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avrg: GFI1 WT vs 36n/n vs KD

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Results for Prox1

Z-value: 0.89

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Transcription factors associated with Prox1

Gene Symbol Gene ID Gene Info
Prox1
ENSMUSG00000010175.14 prospero homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Prox1mm39_v1_chr1_-_189902868_189902942-0.829.0e-02Click!

Activity profile of Prox1 motif

Sorted Z-values of Prox1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_67378886 0.73 ENSMUST00000073054.5
Mppe1
metallophosphoesterase 1
chr2_+_36120438 0.61 ENSMUST00000062069.6
Ptgs1
prostaglandin-endoperoxide synthase 1
chr13_+_9326513 0.56 ENSMUST00000174552.8
Dip2c
disco interacting protein 2 homolog C
chr4_-_133694607 0.50 ENSMUST00000105893.8
Hmgn2
high mobility group nucleosomal binding domain 2
chr19_-_15901919 0.50 ENSMUST00000162053.8
Psat1
phosphoserine aminotransferase 1
chr19_-_8691797 0.48 ENSMUST00000206797.2
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr4_+_140428777 0.42 ENSMUST00000138808.8
ENSMUST00000038893.6
Rcc2
regulator of chromosome condensation 2
chr17_-_35827676 0.38 ENSMUST00000160885.2
ENSMUST00000159009.2
ENSMUST00000161012.8
Tcf19
transcription factor 19
chr5_+_24305577 0.37 ENSMUST00000030841.10
ENSMUST00000163409.5
Klhl7
kelch-like 7
chr8_-_85807281 0.35 ENSMUST00000152785.8
Wdr83
WD repeat domain containing 83
chr18_-_67378512 0.35 ENSMUST00000237631.2
Mppe1
metallophosphoesterase 1
chr9_-_106124917 0.34 ENSMUST00000112524.9
ENSMUST00000219129.2
Alas1
aminolevulinic acid synthase 1
chr9_-_64633865 0.33 ENSMUST00000168366.2
Rab11a
RAB11A, member RAS oncogene family
chr5_-_124492734 0.31 ENSMUST00000031341.11
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr8_-_85807308 0.30 ENSMUST00000093357.12
Wdr83
WD repeat domain containing 83
chr19_+_41900360 0.29 ENSMUST00000011896.8
Pgam1
phosphoglycerate mutase 1
chr17_+_28059129 0.28 ENSMUST00000233657.2
Snrpc
U1 small nuclear ribonucleoprotein C
chr17_+_24645615 0.27 ENSMUST00000234304.2
ENSMUST00000024946.7
ENSMUST00000234150.2
Eci1
enoyl-Coenzyme A delta isomerase 1
chr5_+_139238069 0.26 ENSMUST00000026976.12
Get4
golgi to ER traffic protein 4
chr4_-_133694543 0.26 ENSMUST00000123234.8
Hmgn2
high mobility group nucleosomal binding domain 2
chr2_-_26800581 0.26 ENSMUST00000015920.12
ENSMUST00000139815.2
ENSMUST00000102899.10
Med22
mediator complex subunit 22
chr5_+_124250360 0.24 ENSMUST00000024470.13
ENSMUST00000119269.6
ENSMUST00000196627.5
ENSMUST00000199457.5
ENSMUST00000198505.2
Ogfod2
2-oxoglutarate and iron-dependent oxygenase domain containing 2
chr6_+_58617521 0.23 ENSMUST00000145161.8
ENSMUST00000203146.3
ENSMUST00000114294.8
ENSMUST00000204948.2
Abcg2
ATP binding cassette subfamily G member 2 (Junior blood group)
chr7_+_141995545 0.23 ENSMUST00000105971.8
ENSMUST00000145287.8
Tnni2
troponin I, skeletal, fast 2
chr1_+_134487928 0.22 ENSMUST00000112198.3
Kdm5b
lysine (K)-specific demethylase 5B
chr7_+_28416194 0.21 ENSMUST00000032818.13
Fbxo17
F-box protein 17
chr6_-_131365380 0.19 ENSMUST00000032309.13
ENSMUST00000087865.4
Ybx3
Y box protein 3
chr5_+_139238089 0.19 ENSMUST00000130326.8
Get4
golgi to ER traffic protein 4
chr17_+_29538157 0.19 ENSMUST00000114699.9
ENSMUST00000155348.3
ENSMUST00000234618.2
Pi16
peptidase inhibitor 16
chr19_-_8691220 0.18 ENSMUST00000010239.6
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr12_+_111409087 0.18 ENSMUST00000109792.8
Tnfaip2
tumor necrosis factor, alpha-induced protein 2
chr4_-_63779562 0.16 ENSMUST00000030047.3
Tnfsf8
tumor necrosis factor (ligand) superfamily, member 8
chr19_-_43512929 0.16 ENSMUST00000026196.14
Got1
glutamic-oxaloacetic transaminase 1, soluble
chr3_-_148696155 0.16 ENSMUST00000196526.5
ENSMUST00000200543.5
ENSMUST00000200154.5
Adgrl2
adhesion G protein-coupled receptor L2
chr17_+_28059099 0.16 ENSMUST00000233752.2
Snrpc
U1 small nuclear ribonucleoprotein C
chr7_+_28416270 0.16 ENSMUST00000108279.9
Fbxo17
F-box protein 17
chr18_-_12952925 0.15 ENSMUST00000119043.8
Osbpl1a
oxysterol binding protein-like 1A
chr2_+_34296894 0.15 ENSMUST00000113123.8
Mapkap1
mitogen-activated protein kinase associated protein 1
chr14_-_59835285 0.14 ENSMUST00000022555.11
ENSMUST00000225839.2
ENSMUST00000056997.15
ENSMUST00000171683.3
ENSMUST00000167100.9
Cdadc1
cytidine and dCMP deaminase domain containing 1
chr7_+_23781311 0.12 ENSMUST00000207002.2
ENSMUST00000068975.6
ENSMUST00000203854.3
Zfp180
zinc finger protein 180
chr2_+_34296783 0.10 ENSMUST00000149383.8
ENSMUST00000124443.8
ENSMUST00000141253.2
ENSMUST00000113124.8
Mapkap1
mitogen-activated protein kinase associated protein 1
chr8_-_70929555 0.10 ENSMUST00000066597.13
ENSMUST00000210250.2
ENSMUST00000209415.2
ENSMUST00000166976.3
Klhl26
kelch-like 26
chr17_-_35191127 0.09 ENSMUST00000087328.4
Hspa1a
heat shock protein 1A
chr11_+_115671523 0.09 ENSMUST00000239299.2
Tmem94
transmembrane protein 94
chr8_+_31601837 0.09 ENSMUST00000046941.8
ENSMUST00000217278.2
Rnf122
ring finger protein 122
chr2_-_136733282 0.09 ENSMUST00000028730.13
ENSMUST00000110089.9
ENSMUST00000227806.2
Mkks
ENSMUSG00000115423.3
McKusick-Kaufman syndrome
novel protein
chr17_-_83821716 0.08 ENSMUST00000025095.9
ENSMUST00000167741.9
Cox7a2l
cytochrome c oxidase subunit 7A2 like
chr2_+_26800757 0.08 ENSMUST00000102898.5
Rpl7a
ribosomal protein L7A
chr11_+_19874403 0.08 ENSMUST00000093298.12
Spred2
sprouty-related EVH1 domain containing 2
chr3_+_20111958 0.07 ENSMUST00000002502.12
Hltf
helicase-like transcription factor
chr17_+_28059036 0.06 ENSMUST00000071006.9
Snrpc
U1 small nuclear ribonucleoprotein C
chr7_-_80597246 0.06 ENSMUST00000120285.8
Sec11a
SEC11 homolog A, signal peptidase complex subunit
chrY_-_90850446 0.06 ENSMUST00000179623.2
Gm21748
predicted gene, 21748
chr8_+_89015705 0.06 ENSMUST00000171456.9
Adcy7
adenylate cyclase 7
chr11_-_115503704 0.06 ENSMUST00000106506.8
Mif4gd
MIF4G domain containing
chr7_-_126460820 0.05 ENSMUST00000129812.2
ENSMUST00000106342.8
Ino80e
INO80 complex subunit E
chr4_+_99717671 0.05 ENSMUST00000239518.1
ENSMUST00000239520.1
ENSMUST00000136874.4
Efcab7
EF-hand calcium binding domain 7
chr8_+_61085890 0.05 ENSMUST00000160719.8
Mfap3l
microfibrillar-associated protein 3-like
chr11_-_115824290 0.05 ENSMUST00000021097.10
Recql5
RecQ protein-like 5
chr10_+_67371295 0.05 ENSMUST00000145754.8
ENSMUST00000145936.2
Egr2
early growth response 2
chr1_+_78794475 0.04 ENSMUST00000057262.8
ENSMUST00000187432.2
Kcne4
potassium voltage-gated channel, Isk-related subfamily, gene 4
chr11_+_4936824 0.04 ENSMUST00000109897.8
ENSMUST00000009234.16
Ap1b1
adaptor protein complex AP-1, beta 1 subunit
chr1_+_134487893 0.04 ENSMUST00000047714.14
Kdm5b
lysine (K)-specific demethylase 5B
chr17_+_37356872 0.03 ENSMUST00000174456.8
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr11_+_19874354 0.03 ENSMUST00000093299.13
Spred2
sprouty-related EVH1 domain containing 2
chr10_-_80649315 0.03 ENSMUST00000181039.8
ENSMUST00000180438.2
Jsrp1
junctional sarcoplasmic reticulum protein 1
chr5_-_86780277 0.03 ENSMUST00000116553.9
Tmprss11f
transmembrane protease, serine 11f
chr2_-_89159994 0.02 ENSMUST00000213860.2
ENSMUST00000215679.2
Olfr1232
olfactory receptor 1232
chr1_+_161222980 0.02 ENSMUST00000028024.5
Tnfsf4
tumor necrosis factor (ligand) superfamily, member 4
chr14_+_43156329 0.02 ENSMUST00000228117.2
Gm9732
predicted gene 9732
chr9_-_38614969 0.02 ENSMUST00000215612.2
Olfr919
olfactory receptor 919
chr5_+_62968993 0.02 ENSMUST00000238474.2
Dthd1
death domain containing 1
chr4_-_68872585 0.02 ENSMUST00000030036.6
Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr17_-_37574640 0.02 ENSMUST00000080759.5
Olfr98
olfactory receptor 98
chr10_-_128969635 0.02 ENSMUST00000062314.4
Olfr770
olfactory receptor 770
chr18_+_24786748 0.02 ENSMUST00000068006.9
Mocos
molybdenum cofactor sulfurase
chr18_-_68562385 0.01 ENSMUST00000052347.8
Mc2r
melanocortin 2 receptor
chr14_-_56181993 0.01 ENSMUST00000022834.7
ENSMUST00000226280.2
Cma1
chymase 1, mast cell
chr4_+_130640611 0.01 ENSMUST00000156225.8
ENSMUST00000156742.8
Laptm5
lysosomal-associated protein transmembrane 5
chr14_+_53754386 0.01 ENSMUST00000103584.4
Trav6-6
T cell receptor alpha variable 6-6
chr16_+_22965330 0.01 ENSMUST00000171309.2
Adipoq
adiponectin, C1Q and collagen domain containing
chr15_-_86070338 0.01 ENSMUST00000044332.16
Cerk
ceramide kinase
chrX_-_42363663 0.01 ENSMUST00000016294.8
Tenm1
teneurin transmembrane protein 1
chr14_+_50759296 0.01 ENSMUST00000215793.2
Olfr743
olfactory receptor 743
chr2_-_168576155 0.01 ENSMUST00000109175.9
Atp9a
ATPase, class II, type 9A
chr3_+_153549846 0.01 ENSMUST00000044089.4
Asb17
ankyrin repeat and SOCS box-containing 17
chr9_-_7388047 0.01 ENSMUST00000047888.8
Mmp1b
matrix metallopeptidase 1b (interstitial collagenase)
chr11_-_59484115 0.01 ENSMUST00000215626.2
Olfr223
olfactory receptor 223
chr7_+_127376267 0.01 ENSMUST00000144406.8
Setd1a
SET domain containing 1A
chr4_+_74160705 0.01 ENSMUST00000077851.10
Kdm4c
lysine (K)-specific demethylase 4C
chr7_+_107700056 0.01 ENSMUST00000215159.3
Olfr483
olfactory receptor 483
chr14_+_42477895 0.01 ENSMUST00000100696.8
ENSMUST00000166527.2
Gm10378
predicted gene 10378
chr14_+_42132167 0.01 ENSMUST00000089789.11
ENSMUST00000171967.2
Gm7995
predicted gene 7995
chr3_+_92980844 0.01 ENSMUST00000195847.2
ENSMUST00000179064.2
Tdpoz8
TD and POZ domain containing 8
chr4_-_62126126 0.01 ENSMUST00000220873.2
Zfp37
zinc finger protein 37
chr4_-_137137088 0.01 ENSMUST00000024200.7
Cela3a
chymotrypsin-like elastase family, member 3A
chr7_-_48106037 0.01 ENSMUST00000188095.2
Mrgprb1
MAS-related GPR, member B1
chr10_-_41487315 0.01 ENSMUST00000219054.2
Ccdc162
coiled-coil domain containing 162
chr6_-_73446560 0.01 ENSMUST00000070163.6
4931417E11Rik
RIKEN cDNA 4931417E11 gene
chr4_-_36951223 0.01 ENSMUST00000108122.8
Lingo2
leucine rich repeat and Ig domain containing 2
chr1_-_169575203 0.01 ENSMUST00000027991.12
ENSMUST00000111357.2
Rgs4
regulator of G-protein signaling 4
chr12_-_83534482 0.00 ENSMUST00000177959.8
ENSMUST00000178756.8
Dpf3
D4, zinc and double PHD fingers, family 3
chr18_-_32082624 0.00 ENSMUST00000064016.6
Gpr17
G protein-coupled receptor 17
chr18_+_46983105 0.00 ENSMUST00000025358.4
ENSMUST00000234519.2
Lvrn
laeverin
chr3_-_121076745 0.00 ENSMUST00000135818.8
ENSMUST00000137234.2
Tlcd4
TLC domain containing 4
chr18_+_89215438 0.00 ENSMUST00000237110.2
Cd226
CD226 antigen
chr5_+_95891653 0.00 ENSMUST00000136313.2
ENSMUST00000101011.4
Gm7982
predicted gene 7982

Network of associatons between targets according to the STRING database.

First level regulatory network of Prox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.1 0.7 GO:0060356 leucine import(GO:0060356)
0.1 0.6 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.2 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 0.2 GO:0019389 glucuronoside metabolic process(GO:0019389)
0.1 0.3 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.1 0.3 GO:0035938 estradiol secretion(GO:0035938) regulation of estradiol secretion(GO:2000864)
0.1 0.5 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.4 GO:0036506 maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 0.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.2 GO:0006533 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533)
0.0 0.3 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.8 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 0.1 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 1.1 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.0 GO:0021666 rhombomere formation(GO:0021594) rhombomere 3 formation(GO:0021660) rhombomere 5 morphogenesis(GO:0021664) rhombomere 5 formation(GO:0021666)
0.0 0.0 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.2 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.2 GO:0051601 exocyst localization(GO:0051601)
0.0 0.4 GO:0044342 type B pancreatic cell proliferation(GO:0044342)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.3 GO:0098837 kinetochore microtubule(GO:0005828) postsynaptic recycling endosome(GO:0098837)
0.0 0.1 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0000243 commitment complex(GO:0000243)
0.0 0.2 GO:0005861 troponin complex(GO:0005861)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.1 0.3 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1 0.3 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 0.3 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 0.2 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.3 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.2 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.2 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.5 GO:0008483 transaminase activity(GO:0008483)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.2 GO:0031418 L-ascorbic acid binding(GO:0031418)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins