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avrg: GFI1 WT vs 36n/n vs KD

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Results for Nkx1-1_Nkx1-2

Z-value: 1.02

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Transcription factors associated with Nkx1-1_Nkx1-2

Gene Symbol Gene ID Gene Info
Nkx1-1
ENSMUSG00000029112.6 NK1 homeobox 1
Nkx1-2
ENSMUSG00000048528.8 NK1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx1-2mm39_v1_chr7_-_132201344_1322013660.983.2e-03Click!

Activity profile of Nkx1-1_Nkx1-2 motif

Sorted Z-values of Nkx1-1_Nkx1-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_51851948 0.94 ENSMUST00000226593.2
Cblb
Casitas B-lineage lymphoma b
chr16_+_51851917 0.88 ENSMUST00000227062.2
Cblb
Casitas B-lineage lymphoma b
chr19_-_12313274 0.75 ENSMUST00000208398.3
Olfr1438-ps1
olfactory receptor 1438, pseudogene 1
chr6_-_57340712 0.71 ENSMUST00000228156.2
ENSMUST00000227186.2
ENSMUST00000228294.2
ENSMUST00000228342.2
Vmn1r17
vomeronasal 1 receptor 17
chr16_+_51851588 0.61 ENSMUST00000114471.3
Cblb
Casitas B-lineage lymphoma b
chr2_-_89855921 0.57 ENSMUST00000216616.3
Olfr1264
olfactory receptor 1264
chr5_-_84565218 0.54 ENSMUST00000113401.4
Epha5
Eph receptor A5
chr8_-_3744167 0.53 ENSMUST00000005678.6
Fcer2a
Fc receptor, IgE, low affinity II, alpha polypeptide
chr10_-_44024843 0.49 ENSMUST00000200401.2
Crybg1
crystallin beta-gamma domain containing 1
chr13_-_105191403 0.48 ENSMUST00000063551.7
Rgs7bp
regulator of G-protein signalling 7 binding protein
chr17_-_37974666 0.47 ENSMUST00000215414.2
ENSMUST00000213638.3
Olfr117
olfactory receptor 117
chr1_-_92412835 0.46 ENSMUST00000214928.3
Olfr1416
olfactory receptor 1416
chr7_+_26895206 0.44 ENSMUST00000179391.8
ENSMUST00000108379.8
BC024978
cDNA sequence BC024978
chr4_-_131802606 0.42 ENSMUST00000146021.8
Epb41
erythrocyte membrane protein band 4.1
chr6_+_57405915 0.42 ENSMUST00000227909.2
Vmn1r20
vomeronasal 1 receptor 20
chr3_-_15902583 0.41 ENSMUST00000108354.8
ENSMUST00000108349.2
ENSMUST00000108352.9
ENSMUST00000108350.8
ENSMUST00000050623.11
Sirpb1c
signal-regulatory protein beta 1C
chr2_-_111843053 0.40 ENSMUST00000213559.3
Olfr1310
olfactory receptor 1310
chr10_-_128875765 0.39 ENSMUST00000204763.3
Olfr764-ps1
olfactory receptor 764, pseudogene 1
chrX_+_159551009 0.37 ENSMUST00000033650.14
Rs1
retinoschisis (X-linked, juvenile) 1 (human)
chr6_-_58195806 0.37 ENSMUST00000228530.2
ENSMUST00000226666.2
Vmn1r27
vomeronasal 1 receptor 27
chr10_+_129539079 0.36 ENSMUST00000213331.2
Olfr804
olfactory receptor 804
chr7_+_140181182 0.35 ENSMUST00000214180.2
ENSMUST00000211771.2
Olfr46
olfactory receptor 46
chr2_-_89423470 0.35 ENSMUST00000217254.2
ENSMUST00000217192.2
ENSMUST00000213221.2
Olfr1246
olfactory receptor 1246
chr1_+_173093568 0.34 ENSMUST00000213420.2
Olfr418
olfactory receptor 418
chr7_+_3648264 0.34 ENSMUST00000206287.2
ENSMUST00000038913.16
Cnot3
CCR4-NOT transcription complex, subunit 3
chr8_+_114362181 0.33 ENSMUST00000179926.9
Mon1b
MON1 homolog B, secretory traffciking associated
chrX_+_102400061 0.33 ENSMUST00000116547.3
Chic1
cysteine-rich hydrophobic domain 1
chr7_-_12829100 0.32 ENSMUST00000209822.3
ENSMUST00000235753.2
Vmn1r85
vomeronasal 1 receptor 85
chr8_+_114362419 0.29 ENSMUST00000035777.10
Mon1b
MON1 homolog B, secretory traffciking associated
chr7_-_11414074 0.29 ENSMUST00000227010.2
ENSMUST00000209638.3
Vmn1r72
vomeronasal 1 receptor 72
chr4_-_131802561 0.27 ENSMUST00000105970.8
ENSMUST00000105975.8
Epb41
erythrocyte membrane protein band 4.1
chr1_-_91386976 0.26 ENSMUST00000069620.10
Per2
period circadian clock 2
chr7_-_100613579 0.25 ENSMUST00000060174.6
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr7_-_73187369 0.25 ENSMUST00000172704.6
Chd2
chromodomain helicase DNA binding protein 2
chr11_+_121128042 0.25 ENSMUST00000103015.4
Narf
nuclear prelamin A recognition factor
chrX_-_73129195 0.22 ENSMUST00000140399.3
ENSMUST00000123362.8
ENSMUST00000100750.10
ENSMUST00000033770.13
Mecp2
methyl CpG binding protein 2
chr12_-_25146078 0.22 ENSMUST00000222667.2
ENSMUST00000020974.7
Id2
inhibitor of DNA binding 2
chr19_+_12364643 0.21 ENSMUST00000217062.3
ENSMUST00000216145.2
ENSMUST00000213657.2
Olfr1440
olfactory receptor 1440
chr11_-_99134885 0.18 ENSMUST00000103132.10
ENSMUST00000038214.7
Krt222
keratin 222
chr1_-_150341911 0.18 ENSMUST00000162367.8
ENSMUST00000161611.8
ENSMUST00000161320.8
ENSMUST00000159035.2
Prg4
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
chr4_-_132191181 0.18 ENSMUST00000102567.4
Med18
mediator complex subunit 18
chr2_-_160950936 0.18 ENSMUST00000039782.14
ENSMUST00000134178.8
Chd6
chromodomain helicase DNA binding protein 6
chr9_-_107749594 0.17 ENSMUST00000183035.2
Rbm6
RNA binding motif protein 6
chr14_-_52277310 0.17 ENSMUST00000216907.2
ENSMUST00000214071.2
ENSMUST00000216188.2
Olfr221
olfactory receptor 221
chr4_-_43710231 0.17 ENSMUST00000217544.2
ENSMUST00000107862.3
Olfr71
olfactory receptor 71
chr12_+_108145802 0.17 ENSMUST00000221167.2
Ccnk
cyclin K
chr15_-_77840856 0.16 ENSMUST00000117725.2
ENSMUST00000016696.13
Foxred2
FAD-dependent oxidoreductase domain containing 2
chr7_-_30251680 0.16 ENSMUST00000215288.2
ENSMUST00000108165.8
ENSMUST00000153594.3
Proser3
proline and serine rich 3
chr6_+_29694181 0.16 ENSMUST00000046750.14
ENSMUST00000115250.4
Tspan33
tetraspanin 33
chr8_+_84262409 0.15 ENSMUST00000214156.2
ENSMUST00000209408.4
Olfr370
olfactory receptor 370
chr9_+_40092216 0.15 ENSMUST00000218134.2
ENSMUST00000216720.2
ENSMUST00000214763.2
Olfr986
olfactory receptor 986
chr17_+_21446349 0.15 ENSMUST00000235895.2
Vmn1r234
vomeronasal 1 receptor 234
chr4_-_141327146 0.15 ENSMUST00000141518.8
ENSMUST00000127455.8
ENSMUST00000105784.8
Fblim1
filamin binding LIM protein 1
chr5_-_74692327 0.15 ENSMUST00000072857.13
ENSMUST00000113542.9
ENSMUST00000151474.3
Scfd2
Sec1 family domain containing 2
chr19_+_11943265 0.14 ENSMUST00000025590.11
Osbp
oxysterol binding protein
chr8_+_84699580 0.14 ENSMUST00000005606.8
Prkaca
protein kinase, cAMP dependent, catalytic, alpha
chr4_+_136038263 0.12 ENSMUST00000105850.8
ENSMUST00000148843.10
Hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr6_-_128339458 0.12 ENSMUST00000155573.3
Rhno1
RAD9-HUS1-RAD1 interacting nuclear orphan 1
chr12_+_4819022 0.12 ENSMUST00000219503.2
Pfn4
profilin family, member 4
chr5_-_143846600 0.12 ENSMUST00000031613.11
ENSMUST00000100483.3
Aimp2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr18_+_4993795 0.12 ENSMUST00000153016.8
Svil
supervillin
chrX_-_49108236 0.12 ENSMUST00000213556.3
ENSMUST00000213463.2
Olfr1323
olfactory receptor 1323
chr11_-_97040858 0.11 ENSMUST00000118375.8
Tbkbp1
TBK1 binding protein 1
chr19_+_5540483 0.10 ENSMUST00000209469.2
ENSMUST00000116560.3
Cfl1
cofilin 1, non-muscle
chr6_-_58452315 0.10 ENSMUST00000177318.3
ENSMUST00000176147.9
ENSMUST00000176023.3
ENSMUST00000228586.2
Vmn1r31
vomeronasal 1 receptor 31
chr14_-_70666513 0.10 ENSMUST00000226426.2
ENSMUST00000048129.6
Piwil2
piwi-like RNA-mediated gene silencing 2
chr4_+_136038301 0.09 ENSMUST00000084219.12
Hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr15_+_98350469 0.09 ENSMUST00000217517.2
Olfr281
olfactory receptor 281
chr11_-_22236795 0.09 ENSMUST00000180360.8
ENSMUST00000109563.9
Ehbp1
EH domain binding protein 1
chr4_+_136038243 0.09 ENSMUST00000131671.8
Hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr2_+_111355548 0.08 ENSMUST00000217845.3
Olfr1293-ps
olfactory receptor 1293, pseudogene
chr19_+_29344846 0.08 ENSMUST00000016640.8
Cd274
CD274 antigen
chr17_-_57338468 0.08 ENSMUST00000007814.10
ENSMUST00000233480.2
Khsrp
KH-type splicing regulatory protein
chr5_-_137101108 0.07 ENSMUST00000077523.4
ENSMUST00000041388.11
Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
chr12_+_52746158 0.07 ENSMUST00000095737.5
Akap6
A kinase (PRKA) anchor protein 6
chr2_-_45002902 0.07 ENSMUST00000076836.13
ENSMUST00000176732.8
ENSMUST00000200844.4
Zeb2
zinc finger E-box binding homeobox 2
chr9_-_26717686 0.07 ENSMUST00000162702.8
ENSMUST00000040398.14
ENSMUST00000066560.13
Glb1l2
galactosidase, beta 1-like 2
chr12_-_4819216 0.06 ENSMUST00000053458.7
ENSMUST00000218575.2
Fam228b
family with sequence similarity 228, member B
chr2_-_165230165 0.06 ENSMUST00000103084.4
Zfp334
zinc finger protein 334
chr2_-_102230602 0.06 ENSMUST00000152929.2
Trim44
tripartite motif-containing 44
chr7_-_26895141 0.06 ENSMUST00000163311.9
ENSMUST00000126211.2
Snrpa
small nuclear ribonucleoprotein polypeptide A
chr2_+_85804239 0.06 ENSMUST00000217244.2
Olfr1029
olfactory receptor 1029
chr7_-_19363280 0.06 ENSMUST00000094762.10
ENSMUST00000049912.15
ENSMUST00000098754.5
Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr16_+_13176238 0.06 ENSMUST00000149359.2
Mrtfb
myocardin related transcription factor B
chr5_+_143846782 0.05 ENSMUST00000148011.8
ENSMUST00000110709.7
Pms2
PMS1 homolog2, mismatch repair system component
chr9_-_66033841 0.05 ENSMUST00000137542.2
Snx1
sorting nexin 1
chr10_+_116137277 0.05 ENSMUST00000092167.7
Ptprb
protein tyrosine phosphatase, receptor type, B
chr16_-_22676264 0.05 ENSMUST00000232075.2
ENSMUST00000004576.8
Tbccd1
TBCC domain containing 1
chr4_-_88595161 0.04 ENSMUST00000105148.2
Ifna16
interferon alpha 16
chr4_-_141327253 0.03 ENSMUST00000147785.8
Fblim1
filamin binding LIM protein 1
chrX_+_57076359 0.03 ENSMUST00000088631.11
ENSMUST00000088629.4
Zic3
zinc finger protein of the cerebellum 3
chr1_+_173924457 0.02 ENSMUST00000213832.2
Olfr427
olfactory receptor 427
chr6_+_37847721 0.02 ENSMUST00000031859.14
ENSMUST00000120428.8
Trim24
tripartite motif-containing 24
chr6_+_145561483 0.02 ENSMUST00000087445.7
Tuba3b
tubulin, alpha 3B
chr2_+_154390808 0.02 ENSMUST00000045116.11
ENSMUST00000109709.4
1700003F12Rik
RIKEN cDNA 1700003F12 gene
chr2_-_89678487 0.02 ENSMUST00000214428.3
Olfr48
olfactory receptor 48
chr5_-_90788323 0.02 ENSMUST00000202784.4
ENSMUST00000031317.10
ENSMUST00000201370.2
Rassf6
Ras association (RalGDS/AF-6) domain family member 6
chrX_+_57075981 0.02 ENSMUST00000088627.11
Zic3
zinc finger protein of the cerebellum 3
chr5_+_9150691 0.01 ENSMUST00000115365.3
Tmem243
transmembrane protein 243, mitochondrial
chr14_+_67148619 0.01 ENSMUST00000089236.11
ENSMUST00000122431.3
Pnma2
paraneoplastic antigen MA2
chr16_+_22965286 0.01 ENSMUST00000023593.6
Adipoq
adiponectin, C1Q and collagen domain containing
chr6_-_69704122 0.01 ENSMUST00000103364.3
Igkv5-48
immunoglobulin kappa variable 5-48
chr1_-_173161069 0.01 ENSMUST00000038227.6
Ackr1
atypical chemokine receptor 1 (Duffy blood group)
chr6_-_128339775 0.01 ENSMUST00000112152.8
ENSMUST00000057421.15
ENSMUST00000112151.2
Rhno1
RAD9-HUS1-RAD1 interacting nuclear orphan 1
chr11_+_116734104 0.01 ENSMUST00000106370.10
Mettl23
methyltransferase like 23
chr7_+_128346655 0.01 ENSMUST00000042942.10
Sec23ip
Sec23 interacting protein
chr1_-_131441962 0.01 ENSMUST00000185445.3
Srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr14_-_59602882 0.00 ENSMUST00000160425.8
ENSMUST00000095157.11
Phf11d
PHD finger protein 11D
chr14_-_70666821 0.00 ENSMUST00000226229.2
Piwil2
piwi-like RNA-mediated gene silencing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.2 0.6 GO:0019085 early viral transcription(GO:0019085)
0.1 0.4 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.3 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.1 0.5 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.1 0.2 GO:2000820 cellular response to isoquinoline alkaloid(GO:0071317) negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.1 0.2 GO:0001966 thigmotaxis(GO:0001966)
0.0 0.2 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0 0.1 GO:1903632 positive regulation of aminoacyl-tRNA ligase activity(GO:1903632)
0.0 0.7 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.5 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.1 GO:0000239 pachytene(GO:0000239)
0.0 0.1 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.2 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.2 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.2 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.4 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.1 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0002944 cyclin K-CDK12 complex(GO:0002944) cyclin K-CDK13 complex(GO:0002945)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0019863 IgE binding(GO:0019863)
0.1 0.3 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.1 0.5 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 2.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.3 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.1 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.1 GO:0035614 snRNA stem-loop binding(GO:0035614)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.4 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.5 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors