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avrg: GFI1 WT vs 36n/n vs KD

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Results for Ppard

Z-value: 0.63

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Transcription factors associated with Ppard

Gene Symbol Gene ID Gene Info
Ppard
ENSMUSG00000002250.17 peroxisome proliferator activator receptor delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ppardmm39_v1_chr17_+_28451674_28451764-0.553.4e-01Click!

Activity profile of Ppard motif

Sorted Z-values of Ppard motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_56339915 0.70 ENSMUST00000015583.2
Ctsg
cathepsin G
chr11_-_69906171 0.37 ENSMUST00000018718.8
ENSMUST00000102574.10
Acadvl
acyl-Coenzyme A dehydrogenase, very long chain
chr3_+_51568588 0.36 ENSMUST00000099106.10
Mgst2
microsomal glutathione S-transferase 2
chr16_-_84632439 0.34 ENSMUST00000138279.2
Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr7_+_43093507 0.32 ENSMUST00000004729.5
ENSMUST00000206286.2
ENSMUST00000206196.2
ENSMUST00000206411.2
Etfb
electron transferring flavoprotein, beta polypeptide
chr2_-_73741664 0.31 ENSMUST00000111996.8
ENSMUST00000018914.3
Atp5g3
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
chr19_-_6899173 0.30 ENSMUST00000025906.12
ENSMUST00000239322.2
Esrra
estrogen related receptor, alpha
chr15_+_101184488 0.30 ENSMUST00000229525.2
ENSMUST00000230525.2
Atg101
autophagy related 101
chr8_-_58106057 0.28 ENSMUST00000034021.12
Galnt7
polypeptide N-acetylgalactosaminyltransferase 7
chr2_-_32594156 0.28 ENSMUST00000127812.3
Fpgs
folylpolyglutamyl synthetase
chr9_+_108539296 0.27 ENSMUST00000035222.6
Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr3_-_79535966 0.25 ENSMUST00000120992.8
Etfdh
electron transferring flavoprotein, dehydrogenase
chr19_-_6899121 0.25 ENSMUST00000173635.2
Esrra
estrogen related receptor, alpha
chr6_+_7844759 0.25 ENSMUST00000040159.6
C1galt1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr3_+_51568625 0.25 ENSMUST00000159554.7
ENSMUST00000161590.4
Mgst2
microsomal glutathione S-transferase 2
chr4_+_118286898 0.24 ENSMUST00000067896.4
Elovl1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr1_-_63215812 0.24 ENSMUST00000185847.2
ENSMUST00000185732.7
ENSMUST00000188370.7
ENSMUST00000168099.9
Ndufs1
NADH:ubiquinone oxidoreductase core subunit S1
chr1_-_120047868 0.23 ENSMUST00000112648.8
Dbi
diazepam binding inhibitor
chr19_-_32038838 0.22 ENSMUST00000096119.5
Asah2
N-acylsphingosine amidohydrolase 2
chr3_-_105708601 0.22 ENSMUST00000197094.5
ENSMUST00000198004.2
Rap1a
RAS-related protein 1a
chr19_+_37184927 0.21 ENSMUST00000024078.15
ENSMUST00000112391.8
Marchf5
membrane associated ring-CH-type finger 5
chr9_-_57169830 0.21 ENSMUST00000215298.2
1700017B05Rik
RIKEN cDNA 1700017B05 gene
chr4_+_118266582 0.21 ENSMUST00000144577.2
Med8
mediator complex subunit 8
chr2_+_92205651 0.21 ENSMUST00000028650.9
Pex16
peroxisomal biogenesis factor 16
chr3_-_83947416 0.20 ENSMUST00000192095.6
ENSMUST00000191758.6
ENSMUST00000052342.9
Tmem131l
transmembrane 131 like
chr1_+_171386752 0.20 ENSMUST00000004829.13
Cd244a
CD244 molecule A
chr5_+_36622342 0.20 ENSMUST00000031099.4
Grpel1
GrpE-like 1, mitochondrial
chr15_-_89310060 0.20 ENSMUST00000109313.9
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr19_+_5510636 0.18 ENSMUST00000225141.2
ENSMUST00000025847.7
Fibp
fibroblast growth factor (acidic) intracellular binding protein
chr4_-_45108038 0.18 ENSMUST00000107809.9
ENSMUST00000107808.3
ENSMUST00000107807.2
ENSMUST00000107810.3
Tomm5
translocase of outer mitochondrial membrane 5
chr6_+_85408953 0.18 ENSMUST00000045693.8
Smyd5
SET and MYND domain containing 5
chr18_+_74912268 0.17 ENSMUST00000041053.11
Acaa2
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
chr19_+_4644365 0.16 ENSMUST00000113825.4
Pcx
pyruvate carboxylase
chr16_-_91728162 0.15 ENSMUST00000139277.8
ENSMUST00000154661.8
Atp5o
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr15_+_25774070 0.15 ENSMUST00000125667.3
Myo10
myosin X
chr1_-_63215952 0.13 ENSMUST00000185412.7
ENSMUST00000027111.15
ENSMUST00000189664.2
Ndufs1
NADH:ubiquinone oxidoreductase core subunit S1
chr4_-_136776006 0.13 ENSMUST00000049583.8
Zbtb40
zinc finger and BTB domain containing 40
chr15_-_102097387 0.13 ENSMUST00000230288.2
Csad
cysteine sulfinic acid decarboxylase
chr15_-_102097466 0.11 ENSMUST00000023805.3
Csad
cysteine sulfinic acid decarboxylase
chr16_-_84632383 0.11 ENSMUST00000114191.8
Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr3_-_79536166 0.10 ENSMUST00000029386.14
Etfdh
electron transferring flavoprotein, dehydrogenase
chr3_+_89958940 0.09 ENSMUST00000159064.8
4933434E20Rik
RIKEN cDNA 4933434E20 gene
chr15_-_27630724 0.09 ENSMUST00000059662.8
Otulin
OTU deubiquitinase with linear linkage specificity
chr2_-_164646794 0.09 ENSMUST00000103094.11
ENSMUST00000017451.7
Acot8
acyl-CoA thioesterase 8
chr16_-_3725515 0.08 ENSMUST00000177221.2
ENSMUST00000177323.8
1700037C18Rik
RIKEN cDNA 1700037C18 gene
chr3_-_137837117 0.08 ENSMUST00000029805.13
Mttp
microsomal triglyceride transfer protein
chr16_-_84632513 0.08 ENSMUST00000023608.14
Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr3_-_8988854 0.08 ENSMUST00000042148.6
Mrps28
mitochondrial ribosomal protein S28
chr4_+_59581617 0.08 ENSMUST00000107528.8
Hsdl2
hydroxysteroid dehydrogenase like 2
chr2_+_84891281 0.06 ENSMUST00000238769.2
Tnks1bp1
tankyrase 1 binding protein 1
chr5_+_114284585 0.06 ENSMUST00000102582.8
Acacb
acetyl-Coenzyme A carboxylase beta
chr1_-_55127183 0.06 ENSMUST00000027123.15
Hspd1
heat shock protein 1 (chaperonin)
chr1_-_133617824 0.06 ENSMUST00000189524.2
ENSMUST00000169295.8
Lax1
lymphocyte transmembrane adaptor 1
chr19_+_10019023 0.06 ENSMUST00000237672.2
Fads3
fatty acid desaturase 3
chr1_-_55127312 0.06 ENSMUST00000127861.8
ENSMUST00000144077.3
Hspd1
heat shock protein 1 (chaperonin)
chr9_-_45923908 0.06 ENSMUST00000217514.2
Pafah1b2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
chr5_-_31854942 0.05 ENSMUST00000031018.10
Rbks
ribokinase
chr1_+_180553569 0.05 ENSMUST00000027780.6
Acbd3
acyl-Coenzyme A binding domain containing 3
chr11_+_4936824 0.05 ENSMUST00000109897.8
ENSMUST00000009234.16
Ap1b1
adaptor protein complex AP-1, beta 1 subunit
chr15_-_89309998 0.04 ENSMUST00000168376.2
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr10_-_125164399 0.04 ENSMUST00000063318.10
Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr17_-_34247016 0.04 ENSMUST00000236627.2
ENSMUST00000237759.2
ENSMUST00000045467.14
ENSMUST00000114303.4
H2-Ke6
H2-K region expressed gene 6
chr1_+_74545203 0.04 ENSMUST00000087215.7
Cnot9
CCR4-NOT transcription complex, subunit 9
chr19_+_4644425 0.04 ENSMUST00000238089.2
Pcx
pyruvate carboxylase
chr2_+_158636727 0.04 ENSMUST00000029186.14
ENSMUST00000109478.9
ENSMUST00000156893.2
Dhx35
DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr18_-_36859732 0.04 ENSMUST00000061829.8
Cd14
CD14 antigen
chr1_+_63216281 0.03 ENSMUST00000188524.2
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr17_-_27247581 0.03 ENSMUST00000143158.3
Bak1
BCL2-antagonist/killer 1
chr16_-_4442802 0.03 ENSMUST00000014445.7
Pam16
presequence translocase-asssociated motor 16 homolog (S. cerevisiae)
chr10_+_128139227 0.02 ENSMUST00000218315.2
ENSMUST00000219721.2
Pan2
PAN2 poly(A) specific ribonuclease subunit
chr1_-_175806680 0.02 ENSMUST00000104983.2
Rbm8a2
RNA binding motif protein 8A2
chr10_+_128139191 0.02 ENSMUST00000005825.8
Pan2
PAN2 poly(A) specific ribonuclease subunit
chr10_+_58091287 0.01 ENSMUST00000057659.14
ENSMUST00000162041.8
ENSMUST00000162860.8
Gcc2
GRIP and coiled-coil domain containing 2
chr4_+_118266526 0.01 ENSMUST00000084319.11
ENSMUST00000106384.10
ENSMUST00000126089.8
ENSMUST00000073881.8
ENSMUST00000019229.15
Med8
mediator complex subunit 8
chr12_+_112555656 0.01 ENSMUST00000220786.2
Inf2
inverted formin, FH2 and WH2 domain containing
chr16_-_23339329 0.01 ENSMUST00000230040.2
ENSMUST00000229619.2
Masp1
mannan-binding lectin serine peptidase 1
chr4_+_98435155 0.01 ENSMUST00000030290.8
Patj
PATJ, crumbs cell polarity complex component
chr6_+_42411469 0.01 ENSMUST00000059534.5
Tas2r126
taste receptor, type 2, member 126
chr2_+_162829250 0.00 ENSMUST00000018012.14
Sgk2
serum/glucocorticoid regulated kinase 2
chr4_+_98434930 0.00 ENSMUST00000102792.10
Patj
PATJ, crumbs cell polarity complex component
chr10_-_14581203 0.00 ENSMUST00000149485.2
ENSMUST00000154132.8
Vta1
vesicle (multivesicular body) trafficking 1
chrX_+_10118544 0.00 ENSMUST00000049910.13
Otc
ornithine transcarbamylase
chr11_+_98337655 0.00 ENSMUST00000019456.5
Grb7
growth factor receptor bound protein 7
chr1_+_139429430 0.00 ENSMUST00000027615.7
F13b
coagulation factor XIII, beta subunit
chrX_+_10118600 0.00 ENSMUST00000115528.3
Otc
ornithine transcarbamylase
chr4_+_101766318 0.00 ENSMUST00000075999.4
Pramel18
PRAME like 18
chr9_+_108270020 0.00 ENSMUST00000035234.6
1700102P08Rik
RIKEN cDNA 1700102P08 gene
chr4_+_101797604 0.00 ENSMUST00000052027.8
Pramel19
PRAME like 19
chr9_+_58395850 0.00 ENSMUST00000085658.5
Insyn1
inhibitory synaptic factor 1
chr16_+_22769844 0.00 ENSMUST00000232422.2
Hrg
histidine-rich glycoprotein
chr2_+_3115250 0.00 ENSMUST00000072955.12
Fam171a1
family with sequence similarity 171, member A1

Network of associatons between targets according to the STRING database.

First level regulatory network of Ppard

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.7 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.0 0.2 GO:0042412 taurine biosynthetic process(GO:0042412)
0.0 0.2 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 0.2 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0 1.0 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.2 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.2 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.2 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.1 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949)
0.0 1.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.2 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.6 GO:0006750 glutathione biosynthetic process(GO:0006750) leukotriene biosynthetic process(GO:0019370)
0.0 0.3 GO:0015879 carnitine transport(GO:0015879)
0.0 0.2 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.2 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0006014 D-ribose metabolic process(GO:0006014)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.0 GO:0071724 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.0 0.1 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.1 0.4 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 0.4 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.2 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 0.2 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.0 0.3 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.2 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.2 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.6 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import