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avrg: GFI1 WT vs 36n/n vs KD

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Results for Smad4

Z-value: 3.17

Motif logo

Transcription factors associated with Smad4

Gene Symbol Gene ID Gene Info
ENSMUSG00000024515.14 SMAD family member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad4mm39_v1_chr18_-_73836810_738368770.866.2e-02Click!

Activity profile of Smad4 motif

Sorted Z-values of Smad4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_23765546 5.96 ENSMUST00000102968.3
H4 clustered histone 4
chr13_+_22227359 5.93 ENSMUST00000110452.2
H2B clustered histone 11
chr13_+_23715220 5.55 ENSMUST00000102972.6
H4 clustered histone 8
chr13_-_23735822 5.42 ENSMUST00000102971.2
H4 clustered histone 6
chr3_-_96128196 5.15 ENSMUST00000090782.4
H2A clustered histone 20
chr13_-_22016364 5.02 ENSMUST00000102979.2
H4 clustered histone 18
chr13_+_21995906 4.53 ENSMUST00000104941.4
H4 clustered histone 17
chr15_+_102885467 3.65 ENSMUST00000001706.7
homeobox C9
chrX_-_71318353 3.64 ENSMUST00000064780.4
gamma-aminobutyric acid (GABA) A receptor, subunit epsilon
chr13_-_24118139 2.86 ENSMUST00000052776.4
H2B clustered histone 1
chr13_-_22227114 2.72 ENSMUST00000091741.6
H2A clustered histone 11
chr11_-_69304501 2.43 ENSMUST00000094077.5
KDM1 lysine (K)-specific demethylase 6B
chr1_-_74130488 2.35 ENSMUST00000187584.7
tensin 1
chr2_-_121211410 1.83 ENSMUST00000038389.15
stereocilin
chr7_+_119495058 1.59 ENSMUST00000106518.9
ENSMUST00000207270.2
ENSMUST00000208424.2
ENSMUST00000208202.2
ENSMUST00000054440.11
LYR motif containing 1
chr15_+_6599001 1.54 ENSMUST00000227175.2
FYN binding protein
chr9_-_49710058 1.46 ENSMUST00000192584.2
ENSMUST00000166811.9
neural cell adhesion molecule 1
chr5_+_23639432 1.43 ENSMUST00000094962.9
ENSMUST00000115128.8
lysine (K)-specific methyltransferase 2E
chr11_+_105866030 1.35 ENSMUST00000001964.8
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr19_+_4282487 1.27 ENSMUST00000235306.2
polymerase (DNA-directed), delta 4
chrX_+_158491589 1.21 ENSMUST00000080394.13
SH3-domain kinase binding protein 1
chr9_-_49710190 1.19 ENSMUST00000114476.8
ENSMUST00000193547.6
neural cell adhesion molecule 1
chr1_+_59802543 1.17 ENSMUST00000087435.7
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr1_+_176642226 1.16 ENSMUST00000056773.15
ENSMUST00000027785.15
serologically defined colon cancer antigen 8
chr1_-_176641607 1.16 ENSMUST00000195717.6
ENSMUST00000192961.6
centrosomal protein 170
chr19_+_4147391 1.12 ENSMUST00000174514.2
ENSMUST00000174149.8
CDK2-associated protein 2
chr16_+_43067641 1.11 ENSMUST00000079441.13
ENSMUST00000114691.8
zinc finger and BTB domain containing 20
chr3_-_102871440 1.11 ENSMUST00000058899.13
nuclear receptor subfamily 1, group H, member 5
chr6_-_149003003 1.10 ENSMUST00000127727.2
DENN/MADD domain containing 5B
chr4_-_119047167 1.10 ENSMUST00000030396.15
erythroblast membrane-associated protein
chr4_-_119047202 1.07 ENSMUST00000239029.2
ENSMUST00000138395.9
ENSMUST00000156746.3
erythroblast membrane-associated protein
chr4_-_148215135 1.02 ENSMUST00000030862.5
dorsal inhibitory axon guidance protein
chr13_-_42000958 0.98 ENSMUST00000072012.10
androgen dependent TFPI regulating protein
chr15_-_103231921 0.91 ENSMUST00000229551.2
zinc finger protein 385A
chr19_-_40260060 0.89 ENSMUST00000068439.13
PDZ and LIM domain 1 (elfin)
chr3_+_63203235 0.87 ENSMUST00000194134.6
membrane metallo endopeptidase
chr7_+_25386418 0.82 ENSMUST00000002678.10
transforming growth factor, beta 1
chr2_+_152578164 0.81 ENSMUST00000038368.9
ENSMUST00000109824.2
inhibitor of DNA binding 1, HLH protein
chr2_+_29759495 0.79 ENSMUST00000047521.7
ENSMUST00000134152.2
cerebral endothelial cell adhesion molecule
chrX_-_7537580 0.79 ENSMUST00000033486.6
proteolipid protein 2
chr19_+_4281953 0.78 ENSMUST00000025773.5
polymerase (DNA-directed), delta 4
chr2_-_45001141 0.78 ENSMUST00000201969.4
ENSMUST00000201623.4
zinc finger E-box binding homeobox 2
chr16_-_44978546 0.77 ENSMUST00000114600.2
solute carrier family 35, member A5
chr11_-_4110286 0.76 ENSMUST00000093381.11
ENSMUST00000101626.9
coiled-coil domain containing 157
chr4_+_150171822 0.72 ENSMUST00000094451.4
G protein-coupled receptor 157
chr4_-_148584906 0.69 ENSMUST00000030840.4
angiopoietin-like 7
chr15_-_103161237 0.68 ENSMUST00000154510.8
nuclear factor, erythroid derived 2
chr2_+_111205867 0.68 ENSMUST00000062407.6
olfactory receptor 1284
chr4_+_42950367 0.62 ENSMUST00000084662.12
DnaJ heat shock protein family (Hsp40) member B5
chr7_+_101010447 0.61 ENSMUST00000137384.8
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr14_+_76652369 0.61 ENSMUST00000110888.8
TSC22 domain family, member 1
chr2_-_155676765 0.60 ENSMUST00000029143.7
ENSMUST00000239423.2
family with sequence similarity 83, member C
chr17_-_30107544 0.60 ENSMUST00000171691.9
MAM domain containing glycosylphosphatidylinositol anchor 1
chr6_+_54016543 0.59 ENSMUST00000046856.14
chimerin 2
chr9_+_61280501 0.58 ENSMUST00000162583.8
ENSMUST00000161993.8
ENSMUST00000160882.8
ENSMUST00000160724.8
ENSMUST00000162973.8
ENSMUST00000159050.8
transducin-like enhancer of split 3
chr7_+_127084283 0.58 ENSMUST00000048896.8
fibrosin
chr9_+_61280764 0.57 ENSMUST00000160541.8
ENSMUST00000161207.8
ENSMUST00000159630.8
transducin-like enhancer of split 3
chr11_+_59433554 0.57 ENSMUST00000149126.2
NLR family, pyrin domain containing 3
chr12_+_36431449 0.53 ENSMUST00000221452.2
ENSMUST00000062041.6
ENSMUST00000220519.2
ENSMUST00000221895.2
CDP-L-ribitol pyrophosphorylase A
chr6_-_90758954 0.52 ENSMUST00000238821.2
IQ motif and Sec7 domain 1
chr3_-_96833336 0.51 ENSMUST00000062944.7
gap junction protein, alpha 8
chr7_+_55417967 0.51 ENSMUST00000060416.15
ENSMUST00000094360.13
ENSMUST00000165045.9
ENSMUST00000173835.2
sialic acid binding Ig-like lectin H
chrX_+_150586309 0.50 ENSMUST00000026292.15
HECT, UBA and WWE domain containing 1
chr7_+_44865177 0.49 ENSMUST00000033060.14
ENSMUST00000210447.2
ENSMUST00000211744.2
ENSMUST00000107801.10
TEA domain family member 2
chr14_+_65187485 0.49 ENSMUST00000043914.8
ENSMUST00000239450.2
integrator complex subunit 9
chr9_+_61280890 0.48 ENSMUST00000161689.8
transducin-like enhancer of split 3
chr11_-_106050927 0.47 ENSMUST00000045923.10
LIM domain containing 2
chr5_-_137739364 0.47 ENSMUST00000149512.3
neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1
chrX_-_37653396 0.46 ENSMUST00000016681.15
cullin 4B
chr5_+_64960705 0.45 ENSMUST00000165536.8
Kruppel-like factor 3 (basic)
chr5_+_120569764 0.43 ENSMUST00000031591.10
LIM homeobox protein 5
chr2_+_96148418 0.42 ENSMUST00000135431.8
ENSMUST00000162807.9
leucine rich repeat containing 4C
chr11_-_5394838 0.42 ENSMUST00000109867.8
ENSMUST00000143746.3
zinc and ring finger 3
chr6_+_54017063 0.41 ENSMUST00000127323.3
chimerin 2
chr11_+_4110346 0.40 ENSMUST00000002198.4
splicing factor 3a, subunit 1
chr15_-_96358612 0.39 ENSMUST00000047835.8
SR-related CTD-associated factor 11
chr6_-_129428869 0.38 ENSMUST00000203162.3
C-type lectin domain family 1, member a
chr1_+_63655127 0.38 ENSMUST00000226288.2
predicted gene, 39653
chr1_-_133728779 0.36 ENSMUST00000143567.8
ATPase, Ca++ transporting, plasma membrane 4
chr11_-_3454766 0.36 ENSMUST00000044507.12
inositol polyphosphate 5-phosphatase J
chr19_-_40260286 0.36 ENSMUST00000182432.2
PDZ and LIM domain 1 (elfin)
chr14_-_65187076 0.36 ENSMUST00000176832.8
homeobox containing 1
chr15_-_38299934 0.36 ENSMUST00000228772.2
Kruppel-like factor 10
chr4_+_97660971 0.36 ENSMUST00000152023.8
nuclear factor I/A
chr15_-_38300937 0.35 ENSMUST00000227920.2
ENSMUST00000074043.7
ENSMUST00000228416.2
Kruppel-like factor 10
chr14_-_65187287 0.35 ENSMUST00000067843.10
ENSMUST00000176489.8
ENSMUST00000175905.8
ENSMUST00000022544.14
ENSMUST00000175744.8
ENSMUST00000176128.8
homeobox containing 1
chr19_+_5790918 0.35 ENSMUST00000081496.6
latent transforming growth factor beta binding protein 3
chr15_+_81820954 0.35 ENSMUST00000038757.8
ENSMUST00000230633.2
cold shock domain containing C2, RNA binding
chr17_-_35381945 0.34 ENSMUST00000174805.2
proline-rich coiled-coil 2A
chr14_+_4137837 0.34 ENSMUST00000022296.7
ubiquitin-conjugating enzyme E2E 1
chr7_-_4781140 0.33 ENSMUST00000094892.12
interleukin 11
chr13_+_24685508 0.33 ENSMUST00000238974.2
RHO family interacting cell polarization regulator 2
chr1_-_64160557 0.32 ENSMUST00000055001.10
ENSMUST00000114086.8
Kruppel-like factor 7 (ubiquitous)
chr10_+_33780993 0.30 ENSMUST00000169670.8
radial spoke head 4 homolog A (Chlamydomonas)
chr5_+_65694687 0.30 ENSMUST00000200946.3
ENSMUST00000201383.2
ubiquitin-conjugating enzyme E2K
chr5_+_65694598 0.29 ENSMUST00000201266.4
ENSMUST00000201292.4
ENSMUST00000201984.4
ENSMUST00000202679.4
ENSMUST00000202082.4
ubiquitin-conjugating enzyme E2K
chr7_+_116980173 0.29 ENSMUST00000032892.7
xylosyltransferase 1
chr5_+_111565129 0.28 ENSMUST00000094463.5
meningioma 1
chr5_+_117979899 0.28 ENSMUST00000142742.9
nitric oxide synthase 1, neuronal
chr17_-_47169380 0.28 ENSMUST00000233455.2
BRD4 interacting chromatin remodeling complex associated protein like
chr10_+_79986988 0.28 ENSMUST00000146516.8
ENSMUST00000144526.2
midnolin
chr11_-_3881995 0.27 ENSMUST00000020710.11
ENSMUST00000109989.10
ENSMUST00000109991.8
ENSMUST00000109993.9
transcobalamin 2
chr4_+_132738787 0.26 ENSMUST00000105915.8
ENSMUST00000105916.8
AT hook, DNA binding motif, containing 1
chr18_-_33596890 0.26 ENSMUST00000237066.2
neuronal regeneration related protein
chr5_+_65694552 0.24 ENSMUST00000142407.8
ubiquitin-conjugating enzyme E2K
chr17_+_38082190 0.24 ENSMUST00000217119.2
olfactory receptor 122
chr11_-_3881789 0.23 ENSMUST00000109992.8
ENSMUST00000109988.2
transcobalamin 2
chr11_+_11414256 0.23 ENSMUST00000020410.11
spermatogenesis associated 48
chr11_-_118233326 0.23 ENSMUST00000103024.4
CEP295 N-terminal like
chr11_+_101875095 0.22 ENSMUST00000176722.8
ENSMUST00000175972.2
CFAP97 domain containing 1
chr11_-_3881960 0.22 ENSMUST00000109990.8
transcobalamin 2
chr16_+_34605282 0.21 ENSMUST00000023538.9
myosin, light polypeptide kinase
chr6_+_121320008 0.21 ENSMUST00000166457.8
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr2_+_70393782 0.20 ENSMUST00000123330.3
glutamate decarboxylase 1
chr19_-_10716335 0.20 ENSMUST00000025571.9
ENSMUST00000238167.2
CD5 antigen
chr12_-_109566764 0.19 ENSMUST00000149046.4
retrotransposon Gaglike 1
chr15_+_82230155 0.19 ENSMUST00000023086.15
single-pass membrane protein with aspartate rich tail 1
chr6_+_38410848 0.18 ENSMUST00000160583.8
ubinuclein 2
chrX_-_149371067 0.18 ENSMUST00000140207.8
ENSMUST00000112719.2
ENSMUST00000112727.10
ENSMUST00000112721.10
ENSMUST00000026303.16
apurinic/apyrimidinic endonuclease 2
chr6_-_30693675 0.18 ENSMUST00000169422.8
ENSMUST00000115131.8
ENSMUST00000115130.3
ENSMUST00000031810.15
centrosomal protein 41
chr11_-_101062111 0.18 ENSMUST00000164474.8
ENSMUST00000043397.14
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr14_-_30890544 0.18 ENSMUST00000036618.14
stabilin 1
chr14_-_25903524 0.18 ENSMUST00000052286.16
placenta specific 9a
chr14_-_20546848 0.18 ENSMUST00000022353.5
MSS51 mitochondrial translational activator
chr11_+_53324126 0.17 ENSMUST00000018382.7
growth differentiation factor 9
chr16_+_43056218 0.17 ENSMUST00000146708.8
zinc finger and BTB domain containing 20
chr11_+_69737437 0.17 ENSMUST00000152566.8
ENSMUST00000108633.9
phospholipid scramblase 3
chr7_-_131918926 0.17 ENSMUST00000080215.6
carbohydrate sulfotransferase 15
chr7_-_70010341 0.16 ENSMUST00000032768.15
nuclear receptor subfamily 2, group F, member 2
chr6_+_68414401 0.15 ENSMUST00000103324.3
immunoglobulin kappa chain variable 15-103
chr1_-_57010921 0.15 ENSMUST00000114415.10
special AT-rich sequence binding protein 2
chr9_+_21336300 0.15 ENSMUST00000172482.8
ENSMUST00000174050.8
dynamin 2
chr7_-_119494669 0.15 ENSMUST00000098080.9
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr11_-_103099349 0.15 ENSMUST00000174567.3
ENSMUST00000021323.11
ENSMUST00000107026.9
EF-hand calcium binding domain 15
chr13_-_42001102 0.14 ENSMUST00000121404.8
androgen dependent TFPI regulating protein
chr4_+_130640611 0.14 ENSMUST00000156225.8
ENSMUST00000156742.8
lysosomal-associated protein transmembrane 5
chr18_-_33596792 0.14 ENSMUST00000051087.16
neuronal regeneration related protein
chr7_-_119494918 0.14 ENSMUST00000059851.14
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr3_-_135397298 0.13 ENSMUST00000029812.14
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chr11_-_115310743 0.12 ENSMUST00000106537.8
ENSMUST00000043931.9
ENSMUST00000073791.10
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D
chr6_+_125122172 0.12 ENSMUST00000119527.8
ENSMUST00000117675.8
intermediate filament family orphan 1
chr7_+_4693759 0.11 ENSMUST00000048248.9
BR serine/threonine kinase 1
chr17_+_75485791 0.11 ENSMUST00000135447.8
ENSMUST00000112516.8
latent transforming growth factor beta binding protein 1
chr2_+_31530049 0.11 ENSMUST00000113470.3
PR domain containing 12
chr17_-_25300112 0.11 ENSMUST00000024984.7
transmembrane protein 204
chr3_+_60436570 0.11 ENSMUST00000192607.6
muscleblind like splicing factor 1
chrX_-_7765171 0.10 ENSMUST00000115655.8
ENSMUST00000156741.8
polyglutamine binding protein 1
chr17_+_34482183 0.10 ENSMUST00000040828.7
ENSMUST00000237342.2
ENSMUST00000237866.2
histocompatibility 2, class II antigen A, beta 1
chr17_+_34372046 0.10 ENSMUST00000114232.4
histocompatibility 2, class II, locus Mb1
chr7_-_126496534 0.09 ENSMUST00000120007.8
transmembrane protein 219
chr7_+_45434755 0.09 ENSMUST00000233503.2
ENSMUST00000120005.10
ENSMUST00000211609.2
lemur tyrosine kinase 3
chr2_+_125876566 0.09 ENSMUST00000064794.14
fibroblast growth factor 7
chr8_-_41469786 0.08 ENSMUST00000117735.8
mitochondrial tumor suppressor 1
chr12_-_112766266 0.08 ENSMUST00000239525.1
AHNAK nucleoprotein 2
chr17_-_90395771 0.08 ENSMUST00000197268.5
ENSMUST00000173917.8
neurexin I
chr4_+_127881786 0.08 ENSMUST00000184063.3
CUB and Sushi multiple domains 2
chr14_-_55762432 0.07 ENSMUST00000062232.15
neural retina leucine zipper gene
chr3_-_116762617 0.07 ENSMUST00000143611.2
ENSMUST00000040097.14
palmdelphin
chr15_+_102012782 0.07 ENSMUST00000230474.2
tensin 2
chr14_-_55762416 0.07 ENSMUST00000178694.3
neural retina leucine zipper gene
chr11_+_95715295 0.07 ENSMUST00000150134.2
ENSMUST00000054173.4
phosphatase, orphan 1
chr7_-_30062197 0.07 ENSMUST00000046351.7
leucine rich repeat and fibronectin type III domain containing 3
chr10_-_127370408 0.07 ENSMUST00000095266.3
neurexophilin 4
chr7_+_143729250 0.07 ENSMUST00000105900.9
SH3 and multiple ankyrin repeat domains 2
chr9_-_58065800 0.06 ENSMUST00000168864.4
immunoglobulin superfamily containing leucine-rich repeat
chr8_-_49008305 0.06 ENSMUST00000110346.9
ENSMUST00000211976.2
teneurin transmembrane protein 3
chr1_-_74627264 0.06 ENSMUST00000066986.13
zinc finger protein 142
chr11_+_115331365 0.06 ENSMUST00000093914.5
tripartite motif-containing 80
chr6_+_113448388 0.06 ENSMUST00000058300.14
interleukin 17 receptor C
chr2_+_125876883 0.06 ENSMUST00000110442.2
fibroblast growth factor 7
chr12_+_113453131 0.06 ENSMUST00000063317.4
a disintegrin and metallopeptidase domain 6B
chr15_+_89417017 0.06 ENSMUST00000167173.2
SH3 and multiple ankyrin repeat domains 3
chr2_+_70393195 0.06 ENSMUST00000130998.8
glutamate decarboxylase 1
chr11_+_59995796 0.06 ENSMUST00000064190.13
retinoic acid induced 1
chr8_+_96078886 0.06 ENSMUST00000034243.7
matrix metallopeptidase 15
chr3_-_116762476 0.06 ENSMUST00000119557.8
palmdelphin
chr7_-_45519853 0.05 ENSMUST00000211713.2
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
chr9_+_122717536 0.05 ENSMUST00000063980.8
zinc finger with KRAB and SCAN domains 7
chr2_+_31777273 0.05 ENSMUST00000138325.8
ENSMUST00000028187.7
laminin gamma 3
chr18_+_60659257 0.04 ENSMUST00000223984.2
ENSMUST00000025505.7
ENSMUST00000223590.2
dynactin 4
chr7_+_6572992 0.04 ENSMUST00000070985.4
olfactory receptor 1350
chr15_+_102011352 0.04 ENSMUST00000169627.9
tensin 2
chr5_-_41921834 0.04 ENSMUST00000060820.8
NK3 homeobox 2
chr8_+_79754980 0.04 ENSMUST00000087927.11
ENSMUST00000098614.9
zinc finger protein 827
chr18_+_69479211 0.03 ENSMUST00000201235.4
transcription factor 4
chr17_+_75485906 0.03 ENSMUST00000112514.2
latent transforming growth factor beta binding protein 1
chr5_+_73164226 0.03 ENSMUST00000031127.11
ENSMUST00000201304.2
solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chr1_+_162466717 0.03 ENSMUST00000028020.11
myocilin
chr4_+_130640436 0.03 ENSMUST00000151698.8
lysosomal-associated protein transmembrane 5
chr7_+_45063079 0.03 ENSMUST00000058879.8
neurotrophin 5
chr5_+_20112771 0.03 ENSMUST00000200443.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr4_-_137309415 0.03 ENSMUST00000238941.2
low density lipoprotein receptor class A domain containing 2
chr2_+_36827133 0.03 ENSMUST00000095021.2
olfactory receptor 356
chr1_-_180524587 0.03 ENSMUST00000027778.8
Mix1 homeobox-like 1 (Xenopus laevis)
chr14_+_53913598 0.03 ENSMUST00000103662.6
T cell receptor alpha variable 9-4
chr7_+_45055077 0.03 ENSMUST00000107774.3
potassium voltage-gated channel, shaker-related subfamily, member 7
chr5_-_49682106 0.02 ENSMUST00000176191.8
Kv channel interacting protein 4
chr15_-_103275190 0.02 ENSMUST00000023128.8
integrin alpha 5 (fibronectin receptor alpha)
chr3_+_63203516 0.02 ENSMUST00000029400.7
membrane metallo endopeptidase
chr1_-_87029312 0.02 ENSMUST00000113270.3
alkaline phosphatase, intestinal

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.6 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.4 1.3 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.4 1.2 GO:2000137 negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137) cell proliferation involved in heart valve development(GO:2000793)
0.3 0.3 GO:1902462 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.3 2.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.3 0.8 GO:0019049 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.2 0.9 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.2 0.6 GO:1901204 regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.1 0.9 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 0.6 GO:2000321 positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.1 0.4 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.4 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.7 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.8 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.3 GO:1903904 negative regulation of establishment of T cell polarity(GO:1903904)
0.1 0.8 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 0.8 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 0.2 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 1.8 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 3.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.6 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 0.4 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1 1.1 GO:2000035 regulation of stem cell division(GO:2000035)
0.1 1.9 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.1 0.2 GO:1903406 regulation of sodium:potassium-exchanging ATPase activity(GO:1903406)
0.0 0.1 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.0 0.7 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 0.1 GO:1904631 negative regulation of interleukin-12 biosynthetic process(GO:0045083) response to diterpene(GO:1904629) cellular response to diterpene(GO:1904630) response to glucoside(GO:1904631) cellular response to glucoside(GO:1904632)
0.0 1.4 GO:0042119 neutrophil activation(GO:0042119)
0.0 1.0 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.7 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 0.3 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.5 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.3 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.2 GO:0009992 cellular water homeostasis(GO:0009992)
0.0 0.2 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.0 0.1 GO:0002344 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.0 0.0 GO:0061193 taste bud development(GO:0061193)
0.0 0.7 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.5 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 1.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.4 GO:0072189 ureter development(GO:0072189)
0.0 0.1 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.0 3.5 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 0.6 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 0.5 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:1900109 regulation of histone H3-K9 dimethylation(GO:1900109)
0.0 0.2 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.3 GO:0010225 response to UV-C(GO:0010225)
0.0 0.3 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.4 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.7 GO:0006284 base-excision repair(GO:0006284)
0.0 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.1 GO:0097117 guanylate kinase-associated protein clustering(GO:0097117)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.8 GO:0060091 kinocilium(GO:0060091)
0.1 0.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 0.3 GO:0060171 stereocilium membrane(GO:0060171)
0.1 0.6 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.1 0.5 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 3.6 GO:0016235 aggresome(GO:0016235)
0.0 0.1 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 1.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.2 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.8 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:1990246 uniplex complex(GO:1990246)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.2 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.4 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.3 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.8 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.3 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.3 1.3 GO:0031711 bradykinin receptor binding(GO:0031711)
0.1 0.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.4 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 1.2 GO:0036122 BMP binding(GO:0036122) BMP receptor activity(GO:0098821)
0.1 3.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 2.7 GO:0030275 LRR domain binding(GO:0030275)
0.1 0.3 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 0.7 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.7 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 1.9 GO:0034061 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.0 1.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.5 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.0 0.8 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.5 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.8 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.2 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.8 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.4 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.8 GO:0019956 chemokine binding(GO:0019956)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 1.4 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 1.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.3 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 0.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 2.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.8 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.2 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.5 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.0 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 2.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.8 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.5 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes