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avrg: GFI1 WT vs 36n/n vs KD

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Results for Onecut1_Cux2

Z-value: 0.44

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Transcription factors associated with Onecut1_Cux2

Gene Symbol Gene ID Gene Info
Onecut1
ENSMUSG00000043013.11 one cut domain, family member 1
Cux2
ENSMUSG00000042589.19 cut-like homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cux2mm39_v1_chr5_-_122187884_1221879470.903.7e-02Click!
Onecut1mm39_v1_chr9_+_74769166_747692030.692.0e-01Click!

Activity profile of Onecut1_Cux2 motif

Sorted Z-values of Onecut1_Cux2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_172525613 0.53 ENSMUST00000038495.5
Crp
C-reactive protein, pentraxin-related
chr15_-_76093256 0.39 ENSMUST00000071869.12
ENSMUST00000170915.2
Plec
plectin
chr9_-_29874401 0.21 ENSMUST00000075069.11
Ntm
neurotrimin
chr13_-_54836059 0.20 ENSMUST00000122935.2
ENSMUST00000128257.8
Rnf44
ring finger protein 44
chrM_+_14138 0.20 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chrM_-_14061 0.20 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr9_-_50650663 0.19 ENSMUST00000117093.2
ENSMUST00000121634.8
Dixdc1
DIX domain containing 1
chr10_-_128505096 0.18 ENSMUST00000238610.2
ENSMUST00000238712.2
Ikzf4
IKAROS family zinc finger 4
chr1_-_158785937 0.18 ENSMUST00000159861.9
Pappa2
pappalysin 2
chr8_-_13250535 0.18 ENSMUST00000165605.4
ENSMUST00000209691.2
ENSMUST00000211128.2
ENSMUST00000210317.2
Grtp1
GH regulated TBC protein 1
chr3_+_28752050 0.17 ENSMUST00000029240.14
Slc2a2
solute carrier family 2 (facilitated glucose transporter), member 2
chrX_-_48980360 0.17 ENSMUST00000217355.3
Olfr1322
olfactory receptor 1322
chr8_+_56747613 0.17 ENSMUST00000034026.10
Hpgd
hydroxyprostaglandin dehydrogenase 15 (NAD)
chr8_-_32408380 0.17 ENSMUST00000208497.3
ENSMUST00000207584.3
Nrg1
neuregulin 1
chr3_+_101917455 0.16 ENSMUST00000066187.6
ENSMUST00000198675.2
Nhlh2
nescient helix loop helix 2
chr15_+_54975713 0.15 ENSMUST00000096433.10
Deptor
DEP domain containing MTOR-interacting protein
chr11_+_97206542 0.15 ENSMUST00000019026.10
ENSMUST00000132168.2
Mrpl45
mitochondrial ribosomal protein L45
chr4_-_104733580 0.14 ENSMUST00000064873.9
ENSMUST00000106808.10
ENSMUST00000048947.15
C8a
complement component 8, alpha polypeptide
chr2_-_60503998 0.11 ENSMUST00000059888.15
ENSMUST00000154764.2
Itgb6
integrin beta 6
chr3_-_79439181 0.11 ENSMUST00000239298.2
Fnip2
folliculin interacting protein 2
chr12_-_46865709 0.11 ENSMUST00000021438.8
Nova1
NOVA alternative splicing regulator 1
chr2_-_7086018 0.10 ENSMUST00000114923.3
ENSMUST00000182706.8
Celf2
CUGBP, Elav-like family member 2
chr15_+_54975814 0.10 ENSMUST00000100660.11
Deptor
DEP domain containing MTOR-interacting protein
chr18_-_84607615 0.10 ENSMUST00000125763.3
Zfp407
zinc finger protein 407
chr2_+_90575714 0.10 ENSMUST00000238890.2
ENSMUST00000013759.6
Fnbp4
formin binding protein 4
chr11_+_29323618 0.09 ENSMUST00000040182.13
ENSMUST00000109477.2
Ccdc88a
coiled coil domain containing 88A
chr5_-_136596094 0.09 ENSMUST00000175975.9
ENSMUST00000176216.9
ENSMUST00000176745.8
Cux1
cut-like homeobox 1
chr11_+_29324348 0.09 ENSMUST00000239407.2
Ccdc88a
coiled coil domain containing 88A
chr12_-_25146078 0.09 ENSMUST00000222667.2
ENSMUST00000020974.7
Id2
inhibitor of DNA binding 2
chrX_+_40490005 0.08 ENSMUST00000115103.9
ENSMUST00000076349.12
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr7_-_119461027 0.07 ENSMUST00000137888.2
ENSMUST00000142120.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr5_-_5744559 0.07 ENSMUST00000115426.9
Steap2
six transmembrane epithelial antigen of prostate 2
chr10_-_63926044 0.07 ENSMUST00000105439.2
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr6_+_121323577 0.06 ENSMUST00000032200.16
Slc6a12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr14_-_55329734 0.06 ENSMUST00000036328.9
Zfhx2
zinc finger homeobox 2
chrX_-_140979913 0.05 ENSMUST00000042530.4
Gucy2f
guanylate cyclase 2f
chr18_+_36098090 0.05 ENSMUST00000176873.8
ENSMUST00000177432.8
ENSMUST00000175734.2
Psd2
pleckstrin and Sec7 domain containing 2
chr2_-_84605732 0.05 ENSMUST00000023994.10
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr10_-_128237087 0.05 ENSMUST00000042666.13
Slc39a5
solute carrier family 39 (metal ion transporter), member 5
chr2_-_34262012 0.05 ENSMUST00000113132.9
ENSMUST00000040638.15
Pbx3
pre B cell leukemia homeobox 3
chr11_+_110914678 0.05 ENSMUST00000150902.8
ENSMUST00000178798.2
Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr4_+_109200225 0.04 ENSMUST00000030281.12
Eps15
epidermal growth factor receptor pathway substrate 15
chr5_-_3646540 0.04 ENSMUST00000042753.14
Rbm48
RNA binding motif protein 48
chr5_-_122187884 0.04 ENSMUST00000111752.10
Cux2
cut-like homeobox 2
chr8_+_127790772 0.04 ENSMUST00000079777.12
ENSMUST00000160272.8
ENSMUST00000162907.8
ENSMUST00000162536.8
ENSMUST00000026921.13
ENSMUST00000162665.8
ENSMUST00000162602.8
ENSMUST00000160581.8
ENSMUST00000161355.8
ENSMUST00000162531.8
ENSMUST00000160766.8
ENSMUST00000159537.8
Pard3
par-3 family cell polarity regulator
chr12_+_55646209 0.04 ENSMUST00000051857.5
Insm2
insulinoma-associated 2
chr2_+_163444248 0.04 ENSMUST00000152135.8
Ttpal
tocopherol (alpha) transfer protein-like
chr1_-_131161312 0.04 ENSMUST00000212202.2
Rassf5
Ras association (RalGDS/AF-6) domain family member 5
chrX_+_133305291 0.03 ENSMUST00000113228.8
ENSMUST00000153424.8
Drp2
dystrophin related protein 2
chr2_+_147206910 0.03 ENSMUST00000109968.3
Pax1
paired box 1
chr5_-_122188165 0.03 ENSMUST00000154139.8
Cux2
cut-like homeobox 2
chr6_-_136899167 0.02 ENSMUST00000032343.7
Erp27
endoplasmic reticulum protein 27
chr2_-_84605764 0.02 ENSMUST00000111641.2
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr11_+_78389913 0.02 ENSMUST00000017488.5
Vtn
vitronectin
chr9_-_114673158 0.02 ENSMUST00000047013.4
Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr18_+_69652751 0.02 ENSMUST00000200966.4
Tcf4
transcription factor 4
chr7_+_67297152 0.02 ENSMUST00000032774.16
ENSMUST00000107471.8
Ttc23
tetratricopeptide repeat domain 23
chr2_-_7086066 0.02 ENSMUST00000183209.8
Celf2
CUGBP, Elav-like family member 2
chr14_+_69266566 0.02 ENSMUST00000014957.10
Stc1
stanniocalcin 1
chr5_+_144037171 0.02 ENSMUST00000041804.8
Lmtk2
lemur tyrosine kinase 2
chr2_-_92222979 0.01 ENSMUST00000111279.9
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr3_+_60436570 0.01 ENSMUST00000192607.6
Mbnl1
muscleblind like splicing factor 1
chr19_-_37155410 0.01 ENSMUST00000133988.2
Cpeb3
cytoplasmic polyadenylation element binding protein 3
chr12_-_114023935 0.01 ENSMUST00000103469.4
Ighv14-3
immunoglobulin heavy variable V14-3
chr6_-_23132977 0.01 ENSMUST00000031707.14
Aass
aminoadipate-semialdehyde synthase
chr10_-_117074501 0.01 ENSMUST00000159193.8
ENSMUST00000020392.5
9530003J23Rik
RIKEN cDNA 9530003J23 gene
chr11_-_24025054 0.01 ENSMUST00000068360.2
A830031A19Rik
RIKEN cDNA A830031A19 gene
chr8_+_23114035 0.01 ENSMUST00000033936.8
Dkk4
dickkopf WNT signaling pathway inhibitor 4
chr19_+_31060237 0.01 ENSMUST00000066039.8
Cstf2t
cleavage stimulation factor, 3' pre-RNA subunit 2, tau
chr14_-_30665232 0.01 ENSMUST00000006704.17
ENSMUST00000163118.2
Itih1
inter-alpha trypsin inhibitor, heavy chain 1
chr8_+_114369838 0.01 ENSMUST00000095173.3
ENSMUST00000034219.12
ENSMUST00000212269.2
Syce1l
synaptonemal complex central element protein 1 like
chr19_+_4042752 0.01 ENSMUST00000041871.9
Tbx10
T-box 10
chr4_-_46991842 0.01 ENSMUST00000107749.4
Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr7_+_45276906 0.01 ENSMUST00000057927.10
Rasip1
Ras interacting protein 1
chr5_+_92831150 0.01 ENSMUST00000113055.9
Shroom3
shroom family member 3
chr3_+_125197722 0.01 ENSMUST00000173932.8
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr1_-_13197387 0.01 ENSMUST00000047577.7
Prdm14
PR domain containing 14
chr5_+_63806451 0.01 ENSMUST00000159584.3
Nwd2
NACHT and WD repeat domain containing 2
chr9_+_59496571 0.00 ENSMUST00000121266.8
ENSMUST00000118164.3
Celf6
CUGBP, Elav-like family member 6
chr1_+_88334678 0.00 ENSMUST00000027518.12
Spp2
secreted phosphoprotein 2
chr13_+_27278173 0.00 ENSMUST00000225330.2
ENSMUST00000082079.5
Prl3d1
prolactin family 3, subfamily d, member 1
chr19_+_55882942 0.00 ENSMUST00000142291.8
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chrX_-_50294867 0.00 ENSMUST00000114876.9
Mbnl3
muscleblind like splicing factor 3
chr4_+_117706390 0.00 ENSMUST00000132043.9
ENSMUST00000169990.8
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr18_+_57601541 0.00 ENSMUST00000091892.4
ENSMUST00000209782.2
Ctxn3
cortexin 3
chr7_-_140859034 0.00 ENSMUST00000211667.2
ENSMUST00000167790.3
ENSMUST00000046156.13
Sct
secretin
chr18_+_37063237 0.00 ENSMUST00000193839.6
ENSMUST00000070797.7
Pcdha1
protocadherin alpha 1
chr7_+_67305162 0.00 ENSMUST00000107470.2
Ttc23
tetratricopeptide repeat domain 23
chr2_-_35287069 0.00 ENSMUST00000113009.2
ENSMUST00000113010.9
4930402F06Rik
RIKEN cDNA 4930402F06 gene
chr19_+_59207646 0.00 ENSMUST00000065204.8
Kcnk18
potassium channel, subfamily K, member 18
chr12_+_85733415 0.00 ENSMUST00000040536.6
Batf
basic leucine zipper transcription factor, ATF-like
chr5_-_5744326 0.00 ENSMUST00000148333.8
Steap2
six transmembrane epithelial antigen of prostate 2
chr7_+_104705455 0.00 ENSMUST00000098161.2
Olfr677
olfactory receptor 677
chr19_-_12051997 0.00 ENSMUST00000087828.2
Olfr1425
olfactory receptor 1425
chr11_-_55931811 0.00 ENSMUST00000037682.3
Nmur2
neuromedin U receptor 2
chrX_+_100420873 0.00 ENSMUST00000052130.14
Gjb1
gap junction protein, beta 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Onecut1_Cux2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.2 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.2 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:0001966 thigmotaxis(GO:0001966)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0001868 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.0 0.2 GO:0033762 response to glucagon(GO:0033762)
0.0 0.2 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.2 GO:0007567 parturition(GO:0007567)
0.0 0.2 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 0.3 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.1 GO:0009992 cellular water homeostasis(GO:0009992)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 0.2 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300) D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.2 GO:0001848 complement binding(GO:0001848)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters