Project

avrg: GFI1 WT vs 36n/n vs KD

Navigation
Downloads

Results for Pax6

Z-value: 1.05

Motif logo

logo of

Transcription factors associated with Pax6

Gene Symbol Gene ID Gene Info
Pax6
ENSMUSG00000027168.22 paired box 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax6mm39_v1_chr2_+_105505823_1055058720.692.0e-01Click!

Activity profile of Pax6 motif

Sorted Z-values of Pax6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_110416637 1.40 ENSMUST00000167824.3
ENSMUST00000224180.2
Rab3c
RAB3C, member RAS oncogene family
chrX_+_16485937 0.93 ENSMUST00000026013.6
Maoa
monoamine oxidase A
chr4_+_85123654 0.82 ENSMUST00000030212.15
ENSMUST00000107189.8
ENSMUST00000107184.8
Sh3gl2
SH3-domain GRB2-like 2
chr7_+_5054514 0.79 ENSMUST00000069324.7
Zfp580
zinc finger protein 580
chr1_+_59802543 0.74 ENSMUST00000087435.7
Bmpr2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr8_-_73228953 0.69 ENSMUST00000079510.6
Cherp
calcium homeostasis endoplasmic reticulum protein
chr7_+_86645323 0.68 ENSMUST00000233714.2
ENSMUST00000233648.2
ENSMUST00000164462.3
ENSMUST00000233730.2
Vmn2r79
vomeronasal 2, receptor 79
chr8_-_73229056 0.63 ENSMUST00000212991.2
Cherp
calcium homeostasis endoplasmic reticulum protein
chr2_+_36795692 0.59 ENSMUST00000217479.2
Olfr354
olfactory receptor 354
chr1_+_131566044 0.57 ENSMUST00000073350.13
Ctse
cathepsin E
chr2_+_111084861 0.57 ENSMUST00000218065.2
Olfr1276
olfactory receptor 1276
chr4_-_123507494 0.57 ENSMUST00000238866.2
Macf1
microtubule-actin crosslinking factor 1
chr7_+_75259778 0.49 ENSMUST00000207923.2
Akap13
A kinase (PRKA) anchor protein 13
chr8_+_110341049 0.48 ENSMUST00000057344.3
ENSMUST00000212537.2
ENSMUST00000109242.8
Pkd1l3
polycystic kidney disease 1 like 3
chr17_-_57366795 0.43 ENSMUST00000040280.14
Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr2_-_111400026 0.41 ENSMUST00000217772.2
ENSMUST00000207283.3
Olfr1295
olfactory receptor 1295
chr15_-_35938328 0.38 ENSMUST00000014457.15
Cox6c
cytochrome c oxidase subunit 6C
chr7_+_97102411 0.37 ENSMUST00000121987.3
ENSMUST00000050732.14
ENSMUST00000205577.2
ENSMUST00000206279.2
Kctd14
potassium channel tetramerisation domain containing 14
chr6_-_122833109 0.37 ENSMUST00000042081.9
C3ar1
complement component 3a receptor 1
chr10_+_129320621 0.36 ENSMUST00000213236.2
ENSMUST00000213992.2
Olfr789
olfactory receptor 789
chr4_+_148123554 0.34 ENSMUST00000141283.8
Mthfr
methylenetetrahydrofolate reductase
chr11_-_104441218 0.34 ENSMUST00000106962.9
ENSMUST00000106961.2
ENSMUST00000093923.9
Cdc27
cell division cycle 27
chr2_-_111104451 0.33 ENSMUST00000214760.2
Olfr1277
olfactory receptor 1277
chr12_+_76593799 0.32 ENSMUST00000218380.2
ENSMUST00000219751.2
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr11_+_33996920 0.32 ENSMUST00000052413.12
Lcp2
lymphocyte cytosolic protein 2
chrX_+_23559282 0.29 ENSMUST00000035766.13
ENSMUST00000101670.3
Wdr44
WD repeat domain 44
chr18_+_37580692 0.25 ENSMUST00000052387.5
Pcdhb14
protocadherin beta 14
chr11_-_95478517 0.25 ENSMUST00000000122.7
Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr13_-_110417421 0.23 ENSMUST00000223922.2
Rab3c
RAB3C, member RAS oncogene family
chr7_+_140808680 0.23 ENSMUST00000106027.9
Phrf1
PHD and ring finger domains 1
chr9_+_64086553 0.21 ENSMUST00000034965.8
Snapc5
small nuclear RNA activating complex, polypeptide 5
chr6_-_88021999 0.21 ENSMUST00000113598.8
Rab7
RAB7, member RAS oncogene family
chr16_+_3702523 0.21 ENSMUST00000176625.8
ENSMUST00000186375.8
Naa60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
chr19_+_13385213 0.19 ENSMUST00000216910.3
Olfr1469
olfactory receptor 1469
chr7_-_101517874 0.18 ENSMUST00000150184.2
Folr1
folate receptor 1 (adult)
chr11_+_78219241 0.17 ENSMUST00000048073.9
Pigs
phosphatidylinositol glycan anchor biosynthesis, class S
chr6_-_113354337 0.13 ENSMUST00000043333.9
Tada3
transcriptional adaptor 3
chr11_+_69016722 0.13 ENSMUST00000021268.9
Aloxe3
arachidonate lipoxygenase 3
chr7_+_86444235 0.12 ENSMUST00000233099.2
ENSMUST00000164996.2
Vmn2r77
vomeronasal 2, receptor 77
chr2_-_33777874 0.12 ENSMUST00000041555.10
Mvb12b
multivesicular body subunit 12B
chr8_+_106587212 0.11 ENSMUST00000008594.9
Nutf2
nuclear transport factor 2
chr6_-_144994534 0.11 ENSMUST00000032402.12
Bcat1
branched chain aminotransferase 1, cytosolic
chr4_+_138920210 0.11 ENSMUST00000102508.10
ENSMUST00000131912.8
ENSMUST00000102507.10
Capzb
capping protein (actin filament) muscle Z-line, beta
chr6_+_29468067 0.11 ENSMUST00000143101.4
ENSMUST00000149646.3
Atp6v1f
ATPase, H+ transporting, lysosomal V1 subunit F
chr2_+_37029334 0.11 ENSMUST00000214905.2
ENSMUST00000217298.2
ENSMUST00000104995.3
Olfr364-ps1
olfactory receptor 364, pseudogene 1
chr11_+_72981377 0.09 ENSMUST00000006101.4
Itgae
integrin alpha E, epithelial-associated
chr2_-_65068917 0.08 ENSMUST00000090896.10
ENSMUST00000155082.2
Cobll1
Cobl-like 1
chr11_+_67857268 0.08 ENSMUST00000021286.11
ENSMUST00000108675.2
Stx8
syntaxin 8
chr11_-_115503316 0.07 ENSMUST00000106507.9
Mif4gd
MIF4G domain containing
chr16_+_34605282 0.07 ENSMUST00000023538.9
Mylk
myosin, light polypeptide kinase
chr11_-_72097821 0.07 ENSMUST00000204457.3
Gm43951
predicted gene, 43951
chr15_+_95698574 0.07 ENSMUST00000226793.2
Ano6
anoctamin 6
chr8_-_81607140 0.07 ENSMUST00000210676.2
Gab1
growth factor receptor bound protein 2-associated protein 1
chr2_-_117173312 0.06 ENSMUST00000178884.8
Rasgrp1
RAS guanyl releasing protein 1
chr6_-_125213911 0.06 ENSMUST00000112282.3
ENSMUST00000112281.8
ENSMUST00000032486.13
Cd27
CD27 antigen
chr4_-_140787852 0.06 ENSMUST00000144196.2
ENSMUST00000097816.9
Crocc
ciliary rootlet coiled-coil, rootletin
chr13_-_113755082 0.06 ENSMUST00000109241.5
Snx18
sorting nexin 18
chr11_-_121410152 0.05 ENSMUST00000092298.6
Zfp750
zinc finger protein 750
chr13_+_63963054 0.05 ENSMUST00000021926.13
ENSMUST00000067821.13
ENSMUST00000144763.2
ENSMUST00000021925.14
ENSMUST00000238465.2
Ercc6l2
excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2
chr16_+_3702604 0.04 ENSMUST00000115860.8
Naa60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
chr19_+_34268071 0.04 ENSMUST00000112472.4
ENSMUST00000235232.2
Fas
Fas (TNF receptor superfamily member 6)
chr17_-_43854530 0.04 ENSMUST00000178772.3
Ankrd66
ankyrin repeat domain 66
chr4_-_70328659 0.03 ENSMUST00000144099.8
Cdk5rap2
CDK5 regulatory subunit associated protein 2
chrX_+_73784533 0.03 ENSMUST00000114117.2
Ctag2l2
CTAG2 like 2
chr19_+_34560922 0.03 ENSMUST00000102825.4
Ifit3
interferon-induced protein with tetratricopeptide repeats 3
chr7_+_51160754 0.02 ENSMUST00000043944.6
ENSMUST00000207044.2
Ano5
anoctamin 5
chr6_+_60921456 0.02 ENSMUST00000129603.4
ENSMUST00000204333.2
Mmrn1
multimerin 1
chr1_-_174079627 0.02 ENSMUST00000214725.2
Olfr419
olfactory receptor 419
chr11_+_72326337 0.02 ENSMUST00000076443.10
Ggt6
gamma-glutamyltransferase 6
chr17_-_33937565 0.02 ENSMUST00000174040.2
ENSMUST00000173015.8
ENSMUST00000066121.13
ENSMUST00000186022.7
ENSMUST00000173329.8
ENSMUST00000172767.9
Marchf2
membrane associated ring-CH-type finger 2
chr17_+_25585255 0.02 ENSMUST00000234477.2
Tpsb2
tryptase beta 2
chr10_-_127025851 0.02 ENSMUST00000222006.2
ENSMUST00000019611.15
ENSMUST00000219245.2
Arhgef25
Rho guanine nucleotide exchange factor (GEF) 25
chr5_+_110248276 0.01 ENSMUST00000141066.8
Plcxd1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr1_+_21310821 0.01 ENSMUST00000121676.8
ENSMUST00000124990.3
Gsta3
glutathione S-transferase, alpha 3
chr1_+_63215976 0.01 ENSMUST00000129339.8
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr9_+_105520154 0.01 ENSMUST00000190358.2
ENSMUST00000191268.7
ENSMUST00000065778.13
ENSMUST00000188784.2
Pik3r4
phosphoinositide-3-kinase regulatory subunit 4
chr10_+_80192293 0.01 ENSMUST00000039836.15
ENSMUST00000105351.2
Plk5
polo like kinase 5
chr11_-_67856457 0.01 ENSMUST00000021287.12
ENSMUST00000126766.2
Cfap52
cilia and flagella associated protein 52
chr7_-_126408280 0.01 ENSMUST00000207534.3
Aldoa
aldolase A, fructose-bisphosphate
chr8_-_81607109 0.01 ENSMUST00000034150.10
Gab1
growth factor receptor bound protein 2-associated protein 1
chrX_-_111316476 0.01 ENSMUST00000026601.3
Satl1
spermidine/spermine N1-acetyl transferase-like 1
chr2_+_120331784 0.01 ENSMUST00000151342.3
Capn3
calpain 3
chr11_+_72326358 0.01 ENSMUST00000108499.2
Ggt6
gamma-glutamyltransferase 6
chr11_+_104441489 0.01 ENSMUST00000018800.9
Myl4
myosin, light polypeptide 4
chrX_-_73525005 0.01 ENSMUST00000114125.2
Ctag2l1
CTAG2 like 1
chr6_-_144994327 0.01 ENSMUST00000204138.3
Bcat1
branched chain aminotransferase 1, cytosolic
chr12_-_11200306 0.01 ENSMUST00000055673.2
Kcns3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
chr7_+_63803663 0.01 ENSMUST00000206314.2
Trpm1
transient receptor potential cation channel, subfamily M, member 1
chr7_+_51160855 0.01 ENSMUST00000207717.2
Ano5
anoctamin 5
chr4_-_139560229 0.01 ENSMUST00000174681.2
Pax7
paired box 7
chr9_-_49338321 0.00 ENSMUST00000034792.7
Ankk1
ankyrin repeat and kinase domain containing 1
chr7_-_103492361 0.00 ENSMUST00000063957.6
Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr5_+_142615292 0.00 ENSMUST00000036872.16
ENSMUST00000110778.2
Wipi2
WD repeat domain, phosphoinositide interacting 2
chr9_+_15150341 0.00 ENSMUST00000034413.8
Vstm5
V-set and transmembrane domain containing 5
chr13_-_4573312 0.00 ENSMUST00000221564.2
ENSMUST00000078239.5
ENSMUST00000080361.13
Akr1c20
aldo-keto reductase family 1, member C20
chr9_-_54554483 0.00 ENSMUST00000128163.8
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr4_-_71676202 0.00 ENSMUST00000084489.3
Gm11232
predicted gene 11232
chr11_+_72326391 0.00 ENSMUST00000100903.3
Ggt6
gamma-glutamyltransferase 6
chr9_-_117701613 0.00 ENSMUST00000239475.2
Rbms3
RNA binding motif, single stranded interacting protein
chr8_-_27718522 0.00 ENSMUST00000117565.2
Adrb3
adrenergic receptor, beta 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:2000137 negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137) cell proliferation involved in heart valve development(GO:2000793)
0.1 1.3 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.1 0.9 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.4 GO:0097274 urea homeostasis(GO:0097274)
0.1 0.2 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 0.8 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.5 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.3 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 0.5 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.2 GO:1903542 negative regulation of exosomal secretion(GO:1903542)
0.1 0.4 GO:0002461 tolerance induction dependent upon immune response(GO:0002461)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.7 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.6 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0051121 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0002543 activation of blood coagulation via clotting cascade(GO:0002543) phosphatidylserine exposure on blood platelet(GO:0097045)
0.0 0.1 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.8 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.0 0.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 1.6 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.0 GO:0031104 dendrite regeneration(GO:0031104)
0.0 0.1 GO:0032053 ciliary basal body organization(GO:0032053) positive regulation of protein localization to cilium(GO:1903566)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0036398 TCR signalosome(GO:0036398)
0.0 1.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) alveolar lamellar body(GO:0097208)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.7 GO:0098821 BMP binding(GO:0036122) BMP receptor activity(GO:0098821)
0.1 1.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.4 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.5 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.2 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.2 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.8 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.8 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.3 REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B