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avrg: GFI1 WT vs 36n/n vs KD

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Results for Tbx3

Z-value: 1.25

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Transcription factors associated with Tbx3

Gene Symbol Gene ID Gene Info
Tbx3
ENSMUSG00000018604.19 T-box 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx3mm39_v1_chr5_+_119808722_1198087410.932.2e-02Click!

Activity profile of Tbx3 motif

Sorted Z-values of Tbx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_60380243 1.39 ENSMUST00000195724.6
Mbnl1
muscleblind like splicing factor 1
chr1_-_31261678 0.97 ENSMUST00000187892.8
ENSMUST00000233331.2
4931428L18Rik
RIKEN cDNA 4931428L18 gene
chr10_+_75242745 0.82 ENSMUST00000039925.8
Upb1
ureidopropionase, beta
chr8_+_70107131 0.82 ENSMUST00000204285.3
Zfp964
zinc finger protein 964
chr17_-_59320257 0.77 ENSMUST00000174122.2
ENSMUST00000025065.12
Nudt12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr7_-_139941566 0.68 ENSMUST00000215023.2
ENSMUST00000216027.2
ENSMUST00000210932.3
ENSMUST00000211031.3
Olfr60
olfactory receptor 60
chr3_+_60380463 0.67 ENSMUST00000195077.6
ENSMUST00000193647.6
ENSMUST00000195001.2
ENSMUST00000192807.6
Mbnl1
muscleblind like splicing factor 1
chr10_+_56253418 0.55 ENSMUST00000068581.9
ENSMUST00000217789.2
Gja1
gap junction protein, alpha 1
chr2_-_90101376 0.49 ENSMUST00000216383.2
Olfr1271
olfactory receptor 1271
chr12_-_84408576 0.48 ENSMUST00000021659.2
ENSMUST00000065536.9
Fam161b
family with sequence similarity 161, member B
chr19_-_10434837 0.47 ENSMUST00000171400.4
Lrrc10b
leucine rich repeat containing 10B
chr19_+_5754395 0.44 ENSMUST00000052448.4
Kcnk7
potassium channel, subfamily K, member 7
chr2_-_88108746 0.40 ENSMUST00000216887.2
Olfr1173
olfactory receptor 1173
chr7_-_4525426 0.37 ENSMUST00000209148.2
ENSMUST00000098859.10
Tnni3
troponin I, cardiac 3
chr15_-_97806142 0.37 ENSMUST00000023119.15
Vdr
vitamin D (1,25-dihydroxyvitamin D3) receptor
chr8_-_96033213 0.36 ENSMUST00000119870.9
ENSMUST00000093268.5
Cngb1
cyclic nucleotide gated channel beta 1
chr13_-_23372145 0.36 ENSMUST00000228239.2
ENSMUST00000227950.2
ENSMUST00000226651.2
ENSMUST00000227679.2
ENSMUST00000228854.2
Vmn1r220
vomeronasal 1 receptor 220
chr2_+_154393691 0.24 ENSMUST00000104928.2
Actl10
actin-like 10
chr11_+_58549642 0.23 ENSMUST00000214392.2
Olfr322
olfactory receptor 322
chr11_+_73241609 0.19 ENSMUST00000120137.3
Olfr20
olfactory receptor 20
chr1_+_191307748 0.16 ENSMUST00000045450.7
Ints7
integrator complex subunit 7
chr7_-_4525793 0.16 ENSMUST00000140424.8
Tnni3
troponin I, cardiac 3
chr7_+_140500808 0.15 ENSMUST00000106045.8
ENSMUST00000183845.8
Nlrp6
NLR family, pyrin domain containing 6
chr1_-_191307648 0.14 ENSMUST00000027933.11
Dtl
denticleless E3 ubiquitin protein ligase
chr2_+_173561208 0.14 ENSMUST00000073081.6
1700010B08Rik
RIKEN cDNA 1700010B08 gene
chr16_-_19241884 0.14 ENSMUST00000206110.4
Olfr165
olfactory receptor 165
chr2_-_86061745 0.12 ENSMUST00000216056.2
Olfr1047
olfactory receptor 1047
chr7_+_43885573 0.12 ENSMUST00000223070.2
ENSMUST00000205530.2
Gm36864
predicted gene, 36864
chr3_+_89153258 0.12 ENSMUST00000040888.12
Krtcap2
keratinocyte associated protein 2
chr19_+_7471398 0.11 ENSMUST00000170373.9
ENSMUST00000236308.2
ENSMUST00000235557.2
Atl3
atlastin GTPase 3
chr9_+_37808020 0.07 ENSMUST00000086062.4
ENSMUST00000213688.2
Olfr145
olfactory receptor 145
chr14_+_67982630 0.06 ENSMUST00000223929.2
ENSMUST00000111095.4
Gnrh1
gonadotropin releasing hormone 1
chrX_-_20797736 0.05 ENSMUST00000001156.8
Cfp
complement factor properdin
chr10_-_18619439 0.04 ENSMUST00000019999.7
Arfgef3
ARFGEF family member 3
chr13_+_22574543 0.03 ENSMUST00000226157.2
ENSMUST00000227326.2
ENSMUST00000228726.2
Vmn1r200
vomeronasal 1 receptor 200
chr5_-_107074110 0.02 ENSMUST00000117588.8
Hfm1
HFM1, ATP-dependent DNA helicase homolog
chr7_+_28222261 0.01 ENSMUST00000078364.4
Ifnl3
interferon lambda 3
chr4_+_135487016 0.01 ENSMUST00000105854.2
Myom3
myomesin family, member 3
chr16_-_13548833 0.01 ENSMUST00000023364.7
Pla2g10
phospholipase A2, group X
chr3_-_87985602 0.01 ENSMUST00000050258.9
Ttc24
tetratricopeptide repeat domain 24
chr16_-_13548307 0.01 ENSMUST00000115807.9
Pla2g10
phospholipase A2, group X
chrX_-_133377225 0.00 ENSMUST00000009740.9
Taf7l
TATA-box binding protein associated factor 7 like
chr10_+_127350820 0.00 ENSMUST00000035735.11
Ndufa4l2
Ndufa4, mitochondrial complex associated like 2
chr6_-_97037366 0.00 ENSMUST00000089295.6
Tafa4
TAFA chemokine like family member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0010645 atrial ventricular junction remodeling(GO:0003294) regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.2 0.8 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.2 0.8 GO:0006742 NADP catabolic process(GO:0006742)
0.1 0.4 GO:0038183 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) bile acid signaling pathway(GO:0038183)
0.1 0.5 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.0 2.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.1 GO:2000354 regulation of ovarian follicle development(GO:2000354)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.4 GO:0001651 dense fibrillar component(GO:0001651)
0.0 0.6 GO:0005916 fascia adherens(GO:0005916) connexon complex(GO:0005922)
0.0 2.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.8 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.4 GO:1902271 lithocholic acid binding(GO:1902121) D3 vitamins binding(GO:1902271)
0.1 0.6 GO:1903763 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.1 0.5 GO:0030172 troponin C binding(GO:0030172)
0.0 0.4 GO:0043855 cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.6 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels