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avrg: GFI1 WT vs 36n/n vs KD

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Results for Runx3

Z-value: 1.76

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Transcription factors associated with Runx3

Gene Symbol Gene ID Gene Info
Runx3
ENSMUSG00000070691.11 runt related transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Runx3mm39_v1_chr4_+_134879807_1348798650.761.3e-01Click!

Activity profile of Runx3 motif

Sorted Z-values of Runx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_23882437 5.18 ENSMUST00000102967.3
H4c3
H4 clustered histone 3
chr13_-_23735822 4.62 ENSMUST00000102971.2
H4c6
H4 clustered histone 6
chr13_-_22016364 3.13 ENSMUST00000102979.2
H4c18
H4 clustered histone 18
chr13_+_21919225 3.10 ENSMUST00000087714.6
H4c11
H4 clustered histone 11
chr13_-_21934675 3.05 ENSMUST00000102983.2
H4c12
H4 clustered histone 12
chr6_-_136781406 2.79 ENSMUST00000179285.3
H4f16
H4 histone 16
chr13_-_22225527 1.39 ENSMUST00000102977.4
H4c9
H4 clustered histone 9
chr14_-_98406977 1.00 ENSMUST00000071533.13
ENSMUST00000069334.8
Dach1
dachshund family transcription factor 1
chrX_-_97934387 0.81 ENSMUST00000113826.8
ENSMUST00000033560.9
ENSMUST00000142267.2
Ophn1
oligophrenin 1
chr5_-_36987917 0.80 ENSMUST00000031002.10
Man2b2
mannosidase 2, alpha B2
chr12_+_44315927 0.78 ENSMUST00000043082.16
ENSMUST00000218954.2
Pnpla8
patatin-like phospholipase domain containing 8
chr9_+_106306736 0.73 ENSMUST00000098994.7
ENSMUST00000059802.7
ENSMUST00000213448.2
ENSMUST00000217081.2
Rpl29
ribosomal protein L29
chr2_+_37080286 0.70 ENSMUST00000218602.2
Olfr365
olfactory receptor 365
chr9_+_106306598 0.69 ENSMUST00000150576.8
Rpl29
ribosomal protein L29
chr19_-_20368029 0.57 ENSMUST00000235280.2
Anxa1
annexin A1
chr13_-_115238427 0.56 ENSMUST00000224997.2
ENSMUST00000061673.9
Gm49395
Itga1
predicted gene, 49395
integrin alpha 1
chrX_+_162691978 0.52 ENSMUST00000069041.15
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr16_-_10131804 0.43 ENSMUST00000078357.5
Emp2
epithelial membrane protein 2
chr13_+_38009981 0.42 ENSMUST00000110238.10
Rreb1
ras responsive element binding protein 1
chr10_+_42378193 0.40 ENSMUST00000105499.2
Snx3
sorting nexin 3
chr9_+_109760931 0.39 ENSMUST00000165876.8
Map4
microtubule-associated protein 4
chr15_-_78739717 0.39 ENSMUST00000044584.6
Lgals2
lectin, galactose-binding, soluble 2
chr9_+_109760528 0.38 ENSMUST00000035055.15
Map4
microtubule-associated protein 4
chr14_-_72946972 0.38 ENSMUST00000162478.8
Fndc3a
fibronectin type III domain containing 3A
chr5_+_135382149 0.38 ENSMUST00000111180.9
ENSMUST00000065785.4
Trim50
tripartite motif-containing 50
chr1_-_24139263 0.35 ENSMUST00000187369.7
ENSMUST00000187752.7
ENSMUST00000186999.7
Fam135a
family with sequence similarity 135, member A
chr2_+_145627900 0.34 ENSMUST00000110005.8
ENSMUST00000094480.11
Rin2
Ras and Rab interactor 2
chr4_+_19575128 0.33 ENSMUST00000108253.8
ENSMUST00000029888.4
Rmdn1
regulator of microtubule dynamics 1
chr7_+_126690525 0.29 ENSMUST00000056288.7
ENSMUST00000206102.2
AI467606
expressed sequence AI467606
chr17_+_28547548 0.29 ENSMUST00000233895.2
ENSMUST00000232867.2
Rpl10a
ribosomal protein L10A
chr13_-_51888737 0.24 ENSMUST00000110039.2
Sema4d
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr9_+_109760856 0.21 ENSMUST00000169851.8
Map4
microtubule-associated protein 4
chr18_-_47501513 0.19 ENSMUST00000076043.13
ENSMUST00000135790.8
Sema6a
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr1_+_40505136 0.18 ENSMUST00000087983.8
ENSMUST00000195684.6
ENSMUST00000108044.4
Il18r1
interleukin 18 receptor 1
chr3_-_7678785 0.16 ENSMUST00000194279.6
Il7
interleukin 7
chr16_+_4825216 0.16 ENSMUST00000185147.8
Smim22
small integral membrane protein 22
chr1_-_24139387 0.15 ENSMUST00000027337.15
Fam135a
family with sequence similarity 135, member A
chr9_+_110361561 0.15 ENSMUST00000153838.8
Setd2
SET domain containing 2
chr12_-_98225676 0.15 ENSMUST00000021390.9
Galc
galactosylceramidase
chr17_+_27775471 0.14 ENSMUST00000118599.9
ENSMUST00000232265.2
ENSMUST00000232013.2
ENSMUST00000114888.11
ENSMUST00000231874.2
ENSMUST00000119486.9
ENSMUST00000231825.2
ENSMUST00000231866.2
Hmga1
high mobility group AT-hook 1
chr17_+_28547445 0.14 ENSMUST00000042334.16
Rpl10a
ribosomal protein L10A
chr7_+_28508220 0.11 ENSMUST00000172529.8
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr11_-_5828251 0.11 ENSMUST00000102922.10
Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr10_-_80837173 0.10 ENSMUST00000099462.8
ENSMUST00000118233.8
Gng7
guanine nucleotide binding protein (G protein), gamma 7
chr2_-_28356294 0.08 ENSMUST00000127683.2
ENSMUST00000086370.11
1700007K13Rik
RIKEN cDNA 1700007K13 gene
chr17_-_45744637 0.08 ENSMUST00000024727.10
Cdc5l
cell division cycle 5-like (S. pombe)
chr13_+_14238361 0.07 ENSMUST00000129488.8
ENSMUST00000110536.8
ENSMUST00000110534.8
ENSMUST00000039538.15
ENSMUST00000110533.2
Arid4b
AT rich interactive domain 4B (RBP1-like)
chr15_-_95553841 0.07 ENSMUST00000054244.7
Dbx2
developing brain homeobox 2
chr5_-_21629661 0.06 ENSMUST00000115245.8
ENSMUST00000030552.7
Ccdc146
coiled-coil domain containing 146
chr6_+_115908709 0.06 ENSMUST00000032471.9
Rho
rhodopsin
chr1_-_154602102 0.06 ENSMUST00000187541.7
Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr13_+_46822992 0.06 ENSMUST00000099547.4
Fam8a1
family with sequence similarity 8, member A1
chr1_+_82938007 0.06 ENSMUST00000223536.2
Gm47955
predicted gene, 47955
chr7_-_141710850 0.06 ENSMUST00000209599.2
Gm29735
predicted gene, 29735
chr10_-_128133953 0.05 ENSMUST00000026449.3
Il23a
interleukin 23, alpha subunit p19
chr2_+_155359868 0.05 ENSMUST00000029135.15
ENSMUST00000065973.9
Acss2
acyl-CoA synthetase short-chain family member 2
chr13_+_38009951 0.05 ENSMUST00000138043.8
Rreb1
ras responsive element binding protein 1
chr6_+_21949570 0.05 ENSMUST00000031680.10
ENSMUST00000115389.8
ENSMUST00000151473.8
Ing3
inhibitor of growth family, member 3
chr17_-_23818458 0.04 ENSMUST00000057029.5
Zfp13
zinc finger protein 13
chr9_-_58065800 0.04 ENSMUST00000168864.4
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr2_-_71377088 0.04 ENSMUST00000024159.8
Dlx2
distal-less homeobox 2
chr6_-_135231168 0.04 ENSMUST00000111909.8
Gsg1
germ cell associated 1
chr10_+_79590910 0.03 ENSMUST00000219981.2
ENSMUST00000219228.2
ENSMUST00000020577.4
Fgf22
fibroblast growth factor 22
chr7_-_44624165 0.03 ENSMUST00000212836.2
ENSMUST00000212255.2
ENSMUST00000063761.8
Cpt1c
carnitine palmitoyltransferase 1c
chrX_-_146337046 0.03 ENSMUST00000112819.9
ENSMUST00000136789.8
Lrch2
leucine-rich repeats and calponin homology (CH) domain containing 2
chr7_+_141755098 0.03 ENSMUST00000187512.2
ENSMUST00000084414.6
Krtap5-3
keratin associated protein 5-3
chr8_+_27937691 0.02 ENSMUST00000081321.5
Poteg
POTE ankyrin domain family, member G
chr2_+_85822163 0.02 ENSMUST00000050942.3
Olfr1031
olfactory receptor 1031
chr7_-_141698342 0.02 ENSMUST00000210537.2
Gm45337
predicted gene 45337
chr12_+_103277234 0.02 ENSMUST00000191218.7
Fam181a
family with sequence similarity 181, member A
chr11_-_32217547 0.02 ENSMUST00000109389.9
ENSMUST00000129010.2
ENSMUST00000020530.12
Nprl3
nitrogen permease regulator-like 3
chr9_+_121548469 0.02 ENSMUST00000182225.8
Nktr
natural killer tumor recognition sequence
chr4_-_133225849 0.02 ENSMUST00000125541.2
Trnp1
TMF1-regulated nuclear protein 1
chr18_-_50701793 0.02 ENSMUST00000056460.4
Pudp
pseudouridine 5'-phosphatase
chr1_-_82921109 0.02 ENSMUST00000222600.2
A030003K21Rik
RIKEN cDNA A030003K21 gene
chr3_-_7678796 0.02 ENSMUST00000192202.6
Il7
interleukin 7
chr4_-_70328659 0.01 ENSMUST00000144099.8
Cdk5rap2
CDK5 regulatory subunit associated protein 2
chr15_+_98953776 0.01 ENSMUST00000229268.2
Prph
peripherin
chr1_+_82902636 0.01 ENSMUST00000223400.2
A030014E15Rik
RIKEN cDNA A030014E15 gene
chr4_+_134070492 0.01 ENSMUST00000105873.8
ENSMUST00000105874.9
Slc30a2
solute carrier family 30 (zinc transporter), member 2
chr11_-_100098333 0.01 ENSMUST00000007272.8
Krt14
keratin 14
chr16_-_20972750 0.01 ENSMUST00000170665.3
Teddm3
transmembrane epididymal family member 3
chr2_+_155360015 0.01 ENSMUST00000103142.12
Acss2
acyl-CoA synthetase short-chain family member 2
chr1_+_74317709 0.01 ENSMUST00000077985.4
Gpbar1
G protein-coupled bile acid receptor 1
chr9_+_58395850 0.01 ENSMUST00000085658.5
Insyn1
inhibitory synaptic factor 1
chr8_-_55177510 0.00 ENSMUST00000175915.8
Wdr17
WD repeat domain 17
chrY_-_6917117 0.00 ENSMUST00000178016.2
Gm20830
predicted gene, 20830
chr2_+_157756535 0.00 ENSMUST00000109523.2
Vstm2l
V-set and transmembrane domain containing 2-like
chr7_-_141794815 0.00 ENSMUST00000211591.2
Gm40460
predicted gene, 40460
chr11_-_57722830 0.00 ENSMUST00000036917.3
Hand1
heart and neural crest derivatives expressed 1
chr7_-_25516041 0.00 ENSMUST00000043314.10
Cyp2s1
cytochrome P450, family 2, subfamily s, polypeptide 1
chr7_+_106507208 0.00 ENSMUST00000215949.2
ENSMUST00000207492.3
Olfr1532-ps1
olfactory receptor 1532, pseudogene 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.2 1.0 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 1.0 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.4 GO:0070676 intralumenal vesicle formation(GO:0070676) negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 0.6 GO:0097350 neutrophil clearance(GO:0097350)
0.1 0.2 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 0.8 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.4 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.0 0.1 GO:0035441 cell migration involved in vasculogenesis(GO:0035441)
0.0 0.4 GO:2001212 caveola assembly(GO:0070836) regulation of vasculogenesis(GO:2001212)
0.0 0.0 GO:0010726 positive regulation of hydrogen peroxide metabolic process(GO:0010726)
0.0 0.6 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.1 GO:0019413 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate biosynthetic process(GO:0019542)
0.0 0.1 GO:2000328 positive regulation of memory T cell differentiation(GO:0043382) regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.0 1.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 1.3 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 0.1 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.2 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655)
0.0 0.1 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.3 GO:0000470 maturation of LSU-rRNA(GO:0000470)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.1 1.4 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.6 GO:0042629 mast cell granule(GO:0042629)
0.0 0.4 GO:0032009 early phagosome(GO:0032009)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.6 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.8 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.1 0.6 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.8 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.2 GO:0042008 interleukin-18 receptor activity(GO:0042008)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.8 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.8 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation