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avrg: GFI1 WT vs 36n/n vs KD

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Results for Nfia

Z-value: 0.97

Motif logo

Transcription factors associated with Nfia

Gene Symbol Gene ID Gene Info
ENSMUSG00000028565.19 nuclear factor I/A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfiamm39_v1_chr4_+_97665992_97666071-0.365.6e-01Click!

Activity profile of Nfia motif

Sorted Z-values of Nfia motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_21938258 1.51 ENSMUST00000091709.3
H2B clustered histone 15
chr13_-_23806530 1.26 ENSMUST00000062045.4
H1.4 linker histone, cluster member
chr13_-_23945189 0.97 ENSMUST00000102964.4
H4 clustered histone 1
chr13_-_23735822 0.88 ENSMUST00000102971.2
H4 clustered histone 6
chr13_-_23746543 0.76 ENSMUST00000105107.2
H3 clustered histone 6
chr13_-_21937997 0.74 ENSMUST00000074752.4
H2A clustered histone 15
chr13_+_21906214 0.74 ENSMUST00000224651.2
H2B clustered histone 14
chr13_+_21919225 0.66 ENSMUST00000087714.6
H4 clustered histone 11
chr10_-_128245501 0.62 ENSMUST00000172348.8
ENSMUST00000166608.8
ENSMUST00000164199.8
ENSMUST00000171370.2
ENSMUST00000026439.14
nucleic acid binding protein 2
chr7_+_43000765 0.53 ENSMUST00000012798.14
ENSMUST00000122423.8
sialic acid binding Ig-like lectin F
chr7_+_43000838 0.44 ENSMUST00000206299.2
ENSMUST00000121494.2
sialic acid binding Ig-like lectin F
chr17_+_7292967 0.41 ENSMUST00000097422.6
predicted gene 1604b
chr1_+_107456731 0.41 ENSMUST00000182198.8
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10
chr13_+_22017906 0.40 ENSMUST00000180288.2
H2B clustered histone 24
chr7_+_46700349 0.38 ENSMUST00000010451.8
transmembrane protein 86A
chr8_+_66419809 0.38 ENSMUST00000072482.13
membrane associated ring-CH-type finger 1
chr12_-_45120895 0.38 ENSMUST00000120531.8
ENSMUST00000143376.8
syntaxin binding protein 6 (amisyn)
chr9_-_48747232 0.37 ENSMUST00000093852.5
zinc finger and BTB domain containing 16
chr17_-_26727437 0.35 ENSMUST00000236661.2
ENSMUST00000025025.7
dual specificity phosphatase 1
chr2_+_121978156 0.33 ENSMUST00000102476.5
beta-2 microglobulin
chrX_-_71318353 0.31 ENSMUST00000064780.4
gamma-aminobutyric acid (GABA) A receptor, subunit epsilon
chr5_+_52521133 0.31 ENSMUST00000101208.6
superoxide dismutase 3, extracellular
chr7_+_26895206 0.30 ENSMUST00000179391.8
ENSMUST00000108379.8
cDNA sequence BC024978
chr7_-_43956326 0.30 ENSMUST00000004587.11
C-type lectin domain family 11, member a
chr14_+_20732804 0.27 ENSMUST00000228545.2
Sec24 related gene family, member C (S. cerevisiae)
chr2_-_5680801 0.27 ENSMUST00000114987.4
calcium/calmodulin-dependent protein kinase ID
chr9_-_48747474 0.27 ENSMUST00000216150.2
zinc finger and BTB domain containing 16
chr17_+_84819260 0.26 ENSMUST00000047206.7
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr2_-_32277773 0.25 ENSMUST00000050785.14
lipocalin 2
chr8_-_106723026 0.24 ENSMUST00000227363.2
ENSMUST00000081998.13
dipeptidase 2
chr15_-_76501525 0.24 ENSMUST00000230977.2
solute carrier family 39 (zinc transporter), member 4
chr8_+_69333143 0.23 ENSMUST00000015712.15
lipoprotein lipase
chr7_+_79939747 0.23 ENSMUST00000205864.2
vacuolar protein sorting 33B
chr11_+_106916430 0.23 ENSMUST00000140447.4
RIKEN cDNA 1810010H24 gene
chr15_-_101268036 0.23 ENSMUST00000077196.6
keratin 80
chr4_-_4138432 0.23 ENSMUST00000070375.8
preproenkephalin
chr18_-_62313019 0.22 ENSMUST00000053640.5
adrenergic receptor, beta 2
chr7_-_26895561 0.22 ENSMUST00000122202.8
ENSMUST00000080356.10
small nuclear ribonucleoprotein polypeptide A
chr11_+_69471219 0.22 ENSMUST00000108657.4
transformation related protein 53
chr15_+_81350538 0.22 ENSMUST00000230219.2
ring-box 1
chr4_+_47091909 0.21 ENSMUST00000045041.12
ENSMUST00000107744.2
polypeptide N-acetylgalactosaminyltransferase 12
chr7_-_25358406 0.21 ENSMUST00000071329.8
branched chain ketoacid dehydrogenase E1, alpha polypeptide
chr10_+_128061699 0.21 ENSMUST00000026455.8
major intrinsic protein of lens fiber
chr11_-_50183129 0.21 ENSMUST00000059458.5
mastermind like transcriptional coactivator 1
chr11_+_69214971 0.21 ENSMUST00000108662.2
trafficking protein particle complex 1
chr13_-_22225527 0.21 ENSMUST00000102977.4
H4 clustered histone 9
chr16_+_51851917 0.20 ENSMUST00000227062.2
Casitas B-lineage lymphoma b
chr11_+_77239098 0.20 ENSMUST00000181283.3
slingshot protein phosphatase 2
chr11_+_116324913 0.20 ENSMUST00000057676.7
UBA-like domain containing 2
chr6_+_49013601 0.20 ENSMUST00000204260.2
glycoprotein (transmembrane) nmb
chr3_-_115923098 0.20 ENSMUST00000196449.5
vascular cell adhesion molecule 1
chr7_+_26958150 0.20 ENSMUST00000079258.7
numb-like
chr10_-_30679289 0.19 ENSMUST00000215725.2
nuclear receptor coactivator 7
chr2_-_170248421 0.19 ENSMUST00000154650.8
breast carcinoma amplified sequence 1
chr5_+_135093056 0.19 ENSMUST00000071263.7
DnaJ heat shock protein family (Hsp40) member C30
chr8_+_71917554 0.19 ENSMUST00000048914.8
mitochondrial ribosomal protein L34
chr8_-_72763462 0.19 ENSMUST00000003574.5
cytochrome P450, family 4, subfamily f, polypeptide 18
chr7_-_19411866 0.19 ENSMUST00000142352.9
apolipoprotein C-II
chr7_-_19415301 0.18 ENSMUST00000150569.9
ENSMUST00000127648.4
ENSMUST00000003071.10
predicted gene 44805
apolipoprotein C-IV
chr19_-_24454720 0.18 ENSMUST00000099556.2
family with sequence similarity 122, member A
chr9_-_49479791 0.18 ENSMUST00000194252.6
neural cell adhesion molecule 1
chr7_+_25386418 0.17 ENSMUST00000002678.10
transforming growth factor, beta 1
chr8_+_120729459 0.17 ENSMUST00000108972.4
cysteine-rich secretory protein LCCL domain containing 2
chr12_-_44257109 0.17 ENSMUST00000015049.5
DnaJ heat shock protein family (Hsp40) member B9
chr7_-_24459736 0.17 ENSMUST00000063956.7
CD177 antigen
chr11_+_77107006 0.17 ENSMUST00000156488.8
ENSMUST00000037912.12
slingshot protein phosphatase 2
chr17_+_24946793 0.16 ENSMUST00000170239.9
ribosomal protein L3-like
chr10_-_31485180 0.16 ENSMUST00000081989.8
ring finger protein 217
chr4_-_155947819 0.16 ENSMUST00000030949.4
taste receptor, type 1, member 3
chr7_-_26895141 0.16 ENSMUST00000163311.9
ENSMUST00000126211.2
small nuclear ribonucleoprotein polypeptide A
chr6_+_49013517 0.16 ENSMUST00000031840.10
glycoprotein (transmembrane) nmb
chr16_+_17269845 0.16 ENSMUST00000006293.5
ENSMUST00000231228.2
v-crk avian sarcoma virus CT10 oncogene homolog-like
chr11_+_33997114 0.16 ENSMUST00000109329.9
lymphocyte cytosolic protein 2
chr16_+_10363222 0.15 ENSMUST00000155633.8
ENSMUST00000066345.15
C-type lectin domain family 16, member A
chr8_+_13455080 0.15 ENSMUST00000033827.8
ENSMUST00000209909.2
G protein-coupled receptor kinase 1
chr7_+_140658101 0.15 ENSMUST00000106039.9
plakophilin 3
chr1_-_44258112 0.15 ENSMUST00000054801.4
methyltransferase like 21E
chr12_-_70394074 0.15 ENSMUST00000223160.2
ENSMUST00000222316.2
ENSMUST00000167755.3
ENSMUST00000110520.10
ENSMUST00000110522.10
ENSMUST00000221041.2
ENSMUST00000222603.3
tripartite motif-containing 9
chr17_+_46991906 0.15 ENSMUST00000233430.2
male enhanced antigen 1
chrX_-_47297436 0.15 ENSMUST00000037960.11
zinc finger, DHHC domain containing 9
chr17_+_46991972 0.15 ENSMUST00000002845.8
male enhanced antigen 1
chr5_+_34817704 0.15 ENSMUST00000074651.11
ENSMUST00000001112.14
G protein-coupled receptor kinase 4
chr16_+_20492861 0.15 ENSMUST00000151679.3
eukaryotic translation initiation factor 4, gamma 1
chr1_+_88022776 0.15 ENSMUST00000150634.8
ENSMUST00000058237.14
UDP glucuronosyltransferase 1 family, polypeptide A7C
chr13_-_100881117 0.15 ENSMUST00000078573.5
ENSMUST00000109333.8
mitochondrial ribosomal protein S36
chr7_+_27878894 0.15 ENSMUST00000085901.13
ENSMUST00000172761.8
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr16_+_10363203 0.15 ENSMUST00000115824.10
C-type lectin domain family 16, member A
chr7_+_142030744 0.14 ENSMUST00000149521.8
lymphocyte specific 1
chr6_+_138117295 0.14 ENSMUST00000008684.11
microsomal glutathione S-transferase 1
chr15_-_5273659 0.14 ENSMUST00000047379.15
prostaglandin E receptor 4 (subtype EP4)
chr5_-_113957362 0.14 ENSMUST00000202555.2
selectin, platelet (p-selectin) ligand
chr10_-_128759331 0.14 ENSMUST00000153731.8
ENSMUST00000026405.10
biogenesis of lysosomal organelles complex-1, subunit 1
chr19_+_45036220 0.14 ENSMUST00000084493.8
sideroflexin 3
chr8_+_122457302 0.14 ENSMUST00000026357.12
junctophilin 3
chr19_+_8828132 0.14 ENSMUST00000235683.2
ENSMUST00000096257.3
LRRN4 C-terminal like
chr12_-_85421467 0.14 ENSMUST00000040766.9
transmembrane p24 trafficking protein 10
chr15_-_5273645 0.14 ENSMUST00000120563.2
prostaglandin E receptor 4 (subtype EP4)
chr2_-_73284262 0.14 ENSMUST00000102679.8
WAS/WASL interacting protein family, member 1
chr14_-_64654397 0.14 ENSMUST00000210428.2
methionine sulfoxide reductase A
chr16_+_51851588 0.14 ENSMUST00000114471.3
Casitas B-lineage lymphoma b
chr8_-_33374282 0.13 ENSMUST00000209107.4
ENSMUST00000209022.3
neuregulin 1
chrX_+_158491589 0.13 ENSMUST00000080394.13
SH3-domain kinase binding protein 1
chr11_+_62737936 0.13 ENSMUST00000150989.8
ENSMUST00000176577.2
F-box and WD-40 domain protein 10
chr7_-_101513300 0.13 ENSMUST00000106981.8
folate receptor 1 (adult)
chr1_+_165591315 0.13 ENSMUST00000111432.10
cellular repressor of E1A-stimulated genes 1
chr8_+_13034245 0.13 ENSMUST00000110873.10
ENSMUST00000173006.8
ENSMUST00000145067.8
mcf.2 transforming sequence-like
chr19_+_8817883 0.13 ENSMUST00000086058.13
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_-_106469938 0.13 ENSMUST00000103070.3
testis expressed gene 2
chr6_+_135174975 0.13 ENSMUST00000111915.8
ENSMUST00000111916.2
family with sequence similarity 234, member B
chr11_-_69304501 0.13 ENSMUST00000094077.5
KDM1 lysine (K)-specific demethylase 6B
chr19_+_45036037 0.13 ENSMUST00000062213.13
sideroflexin 3
chr2_+_164611812 0.13 ENSMUST00000088248.13
ENSMUST00000001439.7
ubiquitin-conjugating enzyme E2C
chr14_-_33700719 0.13 ENSMUST00000166737.2
zinc finger protein 488
chr19_-_7194912 0.13 ENSMUST00000039758.6
cytochrome c oxidase subunit 8A
chrX_+_162691978 0.13 ENSMUST00000069041.15
adaptor-related protein complex 1, sigma 2 subunit
chr5_+_64969679 0.13 ENSMUST00000166409.6
ENSMUST00000197879.2
Kruppel-like factor 3 (basic)
chr18_+_75500600 0.13 ENSMUST00000026999.10
SMAD family member 7
chr9_-_103569984 0.12 ENSMUST00000049452.15
transmembrane protein 108
chr11_+_69214789 0.12 ENSMUST00000102602.8
trafficking protein particle complex 1
chr10_-_62363217 0.12 ENSMUST00000160987.8
serglycin
chr8_-_123338157 0.12 ENSMUST00000015171.11
galactosamine (N-acetyl)-6-sulfate sulfatase
chr12_+_84820024 0.12 ENSMUST00000021667.7
ENSMUST00000222449.2
ENSMUST00000222982.2
iron-sulfur cluster assembly 2
chr13_-_98951890 0.12 ENSMUST00000040340.16
ENSMUST00000179563.8
ENSMUST00000109403.2
FCH domain only 2
chr17_-_57529827 0.12 ENSMUST00000177425.2
complement component 3
chrX_-_47297746 0.12 ENSMUST00000088935.4
zinc finger, DHHC domain containing 9
chrX_+_72760183 0.12 ENSMUST00000002084.14
ATP-binding cassette, sub-family D (ALD), member 1
chr7_+_27173187 0.12 ENSMUST00000068641.8
SERTA domain containing 3
chr6_+_138117519 0.12 ENSMUST00000120939.8
ENSMUST00000204628.3
ENSMUST00000140932.2
ENSMUST00000120302.8
microsomal glutathione S-transferase 1
chr11_-_100288566 0.12 ENSMUST00000001592.15
ENSMUST00000107403.2
junction plakoglobin
chr17_-_47813201 0.12 ENSMUST00000233174.2
ENSMUST00000233121.2
ENSMUST00000067103.4
TATA-box binding protein associated factor 8
chr8_+_95710977 0.12 ENSMUST00000093271.8
adhesion G protein-coupled receptor G1
chr6_-_52203146 0.12 ENSMUST00000114425.3
homeobox A9
chr11_-_78313043 0.12 ENSMUST00000001122.6
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr15_-_42540363 0.11 ENSMUST00000022921.7
angiopoietin 1
chr13_+_109397184 0.11 ENSMUST00000153234.8
phosphodiesterase 4D, cAMP specific
chr11_-_109502243 0.11 ENSMUST00000103060.10
ENSMUST00000047186.10
ENSMUST00000106689.2
WD repeat domain, phosphoinositide interacting 1
chr8_+_56393488 0.11 ENSMUST00000000275.10
glycine receptor, alpha 3 subunit
chr10_+_125802084 0.11 ENSMUST00000074807.8
leucine-rich repeats and immunoglobulin-like domains 3
chr11_+_100960838 0.11 ENSMUST00000001802.10
alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
chr14_-_64654592 0.11 ENSMUST00000210363.2
methionine sulfoxide reductase A
chr11_-_46203047 0.11 ENSMUST00000129474.2
ENSMUST00000093166.11
ENSMUST00000165599.9
cytoplasmic FMR1 interacting protein 2
chr5_+_102916637 0.11 ENSMUST00000112852.8
Rho GTPase activating protein 24
chr16_+_20492564 0.11 ENSMUST00000141034.8
eukaryotic translation initiation factor 4, gamma 1
chr9_+_44684450 0.11 ENSMUST00000238800.2
ENSMUST00000147559.8
intraflagellar transport 46
chr19_-_10859087 0.11 ENSMUST00000144681.2
transmembrane protein 109
chr14_-_55909314 0.11 ENSMUST00000163750.8
neural precursor cell expressed, developmentally down-regulated gene 8
chr5_+_150119860 0.11 ENSMUST00000202600.4
FRY microtubule binding protein
chr7_+_112806672 0.11 ENSMUST00000047321.9
ENSMUST00000210074.2
ENSMUST00000210238.2
aryl hydrocarbon receptor nuclear translocator-like
chr6_-_124733441 0.11 ENSMUST00000088357.12
atrophin 1
chr16_+_20492014 0.11 ENSMUST00000154950.8
ENSMUST00000115461.8
ENSMUST00000136713.5
eukaryotic translation initiation factor 4, gamma 1
chr3_-_88366159 0.11 ENSMUST00000147200.8
ENSMUST00000169222.8
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr11_+_75400889 0.11 ENSMUST00000042972.7
Rab interacting lysosomal protein
chr9_-_87613301 0.11 ENSMUST00000034991.8
T-box18
chr7_+_3648264 0.11 ENSMUST00000206287.2
ENSMUST00000038913.16
CCR4-NOT transcription complex, subunit 3
chr10_-_49664839 0.11 ENSMUST00000220263.2
ENSMUST00000218823.2
glutamate receptor, ionotropic, kainate 2 (beta 2)
chr1_+_59952131 0.10 ENSMUST00000036540.12
family with sequence similarity 117, member B
chr17_+_34824827 0.10 ENSMUST00000037489.15
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr4_+_137196080 0.10 ENSMUST00000030547.15
ENSMUST00000171332.2
perlecan (heparan sulfate proteoglycan 2)
chr16_+_27208660 0.10 ENSMUST00000143823.2
coiled-coil domain containing 50
chr16_-_4831349 0.10 ENSMUST00000201077.2
ENSMUST00000202281.4
ENSMUST00000090453.9
ENSMUST00000023191.17
rogdi homolog
chr11_+_77353218 0.10 ENSMUST00000102493.8
coronin 6
chr11_+_62737887 0.10 ENSMUST00000036085.11
F-box and WD-40 domain protein 10
chr9_+_89791943 0.10 ENSMUST00000189545.2
ENSMUST00000034909.11
ENSMUST00000034912.6
RAS protein-specific guanine nucleotide-releasing factor 1
chr8_+_71207326 0.10 ENSMUST00000110093.9
ENSMUST00000143118.3
ENSMUST00000034301.12
ENSMUST00000110090.8
RAB3A, member RAS oncogene family
chr9_+_39932760 0.10 ENSMUST00000215956.3
olfactory receptor 981
chr4_-_133695264 0.10 ENSMUST00000102553.11
high mobility group nucleosomal binding domain 2
chr4_+_48045143 0.10 ENSMUST00000030025.10
nuclear receptor subfamily 4, group A, member 3
chr5_+_102629240 0.10 ENSMUST00000073302.12
ENSMUST00000094559.9
Rho GTPase activating protein 24
chr7_+_27879650 0.10 ENSMUST00000172467.8
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr17_-_7215682 0.10 ENSMUST00000024572.10
radial spoke 3B homolog (Chlamydomonas)
chr18_-_78166595 0.10 ENSMUST00000091813.12
solute carrier family 14 (urea transporter), member 1
chr14_-_73622638 0.10 ENSMUST00000228637.2
ENSMUST00000022704.9
integral membrane protein 2B
chr12_-_44256843 0.10 ENSMUST00000220421.2
DnaJ heat shock protein family (Hsp40) member B9
chr15_-_103161237 0.10 ENSMUST00000154510.8
nuclear factor, erythroid derived 2
chr7_-_80053063 0.10 ENSMUST00000147150.2
furin (paired basic amino acid cleaving enzyme)
chr19_+_16933471 0.10 ENSMUST00000087689.5
prune homolog 2
chr8_+_95712151 0.10 ENSMUST00000212799.2
adhesion G protein-coupled receptor G1
chr9_-_26717686 0.10 ENSMUST00000162702.8
ENSMUST00000040398.14
ENSMUST00000066560.13
galactosidase, beta 1-like 2
chr17_+_29537798 0.09 ENSMUST00000114701.10
peptidase inhibitor 16
chr4_-_135221810 0.09 ENSMUST00000105856.9
NIPA-like domain containing 3
chr8_+_125302843 0.09 ENSMUST00000093033.6
ENSMUST00000133086.2
calpain 9
chr13_+_49658249 0.09 ENSMUST00000051504.8
extracellular matrix protein 2, female organ and adipocyte specific
chr11_-_94492688 0.09 ENSMUST00000103164.4
acyl-CoA synthetase family member 2
chr10_-_57408585 0.09 ENSMUST00000020027.11
serine incorporator 1
chr11_+_69804714 0.09 ENSMUST00000072581.9
ENSMUST00000116358.8
G protein pathway suppressor 2
chr11_+_69214883 0.09 ENSMUST00000102601.10
trafficking protein particle complex 1
chr2_-_129139125 0.09 ENSMUST00000052708.7
cytoskeleton associated protein 2-like
chr19_+_23736205 0.09 ENSMUST00000025830.9
amyloid beta (A4) precursor protein binding, family A, member 1
chr10_+_67373691 0.09 ENSMUST00000048289.14
ENSMUST00000130933.2
ENSMUST00000105438.9
ENSMUST00000146986.2
early growth response 2
chr3_+_146156220 0.09 ENSMUST00000061937.13
ENSMUST00000029840.4
chitobiase
chr7_-_126101555 0.09 ENSMUST00000167759.8
ataxin 2-like
chr5_+_123153072 0.09 ENSMUST00000051016.5
ENSMUST00000121652.8
ORAI calcium release-activated calcium modulator 1
chr16_+_84571249 0.09 ENSMUST00000098407.3
junction adhesion molecule 2
chr4_+_141095415 0.09 ENSMUST00000006380.5
family with sequence similarity 131, member C
chr10_+_75242745 0.09 ENSMUST00000039925.8
ureidopropionase, beta
chr7_-_126101484 0.09 ENSMUST00000166682.9
ataxin 2-like
chr8_+_84682136 0.09 ENSMUST00000005607.9
anti-silencing function 1B histone chaperone
chr7_+_44667377 0.09 ENSMUST00000044111.10
related RAS viral (r-ras) oncogene
chr15_+_81350497 0.09 ENSMUST00000023036.7
ring-box 1
chr11_+_78006391 0.09 ENSMUST00000155571.2
family with sequence similarity 222, member B

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfia

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1904766 negative regulation of macroautophagy by TORC1 signaling(GO:1904766)
0.1 0.3 GO:1904438 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
0.1 0.3 GO:1990773 negative regulation of integrin activation(GO:0033624) regulation of matrix metallopeptidase secretion(GO:1904464) matrix metallopeptidase secretion(GO:1990773) positive regulation of ovarian follicle development(GO:2000386) regulation of antral ovarian follicle growth(GO:2000387) positive regulation of antral ovarian follicle growth(GO:2000388) negative regulation of eosinophil migration(GO:2000417)
0.1 0.2 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.1 0.2 GO:1902689 negative regulation of NAD metabolic process(GO:1902689) negative regulation of glucose catabolic process to lactate via pyruvate(GO:1904024)
0.1 0.6 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.1 GO:0006689 ganglioside catabolic process(GO:0006689)
0.1 0.3 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.2 GO:0042376 menaquinone metabolic process(GO:0009233) phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.1 0.2 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.2 GO:1904172 positive regulation of bleb assembly(GO:1904172)
0.1 0.2 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.1 0.2 GO:2000845 positive regulation of testosterone secretion(GO:2000845)
0.1 0.2 GO:0003162 atrioventricular node development(GO:0003162)
0.1 0.4 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.2 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.0 0.1 GO:0006711 estrogen catabolic process(GO:0006711)
0.0 0.2 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.0 0.3 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.0 0.2 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 0.4 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.0 0.3 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.0 0.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.1 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
0.0 0.1 GO:0021594 rhombomere formation(GO:0021594) rhombomere 3 formation(GO:0021660) rhombomere 5 morphogenesis(GO:0021664) rhombomere 5 formation(GO:0021666)
0.0 0.1 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.4 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.3 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.0 0.1 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.1 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.0 0.2 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.1 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.1 GO:1900625 positive regulation of mast cell cytokine production(GO:0032765) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0090472 dibasic protein processing(GO:0090472)
0.0 0.1 GO:0099558 maintenance of synapse structure(GO:0099558)
0.0 0.6 GO:0070200 establishment of protein localization to telomere(GO:0070200)
0.0 0.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter(GO:1900477)
0.0 0.1 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563) cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.2 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.1 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.0 0.1 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.1 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.0 0.1 GO:0072249 metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313)
0.0 0.1 GO:0033371 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
0.0 0.1 GO:0035964 COPI-coated vesicle budding(GO:0035964)
0.0 0.1 GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.3 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.0 0.2 GO:0021873 forebrain neuroblast division(GO:0021873)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.1 GO:0060434 bronchus morphogenesis(GO:0060434)
0.0 0.1 GO:0000239 pachytene(GO:0000239)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.2 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.0 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.0 0.1 GO:0050968 detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.0 0.1 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.0 0.0 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.0 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0 0.1 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.0 0.1 GO:0070625 zymogen granule exocytosis(GO:0070625)
0.0 0.1 GO:1900108 sequestering of BMP in extracellular matrix(GO:0035582) negative regulation of nodal signaling pathway(GO:1900108)
0.0 0.2 GO:0002118 aggressive behavior(GO:0002118)
0.0 0.1 GO:0044565 dendritic cell proliferation(GO:0044565)
0.0 0.2 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0 0.0 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.0 0.0 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.0 0.2 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.1 GO:0060376 positive regulation of mast cell differentiation(GO:0060376)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.1 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.1 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0 0.1 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.0 GO:0030070 insulin processing(GO:0030070)
0.0 0.3 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.1 GO:0006668 sphinganine-1-phosphate metabolic process(GO:0006668)
0.0 0.0 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.4 GO:0045116 protein neddylation(GO:0045116)
0.0 0.0 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.1 GO:0009115 xanthine catabolic process(GO:0009115)
0.0 0.1 GO:0097466 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 0.0 GO:0042732 D-xylose metabolic process(GO:0042732)
0.0 0.2 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.1 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.0 0.0 GO:2000836 positive regulation of androgen secretion(GO:2000836)
0.0 0.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.0 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.0 GO:0016584 nucleosome positioning(GO:0016584)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0036020 endolysosome membrane(GO:0036020)
0.1 0.6 GO:0070876 SOSS complex(GO:0070876)
0.1 0.2 GO:0036398 TCR signalosome(GO:0036398)
0.1 0.3 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.1 0.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 0.2 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.2 GO:0046691 intracellular canaliculus(GO:0046691)
0.0 0.1 GO:0098833 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.2 GO:0005914 spot adherens junction(GO:0005914)
0.0 0.1 GO:0070722 Tle3-Aes complex(GO:0070722)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0017177 glucosidase II complex(GO:0017177)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.3 GO:0097451 glial limiting end-foot(GO:0097451)
0.0 0.6 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.1 GO:0005608 laminin-3 complex(GO:0005608)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.4 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 0.4 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.2 GO:0003863 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.1 0.2 GO:0052871 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871)
0.1 0.2 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.2 GO:0031711 bradykinin receptor binding(GO:0031711)
0.1 0.3 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.3 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.1 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.0 0.3 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.6 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.3 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.1 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.1 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:0016015 morphogen activity(GO:0016015)
0.0 0.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.3 GO:0005372 water transmembrane transporter activity(GO:0005372)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.0 GO:0045030 UTP-activated nucleotide receptor activity(GO:0045030)
0.0 0.0 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.3 GO:0015929 hexosaminidase activity(GO:0015929)
0.0 0.1 GO:0030151 xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726) molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.0 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.1 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.0 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.0 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.3 GO:0004890 GABA-A receptor activity(GO:0004890)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers