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avrg: GFI1 WT vs 36n/n vs KD
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Results for Nkx6-1_Evx1_Hesx1
Z-value: 2.94
Motif logo
Transcription factors associated with Nkx6-1_Evx1_Hesx1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
Nkx6-1
|
ENSMUSG00000035187.11 | NK6 homeobox 1 |
|
Evx1
|
ENSMUSG00000005503.9 | even-skipped homeobox 1 |
|
Hesx1
|
ENSMUSG00000040726.11 | homeobox gene expressed in ES cells |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Evx1 | mm39_v1_chr6_+_52290415_52290537 | 0.67 | 2.2e-01 | Click! |
| Nkx6-1 | mm39_v1_chr5_-_101812862_101812862 | 0.56 | 3.2e-01 | Click! |
| Hesx1 | mm39_v1_chr14_+_26722319_26722463 | -0.28 | 6.5e-01 | Click! |
Activity profile of Nkx6-1_Evx1_Hesx1 motif
Sorted Z-values of Nkx6-1_Evx1_Hesx1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of Nkx6-1_Evx1_Hesx1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.3 | GO:0006429 | leucyl-tRNA aminoacylation(GO:0006429) |
| 0.9 | 6.3 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.6 | 2.5 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.6 | 2.4 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.6 | 2.4 | GO:1904207 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.6 | 2.3 | GO:1905053 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 0.4 | 1.5 | GO:0003017 | lymph circulation(GO:0003017) |
| 0.4 | 1.1 | GO:2000536 | negative regulation of entry of bacterium into host cell(GO:2000536) |
| 0.4 | 2.1 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.3 | 2.7 | GO:0044828 | negative regulation by host of viral genome replication(GO:0044828) |
| 0.3 | 2.7 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
| 0.2 | 5.2 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.2 | 0.7 | GO:2000040 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 0.2 | 0.9 | GO:0098582 | innate vocalization behavior(GO:0098582) |
| 0.2 | 0.7 | GO:0003162 | atrioventricular node development(GO:0003162) |
| 0.2 | 0.9 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.2 | 0.6 | GO:0034378 | chylomicron assembly(GO:0034378) |
| 0.2 | 0.6 | GO:0050973 | detection of mechanical stimulus involved in equilibrioception(GO:0050973) |
| 0.2 | 14.2 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.2 | 0.6 | GO:0032685 | negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685) |
| 0.2 | 0.6 | GO:0032805 | positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805) regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
| 0.2 | 0.6 | GO:2001055 | positive regulation of mesenchymal cell apoptotic process(GO:2001055) |
| 0.2 | 0.8 | GO:0036060 | filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) |
| 0.2 | 0.6 | GO:0036367 | adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367) |
| 0.2 | 1.7 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.2 | 1.1 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.2 | 0.5 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.2 | 0.9 | GO:0023016 | signal transduction by trans-phosphorylation(GO:0023016) |
| 0.2 | 1.0 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.2 | 1.0 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 0.2 | 0.7 | GO:0045575 | basophil activation(GO:0045575) |
| 0.2 | 1.0 | GO:1900020 | prolactin secretion(GO:0070459) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020) |
| 0.2 | 0.5 | GO:0061033 | bronchiole development(GO:0060435) secretion by lung epithelial cell involved in lung growth(GO:0061033) |
| 0.2 | 1.1 | GO:0007527 | adult somatic muscle development(GO:0007527) |
| 0.2 | 1.1 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.1 | 2.1 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
| 0.1 | 0.6 | GO:2000395 | regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397) |
| 0.1 | 0.4 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.1 | 0.8 | GO:0032439 | endosome localization(GO:0032439) |
| 0.1 | 0.5 | GO:0021502 | neural fold elevation formation(GO:0021502) |
| 0.1 | 0.6 | GO:0006742 | NADP catabolic process(GO:0006742) |
| 0.1 | 1.4 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.1 | 1.0 | GO:0016056 | rhodopsin mediated signaling pathway(GO:0016056) |
| 0.1 | 16.1 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.1 | 0.9 | GO:0035878 | nail development(GO:0035878) |
| 0.1 | 0.6 | GO:0002023 | reduction of food intake in response to dietary excess(GO:0002023) |
| 0.1 | 0.3 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.1 | 0.4 | GO:0035694 | mitochondrial protein catabolic process(GO:0035694) |
| 0.1 | 0.4 | GO:0019858 | cytosine metabolic process(GO:0019858) |
| 0.1 | 0.8 | GO:0090656 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) t-circle formation(GO:0090656) |
| 0.1 | 0.9 | GO:0086023 | adrenergic receptor signaling pathway involved in heart process(GO:0086023) |
| 0.1 | 0.8 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.1 | 5.0 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
| 0.1 | 0.7 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 0.1 | 4.1 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 0.3 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.1 | 0.2 | GO:0002386 | immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells(GO:0002414) |
| 0.1 | 0.7 | GO:0051596 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.1 | 2.5 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.1 | 0.6 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.1 | 0.4 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.1 | 0.3 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.1 | 1.1 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.1 | 1.0 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.1 | 0.2 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 0.1 | 0.1 | GO:0060060 | post-embryonic retina morphogenesis in camera-type eye(GO:0060060) |
| 0.1 | 0.4 | GO:0002729 | positive regulation of natural killer cell cytokine production(GO:0002729) |
| 0.1 | 19.9 | GO:0050907 | detection of chemical stimulus involved in sensory perception(GO:0050907) |
| 0.1 | 0.3 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.1 | 0.4 | GO:0031161 | phosphatidylinositol catabolic process(GO:0031161) |
| 0.1 | 0.3 | GO:1903054 | negative regulation of extracellular matrix organization(GO:1903054) |
| 0.1 | 0.1 | GO:0060450 | positive regulation of hindgut contraction(GO:0060450) |
| 0.1 | 0.5 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.1 | 0.3 | GO:0006538 | glutamate catabolic process(GO:0006538) |
| 0.0 | 0.2 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.0 | 0.4 | GO:0090306 | spindle assembly involved in meiosis(GO:0090306) |
| 0.0 | 0.1 | GO:0018879 | biphenyl metabolic process(GO:0018879) |
| 0.0 | 0.7 | GO:0035745 | T-helper 2 cell cytokine production(GO:0035745) |
| 0.0 | 0.3 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.0 | 0.2 | GO:0007198 | adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) negative regulation of serotonin secretion(GO:0014063) |
| 0.0 | 0.2 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.0 | 0.5 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.0 | 0.2 | GO:0046946 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.0 | 0.1 | GO:1901994 | negative regulation of meiotic cell cycle phase transition(GO:1901994) |
| 0.0 | 0.7 | GO:1904776 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.0 | 43.7 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.1 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.0 | 0.1 | GO:0002545 | chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880) |
| 0.0 | 0.3 | GO:0032485 | regulation of Ral protein signal transduction(GO:0032485) |
| 0.0 | 0.4 | GO:0098814 | spontaneous neurotransmitter secretion(GO:0061669) positive regulation of inhibitory postsynaptic potential(GO:0097151) spontaneous synaptic transmission(GO:0098814) |
| 0.0 | 0.4 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) positive regulation of macrophage apoptotic process(GO:2000111) |
| 0.0 | 0.7 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.0 | 0.4 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 0.7 | GO:0046548 | retinal rod cell development(GO:0046548) |
| 0.0 | 0.7 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.0 | 0.3 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 0.2 | GO:0042421 | norepinephrine biosynthetic process(GO:0042421) |
| 0.0 | 0.2 | GO:0072092 | ureteric bud invasion(GO:0072092) |
| 0.0 | 1.0 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.0 | 0.1 | GO:0012502 | induction of programmed cell death(GO:0012502) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501) positive regulation of apoptotic process by virus(GO:0060139) |
| 0.0 | 0.3 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.0 | 0.1 | GO:1904753 | negative regulation of vascular associated smooth muscle cell migration(GO:1904753) |
| 0.0 | 0.1 | GO:1903238 | positive regulation of leukocyte tethering or rolling(GO:1903238) |
| 0.0 | 0.3 | GO:0032570 | response to progesterone(GO:0032570) |
| 0.0 | 0.5 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 0.1 | GO:0006850 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
| 0.0 | 0.2 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.0 | 0.1 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.0 | 0.5 | GO:0051923 | sulfation(GO:0051923) |
| 0.0 | 0.4 | GO:0035278 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.0 | 0.1 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.0 | 0.1 | GO:0071110 | protein biotinylation(GO:0009305) response to biotin(GO:0070781) histone biotinylation(GO:0071110) |
| 0.0 | 0.1 | GO:0070173 | regulation of enamel mineralization(GO:0070173) |
| 0.0 | 0.1 | GO:0035660 | MyD88-dependent toll-like receptor 4 signaling pathway(GO:0035660) |
| 0.0 | 0.1 | GO:0097275 | creatinine homeostasis(GO:0097273) cellular ammonia homeostasis(GO:0097275) cellular creatinine homeostasis(GO:0097276) cellular urea homeostasis(GO:0097277) |
| 0.0 | 0.5 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
| 0.0 | 0.4 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.0 | 0.1 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.0 | 0.1 | GO:1903375 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375) |
| 0.0 | 0.1 | GO:0097461 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.0 | 1.5 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 0.6 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.0 | 0.2 | GO:0075509 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.0 | 0.2 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.0 | 0.2 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
| 0.0 | 0.1 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.0 | 1.2 | GO:0043407 | negative regulation of MAP kinase activity(GO:0043407) |
| 0.0 | 0.0 | GO:0001982 | baroreceptor response to decreased systemic arterial blood pressure(GO:0001982) |
| 0.0 | 0.1 | GO:0042795 | snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.0 | 0.5 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
| 0.0 | 0.2 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.2 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.0 | 0.2 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 0.0 | 0.4 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity(GO:2000651) |
| 0.0 | 0.1 | GO:0090037 | positive regulation of protein kinase C signaling(GO:0090037) |
| 0.0 | 0.3 | GO:0007602 | phototransduction(GO:0007602) |
| 0.0 | 0.8 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.0 | 0.9 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 0.0 | 0.1 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.0 | 0.1 | GO:0033087 | negative regulation of immature T cell proliferation(GO:0033087) |
| 0.0 | 0.0 | GO:2001226 | negative regulation of chloride transport(GO:2001226) |
| 0.0 | 0.1 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.0 | 0.4 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.0 | 0.2 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 0.0 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.0 | 0.0 | GO:0060789 | hair follicle placode formation(GO:0060789) |
| 0.0 | 1.7 | GO:0007606 | sensory perception of chemical stimulus(GO:0007606) |
| 0.0 | 0.1 | GO:0045162 | protein localization to paranode region of axon(GO:0002175) clustering of voltage-gated sodium channels(GO:0045162) |
| 0.0 | 0.5 | GO:2000036 | regulation of stem cell population maintenance(GO:2000036) |
| 0.0 | 0.1 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0002944 | cyclin K-CDK12 complex(GO:0002944) cyclin K-CDK13 complex(GO:0002945) |
| 0.3 | 1.1 | GO:0034683 | integrin alphav-beta3 complex(GO:0034683) integrin alphav-beta8 complex(GO:0034686) |
| 0.2 | 3.9 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.2 | 1.0 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.2 | 17.9 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.2 | 1.6 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.2 | 0.8 | GO:0035841 | new growing cell tip(GO:0035841) |
| 0.1 | 1.3 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 0.6 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.1 | 0.7 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.1 | 0.5 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 0.3 | GO:0044307 | dendritic branch(GO:0044307) |
| 0.1 | 2.0 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 0.4 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.1 | 0.5 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 0.8 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 0.5 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.0 | 0.7 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.0 | 6.0 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.3 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.0 | 0.1 | GO:0070069 | cytochrome complex(GO:0070069) |
| 0.0 | 0.3 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.0 | 0.6 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.4 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.0 | 0.4 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.0 | 0.9 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 1.0 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.2 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 0.4 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.0 | 0.3 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 0.3 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.4 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.0 | 3.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.1 | GO:0005683 | U7 snRNP(GO:0005683) |
| 0.0 | 0.1 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.0 | 0.3 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.0 | 0.2 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 0.2 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.1 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 0.1 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.0 | 0.2 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.7 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.3 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.1 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 0.4 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.1 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 0.2 | GO:0032279 | asymmetric synapse(GO:0032279) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.3 | GO:0004823 | leucine-tRNA ligase activity(GO:0004823) |
| 0.5 | 2.1 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 0.4 | 13.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 3.4 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.3 | 0.8 | GO:0045030 | UTP-activated nucleotide receptor activity(GO:0045030) |
| 0.2 | 1.0 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.2 | 1.7 | GO:0001851 | complement component C3b binding(GO:0001851) |
| 0.2 | 4.9 | GO:0070513 | death domain binding(GO:0070513) |
| 0.2 | 0.9 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.2 | 0.6 | GO:0046911 | metal chelating activity(GO:0046911) |
| 0.2 | 2.7 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.2 | 0.8 | GO:0042284 | sphingolipid delta-4 desaturase activity(GO:0042284) |
| 0.2 | 1.5 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.2 | 6.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 3.6 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.1 | 1.0 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.1 | 1.3 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.1 | 0.5 | GO:0003681 | bent DNA binding(GO:0003681) |
| 0.1 | 0.9 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.1 | 1.1 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 0.3 | GO:0086059 | voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059) |
| 0.1 | 14.4 | GO:0005550 | pheromone binding(GO:0005550) |
| 0.1 | 0.5 | GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
| 0.1 | 0.8 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.1 | 1.1 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 0.6 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.1 | 0.4 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 0.1 | 0.5 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.1 | 0.7 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.1 | 0.9 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.1 | 0.7 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.1 | 0.4 | GO:0008934 | inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834) |
| 0.1 | 0.4 | GO:0047493 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.1 | 0.9 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 0.4 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.1 | 0.4 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 0.3 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.1 | 1.4 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 0.5 | GO:0047623 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.3 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.0 | 2.0 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 2.2 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.2 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.0 | 0.4 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.0 | 68.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.2 | GO:0004566 | beta-glucuronidase activity(GO:0004566) |
| 0.0 | 1.7 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 0.4 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.0 | 0.2 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.0 | 0.9 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.0 | 0.3 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.0 | 0.2 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 0.0 | 0.5 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 0.3 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.0 | 0.2 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.0 | 2.3 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 0.1 | GO:0071208 | histone pre-mRNA DCP binding(GO:0071208) U7 snRNA binding(GO:0071209) |
| 0.0 | 1.5 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 0.3 | GO:0046790 | virion binding(GO:0046790) |
| 0.0 | 0.1 | GO:0032093 | SAM domain binding(GO:0032093) |
| 0.0 | 0.1 | GO:0004077 | biotin-[acetyl-CoA-carboxylase] ligase activity(GO:0004077) biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity(GO:0004078) biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity(GO:0004079) biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity(GO:0004080) biotin-protein ligase activity(GO:0018271) |
| 0.0 | 0.5 | GO:0016503 | pheromone receptor activity(GO:0016503) |
| 0.0 | 1.6 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 0.2 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.0 | 0.7 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.3 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.0 | 0.2 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.0 | 0.1 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.0 | 0.5 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.1 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.0 | 1.0 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.4 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.0 | GO:0004937 | alpha1-adrenergic receptor activity(GO:0004937) |
| 0.0 | 0.1 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.0 | 0.2 | GO:0051378 | serotonin binding(GO:0051378) |
| 0.0 | 0.8 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 1.1 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.2 | GO:0004117 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 0.4 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.0 | 0.2 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 3.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.4 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 0.1 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.0 | 0.4 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 0.0 | GO:0016492 | G-protein coupled neurotensin receptor activity(GO:0016492) |
| 0.0 | 0.2 | GO:0043855 | cyclic nucleotide-gated ion channel activity(GO:0043855) |
| 0.0 | 0.1 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 0.1 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.0 | 0.0 | GO:0004705 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.0 | 0.1 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.0 | 0.0 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.0 | 0.1 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.0 | 0.2 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.6 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 3.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 2.5 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 1.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.1 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 4.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 0.8 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 1.4 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.6 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.7 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 0.8 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.7 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 1.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.3 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.4 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.8 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.1 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.2 | PID ATM PATHWAY | ATM pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.8 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 1.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 2.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 1.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 1.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 3.1 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 0.7 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 1.0 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 0.8 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 0.6 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.3 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.1 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.7 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.1 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.0 | 0.6 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.6 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.9 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.1 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.4 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.5 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.6 | REACTOME FGFR LIGAND BINDING AND ACTIVATION | Genes involved in FGFR ligand binding and activation |
| 0.0 | 0.5 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.2 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.0 | 3.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.4 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.0 | 0.3 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.5 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.0 | 0.2 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 0.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.0 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 0.2 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.4 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.0 | 0.3 | REACTOME SIGNALING BY FGFR1 MUTANTS | Genes involved in Signaling by FGFR1 mutants |
| 0.0 | 0.1 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |