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avrg: GFI1 WT vs 36n/n vs KD

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Results for Nfatc4

Z-value: 0.71

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Transcription factors associated with Nfatc4

Gene Symbol Gene ID Gene Info
Nfatc4
ENSMUSG00000023411.13 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfatc4mm39_v1_chr14_+_56062422_560624940.553.4e-01Click!

Activity profile of Nfatc4 motif

Sorted Z-values of Nfatc4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_129834788 0.46 ENSMUST00000168644.3
Sec24b
Sec24 related gene family, member B (S. cerevisiae)
chr2_-_73284262 0.45 ENSMUST00000102679.8
Wipf1
WAS/WASL interacting protein family, member 1
chr1_+_34044940 0.39 ENSMUST00000187486.7
ENSMUST00000182697.8
Dst
dystonin
chr4_+_132903646 0.36 ENSMUST00000105912.2
Wasf2
WASP family, member 2
chr19_+_8828132 0.34 ENSMUST00000235683.2
ENSMUST00000096257.3
Lrrn4cl
LRRN4 C-terminal like
chr15_+_3300249 0.32 ENSMUST00000082424.12
ENSMUST00000159158.9
ENSMUST00000159216.10
ENSMUST00000160311.3
Selenop
selenoprotein P
chr12_+_76580386 0.32 ENSMUST00000219063.2
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr19_+_26600820 0.31 ENSMUST00000176584.2
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_-_150341911 0.31 ENSMUST00000162367.8
ENSMUST00000161611.8
ENSMUST00000161320.8
ENSMUST00000159035.2
Prg4
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
chr19_-_24454720 0.29 ENSMUST00000099556.2
Fam122a
family with sequence similarity 122, member A
chr9_+_77543776 0.26 ENSMUST00000057781.8
Klhl31
kelch-like 31
chr10_-_12689345 0.22 ENSMUST00000217899.2
Utrn
utrophin
chr3_-_96501443 0.22 ENSMUST00000145001.2
ENSMUST00000091924.10
Polr3gl
polymerase (RNA) III (DNA directed) polypeptide G like
chrX_-_7537580 0.21 ENSMUST00000033486.6
Plp2
proteolipid protein 2
chr15_-_79816785 0.18 ENSMUST00000089293.11
ENSMUST00000109616.9
Cbx7
chromobox 7
chr8_+_129085719 0.16 ENSMUST00000026917.10
Nrp1
neuropilin 1
chr14_+_65187485 0.15 ENSMUST00000043914.8
ENSMUST00000239450.2
Ints9
integrator complex subunit 9
chr5_+_53747796 0.15 ENSMUST00000113865.5
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr2_+_174171799 0.14 ENSMUST00000109085.8
Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr14_-_79718890 0.12 ENSMUST00000022601.7
Wbp4
WW domain binding protein 4
chr9_-_64858878 0.12 ENSMUST00000037798.8
Slc24a1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr15_-_79816717 0.12 ENSMUST00000177044.2
ENSMUST00000109615.8
Cbx7
chromobox 7
chr19_-_8816530 0.11 ENSMUST00000096259.6
Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr14_-_65187287 0.10 ENSMUST00000067843.10
ENSMUST00000176489.8
ENSMUST00000175905.8
ENSMUST00000022544.14
ENSMUST00000175744.8
ENSMUST00000176128.8
Hmbox1
homeobox containing 1
chr1_-_156766381 0.10 ENSMUST00000188656.7
Ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr9_+_51959534 0.10 ENSMUST00000061352.11
Rdx
radixin
chr10_+_23727325 0.10 ENSMUST00000020190.8
Vnn3
vanin 3
chr2_+_174171860 0.10 ENSMUST00000109087.8
ENSMUST00000109084.8
Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr3_+_94744844 0.09 ENSMUST00000107270.9
Pogz
pogo transposable element with ZNF domain
chr3_-_20329823 0.09 ENSMUST00000011607.6
Cpb1
carboxypeptidase B1 (tissue)
chr6_+_134958681 0.07 ENSMUST00000167323.3
Apold1
apolipoprotein L domain containing 1
chr1_-_169938060 0.07 ENSMUST00000027985.8
ENSMUST00000194690.6
Ddr2
discoidin domain receptor family, member 2
chr19_+_8816663 0.07 ENSMUST00000160556.8
Bscl2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr5_+_53747556 0.07 ENSMUST00000037618.13
ENSMUST00000201912.4
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr17_-_49871291 0.07 ENSMUST00000224595.2
ENSMUST00000057610.8
Daam2
dishevelled associated activator of morphogenesis 2
chr12_+_91367764 0.06 ENSMUST00000021346.14
ENSMUST00000021343.8
Tshr
thyroid stimulating hormone receptor
chr4_-_148244299 0.06 ENSMUST00000151127.8
ENSMUST00000105705.9
Fbxo44
F-box protein 44
chr4_-_3938352 0.06 ENSMUST00000003369.10
Plag1
pleiomorphic adenoma gene 1
chr3_-_86455575 0.06 ENSMUST00000077524.4
Mab21l2
mab-21-like 2
chr4_+_48049080 0.05 ENSMUST00000153369.2
Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr19_-_4993060 0.05 ENSMUST00000133504.2
ENSMUST00000133254.2
ENSMUST00000120475.8
ENSMUST00000025834.15
Peli3
pellino 3
chr16_+_43184507 0.05 ENSMUST00000148775.8
Zbtb20
zinc finger and BTB domain containing 20
chr2_+_156681991 0.05 ENSMUST00000073352.10
Tgif2
TGFB-induced factor homeobox 2
chr13_+_83652150 0.04 ENSMUST00000198199.5
Mef2c
myocyte enhancer factor 2C
chr14_+_120513106 0.04 ENSMUST00000227012.2
ENSMUST00000167459.3
Mbnl2
muscleblind like splicing factor 2
chr14_+_120513076 0.03 ENSMUST00000088419.13
Mbnl2
muscleblind like splicing factor 2
chr2_-_165726610 0.03 ENSMUST00000177633.8
ENSMUST00000018050.14
ENSMUST00000088113.11
Zmynd8
zinc finger, MYND-type containing 8
chr12_-_70033732 0.03 ENSMUST00000021467.8
Sav1
salvador family WW domain containing 1
chr12_-_84497718 0.03 ENSMUST00000085192.7
ENSMUST00000220491.2
Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr2_+_156681927 0.03 ENSMUST00000081335.13
Tgif2
TGFB-induced factor homeobox 2
chr6_-_128599833 0.02 ENSMUST00000171306.5
ENSMUST00000204819.3
ENSMUST00000032512.15
Klrb1a
killer cell lectin-like receptor subfamily B member 1A
chr12_+_84498196 0.02 ENSMUST00000137170.3
Lin52
lin-52 homolog (C. elegans)
chr18_+_73996743 0.02 ENSMUST00000134847.2
Mro
maestro
chr19_-_13080648 0.02 ENSMUST00000076729.4
Olfr1458
olfactory receptor 1458
chr16_+_38182569 0.02 ENSMUST00000023494.13
ENSMUST00000114739.2
Popdc2
popeye domain containing 2
chr14_+_53980561 0.02 ENSMUST00000103667.6
Trav16
T cell receptor alpha variable 16
chr2_+_55325931 0.02 ENSMUST00000067101.10
Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr14_+_70793340 0.02 ENSMUST00000163060.2
Hr
lysine demethylase and nuclear receptor corepressor
chr11_-_35871300 0.01 ENSMUST00000018993.7
Wwc1
WW, C2 and coiled-coil domain containing 1
chr12_-_75463555 0.01 ENSMUST00000051079.4
Gphb5
glycoprotein hormone beta 5
chr9_+_107869662 0.01 ENSMUST00000177173.8
Cdhr4
cadherin-related family member 4
chr11_+_75358866 0.01 ENSMUST00000043598.14
ENSMUST00000108435.2
Tlcd2
TLC domain containing 2
chr7_+_80764564 0.01 ENSMUST00000119083.2
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr2_+_36827133 0.01 ENSMUST00000095021.2
Olfr356
olfactory receptor 356
chrX_+_3076875 0.01 ENSMUST00000189190.2
Btbd35f23
BTB domain containing 35, family member 23
chr17_+_48037758 0.01 ENSMUST00000024782.12
ENSMUST00000144955.2
Pgc
progastricsin (pepsinogen C)
chr13_+_83652280 0.00 ENSMUST00000199450.5
Mef2c
myocyte enhancer factor 2C
chr11_-_47270201 0.00 ENSMUST00000077221.6
Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr7_+_80764547 0.00 ENSMUST00000026820.11
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr2_+_84867783 0.00 ENSMUST00000168266.8
ENSMUST00000130729.3
Ssrp1
structure specific recognition protein 1
chrX_+_56144946 0.00 ENSMUST00000141936.2
Vgll1
vestigial like family member 1
chrX_-_93408176 0.00 ENSMUST00000239046.2
CXorf58
family with sequence similarity 90, member A1B
chr8_-_39128662 0.00 ENSMUST00000118896.2
Sgcz
sarcoglycan zeta
chr14_+_53284744 0.00 ENSMUST00000103606.2
Trav16d-dv11
T cell receptor alpha variable 16D-DV11
chr2_-_73490719 0.00 ENSMUST00000154258.8
Chn1
chimerin 1
chr2_+_3115250 0.00 ENSMUST00000072955.12
Fam171a1
family with sequence similarity 171, member A1

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 0.2 GO:0038190 cell migration involved in vasculogenesis(GO:0035441) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) sensory neuron axon guidance(GO:0097374)
0.0 0.2 GO:1905068 positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.3 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.2 GO:0007527 adult somatic muscle development(GO:0007527)
0.0 0.3 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0 0.2 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.3 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.4 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.1 GO:1900625 positive regulation of mast cell cytokine production(GO:0032765) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.5 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.4 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.0 0.1 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.2 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway