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avrg: GFI1 WT vs 36n/n vs KD

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Results for Smad2

Z-value: 0.56

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Transcription factors associated with Smad2

Gene Symbol Gene ID Gene Info
Smad2
ENSMUSG00000024563.17 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad2mm39_v1_chr18_+_76374959_76375117-0.856.5e-02Click!

Activity profile of Smad2 motif

Sorted Z-values of Smad2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_23936250 1.03 ENSMUST00000091703.3
H3c2
H3 clustered histone 2
chr2_-_143853122 0.45 ENSMUST00000016072.12
ENSMUST00000037875.6
Rrbp1
ribosome binding protein 1
chr10_-_49664839 0.35 ENSMUST00000220263.2
ENSMUST00000218823.2
Grik2
glutamate receptor, ionotropic, kainate 2 (beta 2)
chr12_-_113271532 0.29 ENSMUST00000192188.3
ENSMUST00000103418.3
Ighg2b
immunoglobulin heavy constant gamma 2B
chr4_+_83335947 0.29 ENSMUST00000030206.10
ENSMUST00000071544.11
Snapc3
small nuclear RNA activating complex, polypeptide 3
chr7_+_142030744 0.28 ENSMUST00000149521.8
Lsp1
lymphocyte specific 1
chr6_-_124733441 0.26 ENSMUST00000088357.12
Atn1
atrophin 1
chr12_+_33197776 0.26 ENSMUST00000125192.9
ENSMUST00000136644.8
Atxn7l1
ataxin 7-like 1
chr8_+_91635192 0.24 ENSMUST00000211403.2
Chd9
chromodomain helicase DNA binding protein 9
chr12_+_33197753 0.23 ENSMUST00000146040.9
Atxn7l1
ataxin 7-like 1
chr3_+_135143910 0.23 ENSMUST00000196446.5
ENSMUST00000106291.10
ENSMUST00000199613.5
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr13_-_100240570 0.22 ENSMUST00000038104.12
Bdp1
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chr16_-_17540805 0.21 ENSMUST00000012259.9
ENSMUST00000232236.2
Med15
mediator complex subunit 15
chr3_+_135144304 0.19 ENSMUST00000198685.5
ENSMUST00000197859.5
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr12_-_113294138 0.19 ENSMUST00000194304.6
ENSMUST00000103420.3
Ighg1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_75864195 0.17 ENSMUST00000038563.14
ENSMUST00000167078.8
ENSMUST00000117242.8
Golim4
golgi integral membrane protein 4
chr8_+_66838927 0.15 ENSMUST00000039540.12
ENSMUST00000110253.3
Marchf1
membrane associated ring-CH-type finger 1
chr9_+_110074574 0.13 ENSMUST00000197850.5
Cspg5
chondroitin sulfate proteoglycan 5
chr6_-_113354826 0.13 ENSMUST00000032410.14
Tada3
transcriptional adaptor 3
chr1_-_160079007 0.12 ENSMUST00000191909.6
Rabgap1l
RAB GTPase activating protein 1-like
chr6_+_54017063 0.12 ENSMUST00000127323.3
Chn2
chimerin 2
chr3_+_135144202 0.10 ENSMUST00000166033.6
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr9_-_65487322 0.10 ENSMUST00000068944.9
Plekho2
pleckstrin homology domain containing, family O member 2
chr17_-_24752683 0.10 ENSMUST00000061764.14
Rab26
RAB26, member RAS oncogene family
chr8_-_106363982 0.09 ENSMUST00000182863.2
ENSMUST00000194091.6
Gm5914
Agrp
predicted gene 5914
agouti related neuropeptide
chr4_+_42950367 0.09 ENSMUST00000084662.12
Dnajb5
DnaJ heat shock protein family (Hsp40) member B5
chr6_-_90758954 0.09 ENSMUST00000238821.2
Iqsec1
IQ motif and Sec7 domain 1
chr7_-_44702269 0.08 ENSMUST00000057293.8
Prr12
proline rich 12
chr9_+_123307758 0.08 ENSMUST00000026269.4
Limd1
LIM domains containing 1
chr3_+_135144287 0.08 ENSMUST00000196591.5
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr16_+_18166045 0.08 ENSMUST00000239533.1
ENSMUST00000239534.1
ARVCF
armadillo repeat deleted in velocardiofacial syndrome
chr6_+_54016543 0.07 ENSMUST00000046856.14
Chn2
chimerin 2
chr6_-_142647944 0.07 ENSMUST00000100827.5
ENSMUST00000087527.11
Abcc9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr14_-_20546848 0.06 ENSMUST00000022353.5
Mss51
MSS51 mitochondrial translational activator
chr17_+_36176485 0.06 ENSMUST00000127442.8
ENSMUST00000144382.8
Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr17_+_36176948 0.05 ENSMUST00000122899.8
Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr2_-_148285450 0.05 ENSMUST00000099269.4
Cd93
CD93 antigen
chr2_+_38229270 0.05 ENSMUST00000143783.9
Lhx2
LIM homeobox protein 2
chr2_-_34262012 0.05 ENSMUST00000113132.9
ENSMUST00000040638.15
Pbx3
pre B cell leukemia homeobox 3
chr4_+_11191354 0.04 ENSMUST00000170901.8
Ccne2
cyclin E2
chr14_+_4137837 0.04 ENSMUST00000022296.7
Ube2e1
ubiquitin-conjugating enzyme E2E 1
chr5_-_146521629 0.04 ENSMUST00000200112.2
ENSMUST00000197431.2
ENSMUST00000197825.2
Gpr12
G-protein coupled receptor 12
chr17_-_34834938 0.04 ENSMUST00000097345.10
ENSMUST00000015611.14
Egfl8
EGF-like domain 8
chr6_-_142647985 0.04 ENSMUST00000205202.3
ENSMUST00000073173.12
ENSMUST00000111771.8
Abcc9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr7_-_126062272 0.03 ENSMUST00000032974.13
Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr15_-_84007373 0.03 ENSMUST00000230566.2
ENSMUST00000019012.4
Pnpla5
patatin-like phospholipase domain containing 5
chr15_+_82136598 0.02 ENSMUST00000136948.3
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr4_+_117706390 0.02 ENSMUST00000132043.9
ENSMUST00000169990.8
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr18_-_42712717 0.02 ENSMUST00000054738.5
Gpr151
G protein-coupled receptor 151
chr12_+_51640097 0.02 ENSMUST00000164782.10
ENSMUST00000085412.7
Coch
cochlin
chr17_+_3447465 0.02 ENSMUST00000072156.7
Tiam2
T cell lymphoma invasion and metastasis 2
chrX_-_20797736 0.02 ENSMUST00000001156.8
Cfp
complement factor properdin
chr1_-_150868802 0.01 ENSMUST00000074783.12
ENSMUST00000137197.9
Hmcn1
hemicentin 1
chr16_-_34334314 0.01 ENSMUST00000151491.8
ENSMUST00000114960.9
Kalrn
kalirin, RhoGEF kinase
chr4_+_117692583 0.01 ENSMUST00000169885.8
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr19_+_5928649 0.01 ENSMUST00000136833.8
ENSMUST00000141362.2
Slc25a45
solute carrier family 25, member 45
chr3_+_135144481 0.01 ENSMUST00000199582.5
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr6_+_30639217 0.01 ENSMUST00000031806.10
Cpa1
carboxypeptidase A1, pancreatic
chr4_-_126056412 0.00 ENSMUST00000094760.9
Sh3d21
SH3 domain containing 21
chr16_-_34334454 0.00 ENSMUST00000089655.12
Kalrn
kalirin, RhoGEF kinase
chr4_+_115741581 0.00 ENSMUST00000097918.3
Kncn
kinocilin
chr9_+_101815680 0.00 ENSMUST00000112841.2
9630041A04Rik
RIKEN cDNA 9630041A04 gene
chr11_+_63022328 0.00 ENSMUST00000018361.10
Pmp22
peripheral myelin protein 22
chr4_-_126057263 0.00 ENSMUST00000097891.4
Sh3d21
SH3 domain containing 21
chr1_-_173195236 0.00 ENSMUST00000005470.5
ENSMUST00000111220.8
Cadm3
cell adhesion molecule 3
chr10_-_77533067 0.00 ENSMUST00000220084.2
Gm9508
predicted gene 9508
chr11_+_69737437 0.00 ENSMUST00000152566.8
ENSMUST00000108633.9
Plscr3
phospholipid scramblase 3
chr17_-_34834745 0.00 ENSMUST00000168353.4
Egfl8
EGF-like domain 8

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.3 GO:0009405 pathogenesis(GO:0009405)
0.0 0.3 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.0 GO:0090076 maintenance of mitochondrion location(GO:0051659) relaxation of skeletal muscle(GO:0090076)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.2 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.1 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0019002 GMP binding(GO:0019002)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors