Project

avrg: GFI1 WT vs 36n/n vs KD

Navigation
Downloads

Results for Rfx5

Z-value: 2.61

Motif logo

logo of

Transcription factors associated with Rfx5

Gene Symbol Gene ID Gene Info
Rfx5
ENSMUSG00000005774.13 regulatory factor X, 5 (influences HLA class II expression)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rfx5mm39_v1_chr3_+_94861386_948615370.454.4e-01Click!

Activity profile of Rfx5 motif

Sorted Z-values of Rfx5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_35658131 4.48 ENSMUST00000071951.14
ENSMUST00000116598.10
ENSMUST00000078205.14
ENSMUST00000076256.8
H2-Q7
histocompatibility 2, Q region locus 7
chr17_+_35598583 2.92 ENSMUST00000081435.5
H2-Q4
histocompatibility 2, Q region locus 4
chr17_-_34406193 2.84 ENSMUST00000173831.3
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr17_+_34416707 2.45 ENSMUST00000025196.9
Psmb8
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
chr17_-_34219225 2.45 ENSMUST00000238098.2
ENSMUST00000087189.7
ENSMUST00000173075.3
ENSMUST00000172912.8
ENSMUST00000236740.2
ENSMUST00000025181.18
H2-K1
histocompatibility 2, K1, K region
chr17_+_34416689 2.26 ENSMUST00000173441.9
Psmb8
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
chr7_+_46490899 1.74 ENSMUST00000147535.8
Ldha
lactate dehydrogenase A
chr17_+_34406762 1.74 ENSMUST00000041633.15
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_37581103 1.74 ENSMUST00000038580.7
H2-M3
histocompatibility 2, M region locus 3
chr17_+_34406523 1.63 ENSMUST00000170086.8
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr5_-_123663440 1.60 ENSMUST00000197682.6
Gm49027
predicted gene, 49027
chr7_-_30364394 1.35 ENSMUST00000019697.9
Haus5
HAUS augmin-like complex, subunit 5
chr2_-_152239966 1.25 ENSMUST00000063332.9
ENSMUST00000182625.2
Sox12
SRY (sex determining region Y)-box 12
chr11_+_106167541 0.97 ENSMUST00000044462.4
Tcam1
testicular cell adhesion molecule 1
chr9_-_21202353 0.94 ENSMUST00000086374.8
Cdkn2d
cyclin dependent kinase inhibitor 2D
chr19_+_37364791 0.92 ENSMUST00000012587.4
Kif11
kinesin family member 11
chr17_-_25105277 0.91 ENSMUST00000234583.2
ENSMUST00000234968.2
ENSMUST00000044252.7
Nubp2
nucleotide binding protein 2
chr10_-_7539009 0.91 ENSMUST00000163085.8
ENSMUST00000159917.8
Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr8_+_27532623 0.91 ENSMUST00000209856.2
ENSMUST00000098851.12
ENSMUST00000211393.2
ENSMUST00000211518.2
Plpbp
pyridoxal phosphate binding protein
chr8_+_94941192 0.89 ENSMUST00000079961.14
ENSMUST00000212824.2
Nup93
nucleoporin 93
chr7_+_101027390 0.84 ENSMUST00000084895.12
Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chrX_-_158921370 0.83 ENSMUST00000033662.9
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr17_+_25105617 0.82 ENSMUST00000117890.8
ENSMUST00000168265.8
ENSMUST00000120943.8
ENSMUST00000068508.13
ENSMUST00000119829.8
Spsb3
splA/ryanodine receptor domain and SOCS box containing 3
chr7_+_100186399 0.79 ENSMUST00000120454.3
Coa4
cytochrome c oxidase assembly factor 4
chr1_-_155022501 0.76 ENSMUST00000027744.10
Mr1
major histocompatibility complex, class I-related
chr10_-_7539333 0.76 ENSMUST00000162606.8
Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr9_-_21202693 0.72 ENSMUST00000213407.2
Cdkn2d
cyclin dependent kinase inhibitor 2D
chr6_+_94477294 0.71 ENSMUST00000061118.11
Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr8_+_27532583 0.67 ENSMUST00000033875.10
ENSMUST00000209525.2
Plpbp
pyridoxal phosphate binding protein
chr17_+_34524884 0.63 ENSMUST00000074557.11
H2-Eb1
histocompatibility 2, class II antigen E beta
chr5_-_140346132 0.63 ENSMUST00000196130.5
Snx8
sorting nexin 8
chr4_-_116485118 0.56 ENSMUST00000030456.14
Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr13_+_25015653 0.48 ENSMUST00000038039.3
ENSMUST00000223804.2
Tdp2
tyrosyl-DNA phosphodiesterase 2
chr19_+_34194990 0.47 ENSMUST00000119603.2
Stambpl1
STAM binding protein like 1
chr1_+_134333720 0.47 ENSMUST00000173908.8
Cyb5r1
cytochrome b5 reductase 1
chr2_-_92264374 0.46 ENSMUST00000111278.2
ENSMUST00000090559.12
Cry2
cryptochrome 2 (photolyase-like)
chr9_-_21202545 0.46 ENSMUST00000215619.2
Cdkn2d
cyclin dependent kinase inhibitor 2D
chr11_+_98573377 0.43 ENSMUST00000017365.15
Psmd3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr5_-_125371162 0.43 ENSMUST00000127148.2
Scarb1
scavenger receptor class B, member 1
chr1_-_182929025 0.41 ENSMUST00000171366.7
Disp1
dispatched RND transporter family member 1
chr16_-_31898088 0.40 ENSMUST00000023467.9
Pak2
p21 (RAC1) activated kinase 2
chr17_+_34482183 0.32 ENSMUST00000040828.7
ENSMUST00000237342.2
ENSMUST00000237866.2
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr4_+_137989783 0.30 ENSMUST00000105821.3
Kif17
kinesin family member 17
chr5_-_134485081 0.28 ENSMUST00000111244.5
Gtf2ird1
general transcription factor II I repeat domain-containing 1
chr17_+_34524841 0.26 ENSMUST00000235530.2
H2-Eb1
histocompatibility 2, class II antigen E beta
chr1_+_194302123 0.22 ENSMUST00000027952.12
Plxna2
plexin A2
chr11_+_61395964 0.21 ENSMUST00000102657.10
B9d1
B9 protein domain 1
chr1_+_134333506 0.19 ENSMUST00000027726.14
Cyb5r1
cytochrome b5 reductase 1
chr7_-_101570393 0.17 ENSMUST00000106965.8
ENSMUST00000106968.8
ENSMUST00000106967.8
Lrrc51
leucine rich repeat containing 51
chr17_+_34372046 0.16 ENSMUST00000114232.4
H2-DMb1
histocompatibility 2, class II, locus Mb1
chr10_-_123032821 0.15 ENSMUST00000219619.2
ENSMUST00000020334.9
Usp15
ubiquitin specific peptidase 15
chr6_-_29164981 0.14 ENSMUST00000007993.16
Rbm28
RNA binding motif protein 28
chr7_-_101570382 0.11 ENSMUST00000098236.9
Lrrc51
leucine rich repeat containing 51
chr19_-_4665509 0.11 ENSMUST00000053597.3
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr10_-_78143384 0.11 ENSMUST00000150828.2
ENSMUST00000239481.2
Agpat3
ENSMUSG00000118646.2
1-acylglycerol-3-phosphate O-acyltransferase 3
chr19_-_4665668 0.10 ENSMUST00000113822.3
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr4_+_66745803 0.09 ENSMUST00000048096.12
ENSMUST00000107365.3
Tlr4
toll-like receptor 4
chr17_+_34457868 0.08 ENSMUST00000095342.11
ENSMUST00000167280.8
ENSMUST00000236838.2
H2-Ob
histocompatibility 2, O region beta locus
chr14_-_50322136 0.08 ENSMUST00000072370.3
Olfr726
olfactory receptor 726
chr4_-_35845204 0.08 ENSMUST00000164772.8
ENSMUST00000065173.9
Lingo2
leucine rich repeat and Ig domain containing 2
chr9_+_44684324 0.07 ENSMUST00000214854.3
ENSMUST00000125877.8
Ift46
intraflagellar transport 46
chr1_-_133681419 0.07 ENSMUST00000125659.8
ENSMUST00000048953.14
ENSMUST00000165602.9
Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr7_+_100186259 0.06 ENSMUST00000054310.4
Coa4
cytochrome c oxidase assembly factor 4
chr14_+_53607470 0.06 ENSMUST00000103652.5
Trav14n-3
T cell receptor alpha variable 14N-3
chr10_+_78749005 0.05 ENSMUST00000204587.4
ENSMUST00000217073.3
Olfr1354
olfactory receptor 1354
chr2_+_88323664 0.04 ENSMUST00000075025.7
Olfr1185-ps1
olfactory receptor 1185, pseudogene 1
chr11_-_99689758 0.04 ENSMUST00000105057.2
Gm11569
predicted gene 11569
chr8_+_82582953 0.04 ENSMUST00000109851.3
Inpp4b
inositol polyphosphate-4-phosphatase, type II
chr4_-_112291169 0.04 ENSMUST00000058605.3
Skint9
selection and upkeep of intraepithelial T cells 9
chr5_+_104318542 0.04 ENSMUST00000112771.2
Dspp
dentin sialophosphoprotein
chr7_+_106443820 0.03 ENSMUST00000098142.4
Olfr703
olfactory receptor 703
chr6_-_124756645 0.03 ENSMUST00000147669.2
ENSMUST00000128697.8
ENSMUST00000032218.10
ENSMUST00000112475.9
Lrrc23
leucine rich repeat containing 23
chr3_+_16237371 0.03 ENSMUST00000108345.9
ENSMUST00000191774.6
ENSMUST00000108346.5
Ythdf3
YTH N6-methyladenosine RNA binding protein 3
chr5_-_145816774 0.02 ENSMUST00000035918.8
Cyp3a11
cytochrome P450, family 3, subfamily a, polypeptide 11
chr13_-_23673000 0.02 ENSMUST00000223877.2
ENSMUST00000041541.11
ENSMUST00000110432.2
ENSMUST00000110433.10
Btn2a2
butyrophilin, subfamily 2, member A2
chr10_+_90665270 0.02 ENSMUST00000182202.8
ENSMUST00000182966.8
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr10_+_90665399 0.02 ENSMUST00000179694.9
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr7_+_54485336 0.02 ENSMUST00000082373.8
Luzp2
leucine zipper protein 2
chr8_+_41276027 0.02 ENSMUST00000066814.7
Adam39
a disintegrin and metallopeptidase domain 39
chr5_+_11234174 0.01 ENSMUST00000168407.3
Gm5861
predicted gene 5861
chr7_-_31910570 0.01 ENSMUST00000188293.2
Scgb2b11
secretoglobin, family 2B, member 11
chr14_+_111912529 0.01 ENSMUST00000042767.9
Slitrk5
SLIT and NTRK-like family, member 5
chr5_+_11178835 0.01 ENSMUST00000178863.2
Gm8879
predicted gene 8879
chr5_+_11733203 0.01 ENSMUST00000178989.2
Gm8922
predicted gene 8922
chr2_-_28453374 0.01 ENSMUST00000028161.6
Cel
carboxyl ester lipase
chr5_+_11467593 0.01 ENSMUST00000179679.2
Gm8897
predicted gene 8897
chr5_+_11392646 0.01 ENSMUST00000179482.2
Speer1
spermatogenesis associated glutamate (E)-rich protein 1
chr5_+_11821653 0.01 ENSMUST00000178158.2
Gm8926
predicted gene 8926
chr5_+_11307124 0.01 ENSMUST00000177727.2
Gm8890
predicted gene 8890
chr7_-_32873289 0.01 ENSMUST00000186529.2
Scgb2b18
secretoglobin, family 2B, member 18
chr4_-_126219465 0.01 ENSMUST00000102616.8
Tekt2
tektin 2
chr7_+_80764564 0.00 ENSMUST00000119083.2
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr1_+_88139678 0.00 ENSMUST00000073049.7
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr7_-_32529087 0.00 ENSMUST00000182975.2
Scgb2b15
secretoglobin, family 2B, member 15
chr1_-_53031814 0.00 ENSMUST00000190831.7
ENSMUST00000190726.2
1700019D03Rik
RIKEN cDNA 1700019D03 gene
chr8_+_41246310 0.00 ENSMUST00000056331.8
Adam20
a disintegrin and metallopeptidase domain 20
chr14_+_53886861 0.00 ENSMUST00000103660.4
Trav15-2-dv6-2
T cell receptor alpha variable 15-2-DV6-2

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0046967 cytosol to ER transport(GO:0046967)
0.9 1.7 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.6 2.4 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.2 0.7 GO:0051182 coenzyme transport(GO:0051182)
0.2 1.7 GO:0019659 glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.2 0.5 GO:2000847 negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.1 0.4 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.1 2.1 GO:0048102 autophagic cell death(GO:0048102)
0.1 0.4 GO:0007225 patched ligand maturation(GO:0007225) signal maturation(GO:0035638)
0.1 6.0 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 0.9 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.1 0.3 GO:0002344 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.1 0.4 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 1.7 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.1 0.8 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 5.9 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 0.9 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.8 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.0 0.6 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.9 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.1 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.0 0.1 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
0.0 0.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.2 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.8 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.0 GO:0071460 positive regulation of enamel mineralization(GO:0070175) cellular response to cell-matrix adhesion(GO:0071460)
0.0 1.4 GO:0051225 spindle assembly(GO:0051225)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 7.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.6 9.0 GO:0042612 MHC class I protein complex(GO:0042612)
0.4 3.4 GO:0042825 TAP complex(GO:0042825)
0.3 2.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.2 1.4 GO:0070652 HAUS complex(GO:0070652)
0.1 0.8 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 1.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:1990075 periciliary membrane compartment(GO:1990075)
0.0 0.4 GO:0042611 MHC protein complex(GO:0042611)
0.0 0.9 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.6 GO:0030904 retromer complex(GO:0030904)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.7 9.9 GO:0046977 TAP binding(GO:0046977)
0.3 1.7 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.3 7.5 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 0.8 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.2 1.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.7 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.4 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.1 2.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.5 GO:0042605 peptide antigen binding(GO:0042605)
0.1 0.7 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.8 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.5 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.4 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 1.6 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 1.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.6 GO:0051879 Hsp90 protein binding(GO:0051879)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 3.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.4 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.0 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.8 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.1 2.6 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 2.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.9 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.6 REACTOME KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion