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avrg: GFI1 WT vs 36n/n vs KD
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Results for Tbp
Z-value: 6.36
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Transcription factors associated with Tbp
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tbp | mm39_v1_chr17_+_15720150_15720222 | 0.55 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_23765546 Show fit | 17.50 |
ENSMUST00000102968.3
|
H4 clustered histone 4 |
|
| chr13_-_24118139 Show fit | 16.14 |
ENSMUST00000052776.4
|
H2B clustered histone 1 |
|
| chr13_+_23936250 Show fit | 14.57 |
ENSMUST00000091703.3
|
H3 clustered histone 2 |
|
| chr13_-_23882437 Show fit | 13.87 |
ENSMUST00000102967.3
|
H4 clustered histone 3 |
|
| chr13_-_23806530 Show fit | 13.30 |
ENSMUST00000062045.4
|
H1.4 linker histone, cluster member |
|
| chr6_-_72935382 Show fit | 12.55 |
ENSMUST00000144337.2
|
thymosin, beta 10 |
|
| chr13_+_21901791 Show fit | 12.35 |
ENSMUST00000188775.2
|
H3 clustered histone 10 |
|
| chr3_+_96154001 Show fit | 12.27 |
ENSMUST00000176059.2
ENSMUST00000177796.2 |
H3 clustered histone 14 |
|
| chr13_-_21934675 Show fit | 12.26 |
ENSMUST00000102983.2
|
H4 clustered histone 12 |
|
| chr3_+_96175970 Show fit | 11.41 |
ENSMUST00000098843.3
|
H3 clustered histone 13 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tbp
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.8 | GO:0051026 | chiasma assembly(GO:0051026) |
| 0.5 | 5.5 | GO:0002002 | regulation of angiotensin levels in blood(GO:0002002) |
| 0.7 | 5.2 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 0.1 | 4.0 | GO:0031424 | keratinization(GO:0031424) |
| 0.1 | 3.8 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.4 | 3.1 | GO:0034616 | response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499) |
| 0.2 | 2.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 2.8 | GO:0042129 | regulation of T cell proliferation(GO:0042129) |
| 0.8 | 2.4 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 0.3 | 2.4 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 7.9 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 7.9 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.1 | 3.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 2.7 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.2 | 2.4 | GO:0005883 | neurofilament(GO:0005883) |
| 0.1 | 1.8 | GO:0045120 | pronucleus(GO:0045120) |
| 0.4 | 1.6 | GO:0071821 | FANCM-MHF complex(GO:0071821) |
| 0.0 | 1.0 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 0.8 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.0 | 0.8 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.1 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.2 | 7.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 5.9 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 1.7 | 5.2 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 0.0 | 4.4 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.4 | 3.9 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.2 | 3.7 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 3.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 2.8 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 2.4 | GO:0015643 | toxic substance binding(GO:0015643) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 1.7 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 1.5 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.4 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.1 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 1.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.2 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 3.0 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 2.2 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 1.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.1 | REACTOME GRB2 EVENTS IN ERBB2 SIGNALING | Genes involved in GRB2 events in ERBB2 signaling |
| 0.0 | 1.1 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 1.0 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.0 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 0.8 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 0.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |