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avrg: GFI1 WT vs 36n/n vs KD

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Results for Nr3c2

Z-value: 1.10

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Transcription factors associated with Nr3c2

Gene Symbol Gene ID Gene Info
Nr3c2
ENSMUSG00000031618.14 nuclear receptor subfamily 3, group C, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr3c2mm39_v1_chr8_+_77626400_776264560.903.8e-02Click!

Activity profile of Nr3c2 motif

Sorted Z-values of Nr3c2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_123195986 3.19 ENSMUST00000038863.9
ENSMUST00000216843.2
Lars2
leucyl-tRNA synthetase, mitochondrial
chr17_-_23531402 1.20 ENSMUST00000168033.3
Vmn2r114
vomeronasal 2, receptor 114
chr11_+_68989763 1.08 ENSMUST00000021271.14
Per1
period circadian clock 1
chr5_+_123280250 0.82 ENSMUST00000174836.8
ENSMUST00000163030.9
Setd1b
SET domain containing 1B
chr14_+_14159978 0.82 ENSMUST00000137133.2
ENSMUST00000036070.15
ENSMUST00000121887.8
Fam107a
family with sequence similarity 107, member A
chr17_+_22819932 0.77 ENSMUST00000097381.5
ENSMUST00000234882.2
Vmn2r112
vomeronasal 2, receptor 112
chr6_-_146403410 0.59 ENSMUST00000053273.15
Itpr2
inositol 1,4,5-triphosphate receptor 2
chr14_+_35816874 0.59 ENSMUST00000226305.2
4930474N05Rik
RIKEN cDNA 4930474N05 gene
chr10_+_128061699 0.57 ENSMUST00000026455.8
Mip
major intrinsic protein of lens fiber
chr11_+_50905063 0.55 ENSMUST00000217480.2
ENSMUST00000215409.2
Olfr54
olfactory receptor 54
chr17_-_22792463 0.54 ENSMUST00000092491.7
ENSMUST00000234223.2
ENSMUST00000234296.2
ENSMUST00000234027.2
Vmn2r111
vomeronasal 2, receptor 111
chr5_-_135494775 0.45 ENSMUST00000212301.2
Hip1
huntingtin interacting protein 1
chr6_-_146403638 0.45 ENSMUST00000079573.13
Itpr2
inositol 1,4,5-triphosphate receptor 2
chr17_-_38370970 0.42 ENSMUST00000216476.2
Olfr129
olfactory receptor 129
chr11_-_71092282 0.36 ENSMUST00000108515.9
Nlrp1b
NLR family, pyrin domain containing 1B
chr6_+_136495818 0.35 ENSMUST00000186577.7
Atf7ip
activating transcription factor 7 interacting protein
chr11_+_96822213 0.28 ENSMUST00000107633.2
Prr15l
proline rich 15-like
chr16_-_95993420 0.26 ENSMUST00000113804.8
ENSMUST00000054855.14
Lca5l
Leber congenital amaurosis 5-like
chr11_-_71092124 0.23 ENSMUST00000108514.10
Nlrp1b
NLR family, pyrin domain containing 1B
chr10_-_14593935 0.21 ENSMUST00000020016.5
Gje1
gap junction protein, epsilon 1
chr2_+_172314433 0.21 ENSMUST00000029007.3
Fam209
family with sequence similarity 209
chr6_+_136495784 0.18 ENSMUST00000032335.13
ENSMUST00000185724.7
Atf7ip
activating transcription factor 7 interacting protein
chr7_+_106630381 0.17 ENSMUST00000213623.2
Olfr713
olfactory receptor 713
chr16_+_31247562 0.13 ENSMUST00000115227.10
Bdh1
3-hydroxybutyrate dehydrogenase, type 1
chr6_+_125297596 0.11 ENSMUST00000176655.8
ENSMUST00000176110.8
Scnn1a
sodium channel, nonvoltage-gated 1 alpha
chr11_-_75345482 0.11 ENSMUST00000173320.8
Wdr81
WD repeat domain 81
chr10_-_117118226 0.09 ENSMUST00000092163.9
Lyz2
lysozyme 2
chr3_-_95811993 0.07 ENSMUST00000147962.3
ENSMUST00000036181.15
Car14
carbonic anhydrase 14
chr17_+_23562715 0.06 ENSMUST00000168175.3
ENSMUST00000234796.2
Vmn2r115
vomeronasal 2, receptor 115
chr15_+_102011352 0.05 ENSMUST00000169627.9
Tns2
tensin 2
chr8_-_95328348 0.04 ENSMUST00000212547.2
ENSMUST00000212507.2
ENSMUST00000034226.8
Psme3ip1
proteasome activator subunit 3 interacting protein 1
chr5_+_31855009 0.03 ENSMUST00000201352.4
ENSMUST00000202815.4
Babam2
BRISC and BRCA1 A complex member 2
chr15_+_102011415 0.01 ENSMUST00000046144.10
Tns2
tensin 2
chr5_+_146418775 0.01 ENSMUST00000179032.3
Gm6408
predicted gene 6408
chr14_+_44822935 0.01 ENSMUST00000178759.2
Gm8247
predicted gene 8247
chr6_-_69394425 0.01 ENSMUST00000199160.2
Igkv4-61
immunoglobulin kappa chain variable 4-61
chr6_-_69037208 0.01 ENSMUST00000103343.4
Igkv4-78
immunoglobulin kappa variable 4-78
chr6_-_69245427 0.00 ENSMUST00000103348.3
Igkv4-70
immunoglobulin kappa chain variable 4-70
chr2_-_164435508 0.00 ENSMUST00000103100.2
Eppin
epididymal peptidase inhibitor
chr5_-_146097347 0.00 ENSMUST00000199463.2
Gm5565
predicted gene 5565
chr4_-_49408040 0.00 ENSMUST00000081541.9
Acnat2
acyl-coenzyme A amino acid N-acyltransferase 2
chr5_-_146107531 0.00 ENSMUST00000174320.2
Gm6309
predicted gene 6309

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr3c2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0006429 leucyl-tRNA aminoacylation(GO:0006429)
0.2 1.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 0.6 GO:1904784 NLRP1 inflammasome complex assembly(GO:1904784)
0.1 0.4 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.1 0.6 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 1.0 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 0.5 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0046691 intracellular canaliculus(GO:0046691)
0.1 0.6 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.1 0.4 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
0.0 1.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0004823 leucine-tRNA ligase activity(GO:0004823)
0.2 1.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.4 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.6 GO:0015250 water channel activity(GO:0015250)
0.0 1.1 GO:0070888 E-box binding(GO:0070888)
0.0 0.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 1.0 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.1 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression