSMUST00000028858.8
BUB1, mitotic checkpoint serine/threonine kinase
chr2_-_69036472 0.43 ENSMUST00000112320.8
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr7_-_7301760 0.42 ENSMUST00000210061.2
chloride channel, voltage-sensitive 4
chr14_-_20844074 0.38 ENSMUST00000080440.14
ENSMUST00000100837.11
ENSMUST00000071816.7
calcium/calmodulin-dependent protein kinase II gamma
chr14_+_30853010 0.37 ENSMUST00000227096.2
5'-nucleotidase domain containing 2
chr18_+_13107535 0.36 ENSMUST00000234035.2
ENSMUST00000235053.2
impact, RWD domain protein
chr4_-_109333866 0.33 ENSMUST00000030284.10
ring finger protein 11
chr11_-_109364424 0.32 ENSMUST00000070152.12
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr10_+_62756426 0.32 ENSMUST00000144459.2
solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
chr4_-_139079842 0.31 ENSMUST00000102503.10
mRNA turnover 4, ribosome maturation factor
chr4_-_141412910 0.30 ENSMUST00000105782.2
regulatory solute carrier protein, family 1, member 1
chr17_+_28059129 0.30 ENSMUST00000233657.2
U1 small nuclear ribonucleoprotein C
chr4_-_25281750 0.29 ENSMUST00000038705.8
ENSMUST00000102994.10
UFM1 specific ligase 1
chr6_+_83771953 0.28 ENSMUST00000037376.14
N-acetylglucosamine kinase
chr11_-_120521382 0.27 ENSMUST00000106181.8
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr17_+_71511642 0.26 ENSMUST00000126681.8
lipin 2
chr5_+_107112186 0.26 ENSMUST00000117196.9
ENSMUST00000031221.12
ENSMUST00000076467.13
cell division cycle 7 (S. cerevisiae)
chr9_+_45749869 0.25 ENSMUST00000078111.11
ENSMUST00000034591.11
beta-site APP cleaving enzyme 1
chr11_-_120520954 0.25 ENSMUST00000106180.2
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr13_-_23894828 0.24 ENSMUST00000091706.14
homeostatic iron regulator
chr7_+_30014235 0.23 ENSMUST00000054594.15
ENSMUST00000177078.8
ENSMUST00000176504.8
ENSMUST00000176304.8
spectrin repeat containing, nuclear envelope family member 4
chr7_-_7302468 0.23 ENSMUST00000000619.8
chloride channel, voltage-sensitive 4
chr17_+_28059099 0.23 ENSMUST00000233752.2
U1 small nuclear ribonucleoprotein C
chr7_+_44117511 0.22 ENSMUST00000121922.3
ENSMUST00000208117.2
Josephin domain containing 2
chr2_-_20948230 0.22 ENSMUST00000140230.2
Rho GTPase activating protein 21
chr8_-_84420633 0.21 ENSMUST00000144258.8
protein kinase N1
chr3_+_127584449 0.21 ENSMUST00000171621.3
TRAF-interacting protein with forkhead-associated domain
chr7_+_44117444 0.20 ENSMUST00000206887.2
ENSMUST00000117324.8
ENSMUST00000120852.8
ENSMUST00000134398.3
ENSMUST00000118628.8
Josephin domain containing 2
chr4_+_102278715 0.17 ENSMUST00000106904.9
phosphodiesterase 4B, cAMP specific
chr19_+_8906916 0.17 ENSMUST00000096241.6
echinoderm microtubule associated protein like 3
chr19_-_57185988 0.17 ENSMUST00000099294.9
actin-binding LIM protein 1
chr7_-_12771554 0.16 ENSMUST00000125964.8
ubiquitin-conjugating enzyme E2M
chr1_-_58735106 0.15 ENSMUST00000055313.14
ENSMUST00000188772.7
flagellum associated containing coiled-coil domains 1
chr3_+_28859585 0.15 ENSMUST00000043867.11
ENSMUST00000194649.2
ribosomal protein L22 like 1
chr11_+_119119925 0.15 ENSMUST00000053440.8
coiled-coil domain containing 40
chr11_-_106163753 0.14 ENSMUST00000021052.16
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chrX_+_92718695 0.13 ENSMUST00000045898.4
phosphate cytidylyltransferase 1, choline, beta isoform
chr8_-_12722099 0.12 ENSMUST00000000776.15
tubulin, gamma complex associated protein 3
chr7_+_44117404 0.12 ENSMUST00000035844.11
Josephin domain containing 2
chr10_+_62756409 0.12 ENSMUST00000044977.10
solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
chr7_-_4909515 0.11 ENSMUST00000210663.2
predicted gene, 36210
chr15_-_76406602 0.11 ENSMUST00000096365.5
scratch family zinc finger 1
chr7_+_44117475 0.11 ENSMUST00000118493.8
Josephin domain containing 2
chr17_+_35863025 0.11 ENSMUST00000044804.8
corneodesmosin
chr1_-_120001752 0.10 ENSMUST00000056089.8
transmembrane protein 37
chr11_-_69471056 0.10 ENSMUST00000132548.2
WD repeat containing, antisense to Trp53
chr11_+_81992662 0.09 ENSMUST00000000194.4
chemokine (C-C motif) ligand 12
chr12_+_104229376 0.08 ENSMUST00000109958.3
serine (or cysteine) peptidase inhibitor, clade A, member 3I
chr1_+_72346572 0.07 ENSMUST00000027379.10
X-ray repair complementing defective repair in Chinese hamster cells 5
chr18_-_39652468 0.07 ENSMUST00000237944.2
nuclear receptor subfamily 3, group C, member 1
chr10_-_88440996 0.06 ENSMUST00000121629.8
myosin binding protein C, slow-type
chr3_-_59170245 0.05 ENSMUST00000050360.14
ENSMUST00000199609.2
purinergic receptor P2Y, G-protein coupled 12
chr11_+_67167950 0.05 ENSMUST00000019625.12
myosin, heavy polypeptide 8, skeletal muscle, perinatal
chr19_-_8906686 0.05 ENSMUST00000096242.5
rod outer segment membrane protein 1
chr1_-_172964941 0.05 ENSMUST00000200689.5
olfactory receptor 1408
chr11_+_82006001 0.04 ENSMUST00000009329.3
chemokine (C-C motif) ligand 8
chr15_+_25933632 0.04 ENSMUST00000228327.2
reticulophagy regulator 1
chr10_-_88440869 0.04 ENSMUST00000119185.8
ENSMUST00000238199.2
myosin binding protein C, slow-type
chr9_-_111519382 0.04 ENSMUST00000035083.8
src homology three (SH3) and cysteine rich domain
chr3_+_58322119 0.03 ENSMUST00000099090.7
ENSMUST00000199164.2
TSC22 domain family, member 2
chr17_-_68257900 0.03 ENSMUST00000164647.8
Rho GTPase activating protein 28
chr9_+_65121944 0.03 ENSMUST00000069000.9
poly (ADP-ribose) polymerase family, member 16
chr10_+_77551601 0.03 ENSMUST00000179767.2
predicted gene 10142
chr14_+_15369152 0.03 ENSMUST00000167923.8
predicted gene 3696
chr6_-_70036183 0.03 ENSMUST00000197429.5
ENSMUST00000103376.3
immunoglobulin kappa chain variable 7-33
chr10_+_77650454 0.03 ENSMUST00000220062.2
ENSMUST00000220393.2
predicted gene, 49918
chr8_+_27937128 0.02 ENSMUST00000209669.2
predicted gene 45861
chr1_-_107011236 0.02 ENSMUST00000023861.5
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D
chr6_+_40941688 0.02 ENSMUST00000076638.7
RIKEN cDNA 1810009J06 gene
chr14_-_52610508 0.02 ENSMUST00000071221.2
olfactory receptor 1512
chr10_-_128882930 0.02 ENSMUST00000071559.3
olfactory receptor 765
chr7_+_30193047 0.02 ENSMUST00000058280.13
ENSMUST00000133318.8
ENSMUST00000142575.8
ENSMUST00000131040.2
proline dehydrogenase (oxidase) 2
chr19_-_11301919 0.02 ENSMUST00000159269.2
membrane-spanning 4-domains, subfamily A, member 7
chr16_+_96295011 0.02 ENSMUST00000233816.2
Purkinje cell protein 4
chr10_+_68987257 0.02 ENSMUST00000167286.8
Rho-related BTB domain containing 1
chr5_-_113229445 0.02 ENSMUST00000131708.2
ENSMUST00000117143.8
ENSMUST00000119627.8
crystallin, beta B3
chr14_+_119025306 0.01 ENSMUST00000047761.13
ENSMUST00000071546.14
claudin 10
chr6_-_40976413 0.01 ENSMUST00000166306.3
predicted gene 2663
chr10_+_101517556 0.01 ENSMUST00000156751.8
MGAT4 family, member C
chr15_-_33687986 0.01 ENSMUST00000042021.5
testis-specific protein, Y-encoded-like 5
chr14_-_52587501 0.01 ENSMUST00000089739.2
olfactory receptor 1513
chr6_+_115908709 0.01 ENSMUST00000032471.9
rhodopsin
chr2_-_85962005 0.01 ENSMUST00000099910.2
olfactory receptor 1039
chr7_+_102203493 0.01 ENSMUST00000098227.2
olfactory receptor 549
chr1_+_174276191 0.01 ENSMUST00000085861.3
olfactory receptor 220
chr6_+_41945074 0.01 ENSMUST00000080742.3
seminal vesicle antigen-like 3
chr4_-_71676202 0.01 ENSMUST00000084489.3
predicted gene 11232
chrX_+_37861548 0.01 ENSMUST00000050744.6
RIKEN cDNA 6030498E09 gene
chr5_+_110988095 0.01 ENSMUST00000198373.2
checkpoint kinase 2
chr13_-_54897425 0.01 ENSMUST00000099506.2
G protein-regulated inducer of neurite outgrowth 1
chr13_-_54897660 0.00 ENSMUST00000135343.2
G protein-regulated inducer of neurite outgrowth 1
chr13_-_27574822 0.00 ENSMUST00000102954.10
ENSMUST00000091678.3
prolactin family 2, subfamily b, member 1
chr7_-_64575308 0.00 ENSMUST00000149851.8
family with sequence similarity 189, member A1
chr7_+_44647072 0.00 ENSMUST00000003284.16
ENSMUST00000209066.2
interferon regulatory factor 3
chr8_+_22108199 0.00 ENSMUST00000074343.6
defensin, alpha, 26
chr8_+_88290469 0.00 ENSMUST00000093342.6
RIKEN cDNA 4933402J07 gene
chr1_-_65102460 0.00 ENSMUST00000146122.2
ENSMUST00000045028.15
crystallin, gamma D
chr5_+_20112771 0.00 ENSMUST00000200443.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr1_-_75208734 0.00 ENSMUST00000180101.3
RIKEN cDNA A630095N17 gene
chr2_+_86127161 0.00 ENSMUST00000215090.2
olfactory receptor 1052
chr5_-_67973195 0.00 ENSMUST00000141443.2
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
chr14_+_55170152 0.00 ENSMUST00000037863.6
interleukin 25

Network of associatons between targets according to the STRING database.

First level regulatory network of Maff

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:1900390 negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
0.3 1.2 GO:0043418 homocysteine catabolic process(GO:0043418)
0.1 0.5 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.4 GO:0072755 cellular response to benomyl(GO:0072755) response to benomyl(GO:1901561)
0.1 0.8 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.4 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.1 0.8 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.5 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.3 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.3 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.6 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.0 0.1 GO:0060287 determination of pancreatic left/right asymmetry(GO:0035469) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.0 0.1 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.0 0.5 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0090666 telomere assembly(GO:0032202) scaRNA localization to Cajal body(GO:0090666)
0.0 0.1 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.1 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.4 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 1.2 GO:1990357 terminal web(GO:1990357)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.5 GO:0000243 commitment complex(GO:0000243)
0.0 0.1 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.2 GO:0044453 nuclear membrane part(GO:0044453)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.5 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.1 1.2 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.3 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.1 0.8 GO:0004568 chitinase activity(GO:0004568)
0.1 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.2 GO:0018169 ribosomal S6-glutamic acid ligase activity(GO:0018169)
0.0 0.5 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 1.2 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0038051 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.5 GO:0008536 Ran GTPase binding(GO:0008536)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.0 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE