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avrg: GFI1 WT vs 36n/n vs KD

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Results for Nr6a1

Z-value: 0.76

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Transcription factors associated with Nr6a1

Gene Symbol Gene ID Gene Info
Nr6a1
ENSMUSG00000063972.14 nuclear receptor subfamily 6, group A, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr6a1mm39_v1_chr2_-_38816229_388163660.682.0e-01Click!

Activity profile of Nr6a1 motif

Sorted Z-values of Nr6a1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_64969679 0.61 ENSMUST00000166409.6
ENSMUST00000197879.2
Klf3
Kruppel-like factor 3 (basic)
chr9_+_87026337 0.57 ENSMUST00000113149.8
ENSMUST00000049457.14
ENSMUST00000179313.3
Mrap2
melanocortin 2 receptor accessory protein 2
chr7_+_110368037 0.56 ENSMUST00000213373.2
Ampd3
adenosine monophosphate deaminase 3
chr12_+_44268134 0.55 ENSMUST00000122902.8
Pnpla8
patatin-like phospholipase domain containing 8
chr15_+_84553801 0.44 ENSMUST00000171460.8
Prr5
proline rich 5 (renal)
chr16_+_11140740 0.38 ENSMUST00000180792.8
Snx29
sorting nexin 29
chr18_-_6135888 0.38 ENSMUST00000182383.8
ENSMUST00000062584.14
ENSMUST00000077128.13
ENSMUST00000182038.2
ENSMUST00000182213.8
ENSMUST00000182559.8
Arhgap12
Rho GTPase activating protein 12
chr12_-_115916604 0.37 ENSMUST00000196991.2
Ighv1-82
immunoglobulin heavy variable 1-82
chr12_-_115832846 0.36 ENSMUST00000199373.2
Ighv1-78
immunoglobulin heavy variable 1-78
chr5_-_108822619 0.35 ENSMUST00000119270.2
ENSMUST00000163328.8
ENSMUST00000136227.2
Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr14_-_121742659 0.34 ENSMUST00000088386.8
Slc15a1
solute carrier family 15 (oligopeptide transporter), member 1
chr16_+_11140779 0.33 ENSMUST00000115814.4
Snx29
sorting nexin 29
chr5_-_137609691 0.32 ENSMUST00000031731.14
Pcolce
procollagen C-endopeptidase enhancer protein
chr12_-_114547622 0.27 ENSMUST00000193893.6
ENSMUST00000103498.3
Ighv1-9
immunoglobulin heavy variable V1-9
chr2_+_127267069 0.27 ENSMUST00000062211.4
Gpat2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr4_+_123798690 0.26 ENSMUST00000106202.4
Mycbp
MYC binding protein
chr6_+_21985902 0.26 ENSMUST00000115383.9
Cped1
cadherin-like and PC-esterase domain containing 1
chr5_-_137609634 0.24 ENSMUST00000054564.13
Pcolce
procollagen C-endopeptidase enhancer protein
chr15_-_77653979 0.24 ENSMUST00000229259.2
Myh9
myosin, heavy polypeptide 9, non-muscle
chr15_+_99936516 0.19 ENSMUST00000100203.10
Dip2b
disco interacting protein 2 homolog B
chr5_-_36641456 0.17 ENSMUST00000119916.2
ENSMUST00000031097.8
Tada2b
transcriptional adaptor 2B
chr12_-_115884332 0.17 ENSMUST00000103548.3
Ighv1-81
immunoglobulin heavy variable 1-81
chr17_+_33848054 0.16 ENSMUST00000166627.8
ENSMUST00000073570.12
ENSMUST00000170225.3
Zfp414
zinc finger protein 414
chr12_-_114878652 0.15 ENSMUST00000103515.2
Ighv1-39
immunoglobulin heavy variable 1-39
chr12_-_114752425 0.15 ENSMUST00000103510.2
Ighv1-26
immunoglobulin heavy variable 1-26
chr5_-_5744559 0.14 ENSMUST00000115426.9
Steap2
six transmembrane epithelial antigen of prostate 2
chr15_-_50753061 0.14 ENSMUST00000165201.9
ENSMUST00000184458.8
Trps1
transcriptional repressor GATA binding 1
chr12_-_115825934 0.13 ENSMUST00000198777.2
Ighv1-77
immunoglobulin heavy variable 1-77
chr12_-_114672701 0.12 ENSMUST00000103505.3
ENSMUST00000193855.2
Ighv1-19
immunoglobulin heavy variable V1-19
chr13_+_113931038 0.12 ENSMUST00000091201.7
Arl15
ADP-ribosylation factor-like 15
chr5_-_5744024 0.12 ENSMUST00000115425.9
ENSMUST00000115427.8
ENSMUST00000115424.9
ENSMUST00000015797.11
Steap2
six transmembrane epithelial antigen of prostate 2
chr12_-_114646685 0.12 ENSMUST00000194350.6
ENSMUST00000103504.3
Ighv1-18
immunoglobulin heavy variable V1-18
chr5_-_137608886 0.11 ENSMUST00000142675.8
Pcolce
procollagen C-endopeptidase enhancer protein
chr2_+_172314433 0.11 ENSMUST00000029007.3
Fam209
family with sequence similarity 209
chr18_+_65020910 0.10 ENSMUST00000236736.2
ENSMUST00000235743.2
Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr18_+_65020760 0.10 ENSMUST00000235343.2
Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr18_+_65020885 0.10 ENSMUST00000236209.2
Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr17_+_73225292 0.10 ENSMUST00000024857.14
Lbh
limb-bud and heart
chr1_+_151304293 0.09 ENSMUST00000065625.12
Trmt1l
tRNA methyltransferase 1 like
chr5_-_137015683 0.09 ENSMUST00000034953.14
ENSMUST00000085941.12
Znhit1
zinc finger, HIT domain containing 1
chr6_-_67468831 0.09 ENSMUST00000118364.2
Il23r
interleukin 23 receptor
chr16_-_3535958 0.09 ENSMUST00000023180.15
Mefv
Mediterranean fever
chr12_-_115299134 0.09 ENSMUST00000195359.6
ENSMUST00000103530.3
Ighv1-59
immunoglobulin heavy variable V1-59
chr9_+_50515207 0.08 ENSMUST00000044051.6
Timm8b
translocase of inner mitochondrial membrane 8B
chr16_-_3535940 0.08 ENSMUST00000229725.2
ENSMUST00000100222.4
Mefv
Mediterranean fever
chr12_-_114621406 0.08 ENSMUST00000192077.2
Ighv1-15
immunoglobulin heavy variable 1-15
chr9_+_122634589 0.08 ENSMUST00000052740.14
Tcaim
T cell activation inhibitor, mitochondrial
chr5_-_143278619 0.06 ENSMUST00000212355.2
Zfp853
zinc finger protein 853
chr18_+_65158873 0.06 ENSMUST00000226058.2
Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr12_-_114843941 0.06 ENSMUST00000191862.6
ENSMUST00000103513.3
Ighv1-36
immunoglobulin heavy variable 1-36
chr19_-_5738177 0.06 ENSMUST00000068169.12
Pcnx3
pecanex homolog 3
chr9_+_38382403 0.06 ENSMUST00000214377.2
Olfr905
olfactory receptor 905
chr5_+_129802127 0.05 ENSMUST00000086046.10
ENSMUST00000186265.6
Nipsnap2
nipsnap homolog 2
chr10_+_126911134 0.05 ENSMUST00000239120.2
Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr3_+_107137924 0.05 ENSMUST00000179399.3
A630076J17Rik
RIKEN cDNA A630076J17 gene
chr7_+_133239272 0.05 ENSMUST00000051169.13
Edrf1
erythroid differentiation regulatory factor 1
chr5_-_123711098 0.05 ENSMUST00000031388.13
Vps33a
VPS33A CORVET/HOPS core subunit
chr1_-_79836344 0.04 ENSMUST00000027467.11
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr4_-_45530330 0.04 ENSMUST00000061986.12
Shb
src homology 2 domain-containing transforming protein B
chr5_+_137015873 0.04 ENSMUST00000004968.11
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr1_-_151304191 0.04 ENSMUST00000064771.12
Swt1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr1_+_82702598 0.03 ENSMUST00000078332.13
ENSMUST00000073025.12
ENSMUST00000161648.8
ENSMUST00000160786.8
ENSMUST00000162003.8
Mff
mitochondrial fission factor
chr1_+_160806194 0.03 ENSMUST00000064725.11
ENSMUST00000191936.2
Serpinc1
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chr4_-_124959395 0.03 ENSMUST00000036383.4
Dnali1
dynein, axonemal, light intermediate polypeptide 1
chr4_-_138858340 0.03 ENSMUST00000143971.2
Micos10
mitochondrial contact site and cristae organizing system subunit 10
chr12_-_113896002 0.03 ENSMUST00000103463.3
Ighv14-1
immunoglobulin heavy variable 14-1
chr13_-_25204272 0.03 ENSMUST00000021772.4
Mrs2
MRS2 magnesium transporter
chr7_+_127864847 0.03 ENSMUST00000118169.8
ENSMUST00000206909.2
ENSMUST00000142841.8
Slc5a2
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr4_+_123798625 0.03 ENSMUST00000030400.14
Mycbp
MYC binding protein
chr11_-_100661762 0.02 ENSMUST00000139341.2
ENSMUST00000017891.14
Ghdc
GH3 domain containing
chr16_+_9988080 0.02 ENSMUST00000121292.8
ENSMUST00000044103.6
Rpl39l
ribosomal protein L39-like
chr15_+_27466732 0.02 ENSMUST00000022875.7
Ank
progressive ankylosis
chr12_-_114815280 0.02 ENSMUST00000103512.3
Ighv1-34
immunoglobulin heavy variable 1-34
chr19_+_13037974 0.02 ENSMUST00000213806.2
ENSMUST00000214695.2
ENSMUST00000217568.2
Olfr1454
olfactory receptor 1454
chr5_+_36641922 0.01 ENSMUST00000060100.3
Ccdc96
coiled-coil domain containing 96
chr12_-_11200306 0.01 ENSMUST00000055673.2
Kcns3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr3_-_152232389 0.01 ENSMUST00000200062.2
Ak5
adenylate kinase 5
chr9_-_121668527 0.01 ENSMUST00000135986.9
Ccdc13
coiled-coil domain containing 13
chr4_-_82423511 0.01 ENSMUST00000050872.15
ENSMUST00000064770.9
Nfib
nuclear factor I/B
chr11_-_69712970 0.01 ENSMUST00000045771.7
Spem1
sperm maturation 1
chr5_+_30437579 0.01 ENSMUST00000145167.9
Selenoi
selenoprotein I
chr9_+_45311000 0.00 ENSMUST00000216289.2
Fxyd2
FXYD domain-containing ion transport regulator 2
chr7_+_44890497 0.00 ENSMUST00000213347.2
Slc6a16
solute carrier family 6, member 16

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr6a1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.1 0.2 GO:1903923 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
0.1 0.3 GO:0019532 oxalate transport(GO:0019532)
0.1 0.2 GO:0071640 regulation of macrophage inflammatory protein 1 alpha production(GO:0071640)
0.1 0.6 GO:0032264 IMP salvage(GO:0032264)
0.0 0.4 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.3 GO:0042938 dipeptide transport(GO:0042938)
0.0 0.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.3 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.3 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.0 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.1 GO:2000983 regulation of ATP citrate synthase activity(GO:2000983) negative regulation of ATP citrate synthase activity(GO:2000984)
0.0 1.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.6 GO:0097009 energy homeostasis(GO:0097009)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0097513 myosin II filament(GO:0097513)
0.0 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.0 1.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.1 0.3 GO:0042936 dipeptide transporter activity(GO:0042936)
0.1 0.6 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.5 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.3 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.3 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 1.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.7 GO:0016504 peptidase activator activity(GO:0016504)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.5 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation