ISMARA results: Nfatc1

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avrg: GFI1 WT vs 36n/n vs KD

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Results for Nfatc1

Z-value: 5.23

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Transcription factors associated with Nfatc1

Gene Symbol	Gene ID	Gene Info
Nfatc1 Ensembl NCBI MGI UniProt	ENSMUSG00000033016.17	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nfatc1	mm39_v1_chr18_-_80751327_80751395	0.77	1.3e-01	Click!

Activity profile of Nfatc1 motif

Sorted Z-values of Nfatc1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_3000922 Show fit	15.09	ENSMUST00000151376.3	Gm10722 Ensembl NCBI MGI UniProt Show fit	predicted gene 10722
chr9_+_3023547 Show fit	14.82	ENSMUST00000099046.4	Gm10718 Ensembl NCBI MGI UniProt Show fit	predicted gene 10718
chr9_+_3013140 Show fit	14.29	ENSMUST00000143083.3	Gm10721 Ensembl NCBI MGI UniProt Show fit	predicted gene 10721
chr9_+_3027439 Show fit	13.58	ENSMUST00000179982.2 ENSMUST00000177875.8	Gm10717 Ensembl NCBI MGI UniProt Show fit	predicted gene 10717
chr9_+_3017408 Show fit	12.16	ENSMUST00000099049.4	Gm10719 Ensembl NCBI MGI UniProt Show fit	predicted gene 10719
chr9_+_3004457 Show fit	12.15	ENSMUST00000178348.2	Gm11168 Ensembl NCBI MGI UniProt Show fit	predicted gene 11168
chr9_+_3025417 Show fit	12.01	ENSMUST00000075573.7	Gm10717 Ensembl NCBI MGI UniProt Show fit	predicted gene 10717
chr9_+_3034599 Show fit	11.63	ENSMUST00000178641.2	Gm17535 Ensembl NCBI MGI UniProt Show fit	predicted gene, 17535
chr9_+_3005126 Show fit	10.99	ENSMUST00000179881.2	Gm11168 Ensembl NCBI MGI UniProt Show fit	predicted gene 11168
chr9_+_3018753 Show fit	9.19	ENSMUST00000179272.2	Gm10719 Ensembl NCBI MGI UniProt Show fit	predicted gene 10719

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.5	GO:0050907	detection of chemical stimulus involved in sensory perception(GO:0050907)
0.1	3.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	3.1	GO:0045576	mast cell activation(GO:0045576)
0.9	2.8	GO:0006533	aspartate catabolic process(GO:0006533)
0.2	2.8	GO:2000194	regulation of female gonad development(GO:2000194)
0.3	2.5	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.2	2.4	GO:0002329	pre-B cell differentiation(GO:0002329)
0.1	2.4	GO:0072673	lamellipodium morphogenesis(GO:0072673)
0.1	2.3	GO:0008090	retrograde axonal transport(GO:0008090)
0.3	2.2	GO:0007527	adult somatic muscle development(GO:0007527)

Showing 1 to 10 of 110 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.5	GO:0043020	NADPH oxidase complex(GO:0043020)
0.2	2.4	GO:0031209	SCAR complex(GO:0031209)
0.3	2.3	GO:0031673	H zone(GO:0031673)
0.1	2.2	GO:0070938	contractile ring(GO:0070938)
0.1	2.2	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.4	1.8	GO:0061673	mitotic spindle astral microtubule(GO:0061673)
0.3	1.4	GO:0005956	protein kinase CK2 complex(GO:0005956)
0.1	1.3	GO:0032009	early phagosome(GO:0032009)
0.2	1.2	GO:1990707	subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1	1.2	GO:0061574	ASAP complex(GO:0061574)

Showing 1 to 10 of 36 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	19.9	GO:0004984	olfactory receptor activity(GO:0004984)
0.7	2.8	GO:0003884	D-amino-acid oxidase activity(GO:0003884)
0.2	2.5	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.2	2.4	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.1	2.2	GO:0017166	vinculin binding(GO:0017166)
0.0	2.2	GO:0003785	actin monomer binding(GO:0003785)
0.1	2.1	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.4	2.0	GO:0001225	RNA polymerase II transcription coactivator binding(GO:0001225)
0.6	1.9	GO:0035717	chemokine (C-C motif) ligand 7 binding(GO:0035717)
0.1	1.8	GO:0051011	microtubule minus-end binding(GO:0051011)

Showing 1 to 10 of 76 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.2	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	2.4	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	2.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	2.3	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	1.9	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	1.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.8	PID RAC1 PATHWAY	RAC1 signaling pathway
0.1	1.4	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	1.1	PID IL6 7 PATHWAY	IL6-mediated signaling events

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.8	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.1	3.3	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1	3.1	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.1	3.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	2.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	2.7	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.2	1.9	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.1	1.7	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	1.7	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	1.5	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins

Showing 1 to 10 of 33 entries

Results for Nfatc1

Z-value: 5.23

Motif logo

Transcription factors associated with Nfatc1

Activity-expression correlation:

Activity profile of Nfatc1 motif

Sorted Z-values of Nfatc1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: