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avrg: GFI1 WT vs 36n/n vs KD

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Results for Spib

Z-value: 3.30

Motif logo

Transcription factors associated with Spib

Gene Symbol Gene ID Gene Info
ENSMUSG00000008193.14 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Spibmm39_v1_chr7_-_44180700_44180805-0.523.7e-01Click!

Activity profile of Spib motif

Sorted Z-values of Spib motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_3918484 3.69 ENSMUST00000038176.15
ENSMUST00000206077.2
ENSMUST00000090689.5
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr13_+_23728222 3.24 ENSMUST00000075558.5
H3 clustered histone 7
chr3_+_60380243 2.72 ENSMUST00000195724.6
muscleblind like splicing factor 1
chr1_+_16758629 2.59 ENSMUST00000026881.11
lymphocyte antigen 96
chr13_-_23727549 2.35 ENSMUST00000224359.2
H2B clustered histone 9
chr7_-_3848050 2.27 ENSMUST00000108615.10
ENSMUST00000119469.2
paired-Ig-like receptor A2
chr15_+_6552270 2.20 ENSMUST00000226412.2
FYN binding protein
chr7_+_3339059 2.01 ENSMUST00000096744.8
myeloid-associated differentiation marker
chr7_-_3723381 1.97 ENSMUST00000078451.7
paired Ig-like receptor B
chr7_+_3339077 1.96 ENSMUST00000203566.3
myeloid-associated differentiation marker
chr1_-_171061902 1.85 ENSMUST00000079957.12
Fc receptor, IgE, high affinity I, gamma polypeptide
chr7_+_28834276 1.85 ENSMUST00000161522.8
ENSMUST00000204845.3
ENSMUST00000205027.3
ENSMUST00000204194.3
ENSMUST00000203070.3
ENSMUST00000203380.3
RAS guanyl releasing protein 4
chr6_-_106725929 1.74 ENSMUST00000204659.3
interleukin 5 receptor, alpha
chr2_-_165996716 1.67 ENSMUST00000139266.2
sulfatase 2
chr9_+_106099797 1.63 ENSMUST00000062241.11
toll-like receptor 9
chr4_+_132903646 1.62 ENSMUST00000105912.2
WASP family, member 2
chr7_+_28834350 1.62 ENSMUST00000159975.8
ENSMUST00000094617.11
ENSMUST00000032811.12
RAS guanyl releasing protein 4
chr5_-_66309244 1.55 ENSMUST00000167950.8
RNA binding motif protein 47
chr7_+_28834391 1.50 ENSMUST00000160194.8
RAS guanyl releasing protein 4
chr14_+_54664359 1.48 ENSMUST00000010550.12
ENSMUST00000199195.3
ENSMUST00000196273.2
mitochondrial ribosomal protein L52
chr15_-_78189822 1.41 ENSMUST00000230115.3
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr10_+_80633865 1.40 ENSMUST00000148665.8
splicing factor 3a, subunit 2
chr3_+_60380463 1.37 ENSMUST00000195077.6
ENSMUST00000193647.6
ENSMUST00000195001.2
ENSMUST00000192807.6
muscleblind like splicing factor 1
chr2_+_145776720 1.36 ENSMUST00000152515.8
ENSMUST00000138774.8
ENSMUST00000130168.8
ENSMUST00000133433.8
ENSMUST00000118002.2
cilia and flagella associated protein 61
chr11_+_68322945 1.35 ENSMUST00000021283.8
phosphoinositide-3-kinase regulatory subunit 5
chr2_+_22664094 1.30 ENSMUST00000014290.15
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr9_-_70411000 1.28 ENSMUST00000034739.12
ring finger 111
chr5_+_16758538 1.27 ENSMUST00000199581.5
hepatocyte growth factor
chr6_+_29529275 1.27 ENSMUST00000163511.7
interferon regulatory factor 5
chr6_+_122929591 1.24 ENSMUST00000088468.7
C-type lectin domain family 4, member a3
chr18_+_35695736 1.23 ENSMUST00000235851.2
ENSMUST00000235581.2
matrin 3
chr7_+_75259778 1.22 ENSMUST00000207923.2
A kinase (PRKA) anchor protein 13
chr11_-_76969230 1.21 ENSMUST00000102494.8
nuclear speckle regulatory protein 1
chr19_-_6134703 1.21 ENSMUST00000161548.8
zinc finger like protein 1
chr2_-_181335767 1.19 ENSMUST00000002532.9
regulator of G-protein signaling 19
chr11_+_113548201 1.17 ENSMUST00000148736.8
ENSMUST00000142069.8
ENSMUST00000134418.8
component of oligomeric golgi complex 1
chr2_-_165242307 1.17 ENSMUST00000029213.5
osteoclast stimulatory transmembrane protein
chr3_-_105839980 1.16 ENSMUST00000098758.5
RIKEN cDNA I830077J02 gene
chr4_+_62581857 1.16 ENSMUST00000126338.2
regulator of G-protein signaling 3
chr15_-_76079891 1.14 ENSMUST00000023226.13
plectin
chr2_+_91480513 1.10 ENSMUST00000090614.11
Rho GTPase activating protein 1
chr2_-_165997551 1.10 ENSMUST00000109249.9
ENSMUST00000146497.9
sulfatase 2
chr5_-_116162415 1.08 ENSMUST00000031486.14
ENSMUST00000111999.8
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr2_-_181335697 1.07 ENSMUST00000108779.8
ENSMUST00000108769.8
ENSMUST00000108772.8
regulator of G-protein signaling 19
chr15_-_78189917 1.07 ENSMUST00000096356.5
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr9_-_70410611 1.06 ENSMUST00000215848.2
ENSMUST00000113595.2
ENSMUST00000213647.2
ring finger 111
chr13_+_20978283 1.02 ENSMUST00000021757.5
ENSMUST00000221982.2
acyloxyacyl hydrolase
chr2_+_113271409 1.00 ENSMUST00000081349.9
formin 1
chr7_-_45570828 1.00 ENSMUST00000038876.13
epithelial membrane protein 3
chr5_+_16758777 0.99 ENSMUST00000030683.8
hepatocyte growth factor
chr6_+_137387718 0.98 ENSMUST00000167002.4
protein tyrosine phosphatase, receptor type, O
chr6_-_136918671 0.97 ENSMUST00000032344.12
Rho, GDP dissociation inhibitor (GDI) beta
chr15_+_78210190 0.97 ENSMUST00000229034.2
ENSMUST00000096355.4
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr5_+_123280250 0.97 ENSMUST00000174836.8
ENSMUST00000163030.9
SET domain containing 1B
chr19_+_6413703 0.96 ENSMUST00000131252.8
ENSMUST00000113489.8
splicing factor 1
chr6_+_137387729 0.95 ENSMUST00000203914.2
protein tyrosine phosphatase, receptor type, O
chr8_+_109441276 0.95 ENSMUST00000043896.10
zinc finger homeobox 3
chr7_-_46569617 0.94 ENSMUST00000210664.2
ENSMUST00000156335.9
tumor susceptibility gene 101
chr13_+_30933209 0.93 ENSMUST00000021784.10
ENSMUST00000110307.3
ENSMUST00000222125.2
interferon regulatory factor 4
chr7_+_127078371 0.92 ENSMUST00000205432.3
fibrosin
chr1_+_16758731 0.91 ENSMUST00000190366.2
lymphocyte antigen 96
chr2_+_91480460 0.90 ENSMUST00000111331.9
Rho GTPase activating protein 1
chr16_-_89757693 0.90 ENSMUST00000002588.11
T cell lymphoma invasion and metastasis 1
chr18_+_7869705 0.90 ENSMUST00000166062.8
ENSMUST00000169010.8
WW domain containing adaptor with coiled-coil
chr12_+_110413677 0.89 ENSMUST00000220509.2
protein phosphatase 2, regulatory subunit B', gamma
chr11_+_69214789 0.89 ENSMUST00000102602.8
trafficking protein particle complex 1
chr5_+_16758897 0.86 ENSMUST00000196645.2
hepatocyte growth factor
chr15_+_78210242 0.85 ENSMUST00000229678.2
ENSMUST00000231888.2
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr7_-_46569662 0.84 ENSMUST00000143413.3
ENSMUST00000014546.15
tumor susceptibility gene 101
chr18_+_7869370 0.82 ENSMUST00000092112.11
ENSMUST00000172018.8
ENSMUST00000168446.8
WW domain containing adaptor with coiled-coil
chr8_-_32440071 0.82 ENSMUST00000207678.3
neuregulin 1
chr1_+_135075377 0.81 ENSMUST00000125774.2
ADP-ribosylation factor-like 8A
chrX_+_72760183 0.80 ENSMUST00000002084.14
ATP-binding cassette, sub-family D (ALD), member 1
chr3_+_106628987 0.80 ENSMUST00000130105.2
ligand dependent nuclear receptor interacting factor 1
chr7_-_45546081 0.80 ENSMUST00000120299.4
ENSMUST00000039049.16
synaptogyrin 4
chr10_+_51356728 0.79 ENSMUST00000102894.6
ENSMUST00000219661.2
ENSMUST00000219696.2
ENSMUST00000217706.2
leukocyte immunoglobulin-like receptor, subfamily B, member 4B
predicted gene, 49339
chr3_+_106629209 0.79 ENSMUST00000106736.3
ENSMUST00000154973.2
ENSMUST00000098750.5
ENSMUST00000150513.2
ligand dependent nuclear receptor interacting factor 1
chr19_+_24976864 0.79 ENSMUST00000025831.8
dedicator of cytokinesis 8
chr3_-_89959739 0.78 ENSMUST00000199929.2
ENSMUST00000090908.11
ENSMUST00000198322.5
ENSMUST00000196843.5
ubiquitin-associated protein 2-like
chr2_-_165997179 0.77 ENSMUST00000088086.4
sulfatase 2
chr1_-_155912159 0.77 ENSMUST00000097527.10
torsin A interacting protein 1
chrX_+_99537897 0.77 ENSMUST00000033570.6
immunoglobulin (CD79A) binding protein 1
chr2_+_145776697 0.77 ENSMUST00000116398.8
ENSMUST00000126415.8
cilia and flagella associated protein 61
chr2_-_181333597 0.77 ENSMUST00000108778.8
ENSMUST00000165416.8
regulator of G-protein signaling 19
chr3_-_89959770 0.77 ENSMUST00000029553.16
ENSMUST00000195995.5
ENSMUST00000064639.15
ENSMUST00000199834.5
ubiquitin-associated protein 2-like
chr2_+_24235300 0.76 ENSMUST00000114485.9
ENSMUST00000114482.3
interleukin 1 receptor antagonist
chr12_+_33365371 0.75 ENSMUST00000154742.2
ataxin 7-like 1
chr11_+_69214971 0.75 ENSMUST00000108662.2
trafficking protein particle complex 1
chr5_-_102217770 0.75 ENSMUST00000053177.14
ENSMUST00000174698.2
WD repeat and FYVE domain containing 3
chr12_-_65012270 0.74 ENSMUST00000222508.2
kelch-like 28
chr3_-_129854477 0.73 ENSMUST00000001079.15
Sec24 related gene family, member B (S. cerevisiae)
chr13_+_9143916 0.72 ENSMUST00000188211.8
ENSMUST00000188939.7
ENSMUST00000190041.7
La ribonucleoprotein domain family, member 4B
chr13_+_110039620 0.71 ENSMUST00000120664.8
phosphodiesterase 4D, cAMP specific
chr6_-_124710030 0.70 ENSMUST00000173647.2
protein tyrosine phosphatase, non-receptor type 6
chr15_-_78456898 0.69 ENSMUST00000043214.8
Rac family small GTPase 2
chr2_-_181335518 0.68 ENSMUST00000108776.8
ENSMUST00000108771.2
regulator of G-protein signaling 19
chr11_+_11635908 0.67 ENSMUST00000065433.12
IKAROS family zinc finger 1
chr9_-_114811807 0.67 ENSMUST00000053150.8
ribosomal protein S27, retrogene
chr2_+_32611067 0.67 ENSMUST00000074248.11
SH2 domain containing 3C
chr7_-_44888532 0.66 ENSMUST00000033063.15
CD37 antigen
chr19_+_26600820 0.66 ENSMUST00000176584.2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_10085299 0.66 ENSMUST00000114897.9
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chr9_+_117869642 0.66 ENSMUST00000134433.8
5-azacytidine induced gene 2
chr8_+_3403415 0.65 ENSMUST00000098966.5
ENSMUST00000239102.2
rho/rac guanine nucleotide exchange factor (GEF) 18
chr2_+_90927053 0.64 ENSMUST00000132741.3
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_34674677 0.63 ENSMUST00000093193.12
ENSMUST00000101365.9
dedicator of cyto-kinesis 2
chr14_+_80237691 0.62 ENSMUST00000228749.2
ENSMUST00000088735.4
olfactomedin 4
chr2_-_10085133 0.62 ENSMUST00000145530.8
ENSMUST00000026887.14
ENSMUST00000114896.8
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chr11_+_69214883 0.62 ENSMUST00000102601.10
trafficking protein particle complex 1
chr16_-_92622972 0.61 ENSMUST00000023673.14
runt related transcription factor 1
chr2_+_126549239 0.61 ENSMUST00000028841.14
ENSMUST00000110416.3
ubiquitin specific peptidase 8
chr15_-_63932176 0.60 ENSMUST00000226675.2
ENSMUST00000228226.2
ENSMUST00000227024.2
CYFIP related Rac1 interactor B
chr1_+_155911518 0.59 ENSMUST00000133152.2
torsin A interacting protein 2
chr1_-_170886924 0.58 ENSMUST00000164044.8
ENSMUST00000169017.8
Fc receptor, IgG, low affinity III
chr7_-_3298243 0.58 ENSMUST00000108653.4
NLR family, pyrin domain containing 12
chr19_+_6107874 0.57 ENSMUST00000178310.9
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)
chr15_-_82917495 0.56 ENSMUST00000231165.2
Nfat activating molecule with ITAM motif 1
chr18_+_75133519 0.56 ENSMUST00000079716.6
ribosomal protein L17
chr6_-_113354826 0.56 ENSMUST00000032410.14
transcriptional adaptor 3
chr2_-_45001141 0.56 ENSMUST00000201969.4
ENSMUST00000201623.4
zinc finger E-box binding homeobox 2
chr13_-_13568106 0.55 ENSMUST00000021738.10
ENSMUST00000220628.2
G protein-coupled receptor 137B
chr11_-_58221145 0.55 ENSMUST00000186859.2
ENSMUST00000065533.3
zinc finger protein 672
chr8_+_111345209 0.55 ENSMUST00000034190.11
Vac14 homolog (S. cerevisiae)
chr5_-_138262178 0.55 ENSMUST00000048421.14
microtubule associated protein 11
chr13_-_103470937 0.54 ENSMUST00000167058.8
ENSMUST00000164111.2
microtubule associated serine/threonine kinase family member 4
chr9_+_64718708 0.54 ENSMUST00000213926.2
DENN/MADD domain containing 4A
chr16_-_22475915 0.53 ENSMUST00000089925.10
diacylglycerol kinase, gamma
chr12_-_28685913 0.52 ENSMUST00000074267.5
ribosomal protein S7
chr2_+_112096154 0.52 ENSMUST00000110991.9
solute carrier family 12, member 6
chr18_-_39622932 0.51 ENSMUST00000152853.2
nuclear receptor subfamily 3, group C, member 1
chr16_-_56537808 0.49 ENSMUST00000065515.14
Trk-fused gene
chr10_+_81229443 0.49 ENSMUST00000118206.2
small integral membrane protein 24
chr13_+_102830029 0.49 ENSMUST00000022124.10
ENSMUST00000171267.2
ENSMUST00000167144.2
ENSMUST00000170878.2
CD180 antigen
chr19_+_4281953 0.49 ENSMUST00000025773.5
polymerase (DNA-directed), delta 4
chr4_-_154245073 0.49 ENSMUST00000105639.4
ENSMUST00000030896.15
transformation related protein 63 regulated like
chr9_+_100956145 0.49 ENSMUST00000189616.2
MSL complex subunit 2
chrX_-_37545311 0.48 ENSMUST00000074913.12
ENSMUST00000016678.14
ENSMUST00000061755.9
lysosomal-associated membrane protein 2
chr11_+_69214895 0.47 ENSMUST00000060956.13
trafficking protein particle complex 1
chr12_-_84408576 0.47 ENSMUST00000021659.2
ENSMUST00000065536.9
family with sequence similarity 161, member B
chr4_+_86666764 0.47 ENSMUST00000045512.15
ENSMUST00000082026.14
DENN/MADD domain containing 4C
chr16_-_22475960 0.47 ENSMUST00000023578.14
diacylglycerol kinase, gamma
chr19_-_6134903 0.47 ENSMUST00000160977.8
ENSMUST00000159859.2
ENSMUST00000025707.9
ENSMUST00000160712.8
ENSMUST00000237738.2
zinc finger like protein 1
chr5_-_25703700 0.47 ENSMUST00000173073.8
ENSMUST00000045291.14
ENSMUST00000173174.2
lysine (K)-specific methyltransferase 2C
chr6_-_106725895 0.46 ENSMUST00000205004.2
interleukin 5 receptor, alpha
chr9_+_117869543 0.46 ENSMUST00000044454.12
5-azacytidine induced gene 2
chr18_-_35348049 0.46 ENSMUST00000091636.5
ENSMUST00000236680.2
leucine rich repeat transmembrane neuronal 2
chr7_+_43057611 0.46 ENSMUST00000005592.7
sialic acid binding Ig-like lectin G
chr4_-_95965767 0.46 ENSMUST00000030305.13
ENSMUST00000107078.9
cytochrome P450, family 2, subfamily j, polypeptide 13
chr16_-_36486429 0.45 ENSMUST00000089620.11
CD86 antigen
chr11_-_103235475 0.45 ENSMUST00000041385.14
Rho GTPase activating protein 27
chr9_+_123901979 0.44 ENSMUST00000171719.8
chemokine (C-C motif) receptor 2
chr2_+_43445333 0.43 ENSMUST00000028223.9
ENSMUST00000112826.8
kynureninase
chr9_+_117869577 0.43 ENSMUST00000133580.8
5-azacytidine induced gene 2
chr13_+_81034214 0.42 ENSMUST00000161441.2
arrestin domain containing 3
chr7_-_28135616 0.42 ENSMUST00000208199.2
sterile alpha motif domain containing 4B
chr8_-_123302187 0.42 ENSMUST00000213062.2
adenine phosphoribosyl transferase
chr5_+_115680964 0.42 ENSMUST00000137716.8
paxillin
chr9_-_37259629 0.41 ENSMUST00000217238.3
coiled-coil domain containing 15
chr4_-_43454600 0.40 ENSMUST00000098105.4
ENSMUST00000098104.10
ENSMUST00000030179.11
CD72 antigen
chr4_-_118266416 0.40 ENSMUST00000075406.12
SZT2 subunit of KICSTOR complex
chr15_-_36609208 0.40 ENSMUST00000001809.15
poly(A) binding protein, cytoplasmic 1
chr3_-_101831729 0.39 ENSMUST00000190824.7
solute carrier family 22 (organic anion/cation transporter), member 15
chr6_+_129326927 0.39 ENSMUST00000065289.6
C-type lectin domain family 12, member a
chr13_+_20369377 0.39 ENSMUST00000221067.2
engulfment and cell motility 1
chr19_-_8751795 0.39 ENSMUST00000010249.7
transmembrane protein 179B
chr2_-_77776524 0.38 ENSMUST00000111824.8
ENSMUST00000111819.8
ENSMUST00000128963.2
CWC22 spliceosome-associated protein
chr2_+_72115981 0.38 ENSMUST00000090824.12
ENSMUST00000135469.8
mitogen-activated protein kinase kinase kinase 20
chr8_+_84262409 0.38 ENSMUST00000214156.2
ENSMUST00000209408.4
olfactory receptor 370
chr4_-_122779837 0.38 ENSMUST00000106255.8
ENSMUST00000106257.10
CAP, adenylate cyclase-associated protein 1 (yeast)
chr13_-_53627110 0.37 ENSMUST00000021922.10
msh homeobox 2
chr14_+_66872699 0.37 ENSMUST00000159365.8
ENSMUST00000054661.8
ENSMUST00000225182.2
ENSMUST00000159068.2
adrenergic receptor, alpha 1a
chr3_-_79439181 0.36 ENSMUST00000239298.2
folliculin interacting protein 2
chr15_+_97259060 0.35 ENSMUST00000228521.2
ENSMUST00000226495.2
PC-esterase domain containing 1B
chr5_-_32903687 0.35 ENSMUST00000135248.2
phosphatidylserine decarboxylase
chr7_+_135207505 0.35 ENSMUST00000210833.2
protein tyrosine phosphatase, receptor type, E
chr13_+_102830104 0.34 ENSMUST00000172138.2
CD180 antigen
chr1_-_80191649 0.34 ENSMUST00000058748.2
family with sequence similarity 124, member B
chr13_-_23650045 0.34 ENSMUST00000041674.14
ENSMUST00000110434.2
butyrophilin, subfamily 1, member A1
chr13_+_44884740 0.34 ENSMUST00000173246.8
jumonji, AT rich interactive domain 2
chr15_-_9529898 0.33 ENSMUST00000228782.2
ENSMUST00000003981.6
interleukin 7 receptor
chr17_-_47015928 0.33 ENSMUST00000002839.9
ENSMUST00000233988.2
protein phosphatase 2, regulatory subunit B', delta
chr12_+_98234884 0.33 ENSMUST00000075072.6
G-protein coupled receptor 65
chr10_+_128584324 0.32 ENSMUST00000065210.10
ENSMUST00000218218.2
PYM homolog 1, exon junction complex associated factor
chr12_-_32258604 0.31 ENSMUST00000053215.14
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
chr3_-_89959917 0.31 ENSMUST00000197903.5
ubiquitin-associated protein 2-like
chr4_+_44012638 0.30 ENSMUST00000107847.10
ENSMUST00000170241.8
ENSMUST00000107849.10
ENSMUST00000107851.10
ENSMUST00000107845.4
clathrin, light polypeptide (Lca)
chr17_+_21165573 0.30 ENSMUST00000007708.14
protein phosphatase 2, regulatory subunit A, alpha
chr12_+_77285770 0.30 ENSMUST00000062804.8
fucosyltransferase 8
chr1_-_38704028 0.30 ENSMUST00000039827.14
AF4/FMR2 family, member 3
chr6_-_30304512 0.30 ENSMUST00000094543.3
ENSMUST00000102993.10
ubiquitin-conjugating enzyme E2H
chr3_-_89294430 0.30 ENSMUST00000107433.8
zinc finger and BTB domain containing 7B
chr19_+_18609291 0.29 ENSMUST00000042392.14
ENSMUST00000237347.2
nicotinamide riboside kinase 1
chr2_-_91480096 0.28 ENSMUST00000099714.10
ENSMUST00000111333.2
zinc finger protein 408
chr17_-_56891576 0.27 ENSMUST00000075510.12
scaffold attachment factor B2
chr2_-_91014163 0.27 ENSMUST00000077941.13
ENSMUST00000111381.9
ENSMUST00000111372.8
ENSMUST00000111371.8
ENSMUST00000075269.10
ENSMUST00000066473.12
MAP-kinase activating death domain
chr1_+_87548026 0.27 ENSMUST00000169754.8
ENSMUST00000042275.15
ENSMUST00000168783.8
inositol polyphosphate-5-phosphatase D
chr10_+_78848306 0.27 ENSMUST00000216030.2
olfactory receptor 1351
chr2_+_43445359 0.27 ENSMUST00000050511.7
kynureninase
chr13_+_9143995 0.26 ENSMUST00000091829.4
La ribonucleoprotein domain family, member 4B
chr6_-_136918495 0.26 ENSMUST00000111892.8
Rho, GDP dissociation inhibitor (GDI) beta

Network of associatons between targets according to the STRING database.

First level regulatory network of Spib

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.5 1.6 GO:0032741 positive regulation of interleukin-18 production(GO:0032741)
0.5 3.5 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.5 4.0 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.5 1.9 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.5 1.9 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.4 1.8 GO:2000395 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.3 1.7 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.3 2.0 GO:1903336 endosome localization(GO:0032439) negative regulation of vacuolar transport(GO:1903336)
0.3 0.9 GO:0045404 interleukin-10 biosynthetic process(GO:0042091) interleukin-13 biosynthetic process(GO:0042231) regulation of interleukin-10 biosynthetic process(GO:0045074) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.3 1.6 GO:0044565 dendritic cell proliferation(GO:0044565)
0.3 0.9 GO:1904266 regulation of Schwann cell chemotaxis(GO:1904266) positive regulation of Schwann cell chemotaxis(GO:1904268) Schwann cell chemotaxis(GO:1990751)
0.3 1.2 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.2 3.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.2 0.5 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
0.2 0.7 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.2 2.3 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 0.9 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.2 0.7 GO:0045660 positive regulation of neutrophil differentiation(GO:0045660)
0.2 0.7 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.2 0.6 GO:0090264 immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) negative regulation of eosinophil activation(GO:1902567) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451)
0.2 0.8 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.2 0.6 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.2 0.9 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.2 0.7 GO:0035973 aggrephagy(GO:0035973)
0.2 1.9 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.2 0.7 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 1.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.2 0.7 GO:0071336 regulation of hair follicle cell proliferation(GO:0071336) positive regulation of progesterone secretion(GO:2000872)
0.2 0.8 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 1.2 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 1.0 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.4 GO:0098749 cerebellar neuron development(GO:0098749)
0.1 1.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 1.4 GO:0035878 nail development(GO:0035878)
0.1 0.6 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1 1.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.4 GO:0090325 regulation of locomotion involved in locomotory behavior(GO:0090325) negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 0.4 GO:0006168 adenine salvage(GO:0006168) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.1 0.9 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.1 0.3 GO:1903537 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.1 0.5 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.1 0.7 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.1 0.4 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.1 0.3 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.1 1.3 GO:0032494 response to peptidoglycan(GO:0032494)
0.1 1.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.3 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 4.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.9 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 0.7 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.8 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 0.6 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 2.2 GO:0032674 regulation of interleukin-5 production(GO:0032674)
0.1 0.8 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 0.7 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.1 0.2 GO:0014739 positive regulation of muscle hyperplasia(GO:0014739)
0.1 0.3 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1 0.4 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.1 0.3 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.1 0.3 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.1 0.4 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 0.4 GO:0002911 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.1 0.2 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.1 0.3 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 4.7 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.1 0.6 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 1.6 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.8 GO:0001771 immunological synapse formation(GO:0001771)
0.0 1.0 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.3 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.3 GO:0033578 protein glycosylation in Golgi(GO:0033578)
0.0 0.1 GO:2000019 negative regulation of male gonad development(GO:2000019)
0.0 1.3 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.6 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.3 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 1.9 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.2 GO:0046874 quinolinate metabolic process(GO:0046874)
0.0 0.1 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.0 0.2 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.0 0.3 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.2 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.0 1.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.2 GO:0035696 monocyte extravasation(GO:0035696)
0.0 0.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.0 0.2 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.0 0.4 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.7 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 2.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.2 GO:0006105 succinate metabolic process(GO:0006105)
0.0 0.5 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 1.5 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.7 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0 0.3 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.6 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.1 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.0 0.2 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.4 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.1 GO:0002268 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)
0.0 0.5 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0031296 B cell costimulation(GO:0031296)
0.0 0.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 1.0 GO:0003170 heart valve development(GO:0003170)
0.0 0.1 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.3 GO:0019363 pyridine nucleotide biosynthetic process(GO:0019363)
0.0 0.9 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.0 0.3 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.1 GO:0009048 dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.4 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.0 0.2 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 0.2 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.9 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.0 0.2 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.0 0.3 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 1.3 GO:0045727 positive regulation of translation(GO:0045727)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0032997 Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
0.4 3.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.3 2.0 GO:0097443 sorting endosome(GO:0097443)
0.3 1.6 GO:0036019 endolysosome(GO:0036019)
0.2 0.7 GO:0097635 Atg12-Atg5-Atg16 complex(GO:0034274) extrinsic component of autophagosome membrane(GO:0097635)
0.2 1.0 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.1 1.8 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.5 GO:0097637 platelet dense granule membrane(GO:0031088) intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 2.7 GO:0030008 TRAPP complex(GO:0030008)
0.1 0.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 0.6 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.4 GO:1990130 Iml1 complex(GO:1990130)
0.1 0.7 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 1.2 GO:0017119 Golgi transport complex(GO:0017119)
0.1 0.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.0 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.5 GO:0072487 MSL complex(GO:0072487)
0.1 0.5 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 2.0 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.9 GO:0060091 kinocilium(GO:0060091)
0.1 1.4 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.8 GO:0031209 SCAR complex(GO:0031209)
0.1 4.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.6 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.2 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 1.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 2.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.8 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.6 GO:0042581 specific granule(GO:0042581)
0.0 0.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)
0.0 0.2 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 3.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 1.6 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.1 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.4 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.5 3.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 1.8 GO:0019767 IgE receptor activity(GO:0019767)
0.3 4.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.3 2.3 GO:0032184 SUMO polymer binding(GO:0032184)
0.3 1.6 GO:0045322 unmethylated CpG binding(GO:0045322)
0.2 1.0 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.2 0.9 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.2 0.6 GO:0035717 chemokine (C-C motif) ligand 7 binding(GO:0035717)
0.2 0.8 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.2 0.7 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.2 0.7 GO:0051435 BH4 domain binding(GO:0051435)
0.1 0.4 GO:0003999 adenine binding(GO:0002055) adenine phosphoribosyltransferase activity(GO:0003999)
0.1 1.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 1.8 GO:0046790 virion binding(GO:0046790)
0.1 1.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.7 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 0.4 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 0.8 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.8 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 1.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.4 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.1 0.3 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.1 0.3 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.1 3.2 GO:0042056 chemoattractant activity(GO:0042056)
0.1 4.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.8 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.1 3.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.7 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 7.0 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 0.4 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 1.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.3 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 0.3 GO:0004883 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 1.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.6 GO:0051525 NFAT protein binding(GO:0051525)
0.0 1.5 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.0 0.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.3 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312) PTB domain binding(GO:0051425)
0.0 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 2.4 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 4.3 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.8 GO:0005521 lamin binding(GO:0005521)
0.0 0.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 1.6 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.4 GO:0030371 translation repressor activity(GO:0030371)
0.0 3.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.2 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 1.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 3.1 PID IL5 PATHWAY IL5-mediated signaling events
0.1 3.4 PID ARF6 PATHWAY Arf6 signaling events
0.1 3.2 PID RAS PATHWAY Regulation of Ras family activation
0.1 2.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 1.4 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 3.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 2.6 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 2.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 3.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 2.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.8 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.3 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.3 PID TNF PATHWAY TNF receptor signaling pathway
0.0 3.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.5 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 3.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.8 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 1.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.3 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 3.8 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 1.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 0.6 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 0.9 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.5 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.1 1.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.2 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 3.7 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.7 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.8 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.0 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 2.5 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.3 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA