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avrg: GFI1 WT vs 36n/n vs KD

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Results for Trp63

Z-value: 0.73

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Transcription factors associated with Trp63

Gene Symbol Gene ID Gene Info
Trp63
ENSMUSG00000022510.15 transformation related protein 63

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trp63mm39_v1_chr16_+_25620652_256206780.894.2e-02Click!

Activity profile of Trp63 motif

Sorted Z-values of Trp63 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_55169000 0.61 ENSMUST00000153665.8
Hk3
hexokinase 3
chr17_+_29309942 0.59 ENSMUST00000119901.9
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr13_-_55169100 0.48 ENSMUST00000148221.8
ENSMUST00000052949.13
Hk3
hexokinase 3
chr4_-_133746138 0.42 ENSMUST00000051674.3
Lin28a
lin-28 homolog A (C. elegans)
chr11_-_101357046 0.42 ENSMUST00000040430.8
Vat1
vesicle amine transport 1
chr18_+_84106796 0.39 ENSMUST00000235383.2
Zadh2
zinc binding alcohol dehydrogenase, domain containing 2
chr12_-_107969853 0.38 ENSMUST00000066060.11
Bcl11b
B cell leukemia/lymphoma 11B
chr9_+_108437485 0.36 ENSMUST00000081111.14
ENSMUST00000193421.2
Impdh2
inosine monophosphate dehydrogenase 2
chr12_-_107969673 0.33 ENSMUST00000109887.8
ENSMUST00000109891.3
Bcl11b
B cell leukemia/lymphoma 11B
chr8_+_85412928 0.30 ENSMUST00000177531.8
Trmt1
tRNA methyltransferase 1
chr19_-_5925239 0.27 ENSMUST00000155227.2
Frmd8
FERM domain containing 8
chr6_-_11907392 0.26 ENSMUST00000204084.3
ENSMUST00000031637.8
ENSMUST00000204978.3
ENSMUST00000204714.2
Ndufa4
Ndufa4, mitochondrial complex associated
chr4_+_43493344 0.25 ENSMUST00000030181.12
ENSMUST00000107922.3
Ccdc107
coiled-coil domain containing 107
chr14_-_55114989 0.23 ENSMUST00000168622.2
ENSMUST00000177403.2
Ppp1r3e
protein phosphatase 1, regulatory subunit 3E
chr7_-_141023199 0.22 ENSMUST00000106005.9
Pidd1
p53 induced death domain protein 1
chr15_+_76580925 0.19 ENSMUST00000023203.6
Gpt
glutamic pyruvic transaminase, soluble
chr10_-_90918566 0.19 ENSMUST00000162618.8
ENSMUST00000020157.13
ENSMUST00000160788.2
Apaf1
apoptotic peptidase activating factor 1
chr7_+_101732323 0.18 ENSMUST00000124189.3
Trpc2
transient receptor potential cation channel, subfamily C, member 2
chr7_-_113853894 0.18 ENSMUST00000033012.9
Copb1
coatomer protein complex, subunit beta 1
chr9_+_121245036 0.18 ENSMUST00000211187.2
Trak1
trafficking protein, kinesin binding 1
chr14_-_31299275 0.18 ENSMUST00000112027.9
Colq
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr2_-_91795910 0.16 ENSMUST00000239257.2
Dgkz
diacylglycerol kinase zeta
chr6_+_4505493 0.12 ENSMUST00000031668.10
Col1a2
collagen, type I, alpha 2
chr7_-_125760164 0.11 ENSMUST00000164741.2
Xpo6
exportin 6
chrX_+_158039107 0.11 ENSMUST00000148570.8
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr7_+_24584197 0.10 ENSMUST00000156372.8
ENSMUST00000124035.2
Rps19
ribosomal protein S19
chr9_+_21498591 0.08 ENSMUST00000216160.2
Carm1
coactivator-associated arginine methyltransferase 1
chr19_-_5925296 0.08 ENSMUST00000025728.13
Frmd8
FERM domain containing 8
chr8_-_47805383 0.08 ENSMUST00000110367.10
Stox2
storkhead box 2
chr17_+_47983587 0.08 ENSMUST00000152724.2
Usp49
ubiquitin specific peptidase 49
chr8_-_86159398 0.07 ENSMUST00000047749.7
4921524J17Rik
RIKEN cDNA 4921524J17 gene
chr2_+_59442378 0.07 ENSMUST00000112568.8
ENSMUST00000037526.11
Tanc1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr17_-_84495364 0.07 ENSMUST00000060366.7
Zfp36l2
zinc finger protein 36, C3H type-like 2
chr1_-_9770434 0.06 ENSMUST00000088658.11
Mybl1
myeloblastosis oncogene-like 1
chr6_+_34686373 0.05 ENSMUST00000115021.8
Cald1
caldesmon 1
chr15_-_8739893 0.04 ENSMUST00000157065.2
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_180762587 0.03 ENSMUST00000037361.9
Lefty1
left right determination factor 1
chrX_+_158038915 0.03 ENSMUST00000112492.8
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr4_-_63414188 0.03 ENSMUST00000063650.10
ENSMUST00000102867.8
ENSMUST00000107393.8
ENSMUST00000084510.8
ENSMUST00000095038.8
ENSMUST00000119294.8
ENSMUST00000095037.2
ENSMUST00000063672.10
Whrn
whirlin
chr7_-_115637970 0.03 ENSMUST00000166877.8
Sox6
SRY (sex determining region Y)-box 6
chr4_-_140537957 0.02 ENSMUST00000026377.9
Padi3
peptidyl arginine deiminase, type III
chr6_+_34686543 0.02 ENSMUST00000031775.13
Cald1
caldesmon 1
chr2_+_65499097 0.02 ENSMUST00000200829.4
Scn2a
sodium channel, voltage-gated, type II, alpha
chrX_+_158038778 0.01 ENSMUST00000126686.8
ENSMUST00000033671.13
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr18_-_21433186 0.00 ENSMUST00000049260.7
Garem1
GRB2 associated regulator of MAPK1 subtype 1
chr2_+_119803230 0.00 ENSMUST00000229024.2
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr16_-_23749544 0.00 ENSMUST00000061030.10
Rtp2
receptor transporter protein 2
chr7_+_104700579 0.00 ENSMUST00000213204.2
Olfr677
olfactory receptor 677

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp63

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0097535 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.1 0.3 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 0.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.4 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.1 1.1 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.1 0.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.8 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.2 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.0 0.2 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.0 0.2 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0 0.1 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.0 0.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.2 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 0.2 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.1 GO:0005584 collagen type I trimer(GO:0005584)
0.0 0.2 GO:0043293 apoptosome(GO:0043293)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 1.1 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.4 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.3 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.2 GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635)
0.0 0.4 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.2 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.6 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport