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avrg: GFI1 WT vs 36n/n vs KD

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Results for Pax4

Z-value: 0.91

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Transcription factors associated with Pax4

Gene Symbol Gene ID Gene Info
Pax4
ENSMUSG00000029706.16 paired box 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax4mm39_v1_chr6_-_28449250_284493520.345.7e-01Click!

Activity profile of Pax4 motif

Sorted Z-values of Pax4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_21901791 1.38 ENSMUST00000188775.2
H3c10
H3 clustered histone 10
chr13_+_23922783 1.04 ENSMUST00000040914.3
H1f2
H1.2 linker histone, cluster member
chrM_+_3906 0.90 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr12_+_33364288 0.82 ENSMUST00000144586.2
Atxn7l1
ataxin 7-like 1
chr5_-_116427003 0.61 ENSMUST00000086483.4
ENSMUST00000050178.13
Ccdc60
coiled-coil domain containing 60
chr7_+_102246977 0.57 ENSMUST00000215712.2
Olfr552
olfactory receptor 552
chr9_-_48747232 0.56 ENSMUST00000093852.5
Zbtb16
zinc finger and BTB domain containing 16
chr13_-_40883893 0.51 ENSMUST00000021787.7
Tfap2a
transcription factor AP-2, alpha
chr12_-_84265609 0.47 ENSMUST00000046266.13
ENSMUST00000220974.2
Mideas
mitotic deacetylase associated SANT domain protein
chr13_-_110416637 0.43 ENSMUST00000167824.3
ENSMUST00000224180.2
Rab3c
RAB3C, member RAS oncogene family
chr15_-_50753437 0.42 ENSMUST00000077935.6
Trps1
transcriptional repressor GATA binding 1
chr12_+_71095112 0.40 ENSMUST00000135709.2
Arid4a
AT rich interactive domain 4A (RBP1-like)
chrM_+_11735 0.37 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chrM_+_5319 0.34 ENSMUST00000082402.1
mt-Co1
mitochondrially encoded cytochrome c oxidase I
chr10_+_129153986 0.32 ENSMUST00000215503.2
Olfr780
olfactory receptor 780
chr12_-_80159768 0.30 ENSMUST00000219642.2
ENSMUST00000165114.2
ENSMUST00000218835.2
ENSMUST00000021552.3
Zfp36l1
zinc finger protein 36, C3H type-like 1
chr4_+_150366028 0.28 ENSMUST00000105682.9
Rere
arginine glutamic acid dipeptide (RE) repeats
chr17_+_47604995 0.28 ENSMUST00000190020.4
Trerf1
transcriptional regulating factor 1
chr15_+_80861966 0.27 ENSMUST00000139517.9
ENSMUST00000137255.3
ENSMUST00000137004.2
Sgsm3
small G protein signaling modulator 3
chr16_-_36486429 0.25 ENSMUST00000089620.11
Cd86
CD86 antigen
chr7_+_78563513 0.24 ENSMUST00000038142.15
Isg20
interferon-stimulated protein
chr2_-_89491560 0.23 ENSMUST00000111527.4
Olfr1250
olfactory receptor 1250
chr8_-_32499513 0.23 ENSMUST00000208205.3
Nrg1
neuregulin 1
chr15_-_50753061 0.23 ENSMUST00000165201.9
ENSMUST00000184458.8
Trps1
transcriptional repressor GATA binding 1
chr11_-_18968955 0.21 ENSMUST00000068264.14
ENSMUST00000185131.8
Meis1
Meis homeobox 1
chr1_-_155910546 0.21 ENSMUST00000169241.8
Tor1aip1
torsin A interacting protein 1
chr2_-_111908072 0.20 ENSMUST00000213577.2
ENSMUST00000216071.2
Olfr1313
olfactory receptor 1313
chr17_+_27160203 0.18 ENSMUST00000194598.6
Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat)
chrX_-_99638466 0.17 ENSMUST00000053373.2
P2ry4
pyrimidinergic receptor P2Y, G-protein coupled, 4
chr9_+_14411907 0.16 ENSMUST00000004200.9
Cwc15
CWC15 spliceosome-associated protein
chr18_+_53995156 0.16 ENSMUST00000069597.8
Csnk1g3
casein kinase 1, gamma 3
chr9_+_18848418 0.15 ENSMUST00000218385.2
Olfr832
olfactory receptor 832
chr1_+_42734889 0.15 ENSMUST00000054883.4
Pou3f3
POU domain, class 3, transcription factor 3
chr7_+_43057611 0.15 ENSMUST00000005592.7
Siglecg
sialic acid binding Ig-like lectin G
chr1_+_42734051 0.15 ENSMUST00000239323.2
ENSMUST00000199521.5
ENSMUST00000176807.3
Pou3f3
Gm20646
POU domain, class 3, transcription factor 3
predicted gene 20646
chr10_+_127256993 0.15 ENSMUST00000170336.8
R3hdm2
R3H domain containing 2
chr11_-_18968714 0.15 ENSMUST00000177417.8
Meis1
Meis homeobox 1
chr7_+_7174315 0.14 ENSMUST00000051435.8
Zfp418
zinc finger protein 418
chr5_+_77099154 0.14 ENSMUST00000031160.16
ENSMUST00000120912.8
ENSMUST00000117536.8
Paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
chr9_+_20209828 0.13 ENSMUST00000215540.2
ENSMUST00000075717.7
Olfr873
olfactory receptor 873
chr6_+_136495818 0.13 ENSMUST00000186577.7
Atf7ip
activating transcription factor 7 interacting protein
chr8_-_83128992 0.13 ENSMUST00000210094.2
Il15
interleukin 15
chr3_+_52175757 0.12 ENSMUST00000053764.7
Foxo1
forkhead box O1
chr19_-_12901783 0.12 ENSMUST00000213713.2
ENSMUST00000216888.2
ENSMUST00000213177.2
Olfr1448
olfactory receptor 1448
chr2_-_32976378 0.12 ENSMUST00000049618.9
Garnl3
GTPase activating RANGAP domain-like 3
chr8_-_85500010 0.11 ENSMUST00000109764.8
Nfix
nuclear factor I/X
chr9_-_101076198 0.11 ENSMUST00000066773.9
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr13_+_109769294 0.10 ENSMUST00000135275.8
Pde4d
phosphodiesterase 4D, cAMP specific
chr11_+_106916430 0.10 ENSMUST00000140447.4
1810010H24Rik
RIKEN cDNA 1810010H24 gene
chr9_+_92157799 0.10 ENSMUST00000126911.2
Plscr2
phospholipid scramblase 2
chr19_-_10460238 0.10 ENSMUST00000235392.2
ENSMUST00000237522.2
ENSMUST00000038842.5
Ppp1r32
protein phosphatase 1, regulatory subunit 32
chr9_-_58066484 0.10 ENSMUST00000041477.15
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr19_+_53128861 0.09 ENSMUST00000111741.10
Add3
adducin 3 (gamma)
chr2_-_65068960 0.09 ENSMUST00000112429.9
ENSMUST00000102726.8
ENSMUST00000112430.8
Cobll1
Cobl-like 1
chr7_+_78563184 0.09 ENSMUST00000121645.8
Isg20
interferon-stimulated protein
chr8_-_83129134 0.09 ENSMUST00000209363.2
Il15
interleukin 15
chr3_+_95532282 0.08 ENSMUST00000058230.13
ENSMUST00000037983.6
Ensa
endosulfine alpha
chr2_-_65068917 0.08 ENSMUST00000090896.10
ENSMUST00000155082.2
Cobll1
Cobl-like 1
chr7_+_24561616 0.07 ENSMUST00000170837.3
Gm9844
predicted pseudogene 9844
chr17_+_34457868 0.06 ENSMUST00000095342.11
ENSMUST00000167280.8
ENSMUST00000236838.2
H2-Ob
histocompatibility 2, O region beta locus
chr8_-_22966831 0.06 ENSMUST00000163774.3
ENSMUST00000033935.16
Smim19
small integral membrane protein 19
chr2_+_43445359 0.06 ENSMUST00000050511.7
Kynu
kynureninase
chr7_-_144292288 0.06 ENSMUST00000238848.2
ENSMUST00000118556.9
ENSMUST00000033393.15
Ano1
anoctamin 1, calcium activated chloride channel
chr6_+_136495784 0.06 ENSMUST00000032335.13
ENSMUST00000185724.7
Atf7ip
activating transcription factor 7 interacting protein
chr15_-_59245998 0.05 ENSMUST00000022976.6
Washc5
WASH complex subunit 5
chr10_+_107107477 0.05 ENSMUST00000020057.16
Lin7a
lin-7 homolog A (C. elegans)
chr11_+_78389913 0.05 ENSMUST00000017488.5
Vtn
vitronectin
chr10_-_129509659 0.05 ENSMUST00000213294.2
ENSMUST00000216067.3
ENSMUST00000203424.2
Olfr801
olfactory receptor 801
chr10_-_67384898 0.04 ENSMUST00000075686.7
Ado
2-aminoethanethiol (cysteamine) dioxygenase
chr10_-_63926044 0.04 ENSMUST00000105439.2
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr17_+_17622934 0.03 ENSMUST00000115576.3
Lix1
limb and CNS expressed 1
chr5_+_66833434 0.03 ENSMUST00000031131.11
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr19_-_11058452 0.03 ENSMUST00000025636.8
Ms4a8a
membrane-spanning 4-domains, subfamily A, member 8A
chrX_-_47966588 0.03 ENSMUST00000114928.2
Fsip2l
fibrous sheath-interacting protein 2-like
chr10_+_119828821 0.03 ENSMUST00000105261.9
Grip1
glutamate receptor interacting protein 1
chr4_+_146695418 0.02 ENSMUST00000130825.8
Zfp993
zinc finger protein 993
chr1_-_84912810 0.02 ENSMUST00000027422.7
Slc16a14
solute carrier family 16 (monocarboxylic acid transporters), member 14
chr2_+_158509039 0.02 ENSMUST00000045503.11
Ppp1r16b
protein phosphatase 1, regulatory subunit 16B
chr2_+_181322077 0.02 ENSMUST00000103042.10
Tcea2
transcription elongation factor A (SII), 2
chr16_-_45664591 0.02 ENSMUST00000076333.12
Phldb2
pleckstrin homology like domain, family B, member 2
chrX_-_72140623 0.02 ENSMUST00000114524.9
ENSMUST00000074619.6
Xlr3a
X-linked lymphocyte-regulated 3A
chr16_-_14109219 0.01 ENSMUST00000230397.2
ENSMUST00000231567.2
ENSMUST00000090287.5
Myh11
myosin, heavy polypeptide 11, smooth muscle
chr7_+_23000617 0.01 ENSMUST00000076470.5
Nlrp4e
NLR family, pyrin domain containing 4E
chr18_+_58969739 0.01 ENSMUST00000052907.7
Adamts19
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
chr7_-_144292257 0.01 ENSMUST00000121758.8
Ano1
anoctamin 1, calcium activated chloride channel
chr2_-_160155536 0.01 ENSMUST00000109475.3
Gm826
predicted gene 826
chr7_+_80764564 0.01 ENSMUST00000119083.2
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr17_+_27160356 0.01 ENSMUST00000229490.2
ENSMUST00000201702.5
ENSMUST00000177932.7
ENSMUST00000201349.6
Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat)
chr15_-_88863210 0.01 ENSMUST00000042594.13
ENSMUST00000109368.2
Mlc1
megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
chrX_+_9066105 0.01 ENSMUST00000069763.3
Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr1_+_21419819 0.01 ENSMUST00000088407.4
Khdc1a
KH domain containing 1A
chrX_+_72235828 0.01 ENSMUST00000101486.5
Xlr3b
X-linked lymphocyte-regulated 3B
chr7_+_12246415 0.01 ENSMUST00000032541.5
2900092C05Rik
RIKEN cDNA 2900092C05 gene
chr16_-_13548833 0.01 ENSMUST00000023364.7
Pla2g10
phospholipase A2, group X
chr5_-_121641461 0.01 ENSMUST00000079368.5
Adam1b
a disintegrin and metallopeptidase domain 1b
chr3_-_87985602 0.01 ENSMUST00000050258.9
Ttc24
tetratricopeptide repeat domain 24
chr16_-_13548307 0.01 ENSMUST00000115807.9
Pla2g10
phospholipase A2, group X
chr7_+_80764547 0.01 ENSMUST00000026820.11
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr14_-_56397036 0.01 ENSMUST00000015578.5
Gzmg
granzyme G
chr5_-_103247920 0.01 ENSMUST00000112848.8
Mapk10
mitogen-activated protein kinase 10
chr14_+_9646630 0.00 ENSMUST00000112658.8
ENSMUST00000112657.9
ENSMUST00000177814.2
ENSMUST00000067491.14
Cadps
Ca2+-dependent secretion activator
chr1_-_74974707 0.00 ENSMUST00000094844.4
Cfap65
cilia and flagella associated protein 65
chr11_+_117375194 0.00 ENSMUST00000092394.4
Gm11733
predicted gene 11733
chr15_+_80862074 0.00 ENSMUST00000229727.2
Sgsm3
small G protein signaling modulator 3
chr2_-_111476340 0.00 ENSMUST00000119566.4
Olfr1298
olfactory receptor 1298
chr1_-_65071897 0.00 ENSMUST00000162800.8
ENSMUST00000069142.12
Akr1cl
aldo-keto reductase family 1, member C-like
chr7_-_64575308 0.00 ENSMUST00000149851.8
Fam189a1
family with sequence similarity 189, member A1
chr9_+_36743980 0.00 ENSMUST00000034630.15
Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr3_+_99147677 0.00 ENSMUST00000151606.8
Tbx15
T-box 15
chr5_+_95604665 0.00 ENSMUST00000094593.7
Pramel48
PRAME like 48
chr15_-_79048674 0.00 ENSMUST00000230261.2
ENSMUST00000040019.5
Sox10
SRY (sex determining region Y)-box 10
chr11_+_49039086 0.00 ENSMUST00000059379.2
Olfr1395
olfactory receptor 1395
chr10_+_119655294 0.00 ENSMUST00000105262.9
ENSMUST00000147454.8
ENSMUST00000138410.8
ENSMUST00000144825.8
ENSMUST00000148954.8
ENSMUST00000144959.8
Grip1
glutamate receptor interacting protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0003409 optic cup structural organization(GO:0003409)
0.1 0.3 GO:0072023 ascending thin limb development(GO:0072021) thick ascending limb development(GO:0072023) metanephric ascending thin limb development(GO:0072218) metanephric thick ascending limb development(GO:0072233)
0.1 0.3 GO:1904582 positive regulation of intracellular mRNA localization(GO:1904582)
0.1 0.3 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.6 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.4 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.2 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) extrathymic T cell selection(GO:0045062) cellular response to interleukin-15(GO:0071350)
0.0 0.3 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.6 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.2 GO:0002870 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 0.4 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.4 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.3 GO:0070469 respiratory chain(GO:0070469)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 0.2 GO:0045030 UTP-activated nucleotide receptor activity(GO:0045030)
0.0 1.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.1 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0015111 iodide transmembrane transporter activity(GO:0015111)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway