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avrg: GFI1 WT vs 36n/n vs KD

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Results for Nkx2-1

Z-value: 1.16

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Transcription factors associated with Nkx2-1

Gene Symbol Gene ID Gene Info
Nkx2-1
ENSMUSG00000001496.16 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-1mm39_v1_chr12_-_56581823_565818910.838.5e-02Click!

Activity profile of Nkx2-1 motif

Sorted Z-values of Nkx2-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_23922783 1.19 ENSMUST00000040914.3
H1f2
H1.2 linker histone, cluster member
chr17_-_57289121 1.00 ENSMUST00000056113.5
Acer1
alkaline ceramidase 1
chr5_-_97259447 0.92 ENSMUST00000069453.9
ENSMUST00000112968.2
Paqr3
progestin and adipoQ receptor family member III
chr11_-_96868483 0.89 ENSMUST00000107624.8
Sp2
Sp2 transcription factor
chr17_+_69071546 0.82 ENSMUST00000233625.2
L3mbtl4
L3MBTL4 histone methyl-lysine binding protein
chr10_-_67972401 0.77 ENSMUST00000218532.2
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr7_+_28466160 0.72 ENSMUST00000122915.8
ENSMUST00000072965.5
ENSMUST00000170068.9
Sirt2
sirtuin 2
chr2_+_71811526 0.71 ENSMUST00000090826.12
ENSMUST00000102698.10
Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
chr2_+_128971620 0.66 ENSMUST00000035481.5
Chchd5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr11_+_32483290 0.65 ENSMUST00000102821.4
Stk10
serine/threonine kinase 10
chr9_+_45924105 0.65 ENSMUST00000126865.8
Sik3
SIK family kinase 3
chr3_+_90201388 0.63 ENSMUST00000199607.5
Gatad2b
GATA zinc finger domain containing 2B
chr7_-_28465870 0.59 ENSMUST00000085851.12
ENSMUST00000032815.11
Nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
chr11_+_68989763 0.57 ENSMUST00000021271.14
Per1
period circadian clock 1
chr16_+_24266829 0.57 ENSMUST00000078988.10
Lpp
LIM domain containing preferred translocation partner in lipoma
chr12_-_111638722 0.57 ENSMUST00000001304.9
Ckb
creatine kinase, brain
chr9_+_45924120 0.53 ENSMUST00000120463.9
ENSMUST00000120247.8
Sik3
SIK family kinase 3
chr2_-_88937158 0.52 ENSMUST00000099806.3
ENSMUST00000213288.2
Olfr1220
olfactory receptor 1220
chr13_+_38009981 0.50 ENSMUST00000110238.10
Rreb1
ras responsive element binding protein 1
chr17_-_34846323 0.47 ENSMUST00000168709.3
ENSMUST00000064953.15
ENSMUST00000170345.8
ENSMUST00000171121.9
ENSMUST00000168391.9
ENSMUST00000169067.9
Gm20460
Ppt2
predicted gene 20460
palmitoyl-protein thioesterase 2
chrX_-_73009933 0.47 ENSMUST00000114372.3
ENSMUST00000033761.13
Hcfc1
host cell factor C1
chr2_-_73722874 0.43 ENSMUST00000136958.8
ENSMUST00000112010.9
ENSMUST00000128531.8
ENSMUST00000112017.8
Atf2
activating transcription factor 2
chr9_+_75682637 0.42 ENSMUST00000012281.8
Bmp5
bone morphogenetic protein 5
chr7_+_127845984 0.40 ENSMUST00000164710.8
ENSMUST00000070656.12
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr16_+_90535212 0.38 ENSMUST00000038197.3
Mrap
melanocortin 2 receptor accessory protein
chr2_-_73722932 0.36 ENSMUST00000154456.8
ENSMUST00000090802.11
ENSMUST00000055833.12
ENSMUST00000112007.8
ENSMUST00000112016.9
Atf2
activating transcription factor 2
chrX_+_55391749 0.35 ENSMUST00000101560.4
Zfp449
zinc finger protein 449
chr2_-_121948845 0.33 ENSMUST00000036450.8
Spg11
SPG11, spatacsin vesicle trafficking associated
chr1_-_173363523 0.32 ENSMUST00000139092.8
Ifi214
interferon activated gene 214
chr11_+_70323452 0.32 ENSMUST00000084954.13
ENSMUST00000108568.10
ENSMUST00000079056.9
ENSMUST00000102564.11
ENSMUST00000124943.8
ENSMUST00000150076.8
ENSMUST00000102563.2
Arrb2
arrestin, beta 2
chr7_-_30262659 0.31 ENSMUST00000043898.8
Psenen
presenilin enhancer gamma secretase subunit
chr7_-_28824440 0.31 ENSMUST00000214374.2
ENSMUST00000179893.9
ENSMUST00000032813.10
Ryr1
ryanodine receptor 1, skeletal muscle
chr5_-_97259424 0.30 ENSMUST00000112969.10
Paqr3
progestin and adipoQ receptor family member III
chr11_-_118139312 0.29 ENSMUST00000100181.11
Cyth1
cytohesin 1
chr12_+_85871404 0.28 ENSMUST00000177188.8
ENSMUST00000095536.10
ENSMUST00000110220.9
ENSMUST00000040179.14
Ttll5
tubulin tyrosine ligase-like family, member 5
chr1_+_74193138 0.28 ENSMUST00000027372.8
ENSMUST00000106899.4
Cxcr2
chemokine (C-X-C motif) receptor 2
chr7_-_4755971 0.28 ENSMUST00000183971.8
ENSMUST00000182173.2
ENSMUST00000182738.8
ENSMUST00000182111.8
ENSMUST00000184143.8
ENSMUST00000182048.2
ENSMUST00000063324.14
Cox6b2
cytochrome c oxidase subunit 6B2
chr9_+_40092216 0.27 ENSMUST00000218134.2
ENSMUST00000216720.2
ENSMUST00000214763.2
Olfr986
olfactory receptor 986
chr6_+_113303929 0.27 ENSMUST00000032406.15
Ogg1
8-oxoguanine DNA-glycosylase 1
chr6_+_72281587 0.26 ENSMUST00000183018.8
ENSMUST00000182014.10
Sftpb
surfactant associated protein B
chr13_+_110039620 0.24 ENSMUST00000120664.8
Pde4d
phosphodiesterase 4D, cAMP specific
chr11_-_83353787 0.24 ENSMUST00000021020.13
ENSMUST00000119346.2
ENSMUST00000103209.10
ENSMUST00000108137.9
Mmp28
matrix metallopeptidase 28 (epilysin)
chr1_+_178356678 0.21 ENSMUST00000161017.8
Kif26b
kinesin family member 26B
chr15_-_64254754 0.21 ENSMUST00000177374.8
ENSMUST00000110114.10
ENSMUST00000110115.9
ENSMUST00000023008.16
Asap1
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
chr11_+_69920849 0.21 ENSMUST00000143920.4
Dlg4
discs large MAGUK scaffold protein 4
chr1_+_153750081 0.20 ENSMUST00000055314.4
Teddm1b
transmembrane epididymal protein 1B
chrX_+_56008685 0.19 ENSMUST00000096431.10
Adgrg4
adhesion G protein-coupled receptor G4
chr17_+_6157154 0.18 ENSMUST00000149756.8
Tulp4
tubby like protein 4
chr6_-_38276157 0.18 ENSMUST00000058524.3
Zc3hav1l
zinc finger CCCH-type, antiviral 1-like
chrX_+_72935708 0.18 ENSMUST00000033765.8
ENSMUST00000101470.3
ENSMUST00000114395.2
Avpr2
arginine vasopressin receptor 2
chrX_+_7628891 0.18 ENSMUST00000077680.10
ENSMUST00000079542.13
ENSMUST00000115679.8
ENSMUST00000137467.8
Tfe3
transcription factor E3
chr17_-_34847354 0.17 ENSMUST00000167097.9
Ppt2
palmitoyl-protein thioesterase 2
chr10_+_22520910 0.17 ENSMUST00000042261.5
Slc2a12
solute carrier family 2 (facilitated glucose transporter), member 12
chr11_+_101046708 0.16 ENSMUST00000043654.10
Tubg2
tubulin, gamma 2
chr1_-_80191649 0.15 ENSMUST00000058748.2
Fam124b
family with sequence similarity 124, member B
chr11_+_80319424 0.14 ENSMUST00000173938.8
ENSMUST00000017572.14
Psmd11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr19_-_8816530 0.14 ENSMUST00000096259.6
Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr17_-_26204621 0.14 ENSMUST00000041641.9
ENSMUST00000212520.2
Capn15
calpain 15
chr18_+_49965689 0.13 ENSMUST00000180611.8
Dmxl1
Dmx-like 1
chr2_-_121304521 0.12 ENSMUST00000056732.4
Mfap1b
microfibrillar-associated protein 1B
chr7_-_30443106 0.12 ENSMUST00000182634.8
Gapdhs
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr11_+_68858942 0.12 ENSMUST00000102606.10
ENSMUST00000018884.6
Slc25a35
solute carrier family 25, member 35
chr11_+_69920956 0.11 ENSMUST00000232115.2
Dlg4
discs large MAGUK scaffold protein 4
chr13_+_12580772 0.11 ENSMUST00000220811.2
Ero1b
endoplasmic reticulum oxidoreductase 1 beta
chr12_+_91367764 0.11 ENSMUST00000021346.14
ENSMUST00000021343.8
Tshr
thyroid stimulating hormone receptor
chr11_-_118139331 0.11 ENSMUST00000017276.14
Cyth1
cytohesin 1
chr2_-_89779008 0.11 ENSMUST00000214846.2
Olfr1259
olfactory receptor 1259
chr17_+_48080113 0.10 ENSMUST00000160373.8
ENSMUST00000159641.8
Tfeb
transcription factor EB
chr11_+_74540284 0.09 ENSMUST00000117818.2
ENSMUST00000092915.12
Cluh
clustered mitochondria (cluA/CLU1) homolog
chr2_-_57004933 0.09 ENSMUST00000028166.9
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr1_+_43973167 0.09 ENSMUST00000087933.10
ENSMUST00000188313.7
Tpp2
tripeptidyl peptidase II
chr11_-_96807192 0.08 ENSMUST00000144731.8
ENSMUST00000127048.8
Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr15_-_64254585 0.07 ENSMUST00000176384.8
ENSMUST00000175799.8
Asap1
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
chr2_+_177760768 0.07 ENSMUST00000108917.8
Phactr3
phosphatase and actin regulator 3
chr1_-_162726234 0.07 ENSMUST00000111510.8
ENSMUST00000045902.13
Fmo2
flavin containing monooxygenase 2
chr7_+_34885782 0.07 ENSMUST00000135452.8
ENSMUST00000001854.12
Slc7a10
solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
chrX_+_57075981 0.06 ENSMUST00000088627.11
Zic3
zinc finger protein of the cerebellum 3
chr13_+_38009951 0.06 ENSMUST00000138043.8
Rreb1
ras responsive element binding protein 1
chr3_+_88439616 0.06 ENSMUST00000172699.2
Mex3a
mex3 RNA binding family member A
chr7_-_45463701 0.06 ENSMUST00000210898.2
ENSMUST00000107729.10
ENSMUST00000056820.13
Cyth2
cytohesin 2
chr1_-_136273811 0.05 ENSMUST00000048309.12
Camsap2
calmodulin regulated spectrin-associated protein family, member 2
chrX_+_57076359 0.05 ENSMUST00000088631.11
ENSMUST00000088629.4
Zic3
zinc finger protein of the cerebellum 3
chr6_+_127554931 0.05 ENSMUST00000071563.5
Cracr2a
calcium release activated channel regulator 2A
chr4_+_62278932 0.05 ENSMUST00000084526.12
Slc31a1
solute carrier family 31, member 1
chr16_-_92622659 0.05 ENSMUST00000186296.2
Runx1
runt related transcription factor 1
chr15_+_76579885 0.05 ENSMUST00000231028.2
Gpt
glutamic pyruvic transaminase, soluble
chr14_-_14651778 0.04 ENSMUST00000052678.9
Flnb
filamin, beta
chr18_-_68562385 0.04 ENSMUST00000052347.8
Mc2r
melanocortin 2 receptor
chr13_+_55782814 0.04 ENSMUST00000172272.8
ENSMUST00000099479.4
ENSMUST00000223736.2
Ddx46
DEAD box helicase 46
chr18_+_24842493 0.03 ENSMUST00000037097.9
ENSMUST00000234526.2
ENSMUST00000234834.2
Fhod3
formin homology 2 domain containing 3
chr15_+_80118269 0.03 ENSMUST00000229138.2
ENSMUST00000166030.2
Mief1
mitochondrial elongation factor 1
chr11_-_118139418 0.03 ENSMUST00000106305.9
Cyth1
cytohesin 1
chr9_+_110075133 0.03 ENSMUST00000199736.2
Cspg5
chondroitin sulfate proteoglycan 5
chrX_+_143471903 0.03 ENSMUST00000112843.2
Rtl4
retrotransposon Gag like 4
chr2_-_73605684 0.02 ENSMUST00000112024.10
ENSMUST00000180045.8
Chn1
chimerin 1
chr8_-_13446769 0.02 ENSMUST00000033826.4
Atp4b
ATPase, H+/K+ exchanging, beta polypeptide
chr14_+_67470884 0.02 ENSMUST00000176161.8
Ebf2
early B cell factor 2
chr13_+_105218625 0.02 ENSMUST00000022232.6
Nt5el
5' nucleotidase, ecto-like
chr19_-_5518515 0.02 ENSMUST00000236256.2
ENSMUST00000025844.6
Ctsw
cathepsin W
chrX_-_110372843 0.02 ENSMUST00000096348.10
ENSMUST00000113428.9
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr19_-_5452521 0.02 ENSMUST00000235569.2
Tsga10ip
testis specific 10 interacting protein
chr14_+_26959975 0.02 ENSMUST00000049206.6
Arhgef3
Rho guanine nucleotide exchange factor (GEF) 3
chr16_-_38649107 0.02 ENSMUST00000122078.3
Tex55
testis expressed 55
chr5_+_92135294 0.02 ENSMUST00000178614.3
Odaph
odontogenesis associated phosphoprotein
chr14_-_24054352 0.01 ENSMUST00000190339.2
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr11_+_96183294 0.01 ENSMUST00000173432.3
Hoxb6
homeobox B6
chr17_+_6156738 0.01 ENSMUST00000142030.8
Tulp4
tubby like protein 4
chr9_-_121621544 0.01 ENSMUST00000035110.11
Hhatl
hedgehog acyltransferase-like
chr15_-_7427815 0.01 ENSMUST00000096494.5
Egflam
EGF-like, fibronectin type III and laminin G domains
chrX_-_110372800 0.01 ENSMUST00000137712.9
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr12_-_11200306 0.01 ENSMUST00000055673.2
Kcns3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr17_-_34847013 0.01 ENSMUST00000166040.9
Ppt2
palmitoyl-protein thioesterase 2
chrX_-_110372733 0.01 ENSMUST00000065976.12
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr18_+_37397991 0.01 ENSMUST00000052366.5
Pcdhb1
protocadherin beta 1
chr15_-_7427759 0.01 ENSMUST00000058593.10
Egflam
EGF-like, fibronectin type III and laminin G domains
chr19_+_44481901 0.01 ENSMUST00000041163.5
Wnt8b
wingless-type MMTV integration site family, member 8B
chr5_-_145020840 0.01 ENSMUST00000151196.2
Kpna7
karyopherin alpha 7 (importin alpha 8)
chr11_-_120344299 0.01 ENSMUST00000026452.3
Pde6g
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr1_+_85945790 0.01 ENSMUST00000149469.3
Spata3
spermatogenesis associated 3
chr9_-_4796217 0.01 ENSMUST00000027020.13
ENSMUST00000163309.2
Gria4
glutamate receptor, ionotropic, AMPA4 (alpha 4)
chr18_-_66993567 0.01 ENSMUST00000057942.4
Mc4r
melanocortin 4 receptor
chr7_-_34974953 0.01 ENSMUST00000238407.2
Wdr88
WD repeat domain 88
chr4_-_44704006 0.01 ENSMUST00000146335.8
Pax5
paired box 5
chr1_-_155617773 0.00 ENSMUST00000027740.14
Lhx4
LIM homeobox protein 4
chr18_+_37276556 0.00 ENSMUST00000047479.3
Pcdhac2
protocadherin alpha subfamily C, 2
chr2_-_26098293 0.00 ENSMUST00000054099.16
Lhx3
LIM homeobox protein 3
chr1_+_75427080 0.00 ENSMUST00000113577.8
Asic4
acid-sensing (proton-gated) ion channel family member 4
chr11_+_69920542 0.00 ENSMUST00000232266.2
ENSMUST00000132597.5
Dlg4
discs large MAGUK scaffold protein 4
chr1_+_75427343 0.00 ENSMUST00000037708.10
Asic4
acid-sensing (proton-gated) ion channel family member 4
chr9_-_4796142 0.00 ENSMUST00000063508.15
Gria4
glutamate receptor, ionotropic, AMPA4 (alpha 4)
chr4_-_44703413 0.00 ENSMUST00000186542.2
Pax5
paired box 5
chr2_-_168554774 0.00 ENSMUST00000123156.8
ENSMUST00000156555.2
Atp9a
ATPase, class II, type 9A
chr10_-_62723238 0.00 ENSMUST00000228901.2
Tet1
tet methylcytosine dioxygenase 1
chr9_+_110595224 0.00 ENSMUST00000136695.3
Myl3
myosin, light polypeptide 3
chr9_-_37058590 0.00 ENSMUST00000080754.12
ENSMUST00000188057.7
ENSMUST00000039674.13
Pknox2
Pbx/knotted 1 homeobox 2
chr6_+_113449237 0.00 ENSMUST00000204447.3
Il17rc
interleukin 17 receptor C
chr6_-_40864428 0.00 ENSMUST00000031937.4
Moxd2
monooxygenase, DBH-like 2
chr7_-_144761806 0.00 ENSMUST00000208788.2
Smim38
small integral membrane protein 38
chr2_-_170248421 0.00 ENSMUST00000154650.8
Bcas1
breast carcinoma amplified sequence 1
chr9_-_62029936 0.00 ENSMUST00000185873.2
Glce
glucuronyl C5-epimerase

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1900195 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.2 1.0 GO:0010446 response to alkaline pH(GO:0010446)
0.2 0.8 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 0.7 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.1 0.5 GO:0019046 release from viral latency(GO:0019046)
0.1 0.4 GO:0021502 neural fold elevation formation(GO:0021502)
0.1 0.6 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 0.5 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.8 GO:0060613 fat pad development(GO:0060613)
0.0 0.2 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.3 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.0 0.2 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.3 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.4 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 1.2 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 0.3 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.3 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.3 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.1 GO:1902477 defense response to bacterium, incompatible interaction(GO:0009816) regulation of defense response to bacterium, incompatible interaction(GO:1902477)
0.0 0.3 GO:0098953 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.1 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 0.1 GO:0015825 L-serine transport(GO:0015825)
0.0 1.1 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 0.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:1904587 response to glycoprotein(GO:1904587)
0.0 0.3 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.1 GO:0072592 oxygen metabolic process(GO:0072592)
0.0 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.7 GO:2000401 regulation of lymphocyte migration(GO:2000401)
0.0 0.0 GO:2000872 positive regulation of progesterone secretion(GO:2000872)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0044316 cone cell pedicle(GO:0044316)
0.1 0.7 GO:0033010 paranodal junction(GO:0033010)
0.1 0.3 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.1 GO:0043291 RAVE complex(GO:0043291)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.0 0.3 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.5 GO:0048188 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) Set1C/COMPASS complex(GO:0048188)
0.0 0.3 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1 0.4 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.1 1.0 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 0.6 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.8 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.3 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.1 0.3 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 0.4 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.7 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.3 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.3 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.5 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.7 GO:0030552 cAMP binding(GO:0030552)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.9 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.1 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.3 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.6 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.3 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 1.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors