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avrg: GFI1 WT vs 36n/n vs KD

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Results for Rara

Z-value: 0.62

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Transcription factors associated with Rara

Gene Symbol Gene ID Gene Info
Rara
ENSMUSG00000037992.17 retinoic acid receptor, alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Raramm39_v1_chr11_+_98818640_988186500.474.2e-01Click!

Activity profile of Rara motif

Sorted Z-values of Rara motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_98851238 0.31 ENSMUST00000107473.3
Rara
retinoic acid receptor, alpha
chr2_+_32498997 0.29 ENSMUST00000143625.2
ENSMUST00000128811.2
St6galnac6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr12_-_115832846 0.26 ENSMUST00000199373.2
Ighv1-78
immunoglobulin heavy variable 1-78
chr7_+_16716989 0.26 ENSMUST00000206129.3
Gm42372
predicted gene, 42372
chr4_+_32238712 0.19 ENSMUST00000108180.9
Bach2
BTB and CNC homology, basic leucine zipper transcription factor 2
chr6_+_68233361 0.16 ENSMUST00000103320.3
Igkv14-111
immunoglobulin kappa variable 14-111
chrX_-_104918911 0.15 ENSMUST00000200471.2
Atrx
ATRX, chromatin remodeler
chr6_+_68026941 0.15 ENSMUST00000103316.2
Igkv9-120
immunoglobulin kappa chain variable 9-120
chr7_+_4925781 0.15 ENSMUST00000207527.2
ENSMUST00000207687.2
ENSMUST00000208754.2
Nat14
N-acetyltransferase 14
chr8_+_91681550 0.15 ENSMUST00000210947.2
Chd9
chromodomain helicase DNA binding protein 9
chr14_+_58308004 0.14 ENSMUST00000165526.9
Fgf9
fibroblast growth factor 9
chr4_-_123458465 0.13 ENSMUST00000238731.2
Macf1
microtubule-actin crosslinking factor 1
chr3_-_103716593 0.13 ENSMUST00000063502.13
ENSMUST00000106832.2
ENSMUST00000106834.8
ENSMUST00000029435.15
Dclre1b
DNA cross-link repair 1B
chr7_-_18350423 0.13 ENSMUST00000057810.7
Psg23
pregnancy-specific glycoprotein 23
chr17_+_34812361 0.13 ENSMUST00000174532.2
Pbx2
pre B cell leukemia homeobox 2
chrX_-_104919201 0.13 ENSMUST00000198209.2
Atrx
ATRX, chromatin remodeler
chr13_+_49574694 0.12 ENSMUST00000220447.2
Ippk
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
chr7_+_16884194 0.11 ENSMUST00000108491.8
Ceacam3
carcinoembryonic antigen-related cell adhesion molecule 3
chr14_-_75185281 0.11 ENSMUST00000088970.7
ENSMUST00000228252.2
Lrch1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr5_-_137623331 0.11 ENSMUST00000031732.14
Fbxo24
F-box protein 24
chr1_-_172034251 0.11 ENSMUST00000155109.2
Pea15a
phosphoprotein enriched in astrocytes 15A
chr11_-_50844572 0.11 ENSMUST00000162420.2
ENSMUST00000051159.3
Prop1
paired like homeodomain factor 1
chr2_+_181007177 0.09 ENSMUST00000108807.9
Zgpat
zinc finger, CCCH-type with G patch domain
chr5_+_53747556 0.08 ENSMUST00000037618.13
ENSMUST00000201912.4
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr6_-_124519240 0.08 ENSMUST00000159463.8
ENSMUST00000162844.2
ENSMUST00000160505.8
ENSMUST00000162443.8
C1s1
complement component 1, s subcomponent 1
chr2_-_181007099 0.08 ENSMUST00000108808.8
ENSMUST00000170190.8
ENSMUST00000127988.8
Arfrp1
ADP-ribosylation factor related protein 1
chr14_-_70864666 0.08 ENSMUST00000022694.17
Dmtn
dematin actin binding protein
chr6_-_54949587 0.07 ENSMUST00000060655.15
Nod1
nucleotide-binding oligomerization domain containing 1
chr4_-_128503774 0.07 ENSMUST00000141040.2
ENSMUST00000147876.2
ENSMUST00000097877.9
Zscan20
zinc finger and SCAN domains 20
chr14_+_20724378 0.07 ENSMUST00000224492.2
ENSMUST00000223751.2
ENSMUST00000225108.2
ENSMUST00000224754.2
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr9_-_44624496 0.07 ENSMUST00000144251.8
ENSMUST00000156918.8
Phldb1
pleckstrin homology like domain, family B, member 1
chr9_-_45896663 0.07 ENSMUST00000214179.2
Pafah1b2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
chr14_+_20724366 0.07 ENSMUST00000048657.10
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr2_-_90900525 0.07 ENSMUST00000153367.2
ENSMUST00000079976.10
Slc39a13
solute carrier family 39 (metal ion transporter), member 13
chr4_+_41348996 0.06 ENSMUST00000108060.10
ENSMUST00000072866.12
Ubap1
ubiquitin-associated protein 1
chr14_-_30075424 0.06 ENSMUST00000224198.3
ENSMUST00000238675.2
ENSMUST00000112249.10
ENSMUST00000224785.3
Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr17_+_34131696 0.06 ENSMUST00000174146.3
Daxx
Fas death domain-associated protein
chr5_+_114991722 0.06 ENSMUST00000031547.12
4930519G04Rik
RIKEN cDNA 4930519G04 gene
chr3_+_96011810 0.06 ENSMUST00000132980.8
ENSMUST00000138206.8
ENSMUST00000090785.9
ENSMUST00000035519.12
Otud7b
OTU domain containing 7B
chrX_+_8137881 0.06 ENSMUST00000115590.2
Slc38a5
solute carrier family 38, member 5
chr15_-_103231921 0.06 ENSMUST00000229551.2
Zfp385a
zinc finger protein 385A
chr10_+_4561974 0.06 ENSMUST00000105590.8
ENSMUST00000067086.14
Esr1
estrogen receptor 1 (alpha)
chr16_-_19079594 0.05 ENSMUST00000103752.3
ENSMUST00000197518.2
Iglv2
immunoglobulin lambda variable 2
chr4_+_119590971 0.05 ENSMUST00000084306.5
Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr3_-_94922525 0.05 ENSMUST00000128438.2
ENSMUST00000149747.2
ENSMUST00000019482.8
Zfp687
zinc finger protein 687
chr2_+_173561208 0.04 ENSMUST00000073081.6
1700010B08Rik
RIKEN cDNA 1700010B08 gene
chr11_+_4936824 0.04 ENSMUST00000109897.8
ENSMUST00000009234.16
Ap1b1
adaptor protein complex AP-1, beta 1 subunit
chr9_-_96513529 0.04 ENSMUST00000034984.8
Rasa2
RAS p21 protein activator 2
chr13_+_95012107 0.04 ENSMUST00000022195.13
Otp
orthopedia homeobox
chr5_+_88073438 0.04 ENSMUST00000001667.13
ENSMUST00000113267.8
Csn3
casein kappa
chr17_-_56440817 0.04 ENSMUST00000167545.3
Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr2_+_26209755 0.04 ENSMUST00000066889.13
Gpsm1
G-protein signalling modulator 1 (AGS3-like, C. elegans)
chr11_-_69728560 0.04 ENSMUST00000108634.9
Nlgn2
neuroligin 2
chr19_-_12209960 0.03 ENSMUST00000207710.3
Olfr1432
olfactory receptor 1432
chr13_+_83720457 0.03 ENSMUST00000196730.5
Mef2c
myocyte enhancer factor 2C
chr18_-_39652468 0.03 ENSMUST00000237944.2
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr14_+_55855484 0.03 ENSMUST00000002395.8
Rec8
REC8 meiotic recombination protein
chr3_+_79791798 0.03 ENSMUST00000118853.8
ENSMUST00000145992.2
Gask1b
golgi associated kinase 1B
chr4_-_152402915 0.02 ENSMUST00000170820.3
ENSMUST00000076183.12
Rnf207
ring finger protein 207
chr9_-_56325344 0.02 ENSMUST00000061552.15
Peak1
pseudopodium-enriched atypical kinase 1
chr5_-_113285852 0.02 ENSMUST00000212276.2
2900026A02Rik
RIKEN cDNA 2900026A02 gene
chr9_-_108903117 0.02 ENSMUST00000161521.8
ENSMUST00000045011.9
Atrip
ATR interacting protein
chr3_+_151916106 0.02 ENSMUST00000199202.5
ENSMUST00000200524.5
ENSMUST00000198227.5
ENSMUST00000196739.5
ENSMUST00000196695.5
ENSMUST00000106121.6
Fubp1
far upstream element (FUSE) binding protein 1
chr7_-_16790594 0.02 ENSMUST00000037762.11
Hif3a
hypoxia inducible factor 3, alpha subunit
chr6_+_67873135 0.02 ENSMUST00000103310.3
Igkv14-126
immunoglobulin kappa variable 14-126
chr8_-_120505104 0.01 ENSMUST00000212534.2
ENSMUST00000049156.7
Meak7
MTOR associated protein , eak-7 homolog
chr8_-_72966663 0.01 ENSMUST00000098630.5
Cib3
calcium and integrin binding family member 3
chr9_-_45896075 0.01 ENSMUST00000217636.2
Pafah1b2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
chr9_-_56325307 0.01 ENSMUST00000186735.2
Peak1
pseudopodium-enriched atypical kinase 1
chr7_-_115445352 0.01 ENSMUST00000206369.2
Sox6
SRY (sex determining region Y)-box 6
chr8_+_106877025 0.01 ENSMUST00000212963.2
ENSMUST00000034377.8
Pla2g15
phospholipase A2, group XV
chr6_+_68495964 0.01 ENSMUST00000199510.5
ENSMUST00000103325.3
Igkv14-100
immunoglobulin kappa chain variable 14-100
chr6_+_41107047 0.01 ENSMUST00000103271.2
Trbv13-3
T cell receptor beta, variable 13-3
chr9_-_45896110 0.00 ENSMUST00000215060.2
ENSMUST00000213853.2
ENSMUST00000216334.2
Pafah1b2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
chr11_+_87457544 0.00 ENSMUST00000060360.7
Septin4
septin 4
chr7_+_15484302 0.00 ENSMUST00000098802.10
ENSMUST00000173053.2
Obox5
oocyte specific homeobox 5
chr2_-_25507680 0.00 ENSMUST00000028309.4
Ccdc183
coiled-coil domain containing 183

Network of associatons between targets according to the STRING database.

First level regulatory network of Rara

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.3 GO:1901582 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.0 0.1 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.1 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.0 0.1 GO:1901297 positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.1 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.0 0.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.1 GO:0072738 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.0 0.0 GO:0001966 thigmotaxis(GO:0001966)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:1990707 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0 0.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.1 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
0.0 0.3 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014) retinoic acid-responsive element binding(GO:0044323)
0.0 0.1 GO:0038052 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.1 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)