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avrg: GFI1 WT vs 36n/n vs KD

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Results for Nr0b1

Z-value: 0.75

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Transcription factors associated with Nr0b1

Gene Symbol Gene ID Gene Info
Nr0b1
ENSMUSG00000025056.5 nuclear receptor subfamily 0, group B, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr0b1mm39_v1_chrX_+_85235370_852353880.602.8e-01Click!

Activity profile of Nr0b1 motif

Sorted Z-values of Nr0b1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_31070739 0.61 ENSMUST00000031055.8
Emilin1
elastin microfibril interfacer 1
chr5_-_107873883 0.52 ENSMUST00000159263.3
Gfi1
growth factor independent 1 transcription repressor
chr2_+_157120946 0.50 ENSMUST00000116380.9
ENSMUST00000029171.6
Rpn2
ribophorin II
chr19_-_23425757 0.32 ENSMUST00000036069.8
Mamdc2
MAM domain containing 2
chr9_-_119812042 0.30 ENSMUST00000214058.2
Csrnp1
cysteine-serine-rich nuclear protein 1
chr5_-_31350352 0.27 ENSMUST00000202758.4
ENSMUST00000114603.8
Eif2b4
eukaryotic translation initiation factor 2B, subunit 4 delta
chrX_-_144288071 0.26 ENSMUST00000112835.8
ENSMUST00000143610.3
Amot
angiomotin
chr5_-_137530214 0.26 ENSMUST00000140139.2
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr5_+_31350607 0.22 ENSMUST00000201535.4
Snx17
sorting nexin 17
chr1_+_88015524 0.20 ENSMUST00000113139.2
Ugt1a8
UDP glucuronosyltransferase 1 family, polypeptide A8
chr16_-_20440005 0.19 ENSMUST00000052939.4
Camk2n2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr4_-_123644091 0.18 ENSMUST00000102636.4
Akirin1
akirin 1
chr8_+_56393488 0.18 ENSMUST00000000275.10
Glra3
glycine receptor, alpha 3 subunit
chrX_+_13147209 0.17 ENSMUST00000000804.7
Ddx3x
DEAD box helicase 3, X-linked
chr4_+_148215339 0.17 ENSMUST00000084129.9
Mad2l2
MAD2 mitotic arrest deficient-like 2
chr8_-_106434565 0.16 ENSMUST00000013299.11
Enkd1
enkurin domain containing 1
chr4_+_116078830 0.15 ENSMUST00000030464.14
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
chr8_-_85807281 0.15 ENSMUST00000152785.8
Wdr83
WD repeat domain containing 83
chr5_+_3393893 0.12 ENSMUST00000165117.8
ENSMUST00000197385.2
Cdk6
cyclin-dependent kinase 6
chr8_-_85807308 0.11 ENSMUST00000093357.12
Wdr83
WD repeat domain containing 83
chr10_-_127504416 0.11 ENSMUST00000129252.2
Nab2
Ngfi-A binding protein 2
chr5_-_31350449 0.11 ENSMUST00000166769.8
Eif2b4
eukaryotic translation initiation factor 2B, subunit 4 delta
chr15_-_85918378 0.10 ENSMUST00000016172.10
Celsr1
cadherin, EGF LAG seven-pass G-type receptor 1
chr4_+_53826013 0.10 ENSMUST00000030127.13
Tmem38b
transmembrane protein 38B
chr19_-_6178171 0.10 ENSMUST00000154601.8
ENSMUST00000138931.3
Snx15
sorting nexin 15
chr2_+_27567213 0.10 ENSMUST00000077257.12
Rxra
retinoid X receptor alpha
chr19_-_46028060 0.09 ENSMUST00000056931.14
Ldb1
LIM domain binding 1
chr6_+_83771985 0.08 ENSMUST00000113851.8
Nagk
N-acetylglucosamine kinase
chr6_+_120643323 0.08 ENSMUST00000112686.8
Cecr2
CECR2, histone acetyl-lysine reader
chr7_+_45434755 0.07 ENSMUST00000233503.2
ENSMUST00000120005.10
ENSMUST00000211609.2
Lmtk3
lemur tyrosine kinase 3
chr5_-_108134869 0.07 ENSMUST00000145239.2
ENSMUST00000031198.11
Dipk1a
divergent protein kinase domain 1A
chr6_+_134012916 0.07 ENSMUST00000164648.2
Etv6
ets variant 6
chr8_-_71834543 0.07 ENSMUST00000002466.9
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr5_+_31350566 0.07 ENSMUST00000031029.15
ENSMUST00000201679.4
Snx17
sorting nexin 17
chr16_+_56942050 0.07 ENSMUST00000166897.3
Tomm70a
translocase of outer mitochondrial membrane 70A
chr10_-_128425519 0.06 ENSMUST00000082059.7
Erbb3
erb-b2 receptor tyrosine kinase 3
chr4_-_129590609 0.06 ENSMUST00000102588.10
Tmem39b
transmembrane protein 39b
chr12_+_3857077 0.05 ENSMUST00000174817.8
Dnmt3a
DNA methyltransferase 3A
chr15_+_98532624 0.05 ENSMUST00000003442.9
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chrX_-_47123719 0.05 ENSMUST00000039026.8
Apln
apelin
chr15_-_81931783 0.04 ENSMUST00000080622.9
Snu13
SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)
chr11_-_88608958 0.04 ENSMUST00000107908.2
Msi2
musashi RNA-binding protein 2
chr14_-_61677258 0.04 ENSMUST00000022496.9
Kpna3
karyopherin (importin) alpha 3
chr11_-_115503704 0.04 ENSMUST00000106506.8
Mif4gd
MIF4G domain containing
chr19_-_6127211 0.04 ENSMUST00000160590.2
ENSMUST00000025711.13
Vps51
VPS51 GARP complex subunit
chr11_-_115503316 0.04 ENSMUST00000106507.9
Mif4gd
MIF4G domain containing
chr4_+_116078874 0.04 ENSMUST00000106490.3
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
chr11_+_105072619 0.03 ENSMUST00000092537.10
ENSMUST00000015107.13
ENSMUST00000145048.8
Tlk2
tousled-like kinase 2 (Arabidopsis)
chr7_-_80020590 0.03 ENSMUST00000206212.2
Man2a2
mannosidase 2, alpha 2
chr18_+_35963353 0.03 ENSMUST00000235169.2
Cxxc5
CXXC finger 5
chr9_-_108888779 0.03 ENSMUST00000061973.5
Trex1
three prime repair exonuclease 1
chr5_-_99185201 0.03 ENSMUST00000161490.8
Prkg2
protein kinase, cGMP-dependent, type II
chr11_-_120238917 0.03 ENSMUST00000106215.11
Actg1
actin, gamma, cytoplasmic 1
chr19_+_37423198 0.03 ENSMUST00000025944.9
Hhex
hematopoietically expressed homeobox
chr3_+_105359641 0.03 ENSMUST00000098761.10
Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr6_+_85164420 0.03 ENSMUST00000045942.9
Emx1
empty spiracles homeobox 1
chr10_+_36383008 0.02 ENSMUST00000168572.8
Hs3st5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr10_-_81186222 0.02 ENSMUST00000020454.11
ENSMUST00000105324.9
ENSMUST00000154609.3
ENSMUST00000105323.8
Hmg20b
high mobility group 20B
chr17_-_25652750 0.02 ENSMUST00000159610.8
ENSMUST00000159048.8
ENSMUST00000078496.12
Cacna1h
calcium channel, voltage-dependent, T type, alpha 1H subunit
chr2_-_131194754 0.02 ENSMUST00000059372.11
Rnf24
ring finger protein 24
chr4_-_102883905 0.02 ENSMUST00000084382.6
ENSMUST00000106869.3
Insl5
insulin-like 5
chr10_-_81186137 0.02 ENSMUST00000167481.8
Hmg20b
high mobility group 20B
chr8_-_71308229 0.02 ENSMUST00000212086.2
Kcnn1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr17_+_88837540 0.02 ENSMUST00000038551.8
Ppp1r21
protein phosphatase 1, regulatory subunit 21
chr11_-_69871320 0.02 ENSMUST00000143175.2
Elp5
elongator acetyltransferase complex subunit 5
chr2_-_144174066 0.02 ENSMUST00000037423.4
Ovol2
ovo like zinc finger 2
chr11_+_73819052 0.02 ENSMUST00000205791.2
Olfr396-ps1
olfactory receptor 396, pseudogene 1
chr17_+_23898223 0.02 ENSMUST00000024699.4
ENSMUST00000232719.2
Cldn6
claudin 6
chr1_+_140173787 0.02 ENSMUST00000239229.2
ENSMUST00000120709.8
ENSMUST00000120796.8
ENSMUST00000119786.8
Kcnt2
potassium channel, subfamily T, member 2
chr8_-_71308040 0.01 ENSMUST00000212509.3
Kcnn1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr6_-_72212547 0.01 ENSMUST00000042646.8
Atoh8
atonal bHLH transcription factor 8
chr5_-_99184894 0.01 ENSMUST00000031277.7
Prkg2
protein kinase, cGMP-dependent, type II
chr19_-_46027881 0.01 ENSMUST00000137771.2
Ldb1
LIM domain binding 1
chr2_+_153684901 0.01 ENSMUST00000175856.3
Efcab8
EF-hand calcium binding domain 8
chr15_+_98532866 0.01 ENSMUST00000230490.2
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr2_-_152256947 0.01 ENSMUST00000099207.5
Zcchc3
zinc finger, CCHC domain containing 3
chr4_+_116078787 0.01 ENSMUST00000147292.8
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
chr2_+_4722956 0.01 ENSMUST00000056914.7
Bend7
BEN domain containing 7
chr2_+_81883566 0.01 ENSMUST00000047527.8
Zfp804a
zinc finger protein 804A
chr2_-_157121440 0.01 ENSMUST00000143663.2
Mroh8
maestro heat-like repeat family member 8
chr2_-_144173615 0.01 ENSMUST00000103171.10
Ovol2
ovo like zinc finger 2
chr11_+_19874403 0.01 ENSMUST00000093298.12
Spred2
sprouty-related EVH1 domain containing 2
chr3_-_86827640 0.01 ENSMUST00000195561.6
Dclk2
doublecortin-like kinase 2
chrX_-_37653396 0.00 ENSMUST00000016681.15
Cul4b
cullin 4B
chr5_+_30972067 0.00 ENSMUST00000200692.4
Mapre3
microtubule-associated protein, RP/EB family, member 3
chr9_-_110571645 0.00 ENSMUST00000006005.12
Pth1r
parathyroid hormone 1 receptor
chr8_+_106434901 0.00 ENSMUST00000013302.7
ENSMUST00000211852.2
4933405L10Rik
RIKEN cDNA 4933405L10 gene
chr11_-_52165682 0.00 ENSMUST00000238914.2
Tcf7
transcription factor 7, T cell specific

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr0b1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0070103 regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.1 0.3 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 0.1 GO:0036275 response to 5-fluorouracil(GO:0036275)
0.0 0.1 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.0 0.2 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.1 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.4 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.2 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.1 GO:0045994 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.0 0.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.2 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.0 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 0.0 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.1 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.1 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.1 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.6 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.3 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0097132 cyclin D2-CDK6 complex(GO:0097132)
0.0 0.1 GO:0090537 CERF complex(GO:0090537)
0.0 0.6 GO:0008305 integrin complex(GO:0008305)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.1 0.3 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.5 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0 0.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.2 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.0 0.2 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.0 GO:0030622 U4atac snRNA binding(GO:0030622)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation