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avrg: GFI1 WT vs 36n/n vs KD

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Results for Pou6f2_Pou4f2

Z-value: 1.25

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Transcription factors associated with Pou6f2_Pou4f2

Gene Symbol Gene ID Gene Info
Pou6f2
ENSMUSG00000009734.19 POU domain, class 6, transcription factor 2
Pou4f2
ENSMUSG00000031688.5 POU domain, class 4, transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pou6f2mm39_v1_chr13_-_18556626_185566260.903.7e-02Click!
Pou4f2mm39_v1_chr8_-_79163269_791632780.563.2e-01Click!

Activity profile of Pou6f2_Pou4f2 motif

Sorted Z-values of Pou6f2_Pou4f2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_111820618 1.48 ENSMUST00000216948.2
ENSMUST00000214935.2
ENSMUST00000217452.2
ENSMUST00000215045.2
Olfr1309
olfactory receptor 1309
chr12_-_99529767 1.06 ENSMUST00000176928.3
ENSMUST00000223484.2
Foxn3
forkhead box N3
chr2_-_111843053 1.03 ENSMUST00000213559.3
Olfr1310
olfactory receptor 1310
chrX_+_16485937 0.99 ENSMUST00000026013.6
Maoa
monoamine oxidase A
chr14_-_50586329 0.94 ENSMUST00000216634.2
Olfr735
olfactory receptor 735
chr2_+_37101586 0.90 ENSMUST00000214897.2
Olfr366
olfactory receptor 366
chr7_-_6525801 0.77 ENSMUST00000213504.2
ENSMUST00000216447.2
ENSMUST00000213656.2
ENSMUST00000207820.3
Olfr1349
olfactory receptor 1349
chr11_+_73851643 0.73 ENSMUST00000213134.2
ENSMUST00000216291.2
Olfr397
olfactory receptor 397
chr13_-_56444118 0.73 ENSMUST00000224801.2
Cxcl14
chemokine (C-X-C motif) ligand 14
chr5_-_62923463 0.72 ENSMUST00000076623.8
ENSMUST00000159470.3
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_-_5155347 0.60 ENSMUST00000023835.3
Slc10a2
solute carrier family 10, member 2
chr17_-_37399343 0.59 ENSMUST00000207101.2
ENSMUST00000217397.2
ENSMUST00000215195.2
ENSMUST00000216488.2
Olfr90
olfactory receptor 90
chr14_-_51134930 0.56 ENSMUST00000227271.2
Klhl33
kelch-like 33
chr7_+_23239157 0.53 ENSMUST00000235361.2
Vmn1r168
vomeronasal 1 receptor 168
chr10_+_4284536 0.46 ENSMUST00000239373.2
Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr2_+_88644840 0.44 ENSMUST00000214703.2
Olfr1202
olfactory receptor 1202
chr7_+_23752679 0.43 ENSMUST00000236959.2
Vmn1r183
vomeronasal 1 receptor 183
chr6_-_41681273 0.43 ENSMUST00000031899.14
Kel
Kell blood group
chr15_+_35371644 0.41 ENSMUST00000227455.2
Vps13b
vacuolar protein sorting 13B
chr7_+_23400128 0.39 ENSMUST00000226233.2
ENSMUST00000227987.2
Vmn1r173
vomeronasal 1 receptor 173
chr7_-_106531426 0.38 ENSMUST00000215468.2
Olfr709-ps1
olfactory receptor 709, pseudogene 1
chr19_+_13890894 0.35 ENSMUST00000216623.2
ENSMUST00000216835.2
Olfr1505
olfactory receptor 1505
chr7_+_23451695 0.34 ENSMUST00000228331.2
Vmn1r174
vomeronasal 1 receptor 174
chr14_+_26761023 0.33 ENSMUST00000223942.2
Il17rd
interleukin 17 receptor D
chr2_-_58050494 0.31 ENSMUST00000028175.7
Cytip
cytohesin 1 interacting protein
chr2_+_96148418 0.28 ENSMUST00000135431.8
ENSMUST00000162807.9
Lrrc4c
leucine rich repeat containing 4C
chr13_-_19917092 0.28 ENSMUST00000151029.3
Gpr141b
G protein-coupled receptor 141B
chr2_+_172994841 0.27 ENSMUST00000029017.6
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chr2_-_88157559 0.24 ENSMUST00000214207.2
Olfr1175
olfactory receptor 1175
chr12_-_56581823 0.24 ENSMUST00000178477.9
Nkx2-1
NK2 homeobox 1
chr3_-_88363704 0.23 ENSMUST00000141471.2
ENSMUST00000123753.8
Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr2_-_153079828 0.22 ENSMUST00000109795.2
Plagl2
pleiomorphic adenoma gene-like 2
chr16_+_43067641 0.22 ENSMUST00000079441.13
ENSMUST00000114691.8
Zbtb20
zinc finger and BTB domain containing 20
chr1_+_172168764 0.22 ENSMUST00000056136.4
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr8_+_4288815 0.22 ENSMUST00000003027.14
ENSMUST00000110999.8
Map2k7
mitogen-activated protein kinase kinase 7
chr7_-_10292412 0.21 ENSMUST00000236246.2
Vmn1r68
vomeronasal 1 receptor 68
chr7_+_126184108 0.21 ENSMUST00000039522.8
Apobr
apolipoprotein B receptor
chr16_+_43323970 0.21 ENSMUST00000126100.8
ENSMUST00000123047.8
ENSMUST00000156981.8
Zbtb20
zinc finger and BTB domain containing 20
chr18_-_38068430 0.19 ENSMUST00000025337.14
Diaph1
diaphanous related formin 1
chr3_+_84500854 0.19 ENSMUST00000062623.4
Tigd4
tigger transposable element derived 4
chr15_-_50746202 0.19 ENSMUST00000184885.8
Trps1
transcriptional repressor GATA binding 1
chr18_-_15197138 0.19 ENSMUST00000234864.2
Kctd1
potassium channel tetramerisation domain containing 1
chr19_+_42034231 0.18 ENSMUST00000172244.8
ENSMUST00000081714.5
Hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr7_-_102566717 0.17 ENSMUST00000214160.2
ENSMUST00000215773.2
Olfr571
olfactory receptor 571
chr1_-_192880260 0.16 ENSMUST00000161367.2
Traf3ip3
TRAF3 interacting protein 3
chr8_+_84262409 0.16 ENSMUST00000214156.2
ENSMUST00000209408.4
Olfr370
olfactory receptor 370
chr8_+_4288733 0.16 ENSMUST00000110998.9
ENSMUST00000062686.11
Map2k7
mitogen-activated protein kinase kinase 7
chr18_-_38068456 0.16 ENSMUST00000080033.7
ENSMUST00000115631.8
ENSMUST00000115634.8
Diaph1
diaphanous related formin 1
chr13_-_21744063 0.16 ENSMUST00000217519.2
Olfr1535
olfactory receptor 1535
chr19_+_55730696 0.16 ENSMUST00000153888.9
ENSMUST00000127233.9
ENSMUST00000061496.17
ENSMUST00000111656.8
ENSMUST00000111657.11
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr1_-_143652711 0.15 ENSMUST00000159879.2
Ro60
Ro60, Y RNA binding protein
chr6_+_125529911 0.15 ENSMUST00000112254.8
ENSMUST00000112253.6
Vwf
Von Willebrand factor
chr18_+_20509771 0.15 ENSMUST00000076737.7
Dsg1b
desmoglein 1 beta
chr11_+_73241609 0.14 ENSMUST00000120137.3
Olfr20
olfactory receptor 20
chr14_-_20718337 0.14 ENSMUST00000057090.12
ENSMUST00000117386.2
Synpo2l
synaptopodin 2-like
chrX_-_58211440 0.13 ENSMUST00000119306.2
Fgf13
fibroblast growth factor 13
chr6_-_146855880 0.13 ENSMUST00000111622.2
ENSMUST00000036592.15
1700034J05Rik
RIKEN cDNA 1700034J05 gene
chr2_-_73283010 0.12 ENSMUST00000151939.2
Wipf1
WAS/WASL interacting protein family, member 1
chr12_+_52746158 0.11 ENSMUST00000095737.5
Akap6
A kinase (PRKA) anchor protein 6
chr10_+_127256736 0.11 ENSMUST00000064793.13
R3hdm2
R3H domain containing 2
chr4_-_133329479 0.11 ENSMUST00000057311.4
Sfn
stratifin
chr2_+_84564394 0.11 ENSMUST00000238573.2
ENSMUST00000090729.9
Ypel4
yippee like 4
chr6_+_134958681 0.11 ENSMUST00000167323.3
Apold1
apolipoprotein L domain containing 1
chr4_-_43710231 0.10 ENSMUST00000217544.2
ENSMUST00000107862.3
Olfr71
olfactory receptor 71
chr6_-_41752111 0.10 ENSMUST00000214976.3
Olfr459
olfactory receptor 459
chr14_+_26760898 0.10 ENSMUST00000035336.5
Il17rd
interleukin 17 receptor D
chr10_+_40225272 0.10 ENSMUST00000044672.11
ENSMUST00000095743.4
Cdk19
cyclin-dependent kinase 19
chr3_-_37286714 0.10 ENSMUST00000161015.2
ENSMUST00000029273.8
Il21
interleukin 21
chr1_+_153541020 0.09 ENSMUST00000152114.8
ENSMUST00000111812.8
Rgs8
regulator of G-protein signaling 8
chr5_+_117979899 0.09 ENSMUST00000142742.9
Nos1
nitric oxide synthase 1, neuronal
chr17_-_49871291 0.09 ENSMUST00000224595.2
ENSMUST00000057610.8
Daam2
dishevelled associated activator of morphogenesis 2
chr5_+_135135735 0.09 ENSMUST00000201977.4
ENSMUST00000005507.10
Mlxipl
MLX interacting protein-like
chr10_-_95158827 0.09 ENSMUST00000220279.2
Cradd
CASP2 and RIPK1 domain containing adaptor with death domain
chr17_+_34811217 0.09 ENSMUST00000038149.13
Pbx2
pre B cell leukemia homeobox 2
chr4_+_117706390 0.08 ENSMUST00000132043.9
ENSMUST00000169990.8
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr16_+_56024676 0.08 ENSMUST00000160116.8
ENSMUST00000069936.8
Impg2
interphotoreceptor matrix proteoglycan 2
chr8_+_84393263 0.08 ENSMUST00000019608.7
Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr7_-_86016045 0.08 ENSMUST00000213255.2
ENSMUST00000216700.2
ENSMUST00000213869.2
Olfr305
olfactory receptor 305
chr11_+_67090878 0.08 ENSMUST00000124516.8
ENSMUST00000018637.15
ENSMUST00000129018.8
Myh1
myosin, heavy polypeptide 1, skeletal muscle, adult
chr7_-_73191484 0.07 ENSMUST00000197642.2
ENSMUST00000026895.14
ENSMUST00000169922.9
Chd2
chromodomain helicase DNA binding protein 2
chr14_-_75991903 0.07 ENSMUST00000049168.9
Cog3
component of oligomeric golgi complex 3
chr7_-_126183716 0.07 ENSMUST00000150311.8
Cln3
ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)
chr10_+_127256993 0.07 ENSMUST00000170336.8
R3hdm2
R3H domain containing 2
chr9_-_19289965 0.07 ENSMUST00000216839.3
Olfr847
olfactory receptor 847
chr4_+_117706559 0.07 ENSMUST00000163288.2
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr7_-_115630282 0.06 ENSMUST00000206034.2
ENSMUST00000106612.8
Sox6
SRY (sex determining region Y)-box 6
chrX_-_74460137 0.06 ENSMUST00000033542.11
Mtcp1
mature T cell proliferation 1
chr2_-_79287095 0.06 ENSMUST00000041099.5
Neurod1
neurogenic differentiation 1
chr7_-_28038129 0.06 ENSMUST00000209141.2
ENSMUST00000003527.10
Supt5
suppressor of Ty 5, DSIF elongation factor subunit
chr16_-_45544960 0.06 ENSMUST00000096057.5
Tagln3
transgelin 3
chr9_-_99302205 0.06 ENSMUST00000123771.2
Mras
muscle and microspikes RAS
chr7_+_28580847 0.06 ENSMUST00000066880.6
Capn12
calpain 12
chr17_+_17622934 0.06 ENSMUST00000115576.3
Lix1
limb and CNS expressed 1
chr8_-_3674993 0.05 ENSMUST00000142431.8
Pcp2
Purkinje cell protein 2 (L7)
chrX_+_82898974 0.04 ENSMUST00000239269.2
Dmd
dystrophin, muscular dystrophy
chrX_-_138683102 0.04 ENSMUST00000101217.4
Ripply1
ripply transcriptional repressor 1
chr19_+_55730242 0.04 ENSMUST00000111662.11
ENSMUST00000041717.14
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr12_-_81579614 0.03 ENSMUST00000169158.2
ENSMUST00000164431.2
ENSMUST00000163402.8
ENSMUST00000166664.2
ENSMUST00000164386.8
Synj2bp
Gm20498
synaptojanin 2 binding protein
predicted gene 20498
chr19_-_5610628 0.03 ENSMUST00000025861.3
Ovol1
ovo like zinc finger 1
chr1_+_153541412 0.03 ENSMUST00000111814.8
ENSMUST00000111810.2
Rgs8
regulator of G-protein signaling 8
chr14_+_63673843 0.03 ENSMUST00000121288.2
Fam167a
family with sequence similarity 167, member A
chr17_+_85335775 0.03 ENSMUST00000024944.9
Slc3a1
solute carrier family 3, member 1
chr5_-_90788323 0.02 ENSMUST00000202784.4
ENSMUST00000031317.10
ENSMUST00000201370.2
Rassf6
Ras association (RalGDS/AF-6) domain family member 6
chr3_-_79645101 0.02 ENSMUST00000078527.13
Rxfp1
relaxin/insulin-like family peptide receptor 1
chr2_+_3115250 0.02 ENSMUST00000072955.12
Fam171a1
family with sequence similarity 171, member A1
chr17_-_31417932 0.02 ENSMUST00000114549.4
Tmprss3
transmembrane protease, serine 3
chr14_-_51134906 0.02 ENSMUST00000170855.2
Klhl33
kelch-like 33
chr2_-_92222979 0.01 ENSMUST00000111279.9
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr19_+_55730488 0.01 ENSMUST00000111659.9
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chrX_+_99019176 0.01 ENSMUST00000113781.8
ENSMUST00000113783.8
ENSMUST00000113779.8
ENSMUST00000113776.8
ENSMUST00000113775.8
ENSMUST00000113780.8
ENSMUST00000113778.8
ENSMUST00000113777.8
ENSMUST00000071453.3
Eda
ectodysplasin-A
chr7_-_126183392 0.01 ENSMUST00000128970.8
ENSMUST00000116269.9
Cln3
ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)
chr18_-_55123153 0.01 ENSMUST00000064763.7
Zfp608
zinc finger protein 608
chr17_-_3608056 0.01 ENSMUST00000041003.8
Tfb1m
transcription factor B1, mitochondrial
chr7_+_143729250 0.01 ENSMUST00000105900.9
Shank2
SH3 and multiple ankyrin repeat domains 2
chr4_+_102446883 0.01 ENSMUST00000097949.11
ENSMUST00000106901.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr5_+_29400981 0.01 ENSMUST00000160888.8
ENSMUST00000159272.8
ENSMUST00000001247.12
ENSMUST00000161398.8
ENSMUST00000160246.8
Rnf32
ring finger protein 32
chr11_+_61376257 0.01 ENSMUST00000064783.10
ENSMUST00000040522.7
Mfap4
microfibrillar-associated protein 4
chr4_+_34893772 0.01 ENSMUST00000029975.10
ENSMUST00000135871.8
ENSMUST00000108130.2
Cga
glycoprotein hormones, alpha subunit
chr13_-_103901010 0.01 ENSMUST00000210489.2
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr10_+_101517348 0.01 ENSMUST00000179929.8
ENSMUST00000219195.2
ENSMUST00000127504.9
Mgat4c
MGAT4 family, member C
chr17_+_6026015 0.00 ENSMUST00000115790.8
Synj2
synaptojanin 2
chr4_+_118577335 0.00 ENSMUST00000217334.3
ENSMUST00000213436.3
ENSMUST00000216242.3
Olfr1340
olfactory receptor 1340
chr19_+_55730316 0.00 ENSMUST00000111658.10
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr8_-_3675024 0.00 ENSMUST00000133459.8
Pcp2
Purkinje cell protein 2 (L7)
chr11_+_115725140 0.00 ENSMUST00000173289.8
ENSMUST00000137900.2
Llgl2
LLGL2 scribble cell polarity complex component
chr8_-_3675274 0.00 ENSMUST00000004749.7
Pcp2
Purkinje cell protein 2 (L7)
chr15_+_102845192 0.00 ENSMUST00000055562.3
Hoxc12
homeobox C12
chr10_+_102348076 0.00 ENSMUST00000219445.2
Rassf9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr19_-_18978463 0.00 ENSMUST00000040153.15
ENSMUST00000112828.8
Rorb
RAR-related orphan receptor beta

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou6f2_Pou4f2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 1.0 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.2 GO:0034378 chylomicron assembly(GO:0034378)
0.1 0.4 GO:0031133 regulation of axon diameter(GO:0031133)
0.1 0.3 GO:0061402 glycerol biosynthetic process(GO:0006114) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.1 0.2 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 0.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.1 GO:1901204 regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.0 0.2 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.0 1.1 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0 0.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.4 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.1 GO:2000481 positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.0 0.2 GO:0048625 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.1 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.0 0.0 GO:0021629 olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
0.0 0.1 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.0 0.1 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.0 4.7 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907)
0.0 0.0 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.1 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.3 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1 0.6 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.4 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.7 GO:0008009 chemokine activity(GO:0008009)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.3 GO:0045295 gamma-catenin binding(GO:0045295)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 0.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.4 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1