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avrg: GFI1 WT vs 36n/n vs KD

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Results for Sox30

Z-value: 0.83

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Transcription factors associated with Sox30

Gene Symbol Gene ID Gene Info
Sox30
ENSMUSG00000040489.6 SRY (sex determining region Y)-box 30

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox30mm39_v1_chr11_+_45871135_458711640.982.8e-03Click!

Activity profile of Sox30 motif

Sorted Z-values of Sox30 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_133062677 0.77 ENSMUST00000033611.5
Xkrx
X-linked Kx blood group related, X-linked
chr3_-_102871440 0.61 ENSMUST00000058899.13
Nr1h5
nuclear receptor subfamily 1, group H, member 5
chr9_+_20193647 0.61 ENSMUST00000071725.4
ENSMUST00000212983.3
Olfr39
olfactory receptor 39
chr5_+_146769700 0.59 ENSMUST00000035983.12
Rpl21
ribosomal protein L21
chr19_-_24454720 0.52 ENSMUST00000099556.2
Fam122a
family with sequence similarity 122, member A
chr5_-_136275407 0.51 ENSMUST00000196245.2
Sh2b2
SH2B adaptor protein 2
chr2_+_85545763 0.40 ENSMUST00000216443.3
Olfr1009
olfactory receptor 1009
chr1_-_176641607 0.38 ENSMUST00000195717.6
ENSMUST00000192961.6
Cep170
centrosomal protein 170
chr1_+_176642226 0.38 ENSMUST00000056773.15
ENSMUST00000027785.15
Sdccag8
serologically defined colon cancer antigen 8
chr7_-_12853779 0.38 ENSMUST00000227220.2
ENSMUST00000227700.2
ENSMUST00000226604.2
Vmn1r86
vomeronasal 1 receptor 86
chr4_+_83335947 0.38 ENSMUST00000030206.10
ENSMUST00000071544.11
Snapc3
small nuclear RNA activating complex, polypeptide 3
chr9_-_32452885 0.35 ENSMUST00000016231.14
Fli1
Friend leukemia integration 1
chr6_-_87312743 0.35 ENSMUST00000042025.12
ENSMUST00000205033.2
Antxr1
anthrax toxin receptor 1
chr1_+_178146689 0.34 ENSMUST00000027781.7
Cox20
cytochrome c oxidase assembly protein 20
chr1_-_78488795 0.31 ENSMUST00000170511.3
BC035947
cDNA sequence BC035947
chr4_-_119047167 0.30 ENSMUST00000030396.15
Ermap
erythroblast membrane-associated protein
chr4_-_119047202 0.29 ENSMUST00000239029.2
ENSMUST00000138395.9
ENSMUST00000156746.3
Ermap
erythroblast membrane-associated protein
chr11_-_49005701 0.29 ENSMUST00000060398.3
ENSMUST00000215553.2
ENSMUST00000109201.2
Olfr1396
olfactory receptor 1396
chr5_+_14564932 0.28 ENSMUST00000182407.8
ENSMUST00000030691.17
Pclo
piccolo (presynaptic cytomatrix protein)
chr8_-_23143422 0.28 ENSMUST00000033938.7
Polb
polymerase (DNA directed), beta
chr6_-_116084810 0.28 ENSMUST00000204353.3
Tmcc1
transmembrane and coiled coil domains 1
chr4_+_152160713 0.27 ENSMUST00000239025.2
Plekhg5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr11_-_58521327 0.26 ENSMUST00000214132.2
Olfr323
olfactory receptor 323
chr10_-_62628008 0.25 ENSMUST00000217768.2
ENSMUST00000020268.7
ENSMUST00000218946.2
ENSMUST00000219527.2
Ccar1
cell division cycle and apoptosis regulator 1
chr6_-_122317156 0.25 ENSMUST00000159384.8
Phc1
polyhomeotic 1
chr8_+_109429732 0.25 ENSMUST00000188994.2
Zfhx3
zinc finger homeobox 3
chr4_-_114991478 0.24 ENSMUST00000106545.8
Cyp4x1
cytochrome P450, family 4, subfamily x, polypeptide 1
chr3_-_9898676 0.19 ENSMUST00000108384.9
Pag1
phosphoprotein associated with glycosphingolipid microdomains 1
chr11_-_99134885 0.18 ENSMUST00000103132.10
ENSMUST00000038214.7
Krt222
keratin 222
chr3_-_9898713 0.17 ENSMUST00000161949.8
Pag1
phosphoprotein associated with glycosphingolipid microdomains 1
chr2_+_102488985 0.16 ENSMUST00000080210.10
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr10_-_24712034 0.15 ENSMUST00000218044.2
ENSMUST00000020169.9
Enpp3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr13_-_93774469 0.13 ENSMUST00000099309.6
Bhmt
betaine-homocysteine methyltransferase
chr14_-_19873839 0.11 ENSMUST00000022341.7
Rtraf
RNA transcription, translation and transport factor
chr19_-_56810593 0.10 ENSMUST00000118592.8
Ccdc186
coiled-coil domain containing 186
chr6_-_132291714 0.08 ENSMUST00000048686.9
Prpmp5
proline-rich protein MP5
chr18_+_37610858 0.08 ENSMUST00000051442.7
Pcdhb16
protocadherin beta 16
chr9_+_74883377 0.08 ENSMUST00000081746.7
Fam214a
family with sequence similarity 214, member A
chr17_-_79662514 0.08 ENSMUST00000068958.9
Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr9_-_72018453 0.08 ENSMUST00000183992.8
Tcf12
transcription factor 12
chr1_-_151376544 0.07 ENSMUST00000187991.2
ENSMUST00000187048.7
ENSMUST00000186415.7
Rnf2
ring finger protein 2
chr11_+_21041291 0.07 ENSMUST00000093290.12
Peli1
pellino 1
chr9_+_7764042 0.07 ENSMUST00000052865.16
Tmem123
transmembrane protein 123
chr4_+_109200225 0.06 ENSMUST00000030281.12
Eps15
epidermal growth factor receptor pathway substrate 15
chr9_-_60418286 0.06 ENSMUST00000098660.10
Thsd4
thrombospondin, type I, domain containing 4
chr3_-_113198765 0.05 ENSMUST00000179568.3
Amy2a4
amylase 2a4
chr6_-_12749192 0.05 ENSMUST00000172356.8
Thsd7a
thrombospondin, type I, domain containing 7A
chr2_-_57942844 0.05 ENSMUST00000090940.6
Ermn
ermin, ERM-like protein
chr6_-_136899167 0.04 ENSMUST00000032343.7
Erp27
endoplasmic reticulum protein 27
chr1_-_37535170 0.04 ENSMUST00000148047.2
Mgat4a
mannoside acetylglucosaminyltransferase 4, isoenzyme A
chr5_-_137101108 0.04 ENSMUST00000077523.4
ENSMUST00000041388.11
Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
chr9_-_72019053 0.04 ENSMUST00000183492.8
ENSMUST00000184523.8
ENSMUST00000034755.13
Tcf12
transcription factor 12
chr2_+_69869459 0.04 ENSMUST00000060208.11
Myo3b
myosin IIIB
chr9_-_19968858 0.03 ENSMUST00000216538.2
ENSMUST00000212098.3
Olfr867
olfactory receptor 867
chr7_+_119499322 0.03 ENSMUST00000106516.2
Lyrm1
LYR motif containing 1
chr11_-_116572116 0.03 ENSMUST00000144398.2
St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr5_+_139197689 0.03 ENSMUST00000148772.8
ENSMUST00000110882.8
Sun1
Sad1 and UNC84 domain containing 1
chr7_+_43079512 0.02 ENSMUST00000004732.7
Lim2
lens intrinsic membrane protein 2
chr2_-_65397850 0.02 ENSMUST00000238483.2
ENSMUST00000100069.9
Scn3a
sodium channel, voltage-gated, type III, alpha
chr5_+_102992873 0.02 ENSMUST00000070000.6
Arhgap24
Rho GTPase activating protein 24
chr7_+_43874752 0.02 ENSMUST00000075162.5
Klk1
kallikrein 1
chr18_-_68562385 0.02 ENSMUST00000052347.8
Mc2r
melanocortin 2 receptor
chr17_-_67354971 0.01 ENSMUST00000224862.2
Ptprm
protein tyrosine phosphatase, receptor type, M
chr11_+_43365103 0.01 ENSMUST00000173002.8
ENSMUST00000057679.10
C1qtnf2
C1q and tumor necrosis factor related protein 2
chr2_-_84652890 0.01 ENSMUST00000028471.6
Smtnl1
smoothelin-like 1
chr1_+_38037086 0.01 ENSMUST00000027252.8
Eif5b
eukaryotic translation initiation factor 5B
chr17_-_34337446 0.01 ENSMUST00000095347.13
Brd2
bromodomain containing 2
chr1_+_78488499 0.01 ENSMUST00000012331.7
Mogat1
monoacylglycerol O-acyltransferase 1
chr17_+_31605184 0.01 ENSMUST00000047168.13
ENSMUST00000127929.8
ENSMUST00000134525.9
ENSMUST00000236454.2
ENSMUST00000238091.2
ENSMUST00000235719.2
Pde9a
phosphodiesterase 9A
chr18_+_37875135 0.00 ENSMUST00000003599.9
Pcdhgb6
protocadherin gamma subfamily B, 6
chr2_-_35257741 0.00 ENSMUST00000028243.2
4930568D16Rik
RIKEN cDNA 4930568D16 gene
chr1_+_78488440 0.00 ENSMUST00000152111.2
Mogat1
monoacylglycerol O-acyltransferase 1
chr7_+_43661592 0.00 ENSMUST00000048945.6
Klk1b26
kallikrein 1-related petidase b26
chrX_-_93408176 0.00 ENSMUST00000239046.2
CXorf58
family with sequence similarity 90, member A1B
chr4_+_48585275 0.00 ENSMUST00000123476.8
Tmeff1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr2_+_3115250 0.00 ENSMUST00000072955.12
Fam171a1
family with sequence similarity 171, member A1
chr2_-_101713355 0.00 ENSMUST00000154525.2
Prr5l
proline rich 5 like
chr4_+_48585135 0.00 ENSMUST00000030032.13
Tmeff1
transmembrane protein with EGF-like and two follistatin-like domains 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox30

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.1 0.3 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.1 0.5 GO:0001922 B-1 B cell homeostasis(GO:0001922)
0.0 0.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.3 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.4 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0071267 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.0 0.3 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.0 0.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.0 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.1 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0044317 rod spherule(GO:0044317)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.2 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter