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avrg: GFI1 WT vs 36n/n vs KD

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Results for Nfkb2

Z-value: 1.24

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Transcription factors associated with Nfkb2

Gene Symbol Gene ID Gene Info
Nfkb2
ENSMUSG00000025225.16 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfkb2mm39_v1_chr19_+_46294119_462942350.856.8e-02Click!

Activity profile of Nfkb2 motif

Sorted Z-values of Nfkb2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_90907207 1.02 ENSMUST00000031318.6
Cxcl5
chemokine (C-X-C motif) ligand 5
chr7_+_67925718 0.88 ENSMUST00000210558.2
Fam169b
family with sequence similarity 169, member B
chr4_+_118745806 0.64 ENSMUST00000106361.3
ENSMUST00000105035.3
Olfr1330
olfactory receptor 1330
chr3_+_97565528 0.60 ENSMUST00000045743.13
Prkab2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr9_+_55234197 0.56 ENSMUST00000085754.10
ENSMUST00000034862.5
Tmem266
transmembrane protein 266
chr1_-_5089564 0.54 ENSMUST00000002533.15
Rgs20
regulator of G-protein signaling 20
chr11_-_23720953 0.52 ENSMUST00000102864.5
Rel
reticuloendotheliosis oncogene
chr1_+_166828982 0.52 ENSMUST00000165874.8
ENSMUST00000190081.7
Fam78b
family with sequence similarity 78, member B
chr8_+_109441276 0.51 ENSMUST00000043896.10
Zfhx3
zinc finger homeobox 3
chr6_-_83433357 0.51 ENSMUST00000186548.7
Tet3
tet methylcytosine dioxygenase 3
chr15_-_66158445 0.46 ENSMUST00000070256.9
Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chrX_+_162691978 0.45 ENSMUST00000069041.15
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr11_+_77576981 0.40 ENSMUST00000100802.11
ENSMUST00000181023.2
Nufip2
nuclear fragile X mental retardation protein interacting protein 2
chr1_+_166829001 0.38 ENSMUST00000126198.3
Fam78b
family with sequence similarity 78, member B
chr11_-_71928300 0.38 ENSMUST00000048207.10
Aipl1
aryl hydrocarbon receptor-interacting protein-like 1
chr2_-_37312881 0.38 ENSMUST00000112936.4
ENSMUST00000112934.8
Rc3h2
ring finger and CCCH-type zinc finger domains 2
chr15_-_102154874 0.37 ENSMUST00000063339.14
Rarg
retinoic acid receptor, gamma
chrX_+_162692126 0.37 ENSMUST00000033734.14
ENSMUST00000112294.9
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr7_-_44181477 0.37 ENSMUST00000098483.9
ENSMUST00000035323.6
Spib
Spi-B transcription factor (Spi-1/PU.1 related)
chr7_+_3339059 0.35 ENSMUST00000096744.8
Myadm
myeloid-associated differentiation marker
chr8_-_106016097 0.33 ENSMUST00000171788.8
4931428F04Rik
RIKEN cDNA 4931428F04 gene
chr1_-_63153414 0.33 ENSMUST00000153992.2
ENSMUST00000165066.8
ENSMUST00000172416.8
ENSMUST00000137511.8
Ino80d
INO80 complex subunit D
chr4_-_125021610 0.30 ENSMUST00000036188.8
Zc3h12a
zinc finger CCCH type containing 12A
chr7_-_19363280 0.29 ENSMUST00000094762.10
ENSMUST00000049912.15
ENSMUST00000098754.5
Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr19_+_6391148 0.28 ENSMUST00000025897.13
ENSMUST00000130382.8
Map4k2
mitogen-activated protein kinase kinase kinase kinase 2
chr8_-_106015682 0.28 ENSMUST00000212922.2
ENSMUST00000212219.2
4931428F04Rik
RIKEN cDNA 4931428F04 gene
chr7_+_28988724 0.26 ENSMUST00000207714.2
ENSMUST00000048187.6
Ppp1r14a
protein phosphatase 1, regulatory inhibitor subunit 14A
chr2_-_5719302 0.26 ENSMUST00000044009.14
Camk1d
calcium/calmodulin-dependent protein kinase ID
chr17_+_35816915 0.22 ENSMUST00000025271.17
Pou5f1
POU domain, class 5, transcription factor 1
chr1_-_66856695 0.21 ENSMUST00000068168.10
ENSMUST00000113987.2
Kansl1l
KAT8 regulatory NSL complex subunit 1-like
chr1_-_152778373 0.21 ENSMUST00000073441.13
ENSMUST00000111836.4
Smg7
Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr10_+_80538482 0.20 ENSMUST00000095426.5
Izumo4
IZUMO family member 4
chr7_+_30121147 0.20 ENSMUST00000108176.9
Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr8_+_79754980 0.20 ENSMUST00000087927.11
ENSMUST00000098614.9
Zfp827
zinc finger protein 827
chr7_+_44866635 0.19 ENSMUST00000097216.5
ENSMUST00000209343.2
ENSMUST00000209678.2
Tead2
TEA domain family member 2
chr11_+_101066867 0.19 ENSMUST00000103109.4
Cntnap1
contactin associated protein-like 1
chr3_+_31149201 0.17 ENSMUST00000118470.8
ENSMUST00000029194.12
ENSMUST00000123532.2
Skil
SKI-like
chr8_-_105357941 0.16 ENSMUST00000034351.8
Rrad
Ras-related associated with diabetes
chr7_-_44702269 0.16 ENSMUST00000057293.8
Prr12
proline rich 12
chr7_-_100951227 0.16 ENSMUST00000122116.8
ENSMUST00000120267.9
Atg16l2
autophagy related 16-like 2 (S. cerevisiae)
chr3_+_31149247 0.15 ENSMUST00000117728.8
Skil
SKI-like
chr1_+_132996237 0.14 ENSMUST00000239467.2
Pik3c2b
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
chr1_+_34840785 0.13 ENSMUST00000047664.16
ENSMUST00000211073.2
Arhgef4
SMIM39
Rho guanine nucleotide exchange factor (GEF) 4
novel protein
chrX_-_7537580 0.12 ENSMUST00000033486.6
Plp2
proteolipid protein 2
chr1_-_36982747 0.12 ENSMUST00000185964.3
Tmem131
transmembrane protein 131
chr10_+_127216459 0.11 ENSMUST00000166820.8
R3hdm2
R3H domain containing 2
chr11_+_69920542 0.10 ENSMUST00000232266.2
ENSMUST00000132597.5
Dlg4
discs large MAGUK scaffold protein 4
chr1_-_63153675 0.10 ENSMUST00000097718.9
Ino80d
INO80 complex subunit D
chr10_+_127216668 0.09 ENSMUST00000111628.9
R3hdm2
R3H domain containing 2
chr17_-_36291087 0.08 ENSMUST00000055454.14
Prr3
proline-rich polypeptide 3
chr11_-_54853729 0.07 ENSMUST00000108885.8
ENSMUST00000102730.9
ENSMUST00000018482.13
ENSMUST00000108886.8
ENSMUST00000102731.8
Tnip1
TNFAIP3 interacting protein 1
chr10_-_89522112 0.07 ENSMUST00000092227.12
ENSMUST00000174252.8
Scyl2
SCY1-like 2 (S. cerevisiae)
chr7_+_30121776 0.07 ENSMUST00000108175.8
Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr14_-_30348153 0.07 ENSMUST00000112211.9
ENSMUST00000112210.11
Prkcd
protein kinase C, delta
chr4_+_140815644 0.05 ENSMUST00000051907.3
Spata21
spermatogenesis associated 21
chr8_+_124138163 0.04 ENSMUST00000071134.4
ENSMUST00000212743.2
Tubb3
tubulin, beta 3 class III
chr11_-_84761637 0.04 ENSMUST00000168434.8
Ggnbp2
gametogenetin binding protein 2
chr4_+_124880223 0.04 ENSMUST00000030687.8
Rspo1
R-spondin 1
chr7_-_125799570 0.03 ENSMUST00000009344.16
Xpo6
exportin 6
chr2_-_160155536 0.03 ENSMUST00000109475.3
Gm826
predicted gene 826
chr4_-_118615913 0.03 ENSMUST00000214922.3
ENSMUST00000216559.3
Olfr1338
olfactory receptor 1338
chr7_-_43896112 0.03 ENSMUST00000237383.2
1700028J19Rik
RIKEN cDNA 1700028J19 gene
chr5_+_91039092 0.02 ENSMUST00000031327.9
Cxcl1
chemokine (C-X-C motif) ligand 1
chr2_-_164315634 0.02 ENSMUST00000017864.3
Trp53tg5
transformation related protein 53 target 5
chr11_-_84761472 0.01 ENSMUST00000018547.9
Ggnbp2
gametogenetin binding protein 2
chr11_+_70548622 0.01 ENSMUST00000170716.8
Eno3
enolase 3, beta muscle
chr6_+_68547717 0.00 ENSMUST00000196839.5
ENSMUST00000103327.3
Igkv12-98
immunoglobulin kappa variable 12-98
chr8_-_71315651 0.00 ENSMUST00000212414.2
Kcnn1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfkb2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0070948 regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.1 0.5 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.5 GO:0044727 DNA demethylation of male pronucleus(GO:0044727)
0.1 0.4 GO:0018343 protein farnesylation(GO:0018343)
0.1 0.4 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.2 GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.1 0.5 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1 0.3 GO:1903936 miRNA catabolic process(GO:0010587) cellular response to sodium arsenite(GO:1903936)
0.0 0.4 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.1 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.4 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.3 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.2 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0 0.3 GO:0033085 negative regulation of T cell differentiation in thymus(GO:0033085)
0.0 0.3 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.5 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.1 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
0.0 0.3 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.3 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.8 GO:0036465 synaptic vesicle recycling(GO:0036465)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.5 GO:0001940 male pronucleus(GO:0001940)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.5 GO:0043194 axon initial segment(GO:0043194)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.5 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0004699 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.0 0.1 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.2 GO:0070034 telomerase RNA binding(GO:0070034)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.6 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines