Project

avrg: GFI1 WT vs 36n/n vs KD

Navigation
Downloads

Results for Tfap2e

Z-value: 1.41

Motif logo

logo of

Transcription factors associated with Tfap2e

Gene Symbol Gene ID Gene Info
Tfap2e
ENSMUSG00000042477.8 transcription factor AP-2, epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tfap2emm39_v1_chr4_-_126630028_1266300390.059.3e-01Click!

Activity profile of Tfap2e motif

Sorted Z-values of Tfap2e motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_45120895 1.39 ENSMUST00000120531.8
ENSMUST00000143376.8
Stxbp6
syntaxin binding protein 6 (amisyn)
chr2_-_38177359 1.03 ENSMUST00000102787.10
Dennd1a
DENN/MADD domain containing 1A
chr11_-_51647204 0.93 ENSMUST00000109092.8
ENSMUST00000064297.5
Sec24a
Sec24 related gene family, member A (S. cerevisiae)
chr14_+_57124028 0.90 ENSMUST00000223669.2
Zmym2
zinc finger, MYM-type 2
chr13_+_38009981 0.90 ENSMUST00000110238.10
Rreb1
ras responsive element binding protein 1
chr14_+_51648277 0.80 ENSMUST00000159674.4
ENSMUST00000163019.9
ENSMUST00000233394.2
ENSMUST00000232951.2
ENSMUST00000232797.2
ENSMUST00000233766.2
ENSMUST00000233848.2
ENSMUST00000233280.2
ENSMUST00000233920.2
ENSMUST00000233126.2
ENSMUST00000233651.2
Vmn2r88
vomeronasal 2, receptor 88
chr9_+_109760931 0.74 ENSMUST00000165876.8
Map4
microtubule-associated protein 4
chr6_-_39702127 0.73 ENSMUST00000101497.4
Braf
Braf transforming gene
chr9_+_109760856 0.72 ENSMUST00000169851.8
Map4
microtubule-associated protein 4
chr3_-_94693740 0.71 ENSMUST00000153263.9
ENSMUST00000107272.7
ENSMUST00000155485.4
Cgn
cingulin
chr9_+_108394005 0.65 ENSMUST00000195563.6
Qrich1
glutamine-rich 1
chr18_+_82928782 0.65 ENSMUST00000235793.2
Zfp516
zinc finger protein 516
chr2_+_181632922 0.57 ENSMUST00000071760.8
ENSMUST00000236373.2
ENSMUST00000184507.3
Gm14496
predicted gene 14496
chr4_+_148123554 0.55 ENSMUST00000141283.8
Mthfr
methylenetetrahydrofolate reductase
chr11_+_101151394 0.55 ENSMUST00000103108.8
Wnk4
WNK lysine deficient protein kinase 4
chr18_+_82929451 0.53 ENSMUST00000235902.2
Zfp516
zinc finger protein 516
chr12_-_76756772 0.53 ENSMUST00000166101.2
Sptb
spectrin beta, erythrocytic
chr13_+_43276323 0.51 ENSMUST00000136576.8
Phactr1
phosphatase and actin regulator 1
chrX_+_72760183 0.50 ENSMUST00000002084.14
Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr15_-_103242697 0.47 ENSMUST00000229373.2
Zfp385a
zinc finger protein 385A
chr9_+_21077010 0.45 ENSMUST00000039413.15
Pde4a
phosphodiesterase 4A, cAMP specific
chr11_-_51647290 0.45 ENSMUST00000109097.9
Sec24a
Sec24 related gene family, member A (S. cerevisiae)
chr9_+_108394269 0.43 ENSMUST00000195513.6
ENSMUST00000193258.6
ENSMUST00000112155.9
ENSMUST00000006851.15
Qrich1
glutamine-rich 1
chrX_-_123045649 0.43 ENSMUST00000094491.5
Vmn2r121
vomeronasal 2, receptor 121
chr4_-_128699838 0.43 ENSMUST00000106072.9
ENSMUST00000170934.3
Zfp362
zinc finger protein 362
chr8_+_108020132 0.43 ENSMUST00000151114.8
ENSMUST00000125721.8
ENSMUST00000075922.11
Nfat5
nuclear factor of activated T cells 5
chr3_-_113423774 0.42 ENSMUST00000092154.10
ENSMUST00000106536.8
ENSMUST00000106535.2
Rnpc3
RNA-binding region (RNP1, RRM) containing 3
chr1_+_86082474 0.41 ENSMUST00000113309.9
ENSMUST00000186509.7
ENSMUST00000027434.15
ENSMUST00000131412.8
Armc9
armadillo repeat containing 9
chr6_-_136638926 0.40 ENSMUST00000032336.7
Plbd1
phospholipase B domain containing 1
chr9_+_100525807 0.39 ENSMUST00000133388.2
Stag1
stromal antigen 1
chr18_+_82928959 0.36 ENSMUST00000171238.8
Zfp516
zinc finger protein 516
chr8_+_41692755 0.36 ENSMUST00000210862.2
ENSMUST00000045218.9
ENSMUST00000211247.2
Pcm1
pericentriolar material 1
chr6_-_97594498 0.35 ENSMUST00000113355.9
Frmd4b
FERM domain containing 4B
chr6_+_108190163 0.34 ENSMUST00000203615.3
Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr5_-_109445510 0.33 ENSMUST00000167133.3
ENSMUST00000233141.2
ENSMUST00000233813.2
ENSMUST00000233282.2
Vmn2r15
vomeronasal 2, receptor 15
chr10_+_85763545 0.33 ENSMUST00000170396.3
Ascl4
achaete-scute family bHLH transcription factor 4
chr7_-_103832599 0.32 ENSMUST00000216612.3
Olfr648
olfactory receptor 648
chr2_+_102488985 0.31 ENSMUST00000080210.10
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr6_+_108190050 0.31 ENSMUST00000032192.9
Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr6_-_136804728 0.26 ENSMUST00000146348.4
Wbp11
WW domain binding protein 11
chr19_+_10611574 0.26 ENSMUST00000055115.9
Vwce
von Willebrand factor C and EGF domains
chr12_+_4967376 0.25 ENSMUST00000045664.7
Atad2b
ATPase family, AAA domain containing 2B
chr5_+_139186386 0.25 ENSMUST00000058716.14
ENSMUST00000110883.9
ENSMUST00000110884.9
ENSMUST00000100517.10
ENSMUST00000127045.8
ENSMUST00000143562.8
ENSMUST00000078690.13
ENSMUST00000146715.8
Sun1
Sad1 and UNC84 domain containing 1
chr9_+_100525501 0.24 ENSMUST00000146312.8
ENSMUST00000129269.8
Stag1
stromal antigen 1
chr6_-_137626207 0.24 ENSMUST00000134630.6
ENSMUST00000058210.13
ENSMUST00000111878.8
Eps8
epidermal growth factor receptor pathway substrate 8
chr8_+_108020092 0.24 ENSMUST00000169453.8
Nfat5
nuclear factor of activated T cells 5
chr2_-_129139125 0.23 ENSMUST00000052708.7
Ckap2l
cytoskeleton associated protein 2-like
chr9_+_108394351 0.22 ENSMUST00000192932.6
ENSMUST00000193348.2
ENSMUST00000194385.2
Qrich1
glutamine-rich 1
chr15_-_38299934 0.22 ENSMUST00000228772.2
Klf10
Kruppel-like factor 10
chr5_-_137312424 0.21 ENSMUST00000199121.2
Trip6
thyroid hormone receptor interactor 6
chr15_-_38300937 0.19 ENSMUST00000227920.2
ENSMUST00000074043.7
ENSMUST00000228416.2
Klf10
Kruppel-like factor 10
chr15_-_102433050 0.19 ENSMUST00000023814.9
Npff
neuropeptide FF-amide peptide precursor
chr19_+_42507198 0.19 ENSMUST00000026188.10
ENSMUST00000160107.2
ENSMUST00000160893.2
R3hcc1l
R3H domain and coiled-coil containing 1 like
chr9_+_100525637 0.18 ENSMUST00000041418.13
Stag1
stromal antigen 1
chr14_+_73380539 0.18 ENSMUST00000169513.8
ENSMUST00000165727.8
Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr3_+_89738654 0.16 ENSMUST00000050401.6
She
src homology 2 domain-containing transforming protein E
chr14_+_73380577 0.14 ENSMUST00000165567.8
ENSMUST00000022702.13
Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr4_-_57143437 0.14 ENSMUST00000095076.10
ENSMUST00000030142.4
Epb41l4b
erythrocyte membrane protein band 4.1 like 4b
chr7_-_116042674 0.13 ENSMUST00000170430.3
ENSMUST00000206219.2
Pik3c2a
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
chr13_+_38009951 0.12 ENSMUST00000138043.8
Rreb1
ras responsive element binding protein 1
chr8_-_85414528 0.11 ENSMUST00000001975.6
Nacc1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr7_-_19362328 0.11 ENSMUST00000141586.2
ENSMUST00000153309.8
Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr6_+_54016543 0.11 ENSMUST00000046856.14
Chn2
chimerin 2
chr3_+_60408600 0.10 ENSMUST00000099087.8
Mbnl1
muscleblind like splicing factor 1
chr5_-_146521629 0.10 ENSMUST00000200112.2
ENSMUST00000197431.2
ENSMUST00000197825.2
Gpr12
G-protein coupled receptor 12
chr3_-_88362606 0.10 ENSMUST00000125526.8
Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr7_+_24335969 0.09 ENSMUST00000080718.6
Lypd3
Ly6/Plaur domain containing 3
chr6_-_39702381 0.06 ENSMUST00000002487.15
Braf
Braf transforming gene
chr6_+_136804828 0.06 ENSMUST00000204086.2
BC049715
cDNA sequence BC049715
chr3_+_60408678 0.05 ENSMUST00000191747.6
ENSMUST00000194069.6
Mbnl1
muscleblind like splicing factor 1
chr3_+_103187162 0.05 ENSMUST00000106860.6
Trim33
tripartite motif-containing 33
chr14_-_24054927 0.04 ENSMUST00000145596.3
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr10_+_111919250 0.04 ENSMUST00000148897.8
ENSMUST00000020434.4
Glipr1l2
GLI pathogenesis-related 1 like 2
chrX_-_103024847 0.04 ENSMUST00000121153.8
ENSMUST00000070705.6
Rlim
ring finger protein, LIM domain interacting
chr13_-_53440087 0.03 ENSMUST00000021918.10
Ror2
receptor tyrosine kinase-like orphan receptor 2
chr11_-_59029996 0.03 ENSMUST00000219084.3
Obscn
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr9_+_108394761 0.03 ENSMUST00000192819.2
Qrich1
glutamine-rich 1
chr15_+_89383799 0.03 ENSMUST00000109309.9
Shank3
SH3 and multiple ankyrin repeat domains 3
chr7_-_44174065 0.02 ENSMUST00000165208.4
Mybpc2
myosin binding protein C, fast-type
chr11_-_100139728 0.02 ENSMUST00000007280.9
Krt16
keratin 16
chr15_+_80862074 0.02 ENSMUST00000229727.2
Sgsm3
small G protein signaling modulator 3
chr9_-_44366273 0.01 ENSMUST00000047740.4
Upk2
uroplakin 2
chr4_-_127247864 0.01 ENSMUST00000106090.8
ENSMUST00000060419.2
Gjb4
gap junction protein, beta 4
chr3_-_54962458 0.01 ENSMUST00000199352.2
ENSMUST00000198320.5
ENSMUST00000029368.7
Ccna1
cyclin A1
chr17_+_37356854 0.01 ENSMUST00000025338.16
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr17_-_64170786 0.01 ENSMUST00000050753.4
A930002H24Rik
RIKEN cDNA A930002H24 gene
chrX_+_12937714 0.01 ENSMUST00000169594.9
ENSMUST00000089302.11
Usp9x
ubiquitin specific peptidase 9, X chromosome
chr4_+_42158092 0.01 ENSMUST00000098122.3
Gm13306
predicted gene 13306
chr13_-_47259652 0.00 ENSMUST00000021807.13
ENSMUST00000135278.8
Dek
DEK proto-oncogene (DNA binding)
chr16_-_46317135 0.00 ENSMUST00000149901.2
ENSMUST00000096052.9
Nectin3
nectin cell adhesion molecule 3
chr11_-_109613040 0.00 ENSMUST00000020938.8
Fam20a
FAM20A, golgi associated secretory pathway pseudokinase
chr3_-_54962922 0.00 ENSMUST00000197238.5
Ccna1
cyclin A1
chr7_-_30298287 0.00 ENSMUST00000108150.2
Zbtb32
zinc finger and BTB domain containing 32
chr9_-_46146928 0.00 ENSMUST00000118649.8
Apoc3
apolipoprotein C-III

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2e

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0051012 microtubule sliding(GO:0051012)
0.2 1.4 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.2 1.0 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.0 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.5 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 1.4 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 0.6 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 0.4 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 0.6 GO:0090188 negative regulation of pancreatic juice secretion(GO:0090188)
0.1 0.8 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.6 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.2 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1 0.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.4 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.3 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.0 0.3 GO:0030473 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration(GO:0021817) nuclear migration along microtubule(GO:0030473) nuclear matrix organization(GO:0043578) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) nuclear matrix anchoring at nuclear membrane(GO:0090292) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 1.5 GO:0009409 response to cold(GO:0009409)
0.0 0.2 GO:0070253 somatostatin secretion(GO:0070253)
0.0 0.7 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.3 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.0 0.4 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 1.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.5 GO:0008091 spectrin(GO:0008091)
0.1 1.4 GO:0000145 exocyst(GO:0000145)
0.0 1.0 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.3 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.4 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.7 GO:0072686 mitotic spindle(GO:0072686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.4 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 1.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.6 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.4 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.6 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins