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avrg: GFI1 WT vs 36n/n vs KD

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Results for Sox1

Z-value: 0.99

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Transcription factors associated with Sox1

Gene Symbol Gene ID Gene Info
Sox1
ENSMUSG00000096014.2 SRY (sex determining region Y)-box 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox1mm39_v1_chr8_+_12445287_124452950.385.3e-01Click!

Activity profile of Sox1 motif

Sorted Z-values of Sox1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_127490139 0.91 ENSMUST00000205300.2
ENSMUST00000121394.3
Prss53
protease, serine 53
chr2_+_87185159 0.85 ENSMUST00000215163.3
Olfr1120
olfactory receptor 1120
chr7_+_103620359 0.80 ENSMUST00000209473.4
Olfr635
olfactory receptor 635
chr8_+_83891972 0.69 ENSMUST00000034145.11
Tbc1d9
TBC1 domain family, member 9
chr6_-_66757618 0.61 ENSMUST00000227493.2
Vmn1r38
vomeronasal 1 receptor 38
chr7_-_103710652 0.61 ENSMUST00000074064.5
4930516K23Rik
RIKEN cDNA 4930516K23 gene
chr16_-_37474772 0.60 ENSMUST00000023514.4
Ndufb4
NADH:ubiquinone oxidoreductase subunit B4
chr2_+_37078210 0.58 ENSMUST00000213969.2
Olfr365
olfactory receptor 365
chr5_-_129747129 0.53 ENSMUST00000049778.7
Zfp11
zinc finger protein 11
chr2_+_88217406 0.52 ENSMUST00000214040.3
Olfr1178
olfactory receptor 1178
chr7_+_79992839 0.51 ENSMUST00000032747.7
ENSMUST00000206480.2
ENSMUST00000206074.2
ENSMUST00000206122.2
Hddc3
HD domain containing 3
chr7_-_46569617 0.50 ENSMUST00000210664.2
ENSMUST00000156335.9
Tsg101
tumor susceptibility gene 101
chr14_+_35816874 0.49 ENSMUST00000226305.2
4930474N05Rik
RIKEN cDNA 4930474N05 gene
chr7_-_46569662 0.46 ENSMUST00000143413.3
ENSMUST00000014546.15
Tsg101
tumor susceptibility gene 101
chr17_+_48047955 0.43 ENSMUST00000086932.10
Tfeb
transcription factor EB
chr1_+_171723231 0.42 ENSMUST00000097466.3
Gm10521
predicted gene 10521
chr2_+_88644840 0.39 ENSMUST00000214703.2
Olfr1202
olfactory receptor 1202
chr9_+_123596276 0.34 ENSMUST00000166236.9
ENSMUST00000111454.4
ENSMUST00000168910.2
Ccr9
chemokine (C-C motif) receptor 9
chr15_+_81511486 0.33 ENSMUST00000206833.2
Ep300
E1A binding protein p300
chr9_+_123921573 0.21 ENSMUST00000111442.3
ENSMUST00000171499.3
Ccr5
chemokine (C-C motif) receptor 5
chr11_+_49313894 0.19 ENSMUST00000216641.2
ENSMUST00000217595.2
Olfr1389
olfactory receptor 1389
chr6_+_37507108 0.19 ENSMUST00000040987.11
Akr1d1
aldo-keto reductase family 1, member D1
chr10_-_125225298 0.16 ENSMUST00000210780.2
Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr3_+_60503051 0.15 ENSMUST00000192757.6
ENSMUST00000193518.6
ENSMUST00000195817.3
Mbnl1
muscleblind like splicing factor 1
chr6_+_114625771 0.15 ENSMUST00000182510.8
Atg7
autophagy related 7
chr5_-_140634773 0.12 ENSMUST00000197452.5
ENSMUST00000042661.8
Ttyh3
tweety family member 3
chr14_+_54032814 0.12 ENSMUST00000103671.4
Trav13-5
T cell receptor alpha variable 13-5
chrX_+_100473161 0.10 ENSMUST00000033673.7
Nono
non-POU-domain-containing, octamer binding protein
chr18_+_37630044 0.08 ENSMUST00000059571.7
Pcdhb19
protocadherin beta 19
chr17_+_34482183 0.08 ENSMUST00000040828.7
ENSMUST00000237342.2
ENSMUST00000237866.2
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr19_-_8382424 0.08 ENSMUST00000064507.12
ENSMUST00000120540.2
ENSMUST00000096269.11
Slc22a30
solute carrier family 22, member 30
chr10_+_84591919 0.07 ENSMUST00000060397.13
Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr17_-_48003391 0.07 ENSMUST00000113300.8
Prickle4
prickle planar cell polarity protein 4
chr11_-_69768875 0.07 ENSMUST00000178597.3
Tmem95
transmembrane protein 95
chr8_+_13209141 0.07 ENSMUST00000033824.8
Lamp1
lysosomal-associated membrane protein 1
chr8_-_89362745 0.06 ENSMUST00000034087.9
Snx20
sorting nexin 20
chr13_-_112788829 0.05 ENSMUST00000075748.7
Ddx4
DEAD box helicase 4
chr13_-_112788890 0.05 ENSMUST00000099166.10
Ddx4
DEAD box helicase 4
chr13_+_42454922 0.04 ENSMUST00000021796.9
Edn1
endothelin 1
chr17_-_66901568 0.04 ENSMUST00000024914.4
Themis3
thymocyte selection associated family member 3
chr7_+_67305162 0.02 ENSMUST00000107470.2
Ttc23
tetratricopeptide repeat domain 23
chr14_-_30645503 0.02 ENSMUST00000227995.2
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr17_-_29162794 0.02 ENSMUST00000232977.2
Pxt1
peroxisomal, testis specific 1
chr14_-_30645711 0.01 ENSMUST00000006697.17
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr4_-_120604445 0.01 ENSMUST00000030376.8
Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr11_-_68743944 0.01 ENSMUST00000018880.14
Ndel1
nudE neurodevelopment protein 1 like 1
chr19_-_13292905 0.01 ENSMUST00000207340.3
Olfr1465
olfactory receptor 1465
chr7_+_102977695 0.01 ENSMUST00000098202.3
Olfr598
olfactory receptor 598
chr9_-_108183140 0.01 ENSMUST00000195615.2
Tcta
T cell leukemia translocation altered gene
chr7_-_119744509 0.01 ENSMUST00000208874.2
ENSMUST00000033207.6
Zp2
zona pellucida glycoprotein 2
chr7_-_103661957 0.00 ENSMUST00000106862.3
Olfr639
olfactory receptor 639
chr14_+_65903840 0.00 ENSMUST00000022610.15
Scara5
scavenger receptor class A, member 5
chr14_+_65903878 0.00 ENSMUST00000069226.7
Scara5
scavenger receptor class A, member 5
chrX_+_111510223 0.00 ENSMUST00000113409.8
Zfp711
zinc finger protein 711
chr17_+_40942966 0.00 ENSMUST00000177574.2
Esp3
exocrine gland secreted peptide 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:2000397 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.1 0.3 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.1 0.3 GO:0014737 positive regulation of muscle atrophy(GO:0014737)
0.1 0.4 GO:1902477 defense response to bacterium, incompatible interaction(GO:0009816) regulation of defense response to bacterium, incompatible interaction(GO:1902477)
0.1 0.2 GO:0030573 bile acid catabolic process(GO:0030573)
0.0 0.2 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.0 0.1 GO:0016237 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521) amino acid homeostasis(GO:0080144) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157)
0.0 0.1 GO:0002343 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.0 0.2 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
0.0 0.0 GO:0060584 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.1 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0061474 phagolysosome membrane(GO:0061474)
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0019779 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.0 0.2 GO:0035671 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671)
0.0 0.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.5 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.2 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.0 GO:0031708 endothelin B receptor binding(GO:0031708)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol